IL138645A0 - Use of steroidal alkaloid derivatives as inhibitors of hedghog signalling pathways - Google Patents
Use of steroidal alkaloid derivatives as inhibitors of hedghog signalling pathwaysInfo
- Publication number
- IL138645A0 IL138645A0 IL13864599A IL13864599A IL138645A0 IL 138645 A0 IL138645 A0 IL 138645A0 IL 13864599 A IL13864599 A IL 13864599A IL 13864599 A IL13864599 A IL 13864599A IL 138645 A0 IL138645 A0 IL 138645A0
- Authority
- IL
- Israel
- Prior art keywords
- hedghog
- inhibitors
- signalling pathways
- steroidal alkaloid
- alkaloid derivatives
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8118698P | 1998-04-09 | 1998-04-09 | |
US8126398P | 1998-04-09 | 1998-04-09 | |
US09/090,622 US6432970B2 (en) | 1998-04-09 | 1998-06-04 | Inhibitors of hedgehog signaling pathways, compositions and uses related thereto |
PCT/US1999/007811 WO1999052534A1 (en) | 1998-04-09 | 1999-04-09 | Use of steroidal alkaloid derivatives as inhibitors of hedgehog signaling pathways |
Publications (1)
Publication Number | Publication Date |
---|---|
IL138645A0 true IL138645A0 (en) | 2001-10-31 |
Family
ID=27373925
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL13864599A IL138645A0 (en) | 1998-04-09 | 1999-04-09 | Use of steroidal alkaloid derivatives as inhibitors of hedghog signalling pathways |
IL138645A IL138645A (en) | 1998-04-09 | 2000-09-22 | Use in the history of alkaloid steroids as inhibitors of dejugate pathways |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL138645A IL138645A (en) | 1998-04-09 | 2000-09-22 | Use in the history of alkaloid steroids as inhibitors of dejugate pathways |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP1067939B1 (ja) |
JP (2) | JP5067986B2 (ja) |
AU (1) | AU768130B2 (ja) |
CA (1) | CA2326654C (ja) |
IL (2) | IL138645A0 (ja) |
WO (1) | WO1999052534A1 (ja) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7291626B1 (en) | 1998-04-09 | 2007-11-06 | John Hopkins University School Of Medicine | Inhibitors of hedgehog signaling pathways, compositions and uses related thereto |
WO2000015246A2 (en) | 1998-09-11 | 2000-03-23 | President And Fellows Of Harvard College | Regulation of lung tissue by hedgehog-like polypeptides, and formulations and uses related thereto |
AU2005201269C1 (en) * | 1999-01-13 | 2008-09-04 | Curis, Inc. | Regulators of the PCT or smoothened pathway, compositions and uses related thereto |
US6291516B1 (en) | 1999-01-13 | 2001-09-18 | Curis, Inc. | Regulators of the hedgehog pathway, compositions and uses related thereto |
GB0013674D0 (en) * | 1999-06-08 | 2000-07-26 | Lorantis Ltd | Therapeutic use |
ATE328002T1 (de) | 1999-10-13 | 2006-06-15 | Univ Johns Hopkins Med | Verbindungen zur regulierung des hedgehog- signalwegs, zusammensetzungen und verwendungen davon |
IL133809A0 (en) * | 1999-12-30 | 2001-04-30 | Yeda Res & Dev | Steroidal alkaloids and pharmaceutical compositions comprising them |
US20030022819A1 (en) * | 2000-06-16 | 2003-01-30 | Ling Leona E. | Angiogenesis-modulating compositions and uses |
WO2002030462A2 (en) * | 2000-10-13 | 2002-04-18 | Curis, Inc. | Hedgehog antagonists, methods and uses related thereto |
CA2452152A1 (en) | 2001-07-02 | 2002-10-10 | Sinan Tas | Use of cyclopamine in the treatment of psoriasis |
EP2216022B1 (en) * | 2001-07-02 | 2015-01-07 | Sinan Tas | Use of cyclopamine in the treatment of basal cell carcinoma and other tumors |
CA2483311A1 (en) * | 2002-04-22 | 2003-10-30 | Philip A. Beachy | Modulators of hedgehog signaling pathways, compositions and uses related thereto |
US8653083B2 (en) | 2005-08-22 | 2014-02-18 | The Johns Hopkins University | Hedgehog pathway antagonists to treat disease |
JP2009209099A (ja) * | 2008-03-05 | 2009-09-17 | Kumamoto Univ | 動脈硬化の予防・治療剤 |
BRPI0911618A2 (pt) | 2008-04-29 | 2019-09-24 | Lilly Co Eli | antagonistas da via hedgehog de ftalazina dissubstituída. |
EA018931B1 (ru) | 2008-11-03 | 2013-11-29 | Эли Лилли Энд Компани | ДИЗАМЕЩЕННЫЕ ФТАЛАЗИНЫ-АНТАГОНИСТЫ СИГНАЛЬНОГО ПУТИ Hedgehog |
