IL144727A0 - Antitumor antisense sequences directed against r1 and r2 components of ribonucleotide reductase - Google Patents
Antitumor antisense sequences directed against r1 and r2 components of ribonucleotide reductaseInfo
- Publication number
- IL144727A0 IL144727A0 IL14472700A IL14472700A IL144727A0 IL 144727 A0 IL144727 A0 IL 144727A0 IL 14472700 A IL14472700 A IL 14472700A IL 14472700 A IL14472700 A IL 14472700A IL 144727 A0 IL144727 A0 IL 144727A0
- Authority
- IL
- Israel
- Prior art keywords
- components
- directed against
- antisense sequences
- ribonucleotide reductase
- sequences directed
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/111—Antisense spanning the whole gene, or a large part of it
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Public Health (AREA)
- Plant Pathology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Veterinary Medicine (AREA)
- Microbiology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/249,730 US6121000A (en) | 1999-02-11 | 1999-02-11 | Antitumor antisense sequences directed against R1 and R2 components of ribonucleotide reductase |
PCT/CA2000/000120 WO2000047733A1 (en) | 1999-02-11 | 2000-02-09 | Antitumor antisense sequences directed against r1 and r2 components of ribonucleotide reductase |
Publications (1)
Publication Number | Publication Date |
---|---|
IL144727A0 true IL144727A0 (en) | 2002-06-30 |
Family
ID=22944744
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL14472700A IL144727A0 (en) | 1999-02-11 | 2000-02-09 | Antitumor antisense sequences directed against r1 and r2 components of ribonucleotide reductase |
Country Status (17)
Country | Link |
---|---|
US (1) | US6121000A (de) |
EP (1) | EP1153128B8 (de) |
JP (1) | JP4424857B2 (de) |
KR (1) | KR20020013501A (de) |
CN (1) | CN1345373A (de) |
AR (1) | AR022583A1 (de) |
AT (1) | ATE309346T1 (de) |
AU (1) | AU780455B2 (de) |
BR (1) | BR0008788A (de) |
CA (1) | CA2366487A1 (de) |
DE (1) | DE60023845T2 (de) |
ES (1) | ES2259602T3 (de) |
IL (1) | IL144727A0 (de) |
MX (1) | MXPA01008137A (de) |
NZ (1) | NZ514090A (de) |
RU (1) | RU2001124840A (de) |
WO (1) | WO2000047733A1 (de) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6593305B1 (en) * | 1996-08-02 | 2003-07-15 | Genesense Technologies Inc. | Antitumor antisense sequences directed against R1 and R2 components of ribonucleotide reductase |
JP2006500910A (ja) | 2002-04-18 | 2006-01-12 | アキュイティ ファーマシューティカルズ、インク. | Cnsと眼の標的遺伝子を特異的に調節するための手段と方法及びその同定法 |
US7148342B2 (en) * | 2002-07-24 | 2006-12-12 | The Trustees Of The University Of Pennyslvania | Compositions and methods for sirna inhibition of angiogenesis |
EP1597365B1 (de) * | 2003-02-10 | 2013-10-09 | Lorus Therapeutics Inc. | Antisense-oligonukleotide gerichtet auf die ribonucleotid-reduktase r2 und deren verwendungen zur behandlung von krebs |
EP1615943A4 (de) * | 2003-04-18 | 2006-08-16 | Univ Pennsylvania | Zusammensetzung und verfahren for sirna-inhibierung von angiopoietin 1 und 2 und deren rezeptor tie2 |
CN1302936C (zh) * | 2003-05-02 | 2007-03-07 | 精工爱普生株式会社 | 打印机 |
WO2004104197A1 (en) * | 2003-05-21 | 2004-12-02 | Genesense Technologies Inc. | Antisense oligonucleotides directed to ribonucleotide reductase r1 and uses thereof in the treatment of cancer |
WO2004106518A1 (en) * | 2003-05-31 | 2004-12-09 | Genesense Technologies Inc. | Antisense oligonucleotides directed to ribonucleotide reductase r2 and uses thereof in the treatment of cancer |
EP1648914A4 (de) | 2003-07-31 | 2009-12-16 | Regulus Therapeutics Inc | Oligomere verbindungen und zusammensetzungen zur verwendung bei der modulierung von kleinen nicht-kodienderen rnas |
AU2005203822A1 (en) * | 2004-01-12 | 2005-07-21 | Lorus Therapeutics Inc. | Antisense oligonucleotides directed to ribonucleotide reductase R2 and uses thereof in combination therapies for the treatment of cancer |
EP1744761A4 (de) * | 2004-04-28 | 2010-01-13 | Molecules For Health Inc | Verfahren zur behandlung oder prävention von restenose und anderen proliferativen gefässstörungen |
ATE518954T1 (de) * | 2004-08-18 | 2011-08-15 | Lorus Therapeutics Inc | Kleine interferierende rna-moleküle gegen ribonukleotidreduktase und ihre verwendungen |
US20090130212A1 (en) * | 2006-05-15 | 2009-05-21 | Physical Pharmaceutica, Llc | Composition and improved method for preparation of small particles |
JP2009540011A (ja) * | 2006-06-12 | 2009-11-19 | エクセジェニックス、インク.ディー/ビー/エー オプコ ヘルス、インク. | 血管新生のsiRNA阻害のための組成物及び方法 |
