IL141623A0 - Method of dna vaccination - Google Patents
Method of dna vaccinationInfo
- Publication number
- IL141623A0 IL141623A0 IL14162399A IL14162399A IL141623A0 IL 141623 A0 IL141623 A0 IL 141623A0 IL 14162399 A IL14162399 A IL 14162399A IL 14162399 A IL14162399 A IL 14162399A IL 141623 A0 IL141623 A0 IL 141623A0
- Authority
- IL
- Israel
- Prior art keywords
- compound
- mammal
- disease state
- antigenic peptide
- dna vaccination
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 238000011238 DNA vaccination Methods 0.000 title 1
- 241000124008 Mammalia Species 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 230000000890 antigenic effect Effects 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- XEDONBRPTABQFB-UHFFFAOYSA-N 4-[(2-formyl-3-hydroxyphenoxy)methyl]benzoic acid Chemical compound C1=CC(C(=O)O)=CC=C1COC1=CC=CC(O)=C1C=O XEDONBRPTABQFB-UHFFFAOYSA-N 0.000 abstract 1
- 230000024932 T cell mediated immunity Effects 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 230000028996 humoral immune response Effects 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229950009795 tucaresol Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/04—Mycobacterium, e.g. Mycobacterium tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
- A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16211—Lymphocryptovirus, e.g. human herpesvirus 4, Epstein-Barr Virus
- C12N2710/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Cell Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9818627.3A GB9818627D0 (en) | 1998-08-26 | 1998-08-26 | Improvements in dva vaccination |
PCT/EP1999/006217 WO2000012121A1 (en) | 1998-08-26 | 1999-08-25 | Method of dna vaccination |
Publications (1)
Publication Number | Publication Date |
---|---|
IL141623A0 true IL141623A0 (en) | 2002-03-10 |
Family
ID=10837881
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL14162399A IL141623A0 (en) | 1998-08-26 | 1999-08-25 | Method of dna vaccination |
Country Status (22)
Country | Link |
---|---|
US (1) | US7074770B1 (tr) |
EP (1) | EP1107785B1 (tr) |
JP (1) | JP2002523469A (tr) |
KR (1) | KR20010072983A (tr) |
CN (1) | CN1326358A (tr) |
AT (1) | ATE411043T1 (tr) |
AU (1) | AU747643B2 (tr) |
BR (1) | BR9913323A (tr) |
CA (1) | CA2341544A1 (tr) |
CZ (1) | CZ2001717A3 (tr) |
DE (1) | DE69939747D1 (tr) |
ES (1) | ES2313791T3 (tr) |
GB (1) | GB9818627D0 (tr) |
HU (1) | HUP0103214A3 (tr) |
IL (1) | IL141623A0 (tr) |
NO (1) | NO20010922L (tr) |
NZ (1) | NZ510206A (tr) |
OA (1) | OA11644A (tr) |
PL (1) | PL346299A1 (tr) |
TR (1) | TR200101256T2 (tr) |
WO (1) | WO2000012121A1 (tr) |
ZA (1) | ZA200101539B (tr) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7223739B1 (en) | 1995-06-07 | 2007-05-29 | Powderject Vaccines, Inc. | Adjuvanted genetic vaccines |
US7022320B1 (en) | 1999-02-09 | 2006-04-04 | Powderject Vaccines, Inc. | Mycobacterium tuberculosis immunization |
GB9923309D0 (en) * | 1999-10-01 | 1999-12-08 | Glaxo Group Ltd | Assay |
EP1913957B1 (en) * | 1999-11-03 | 2010-03-17 | Powderject Vaccines, Inc. | Adjuvanted genetic vaccines |
EP1227840B1 (en) * | 1999-11-03 | 2007-10-03 | Powderject Vaccines, Inc. | Adjuvanted genetic vaccines |
WO2001076626A2 (en) * | 2000-04-11 | 2001-10-18 | Galenica Pharmaceuticals, Inc. | Lipophilic aromatic aldehyde and ketone derivatives and the use thereof as immunostimulants and adjuvants |
