IL144708A0 - Methods for the preparation of biphenyl isoxazole sulfonamide derivatives - Google Patents

Methods for the preparation of biphenyl isoxazole sulfonamide derivatives

Info

Publication number
IL144708A0
IL144708A0 IL14470800A IL14470800A IL144708A0 IL 144708 A0 IL144708 A0 IL 144708A0 IL 14470800 A IL14470800 A IL 14470800A IL 14470800 A IL14470800 A IL 14470800A IL 144708 A0 IL144708 A0 IL 144708A0
Authority
IL
Israel
Prior art keywords
preparation
methods
sulfonamide derivatives
biphenyl isoxazole
biphenyl
Prior art date
Application number
IL14470800A
Other languages
English (en)
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of IL144708A0 publication Critical patent/IL144708A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/02—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof
    • C07C303/22—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof from sulfonic acids, by reactions not involving the formation of sulfo or halosulfonyl groups; from sulfonic halides by reactions not involving the formation of halosulfonyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/14—Nitrogen atoms
    • C07D261/16—Benzene-sulfonamido isoxazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/48—Nitrogen atoms not forming part of a nitro radical
    • C07D263/50—Benzene-sulfonamido oxazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL14470800A 1999-03-19 2000-03-02 Methods for the preparation of biphenyl isoxazole sulfonamide derivatives IL144708A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12514899P 1999-03-19 1999-03-19
PCT/US2000/005521 WO2000056685A1 (en) 1999-03-19 2000-03-02 Methods for the preparation of biphenyl isoxazole sulfonamides

Publications (1)

Publication Number Publication Date
IL144708A0 true IL144708A0 (en) 2002-06-30

Family

ID=22418402

Family Applications (1)

Application Number Title Priority Date Filing Date
IL14470800A IL144708A0 (en) 1999-03-19 2000-03-02 Methods for the preparation of biphenyl isoxazole sulfonamide derivatives

Country Status (11)

Country Link
US (1) US6313308B1 (es)
EP (1) EP1165472A4 (es)
JP (1) JP2002540088A (es)
KR (1) KR20020004974A (es)
AU (1) AU3718900A (es)
CA (1) CA2367916A1 (es)
HK (1) HK1039778A1 (es)
HU (1) HUP0201320A2 (es)
IL (1) IL144708A0 (es)
MX (1) MXPA01009362A (es)
WO (1) WO2000056685A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002540088A (ja) * 1999-03-19 2002-11-26 ブリストル−マイヤーズ スクイブ カンパニー ビフェニルイソキサゾール・スルホンアミド化合物の製造法
US6639082B2 (en) 2000-10-17 2003-10-28 Bristol-Myers Squibb Company Methods for the preparation of biphenyl isoxazole sulfonamides
US20040106663A1 (en) * 2002-09-06 2004-06-03 Talley John Jeffrey Inhibitors of fungal invasion

