IL138229A - Method and system for detecting nucleic acids - Google Patents

Method and system for detecting nucleic acids

Info

Publication number
IL138229A
IL138229A IL13822900A IL13822900A IL138229A IL 138229 A IL138229 A IL 138229A IL 13822900 A IL13822900 A IL 13822900A IL 13822900 A IL13822900 A IL 13822900A IL 138229 A IL138229 A IL 138229A
Authority
IL
Israel
Prior art keywords
nucleic acids
detecting nucleic
detecting
acids
nucleic
Prior art date
Application number
IL13822900A
Other languages
English (en)
Other versions
IL138229A0 (en
Inventor
Fernando Patolsky
Amir Lichtenstein
Itamar Willner
Original Assignee
Yissum Res Dev Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yissum Res Dev Co filed Critical Yissum Res Dev Co
Priority to IL13822900A priority Critical patent/IL138229A/xx
Priority to EP01961113A priority patent/EP1379684A2/fr
Priority to US10/363,644 priority patent/US20040023258A1/en
Priority to AU2001282491A priority patent/AU2001282491A1/en
Priority to JP2002525844A priority patent/JP2004526409A/ja
Priority to NZ524956A priority patent/NZ524956A/en
Priority to PCT/IL2001/000808 priority patent/WO2002020838A2/fr
Priority to CA002421204A priority patent/CA2421204A1/fr
Priority to MXPA03001879A priority patent/MXPA03001879A/es
Publication of IL138229A0 publication Critical patent/IL138229A0/xx
Publication of IL138229A publication Critical patent/IL138229A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6825—Nucleic acid detection involving sensors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00527—Sheets
    • B01J2219/00529—DNA chips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/0061—The surface being organic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00612—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports the surface being inorganic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00653—Making arrays on substantially continuous surfaces the compounds being bound to electrodes embedded in or on the solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00709—Type of synthesis
    • B01J2219/00713—Electrochemical synthesis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
IL13822900A 2000-09-04 2000-09-04 Method and system for detecting nucleic acids IL138229A (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
IL13822900A IL138229A (en) 2000-09-04 2000-09-04 Method and system for detecting nucleic acids
EP01961113A EP1379684A2 (fr) 2000-09-04 2001-08-29 Procede et systeme de detection d'acides nucleiques
US10/363,644 US20040023258A1 (en) 2000-09-04 2001-08-29 Method and system or detecting nucleic acids
AU2001282491A AU2001282491A1 (en) 2000-09-04 2001-08-29 Method and system for detecting nucleic acids
JP2002525844A JP2004526409A (ja) 2000-09-04 2001-08-29 核酸を検出するための方法およびシステム
NZ524956A NZ524956A (en) 2000-09-04 2001-08-29 Method and system for detecting nucleic acids
PCT/IL2001/000808 WO2002020838A2 (fr) 2000-09-04 2001-08-29 Procede et systeme de detection d'acides nucleiques
CA002421204A CA2421204A1 (fr) 2000-09-04 2001-08-29 Procede et systeme de detection d'acides nucleiques
MXPA03001879A MXPA03001879A (es) 2000-09-04 2001-08-29 Metodo y sistema para detectar acidos nucleicos.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL13822900A IL138229A (en) 2000-09-04 2000-09-04 Method and system for detecting nucleic acids

Publications (2)

Publication Number Publication Date
IL138229A0 IL138229A0 (en) 2001-10-31
IL138229A true IL138229A (en) 2005-03-20

Family

ID=11074586

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13822900A IL138229A (en) 2000-09-04 2000-09-04 Method and system for detecting nucleic acids

Country Status (9)

Country Link
US (1) US20040023258A1 (fr)
EP (1) EP1379684A2 (fr)
JP (1) JP2004526409A (fr)
AU (1) AU2001282491A1 (fr)
CA (1) CA2421204A1 (fr)
IL (1) IL138229A (fr)
MX (1) MXPA03001879A (fr)
NZ (1) NZ524956A (fr)
WO (1) WO2002020838A2 (fr)