GB0023008D0 (en) * | 2000-09-20 | 2000-11-01 | Glaxo Group Ltd | Improvements in vaccination |
AU2004251949B2 (en) * | 2003-06-27 | 2009-05-07 | Kyowa Hakko Kirin Co., Ltd. | Hsp90 family protein inhibitors |
CN100415876C (zh) * | 2003-09-05 | 2008-09-03 | 杭州浙大康泰生物技术有限公司 | 艾滋病重组腺病毒疫苗 |
CN102770156B (zh) | 2009-12-16 | 2016-01-20 | 克洛恩泰克制药股份公司 | 密码子优化的乙型肝炎病毒核心抗原(hbcag) |
US9457183B2 (en) | 2011-06-15 | 2016-10-04 | Tripep Ab | Injection needle and device |
SI3141542T1 (sl) | 2011-12-28 | 2020-11-30 | Global Blood Therapeutics, Inc. | Substituirane spojine benzaldehida in metode njihove uporabe pri povečanju oksigenacije tkiva |
WO2013102145A1 (en) | 2011-12-28 | 2013-07-04 | Global Blood Therapeutics, Inc. | Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation |
WO2014064534A2 (en) | 2012-10-05 | 2014-05-01 | Chrontech Pharma Ab | Injection needle, device, immunogenic compositions and method of use |
WO2014145040A1 (en) | 2013-03-15 | 2014-09-18 | Global Blood Therapeutics, Inc. | Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation |
US10266551B2 (en) | 2013-03-15 | 2019-04-23 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
CN105246477A (zh) | 2013-03-15 | 2016-01-13 | 全球血液疗法股份有限公司 | 化合物及其用于调节血红蛋白的用途 |
US9422279B2 (en) | 2013-03-15 | 2016-08-23 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
CN105073728A (zh) | 2013-03-15 | 2015-11-18 | 全球血液疗法股份有限公司 | 化合物及其用于调节血红蛋白的用途 |
US8952171B2 (en) | 2013-03-15 | 2015-02-10 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
KR101971385B1 (ko) | 2013-03-15 | 2019-04-22 | 글로벌 블러드 테라퓨틱스, 인크. | 헤모글로빈 조정을 위한 화합물 및 이의 용도 |
US9458139B2 (en) | 2013-03-15 | 2016-10-04 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
EA202092627A1 (ru) | 2013-11-18 | 2021-09-30 | Глобал Блад Терапьютикс, Инк. | Соединения и их применения для модуляции гемоглобина |
EA028529B1 (ru) | 2014-02-07 | 2017-11-30 | Глобал Блад Терапьютикс, Инк. | Кристаллические полиморфные формы свободного основания 2-гидрокси-6-((2-(1-изопропил-1н-пиразол-5-ил)пиридин-3-ил)метокси)бензальдегида |
EP3110448B1 (en) * | 2014-02-26 | 2020-09-09 | The Board of Regents of The University of Texas System | Nitrobenzaldehyde proton release for manipulation of cellular acidosis |
MY190034A (en) | 2015-03-06 | 2022-03-22 | Beyondspring Pharmaceuticals Inc | Method of treating cancer associated with a ras mutation |
US11267807B2 (en) * | 2015-10-28 | 2022-03-08 | The Brigham And Women's Hospital, Inc. | Use of small molecule inhibitors to KLF10 for modulation of T regulatory cells and cancer immunotherapy |
MX2018006832A (es) | 2015-12-04 | 2018-11-09 | Global Blood Therapeutics Inc | Regimenes de dosificacion de 2-hidroxi-6-((2-(1-isopropil-1h-piraz ol-5-il)-piridin-3-il)-metoxi)-benzaldehido. |
MX2018009413A (es) | 2016-02-08 | 2019-05-15 | Beyondspring Pharmaceuticals Inc | Composiciones que contienen tucaresol o sus analogos. |
TWI663160B (zh) | 2016-05-12 | 2019-06-21 | 全球血液治療公司 | 用於合成2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)-吡啶-3-基)甲氧基)苯甲醛之方法 |
TWI778983B (zh) | 2016-10-12 | 2022-10-01 | 美商全球血液治療公司 | 包含2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之片劑 |
EP3565812B1 (en) | 2017-01-06 | 2023-12-27 | Beyondspring Pharmaceuticals, Inc. | Tubulin binding compounds and therapeutic use thereof |
KR20200112881A (ko) | 2018-01-24 | 2020-10-05 | 비욘드스프링 파마수티컬스, 인코포레이티드. | 플리나불린의 투여를 통해 혈소판감소증을 감소시키는 조성물 및 방법 |
