IL142647A0 - A method and kit for measuring proteasome activity - Google Patents

A method and kit for measuring proteasome activity

Info

Publication number
IL142647A0
IL142647A0 IL14264799A IL14264799A IL142647A0 IL 142647 A0 IL142647 A0 IL 142647A0 IL 14264799 A IL14264799 A IL 14264799A IL 14264799 A IL14264799 A IL 14264799A IL 142647 A0 IL142647 A0 IL 142647A0
Authority
IL
Israel
Prior art keywords
proteasome activity
kit
methods
measuring
proteasome
Prior art date
Application number
IL14264799A
Other languages
English (en)
Original Assignee
Millenium Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Millenium Pharmaceuticals Inc filed Critical Millenium Pharmaceuticals Inc
Publication of IL142647A0 publication Critical patent/IL142647A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
IL14264799A 1998-10-20 1999-10-19 A method and kit for measuring proteasome activity IL142647A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10491898P 1998-10-20 1998-10-20
US13138199P 1999-04-28 1999-04-28
PCT/US1999/024356 WO2000023614A1 (en) 1998-10-20 1999-10-19 Method for monitoring proteasome inhibitor drug action

Publications (1)

Publication Number Publication Date
IL142647A0 true IL142647A0 (en) 2002-03-10

Family

ID=26802081

Family Applications (2)

Application Number Title Priority Date Filing Date
IL14264799A IL142647A0 (en) 1998-10-20 1999-10-19 A method and kit for measuring proteasome activity
IL142647A IL142647A (en) 1998-10-20 2001-04-17 Method and kit for measuring proteasome activity

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL142647A IL142647A (en) 1998-10-20 2001-04-17 Method and kit for measuring proteasome activity

Country Status (15)

Country Link
US (1) US6613541B1 (ko)
EP (1) EP1123412B1 (ko)
JP (1) JP4503182B2 (ko)
KR (1) KR20010080267A (ko)
CN (1) CN1331752A (ko)
AT (1) ATE278803T1 (ko)
AU (1) AU762373B2 (ko)
BR (1) BR9914648A (ko)
CA (1) CA2347275C (ko)
DE (1) DE69920940T2 (ko)
ES (1) ES2228118T3 (ko)
HK (1) HK1040533A1 (ko)
IL (2) IL142647A0 (ko)
NZ (1) NZ511197A (ko)
WO (1) WO2000023614A1 (ko)

Families Citing this family (43)