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB804036A (en) 1956-03-02 1958-11-05 Hoffmann La Roche A process for the manufacture of a sulphanilamide of the isoxazole series
DE1059459B (de) 1956-09-04 1959-06-18 Shionogi & Co Verfahren zur Herstellung des therapeutisch wertvollen 3-Sulfanilamido-5-methylisoxazols
US2888455A (en) 1956-09-04 1959-05-26 Shionogi & Co New sulfonamide and process for producing the same
CH364506A (de) 1956-09-04 1962-09-30 Shionogi & Co Verfahren zur Herstellung des therapeutisch wirksamen 3-Sulfanilamido-5-methyl-isoxazols
GB897440A (en) 1960-02-08 1962-05-30 Shionogi & Co Improvements in or relating to sulfonamides
GB1473433A (es) 1975-10-09 1977-05-11 Banyu Pharmaceutical Co Ltd Hi
US4415496A (en) 1981-03-23 1983-11-15 Merck & Co., Inc. Bicyclic lactams
EP0076072B1 (en) 1981-09-24 1987-05-13 BEECHAM - WUELFING GmbH & Co. KG Sulphonamides
US4661479A (en) 1982-02-19 1987-04-28 Merck And Co., Inc. Bicyclic lactams as antihypertensives
EP0194548A3 (de) 1985-03-12 1988-08-17 Dr. Karl Thomae GmbH Neue Sulfonylaminoäthylverbindungen, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
US5514691A (en) 1993-05-20 1996-05-07 Immunopharmaceutics, Inc. N-(4-halo-isoxazolyl)-sulfonamides and derivatives thereof that modulate the activity of endothelin
US5571821A (en) 1993-05-20 1996-11-05 Texas Biotechnology Corporation Sulfonamides and derivatives thereof that modulate the activity of endothelin
US5591761A (en) 1993-05-20 1997-01-07 Texas Biotechnology Corporation Thiophenyl-, furyl-and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
US5464853A (en) 1993-05-20 1995-11-07 Immunopharmaceutics, Inc. N-(5-isoxazolyl)biphenylsulfonamides, N-(3-isoxazolyl)biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin
CA2005741C (en) 1988-12-26 1998-06-02 Hiroyoshi Hidaka Quinoline sulfonoamino compounds having vessel smooth muscle relaxation activity
US5082838A (en) 1989-06-21 1992-01-21 Takeda Chemical Industries, Ltd. Sulfur-containing fused pyrimidine derivatives, their production and use
DE122007000050I1 (de) 1990-02-19 2007-11-08 Novartis Ag Acylverbindungen
EP0523141A4 (en) 1990-03-30 1993-04-21 Merck & Co. Inc. Substituted pyrazoles, isoxazoles and isothiazoles
US5236928A (en) 1991-03-19 1993-08-17 Merck & Co., Inc. Imidazole derivatives bearing acidic functional groups at the 5-position, their compositions and methods of use as angiotensin II antagonists
TW270116B (es) 1991-04-25 1996-02-11 Hoffmann La Roche
RU2086544C1 (ru) 1991-06-13 1997-08-10 Хоффманн-Ля Рош АГ Бензолсульфонамидные производные пиримидина или их соли, фармацевтическая композиция для лечения заболеваний, связанных с активностью эндотелина
RU2125980C1 (ru) 1991-11-05 1999-02-10 Смитклайн Бичам Корпорейшн Антагонисты эндотелиновых рецепторов, фармкомпозиция, способ их получения, способ подавления эндотелиновых рецепторов
SE9103397D0 (sv) 1991-11-18 1991-11-18 Kabi Pharmacia Ab Nya substituerade salicylsyror
US5378715A (en) 1992-02-24 1995-01-03 Bristol-Myers Squibb Co. Sulfonamide endothelin antagonists
TW224462B (es) 1992-02-24 1994-06-01 Squibb & Sons Inc
TW215434B (es) 1992-03-07 1993-11-01 Hoechst Ag
US5514696A (en) 1992-05-06 1996-05-07 Bristol-Myers Squibb Co. Phenyl sulfonamide endothelin antagonists
NZ247440A (en) 1992-05-06 1995-04-27 Squibb & Sons Inc Phenyl sulphonamide derivatives, preparation and pharmaceutical compositions thereof
WO1993023404A1 (en) 1992-05-19 1993-11-25 Immunopharmaceutics, Inc. Compounds that modulate endothelin activity
TW287160B (es) 1992-12-10 1996-10-01 Hoffmann La Roche
US5594201A (en) 1993-05-10 1997-01-14 Reinert, Sr.; Gary L. Adjustable container set apparatus and method
ATE189217T1 (de) 1993-03-19 2000-02-15 Merck & Co Inc Phenoxyphenylessigsäurederivate
EP0626174A3 (en) 1993-04-21 1996-01-03 Takeda Chemical Industries Ltd Method and composition for the prophylaxis and / or treatment of underactive organs.
DE4321644A1 (de) 1993-06-30 1995-01-12 Nord Systemtechnik Vorrichtung zur Feststellung von Undichtigkeiten an Bauteilen
DE59409631D1 (de) 1993-07-15 2001-02-15 Hoffmann La Roche Pharmazeutische Kombination, die einen Hemmer des Renin-Angiotensin-Systems und einen Endothelin-Antagonisten enthält
US5965732A (en) 1993-08-30 1999-10-12 Bristol-Myers Squibb Co. Sulfonamide endothelin antagonists
GB9504854D0 (en) 1994-03-31 1995-04-26 Zeneca Ltd Nitrogen derivatives
GB9409618D0 (en) 1994-05-13 1994-07-06 Zeneca Ltd Pyridine derivatives
US5612359A (en) 1994-08-26 1997-03-18 Bristol-Myers Squibb Company Substituted biphenyl isoxazole sulfonamides
CA2168154A1 (en) 1995-02-06 1996-08-07 Natesan Murugesan Substituted biphenyl sulfonamide endothelin antagonists
US5780473A (en) * 1995-02-06 1998-07-14 Bristol-Myers Squibb Company Substituted biphenyl sulfonamide endothelin antagonists
DE19509950A1 (de) 1995-03-18 1996-09-19 Merck Patent Gmbh Endothelin-Rezeptor-Antagonisten
UA58494C2 (uk) 1995-06-07 2003-08-15 Зенека Лімітед Похідні n-гетероарилпіридинсульфонаміду, фармацевтична композиція, спосіб одержання та спосіб протидії впливам ендотеліну
GB9512697D0 (en) 1995-06-22 1995-08-23 Zeneca Ltd Heterocyclic compounds
US5846990A (en) 1995-07-24 1998-12-08 Bristol-Myers Squibb Co. Substituted biphenyl isoxazole sulfonamides
JPH09124620A (ja) * 1995-10-11 1997-05-13 Bristol Myers Squibb Co 置換ビフェニルスルホンアミドエンドセリン拮抗剤
US5580894A (en) 1996-01-11 1996-12-03 Howard University Isoxazolyl enaminones
US5856507A (en) * 1997-01-21 1999-01-05 Bristol-Myers Squibb Co. Methods for the preparation of biphenyl isoxazole sulfonamides
CZ263098A3 (cs) 1996-02-20 1999-05-12 Bristol-Myers Squibb Company Způsoby přípravy bifenylisoxazolsulfonamidů
US5846985A (en) 1997-03-05 1998-12-08 Bristol-Myers Squibb Co. Substituted biphenyl isoxazole sulfonamides
MY153569A (en) 1998-01-20 2015-02-27 Mitsubishi Tanabe Pharma Corp Inhibitors of ?4 mediated cell adhesion
JP2002540088A (ja) * 1999-03-19 2002-11-26 ブリストル−マイヤーズ スクイブ カンパニー ビフェニルイソキサゾール・スルホンアミド化合物の製造法