US7872118B2 (en) * | 2006-09-08 | 2011-01-18 | Opko Ophthalmics, Llc | siRNA and methods of manufacture |
US20080305157A1 (en) * | 2007-06-08 | 2008-12-11 | University Of Maryland Office Of Technology Commercialization | Encapsulation and separation of charged organic solutes inside catanionic vesicles |
EP2030615A3 (de) * | 2007-08-13 | 2009-12-02 | ELFORD, Howard L. | Ribonukleotidreduktase-Inhibitoren zur Verwendung für die Behandlung oder Vorbeugung von Nervenentzündung- oder Autoimmunerkrankungen |
US20100204305A1 (en) * | 2007-12-11 | 2010-08-12 | Lorus Therapeutics Inc. | Small interfering rna molecules against ribonucleotide reductase and uses thereof |
CA2745832A1 (en) | 2008-12-04 | 2010-06-10 | Opko Ophthalmics, Llc | Compositions and methods for selective inhibition of pro-angiogenic vegf isoforms |
DE102019000490A1 (de) * | 2019-01-23 | 2020-07-23 | HAEMES Verwaltungsgesellschaft mbH | Verwendung von Oligonukleotiden für die Behandlung von Tumoren |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5034506A (en) * | 1985-03-15 | 1991-07-23 | Anti-Gene Development Group | Uncharged morpholino-based polymers having achiral intersubunit linkages |
US5023252A (en) * | 1985-12-04 | 1991-06-11 | Conrex Pharmaceutical Corporation | Transdermal and trans-membrane delivery of drugs |
US5703055A (en) * | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
US5225347A (en) * | 1989-09-25 | 1993-07-06 | Innovir Laboratories, Inc. | Therapeutic ribozyme compositions and expression vectors |
US5719262A (en) * | 1993-11-22 | 1998-02-17 | Buchardt, Deceased; Ole | Peptide nucleic acids having amino acid side chains |
US5766855A (en) * | 1991-05-24 | 1998-06-16 | Buchardt, Deceased; Ole | Peptide nucleic acids having enhanced binding affinity and sequence specificity |
US5681747A (en) * | 1992-03-16 | 1997-10-28 | Isis Pharmaceuticals, Inc. | Nucleic acid sequences encoding protein kinase C and antisense inhibition of expression thereof |
WO1994021661A1 (en) * | 1993-03-23 | 1994-09-29 | The Board Of Trustees Of The Leland Stanford Junior University | Cellular regulation with riboregulators |
EP0917569B1 (de) * | 1996-08-02 | 2005-11-09 | GeneSense Technologies Inc. | Antitumor antisense sequenzen gegen h1 und r2 verbindungen von ribonukleotide reductase |
-
1999
- 1999-02-11 US US09/249,730 patent/US6121000A/en not_active Expired - Fee Related
-
2000
- 2000-02-09 JP JP2000598631A patent/JP4424857B2/ja not_active Expired - Fee Related
- 2000-02-09 EP EP00903456A patent/EP1153128B8/de not_active Expired - Lifetime
- 2000-02-09 AU AU25292/00A patent/AU780455B2/en not_active Ceased
- 2000-02-09 KR KR1020017010204A patent/KR20020013501A/ko not_active Application Discontinuation
- 2000-02-09 AT AT00903456T patent/ATE309346T1/de not_active IP Right Cessation
- 2000-02-09 ES ES00903456T patent/ES2259602T3/es not_active Expired - Lifetime
- 2000-02-09 CA CA002366487A patent/CA2366487A1/en not_active Abandoned
- 2000-02-09 WO PCT/CA2000/000120 patent/WO2000047733A1/en active IP Right Grant
- 2000-02-09 MX MXPA01008137A patent/MXPA01008137A/es not_active Application Discontinuation
- 2000-02-09 IL IL14472700A patent/IL144727A0/xx unknown
- 2000-02-09 CN CN00805667A patent/CN1345373A/zh active Pending
- 2000-02-09 NZ NZ514090A patent/NZ514090A/en not_active IP Right Cessation
- 2000-02-09 DE DE60023845T patent/DE60023845T2/de not_active Expired - Lifetime
- 2000-02-09 BR BR0008788-2A patent/BR0008788A/pt not_active Application Discontinuation
- 2000-02-09 RU RU2001124840/15A patent/RU2001124840A/ru unknown
- 2000-02-11 AR ARP000100613A patent/AR022583A1/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
MXPA01008137A (es) | 2004-08-12 |
RU2001124840A (ru) | 2004-03-27 |
JP2003500006A (ja) | 2003-01-07 |
WO2000047733A1 (en) | 2000-08-17 |
EP1153128B1 (de) | 2005-11-09 |
DE60023845T2 (de) | 2006-08-10 |
AU780455B2 (en) | 2005-03-24 |
JP4424857B2 (ja) | 2010-03-03 |
WO2000047733A9 (en) | 2001-03-15 |
US6121000A (en) | 2000-09-19 |
EP1153128A1 (de) | 2001-11-14 |
DE60023845D1 (de) | 2005-12-15 |
KR20020013501A (ko) | 2002-02-20 |
ES2259602T3 (es) | 2006-10-16 |
ATE309346T1 (de) | 2005-11-15 |
CN1345373A (zh) | 2002-04-17 |
AR022583A1 (es) | 2002-09-04 |
CA2366487A1 (en) | 2000-08-17 |
EP1153128B8 (de) | 2006-01-18 |
BR0008788A (pt) | 2001-11-06 |
NZ514090A (en) | 2005-01-28 |
AU2529200A (en) | 2000-08-29 |
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