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Publication number Priority date Publication date Assignee Title
ATE338564T1 (de) 2000-10-12 2006-09-15 Viromics Gmbh Proteasome inhibitoren zur behandlung von hepatitis-virus infektionen
DE10051716A1 (de) * 2000-10-12 2002-04-25 Ulrich Schubert Mittel zur Hemmung der Freisetzung, Reifung und Replikation von Retroviren
WO2002047610A2 (en) 2000-11-16 2002-06-20 The Regents Of The University Of California Marine actinomycete taxon for drug and fermentation product dicovery
EP1472238B1 (en) * 2002-02-01 2012-07-04 Promega Corporation Bioluminescent protease assay
DE50313092D1 (de) 2002-04-05 2010-10-28 Virologik Gmbh Mittel zur behandlung von flaviviridae-infektionen
US7176232B2 (en) 2002-06-24 2007-02-13 The Regents Of The University Of California Salinosporamides and methods for use thereof
DE10232902A1 (de) * 2002-07-19 2004-01-29 Bayer Cropscience Ag Verfahren zum Identifizieren von Inhibitoren des 20S und 26S Proteasoms
DE602004031614D1 (de) 2003-06-20 2011-04-14 Nereus Pharmaceuticals Inc Verwendung von (3.2.0) heterocyclischen verbindungen und ihren analoga zur behandlung von krebs
ZA200600473B (en) 2003-06-20 2007-04-25 Univ California Salinosporamides and methods for use thereof
ATE410691T1 (de) * 2003-08-08 2008-10-15 Hoffmann La Roche Verwendung des proteins proteasome aktivator untereinheit 3 als marker für kolorektale karzinome
US7576206B2 (en) 2003-08-14 2009-08-18 Cephalon, Inc. Proteasome inhibitors and methods of using the same
US7223745B2 (en) 2003-08-14 2007-05-29 Cephalon, Inc. Proteasome inhibitors and methods of using the same
US7416854B2 (en) 2004-01-22 2008-08-26 Promega Corporation Luminogenic and nonluminogenic multiplex assay
US7553632B2 (en) 2004-01-22 2009-06-30 Promega Corporation Luminogenic and nonluminogenic multiplex assay
WO2005105827A2 (en) * 2004-04-15 2005-11-10 Proteolix, Inc. Compounds for proteasome enzyme inhibition
US8198270B2 (en) * 2004-04-15 2012-06-12 Onyx Therapeutics, Inc. Compounds for proteasome enzyme inhibition
US7579371B2 (en) 2004-04-30 2009-08-25 Nereus Pharmaceuticals, Inc. Methods of using [3.2.0] heterocyclic compounds and analogs thereof
BRPI0509824A (pt) 2004-04-30 2007-10-09 Nereus Pharmaceuticals Inc compostos heterocìclicos [3.2.0] e métodos de uso dos mesmos
US8088741B2 (en) * 2004-05-10 2012-01-03 Onyx Therapeutics, Inc. Compounds for enzyme inhibition
WO2006045066A2 (en) * 2004-10-20 2006-04-27 Proteolix, Inc. Labeled compounds for proteasome inhibition
CN103230394B (zh) 2004-12-03 2016-04-20 达纳-法伯癌症研究公司 治疗肿瘤性疾病的化合物及其用途
US7468383B2 (en) 2005-02-11 2008-12-23 Cephalon, Inc. Proteasome inhibitors and methods of using the same
US20060193844A1 (en) * 2005-02-28 2006-08-31 Proteolix, Inc. Methods for enzyme inhibition
EP1929308A1 (en) * 2005-09-01 2008-06-11 Promega Corporation Cell-based luminogenic and nonluminogenic proteasome assays
PL1948678T3 (pl) 2005-11-09 2013-09-30 Onyx Therapeutics Inc Związki do hamowania enzymów
AR057227A1 (es) * 2005-12-09 2007-11-21 Centocor Inc Metodo para usar antagonistas de il6 con inhibidores del proteasoma
SI2041158T1 (sl) 2006-06-19 2013-09-30 Onyx Therapeutics, Inc. Peptidni epoksiketoni za inhibicijo proteasomov
US20080118940A1 (en) * 2006-11-22 2008-05-22 Maher Albitar Proteasomal peptidase activity and the use thereof in clinical applications
WO2008095195A2 (en) 2007-02-02 2008-08-07 Nereus Pharmaceuticals, Inc. Lyophilized formulations of salinosporamide a
EP2142665B1 (en) 2007-04-13 2013-11-27 Promega Corporation Luminescent live and dead cell assay
US8367617B2 (en) 2007-10-04 2013-02-05 Onyx Therapeutics, Inc. Crystalline peptide epoxy ketone protease inhibitors and the synthesis of amino acid keto-epoxides
US8394816B2 (en) 2007-12-07 2013-03-12 Irene Ghobrial Methods of using [3.2.0] heterocyclic compounds and analogs thereof in treating Waldenstrom's Macroglobulinemia
EP2276765A4 (en) 2008-05-12 2011-10-19 Nereus Pharmaceuticals Inc SALINOSPORAMIDE DERIVATIVES AS PROTEASOMAL HEMMER
JP5675629B2 (ja) 2008-10-21 2015-02-25 オニキス セラピューティクス， インク．Ｏｎｙｘ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． ペプチドエポキシケトンを用いた併用療法
AR075899A1 (es) 2009-03-20 2011-05-04 Onyx Therapeutics Inc Tripeptidos epoxicetonas cristalinos inhibidores de proteasa
US20110053199A1 (en) * 2009-08-25 2011-03-03 Quest Diagnostics Investments Incorporated Ubiquitin proteasome system profiling and the use thereof in clinical applications for cancer diagnosis
US20110053198A1 (en) * 2009-08-25 2011-03-03 Quest Diagnostics Investments Incorporated Ubiquitin proteasome system profiling and the use thereof in clinical applications for proliferative hematological disorders
US20110053197A1 (en) * 2009-08-25 2011-03-03 Quest Diagnostics Investments Incorporated Ubiquitin proteasome system profiling and the use thereof in clinical applications for cancer diagnosis
EP2498793B1 (en) 2009-11-13 2019-07-10 Onyx Therapeutics, Inc. Oprozomib for use in metastasis suppression
CA2785300A1 (en) 2009-12-22 2011-07-21 Cephalon, Inc. Proteasome inhibitors and processes for their preparation, purification and use
MX2012010017A (es) 2010-03-01 2012-10-01 Onyx Therapeutics Inc Compuestos de para la inhibicion de inmunoproteasomas.
MX2012011604A (es) 2010-04-07 2013-02-27 Onyx Therapeutics Inc Inhibidor de inmunoproteasoma de péptido epoxicetona cristalino.
US9309283B2 (en) 2012-07-09 2016-04-12 Onyx Therapeutics, Inc. Prodrugs of peptide epoxy ketone protease inhibitors