Also Published As

Publication number Publication date
JP2002540088A (ja) 2002-11-26
HUP0201320A2 (en) 2002-08-28
US6313308B1 (en) 2001-11-06
AU3718900A (en) 2000-10-09
HK1039778A1 (zh) 2002-05-10
EP1165472A4 (en) 2002-11-20
KR20020004974A (ko) 2002-01-16
WO2000056685A1 (en) 2000-09-28
MXPA01009362A (es) 2002-06-04
EP1165472A1 (en) 2002-01-02
CA2367916A1 (en) 2000-09-28

Similar Documents

Publication Publication Date Title
AU2001240115A1 (en) Method for the preparation of tetrahydrobenzothiepines
IL146579A0 (en) Process for the preparation of herbicidal derivatives
AU7902400A (en) Method for the preparation of 5-carboxyphthalide
IL187126A0 (en) Process for the preparation of 4 - haloalkylnicotinonitriles
HUP0401600A3 (en) Process for the preparation of 14-hydroxymorphine derivatives
AU2001273762A1 (en) Process for the preparation of (r)-2-alkyl-3-phenyl-1-propanols
AU2002238421A1 (en) Process for the preparation of phenethylamine derivatives
IL124542A0 (en) Methods for the preparation of biphenyl isoxazole sulfonamides
IL155318A0 (en) Methods for the preparation of biphenyl isoxazole sulfonamides
IL144708A0 (en) Methods for the preparation of biphenyl isoxazole sulfonamide derivatives
GB2363605B (en) Process for the preparation of alpha-aminoketone derivatives
AU8824201A (en) Process for the preparation of dinapsoline
IL190807A0 (en) Process for the preparation of 2-aminoethylpyridines
IL150897A0 (en) Process for the preparation of acetyl-amidiniophenylalanyl cyclohexylglycyl-pyridinioalaninamides
HUP0202865A3 (en) Process for the preparation of 2-cyanopyridines
IL138691A (en) Process for the preparation of 3-acyl-indoles
AU1130901A (en) Method for the preparation of 5-carboxyphthalide
AU5462901A (en) Process for the preparation of (pyridinylidene)-phthalides
HK1023337A1 (en) Process for the preparation of cyclopropylacetylene derivatives
ITMI992459A0 (it) Procedimento per la preparazione di marbofloxacina
IL146505A0 (en) Methods for the preparation of tetrahydroisoquinolinephenol derivatives
AU2002231651A1 (en) Process for the preparation of morpholinones
GB0012249D0 (en) Process for the preparation of 11-oxaprostaglandins
AU2002224900A1 (en) Method for the preparation of dichlorodiarylmethanes
ZA971289B (en) Methods for the preparation of biphenyl isoxazole sulfonamides