CN102216285B (zh) | 2008-11-17 | 2014-08-13 | 伊莱利利公司 | 四取代的哒嗪hedgehog途径拮抗剂 |
KR101335770B1 (ko) | 2008-11-17 | 2013-12-12 | 일라이 릴리 앤드 캄파니 | 사치환된 피리다진 헷지호그 경로 길항제 |
JP2009143963A (ja) * | 2009-03-25 | 2009-07-02 | Sinan Tas | 腫瘍細胞のアポトーシスを阻害するためにヘッジホッグ/スムーズンド信号を使用する腫瘍を治療するための製薬組成物 |
AR077014A1 (es) | 2009-06-19 | 2011-07-27 | Lilly Co Eli | Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer |
FR2948367A1 (fr) | 2009-07-24 | 2011-01-28 | Centre Nat Rech Scient | Derives d'acyl-guanidines modulateurs de la voie de signalisation des proteines hedgehog |
FR2967498B1 (fr) | 2010-11-16 | 2015-01-02 | Centre Nat Rech Scient | Utilisation de derives de quinolinone comme outil de recherche |
AU2012268036B2 (en) * | 2011-06-06 | 2017-04-06 | THE UNITED STATES OF AMERICA as represented by THE SECRETARY OF STATE OF THE DEPARTMENT OF VETERANS AFFAIRS | Methods of inhibiting muscle atrophy |
FR2980477B1 (fr) | 2011-09-23 | 2013-10-18 | Centre Nat Rech Scient | Nouveaux composes modulateurs de la voie de signalisation des proteines hedgehog, leurs formes marquees, et applications |
JP2014028835A (ja) * | 2013-09-18 | 2014-02-13 | Sinan Tas | 基底細胞癌及び他の腫瘍の治療におけるシクロパミンの使用方法 |
CN106124677B (zh) * | 2015-12-31 | 2018-01-16 | 广西梧州制药(集团)股份有限公司 | 一种平贝母药材指纹图谱的建立方法 |
CN109879933B (zh) * | 2019-01-30 | 2023-06-06 | 河北科技大学 | 一类含磷酰基化合物及其应用 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES258451A1 (es) | 1960-04-01 | 1960-09-16 | Abbott Lab | Un metodo para obtener una composiciën farmaceutica en forma de dosificaciën oral |
US3121043A (en) | 1960-05-11 | 1964-02-11 | Scient Associates Inc | Sustained release pharmaceutical preparation and methods for making same |
AT280497B (de) * | 1968-03-05 | 1970-04-10 | Chemie Linz Ag | Verfahren zur Herstellung von neuen, ungesättigten Aminosteroiden |
AT300214B (de) * | 1970-04-24 | 1972-07-25 | Chemie Linz Ag | Verfahren zur Herstellung von Piperidylsteroiden |
NZ193564A (en) * | 1979-05-02 | 1985-01-31 | Aruba Pty Ltd | Steroid alkaloids from solanum sodomeum and pharmaceutical compositions |
US5026882A (en) * | 1988-12-23 | 1991-06-25 | Smithkline Beecham Corporation | Phosphinic acid substituted steroids as inhibitors of steroid 5α-reductase |
SG50585A1 (en) * | 1990-01-18 | 1998-07-20 | Cura Nominees Pty Ltd | Glycoalkaloids |
KR970005241B1 (ko) | 1990-07-18 | 1997-04-14 | 주식회사 엘지화학 | 두발화장품 조성물 |
JPH04230696A (ja) * | 1990-12-28 | 1992-08-19 | Sanwa Shiyouyaku Kk | 新規なステロイド系化合物および制癌剤 |
CA2184092A1 (en) | 1994-02-25 | 1995-08-31 | Thomas M. Jessell | Dna encoding the vertebrate homolog of hedgehog, vhh-1, expressed by the notochord, and uses thereof |
US6027882A (en) | 1994-10-07 | 2000-02-22 | The Regents Of The University Of California | Patched genes and their use for diagnostics |
AU7979998A (en) * | 1997-06-20 | 1999-01-04 | University Of Utah Research Foundation | Use of plant-alkaloids to enhance innate immunity defense mechanisms |
-
1999
- 1999-04-09 AU AU34860/99A patent/AU768130B2/en not_active Expired
- 1999-04-09 IL IL13864599A patent/IL138645A0/xx active IP Right Grant
- 1999-04-09 EP EP99916563.2A patent/EP1067939B1/en not_active Expired - Lifetime
- 1999-04-09 JP JP2000543144A patent/JP5067986B2/ja not_active Expired - Lifetime
- 1999-04-09 CA CA2326654A patent/CA2326654C/en not_active Expired - Lifetime
- 1999-04-09 WO PCT/US1999/007811 patent/WO1999052534A1/en active IP Right Grant
-
2000
- 2000-09-22 IL IL138645A patent/IL138645A/en not_active IP Right Cessation
-
2010
- 2010-10-08 JP JP2010228790A patent/JP2011037880A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
AU3486099A (en) | 1999-11-01 |
JP2002511415A (ja) | 2002-04-16 |
CA2326654C (en) | 2010-11-09 |
WO1999052534A1 (en) | 1999-10-21 |
JP2011037880A (ja) | 2011-02-24 |
AU768130B2 (en) | 2003-12-04 |
CA2326654A1 (en) | 1999-10-21 |
JP5067986B2 (ja) | 2012-11-07 |
EP1067939A1 (en) | 2001-01-17 |
EP1067939B1 (en) | 2015-09-16 |
IL138645A (en) | 2006-08-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FF | Patent granted | ||
KB | Patent renewed | ||
KB | Patent renewed |