CN109232238B (zh) * | 2018-08-29 | 2022-05-17 | 北京勤邦生物技术有限公司 | 吉非罗齐半抗原、人工抗原和抗体及其制备方法和用途 |
EP3860975B1 (en) | 2018-10-01 | 2023-10-18 | Global Blood Therapeutics, Inc. | Modulators of hemoglobin for the treatment of sickle cell disease |
CN112778155B (zh) * | 2019-11-11 | 2023-08-11 | 大连万春布林医药有限公司 | 妥卡雷琐衍生物及其用途 |
US20230355557A1 (en) * | 2020-08-26 | 2023-11-09 | Gertrude Biomedical Pty Ltd | Antiviral sox inhibitors |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5620896A (en) * | 1992-03-23 | 1997-04-15 | University Of Massachusetts Medical Center | DNA vaccines against rotavirus infections |
DE69306545T2 (de) | 1992-10-01 | 1997-04-03 | Wellcome Found | Tucaresol als Mittel zur Immunopotentierung |
TW360548B (en) * | 1993-04-08 | 1999-06-11 | Powderject Res Ltd | Products for therapeutic use |
DE69536091D1 (de) | 1994-01-27 | 2010-09-09 | Univ Massachusetts Medical | Immunisierung durch Impfung von DNS Transkriptionseinheit |
-
1998
- 1998-08-26 GB GBGB9818627.3A patent/GB9818627D0/en not_active Ceased
-
1999
- 1999-08-25 DE DE69939747T patent/DE69939747D1/de not_active Expired - Lifetime
- 1999-08-25 KR KR1020017002431A patent/KR20010072983A/ko not_active Application Discontinuation
- 1999-08-25 AT AT99944505T patent/ATE411043T1/de not_active IP Right Cessation
- 1999-08-25 EP EP99944505A patent/EP1107785B1/en not_active Expired - Lifetime
- 1999-08-25 BR BR9913323-7A patent/BR9913323A/pt not_active IP Right Cessation
- 1999-08-25 CZ CZ2001717A patent/CZ2001717A3/cs unknown
- 1999-08-25 HU HU0103214A patent/HUP0103214A3/hu unknown
- 1999-08-25 JP JP2000567235A patent/JP2002523469A/ja active Pending
- 1999-08-25 OA OA1200100050A patent/OA11644A/en unknown
- 1999-08-25 CA CA002341544A patent/CA2341544A1/en not_active Abandoned
- 1999-08-25 AU AU57402/99A patent/AU747643B2/en not_active Ceased
- 1999-08-25 IL IL14162399A patent/IL141623A0/xx unknown
- 1999-08-25 ES ES99944505T patent/ES2313791T3/es not_active Expired - Lifetime
- 1999-08-25 US US09/763,462 patent/US7074770B1/en not_active Expired - Fee Related
- 1999-08-25 PL PL99346299A patent/PL346299A1/xx not_active Application Discontinuation
- 1999-08-25 WO PCT/EP1999/006217 patent/WO2000012121A1/en not_active Application Discontinuation
- 1999-08-25 TR TR2001/01256T patent/TR200101256T2/tr unknown
- 1999-08-25 NZ NZ510206A patent/NZ510206A/en unknown
- 1999-08-25 CN CN99812463A patent/CN1326358A/zh active Pending
-
2001
- 2001-02-23 ZA ZA200101539A patent/ZA200101539B/en unknown
- 2001-02-23 NO NO20010922A patent/NO20010922L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
BR9913323A (pt) | 2001-12-04 |
JP2002523469A (ja) | 2002-07-30 |
EP1107785A1 (en) | 2001-06-20 |
CN1326358A (zh) | 2001-12-12 |
EP1107785B1 (en) | 2008-10-15 |
HUP0103214A2 (hu) | 2001-12-28 |
TR200101256T2 (tr) | 2001-10-22 |
CA2341544A1 (en) | 2000-03-09 |
AU747643B2 (en) | 2002-05-16 |
NO20010922D0 (no) | 2001-02-23 |
PL346299A1 (en) | 2002-01-28 |
NO20010922L (no) | 2001-04-23 |
CZ2001717A3 (cs) | 2001-10-17 |
OA11644A (en) | 2004-11-22 |
ES2313791T3 (es) | 2009-03-01 |
DE69939747D1 (de) | 2008-11-27 |
ATE411043T1 (de) | 2008-10-15 |
WO2000012121A1 (en) | 2000-03-09 |
ZA200101539B (en) | 2002-02-25 |
US7074770B1 (en) | 2006-07-11 |
AU5740299A (en) | 2000-03-21 |
NZ510206A (en) | 2003-08-29 |
GB9818627D0 (en) | 1998-10-21 |
HUP0103214A3 (en) | 2003-10-28 |
KR20010072983A (ko) | 2001-07-31 |
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