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5340736A (en) * 1991-05-13 1994-08-23 The President & Fellows Of Harvard College ATP-dependent protease and use of inhibitors for same in the treatment of cachexia and muscle wasting
EP0684829A4 (en) 1993-02-10 1997-05-21 Harvard College THE ROLE OF ATP-UBIQUITIN-DEPENDENT PROTEOLYSIS IN MHC-1 DEPENDENT ANTIGENT PRESENTATION AND RELATED INHIBITORS.
US5693617A (en) * 1994-03-15 1997-12-02 Proscript, Inc. Inhibitors of the 26s proteolytic complex and the 20s proteasome contained therein
US6660268B1 (en) 1994-03-18 2003-12-09 The President And Fellows Of Harvard College Proteasome regulation of NF-KB activity
US5574017A (en) 1994-07-05 1996-11-12 Gutheil; William G. Antibacterial agents
US6083903A (en) * 1994-10-28 2000-07-04 Leukosite, Inc. Boronic ester and acid compounds, synthesis and uses
US5614649A (en) 1994-11-14 1997-03-25 Cephalon, Inc. Multicatalytic protease inhibitors
US5804560A (en) * 1995-01-06 1998-09-08 Sibia Neurosciences, Inc. Peptide and peptide analog protease inhibitors
US6335358B1 (en) 1995-04-12 2002-01-01 President And Fellows Of Harvard College Lactacystin analogs
CA2219867A1 (en) * 1997-10-31 1999-04-30 Jiangping Wu The use of proteasome inhibitors for treating cancer, inflammation, autoimmune disease, graft rejection and septic shock
US6617171B2 (en) 1998-02-27 2003-09-09 The General Hospital Corporation Methods for diagnosing and treating autoimmune disease
WO1999066065A2 (en) * 1998-06-13 1999-12-23 Zarpex Biosciences Limited Proteasomal activity

Also Published As

Publication number Publication date
EP1123412B1 (en) 2004-10-06
CA2347275C (en) 2010-03-09
WO2000023614A8 (en) 2000-07-13
ES2228118T3 (es) 2005-04-01
AU6433399A (en) 2000-05-08
US6613541B1 (en) 2003-09-02
DE69920940T2 (de) 2005-11-17
JP4503182B2 (ja) 2010-07-14
HK1040533A1 (zh) 2002-06-14
DE69920940D1 (de) 2004-11-11
WO2000023614A1 (en) 2000-04-27
BR9914648A (pt) 2001-11-27
CN1331752A (zh) 2002-01-16
EP1123412A1 (en) 2001-08-16
ATE278803T1 (de) 2004-10-15
CA2347275A1 (en) 2000-04-27
IL142647A (en) 2006-04-10
AU762373B2 (en) 2003-06-26
NZ511197A (en) 2003-08-29
KR20010080267A (ko) 2001-08-22
JP2002527114A (ja) 2002-08-27

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