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DE10221885B4 (de) * 2002-05-16 2005-12-29 Infineon Technologies Ag Sensor-Einheit, Sensor-Anordnung und Verfahren zum Betreiben einer Sensor-Einheit
DE10311315A1 (de) 2003-03-14 2004-09-30 Apibio Sas Verfahren und Vorrichtung zur Detektion von Biomolekülen
ATE481502T1 (de) * 2003-05-02 2010-10-15 Geneohm Sciences Elektrochemisches verfahren zur messung der bindung von dna an eine elektrodenoberfläche in gegenwart von molekularem sauerstoff
US7642064B2 (en) 2003-06-24 2010-01-05 Ventana Medical Systems, Inc. Enzyme-catalyzed metal deposition for the enhanced detection of analytes of interest
DE602004025371D1 (de) * 2003-11-10 2010-03-18 Geneohm Sciences Inc Nukleinsäurenachweisverfahren mit erhöhter empfindlichkeit
JP2006182757A (ja) * 2004-10-06 2006-07-13 Japan Science & Technology Agency π共役型電気化学活性非天然ヌクレオシドを用いる相補鎖核酸分子配列検出方法及びＳＮＰ検出方法
DE102005037436A1 (de) * 2005-08-04 2007-02-15 Siemens Ag Verfahren und System zur Konzentrationsbestimmung eines Analyt-Enzym-Komplexes oder Analyt-Enzym-Konjugats, insbesondere zur elektrochemischen Detektion des Analyten, und zugehörige Messvorrichtung
US20070231794A1 (en) * 2005-09-21 2007-10-04 Combimatrix Corporation Process to detect binding events on an electrode microarray using enzymes
US8855955B2 (en) * 2005-09-29 2014-10-07 Custom Array, Inc. Process and apparatus for measuring binding events on a microarray of electrodes
US7820391B2 (en) 2007-11-06 2010-10-26 Osmetech Molecular Diagnostics Baseless nucleotide analogues and uses thereof
CN101241125B (zh) * 2008-03-10 2013-02-13 施晓燕 一种用于液相测量的压电传感器及封装方法
US20100069253A1 (en) * 2008-09-12 2010-03-18 Gindilis Andrei L Impedance Spectroscopy Measurement of DNA
WO2011102065A1 (fr) * 2010-02-17 2011-08-25 株式会社 村田製作所 Procédé de détection utilisant un capteur de détection de masse
GB201207585D0 (en) 2012-05-01 2012-06-13 Isis Innovation An electrode and use thereof
JP2014006208A (ja) * 2012-06-27 2014-01-16 Nippon Dempa Kogyo Co Ltd 感知方法
JP2015529809A (ja) * 2012-07-27 2015-10-08 オームクス コーポレイション 酵素及び他の標的分析物の存在及び活性の切断前検出後の単分子層の電気測定
EP3121288A1 (fr) 2012-07-27 2017-01-25 Ohmx Corporation Mesures électroniques de monocouches à la suite de réactions homogènes de leurs composants
CN105593379A (zh) * 2013-08-07 2016-05-18 艾克泽基因公司 用辅助寡核苷酸电化学检测的系统、方法和装置
WO2015089178A1 (fr) 2013-12-12 2015-06-18 Hollister Incorporated Cathéter se désintégrant dans les toilettes
CA2933518C (fr) 2013-12-12 2020-12-08 Hollister Incorporated Catheters a jeter dans les toilettes
EP3079750B1 (fr) 2013-12-12 2020-05-27 Hollister Incorporated Cathéters pouvant être jetés dans les toilettes
DK3079749T3 (da) 2013-12-12 2019-12-16 Hollister Inc Udskyllelige katetre
CN105866226A (zh) * 2016-06-07 2016-08-17 辽宁科技大学 一种葡萄糖氧化酶生物传感器的制备及使用方法
JP6346242B2 (ja) * 2016-11-04 2018-06-20 株式会社東芝 核酸検出方法及びアッセイキット
CN112326763B (zh) * 2020-09-24 2022-10-21 福建医科大学附属第一医院 一种可用于临床样品等位基因分型的dna纳米筛可再生电化学传感器

Family Cites Families (10)

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Publication number Priority date Publication date Assignee Title
AU583258B2 (en) * 1983-12-16 1989-04-27 Medisense Inc. Assay for nucleic acids
US4851331A (en) * 1986-05-16 1989-07-25 Allied Corporation Method and kit for polynucleotide assay including primer-dependant DNA polymerase
EP0494896B1 (fr) * 1989-10-04 1994-07-06 E.I. Du Pont De Nemours And Company Methode d'analyse pour des complexes de cibles biologiques situes a la surface d'un capteur biologique
US5695926A (en) * 1990-06-11 1997-12-09 Bio Merieux Sandwich hybridization assays using very short capture probes noncovalently bound to a hydrophobic support
US5871906A (en) * 1991-11-08 1999-02-16 The Research Foundation Of State University Of New York Method for detection of amplified nucleic acid products and related diagnostic assays
DE69824716D1 (de) * 1997-04-01 2004-07-29 Manteia S A Methode zur sequenzierung von nukleinsäuren
EP1075541A1 (fr) * 1998-05-06 2001-02-14 Clinical Micro Sensors Detection electronique d'acides nucleiques a l'aide de monocouches
JP2002518998A (ja) * 1998-06-24 2002-07-02 セラセンス、インク． ヌクレオチドシーケンスの電気化学的認識用マルチセンサーアレイおよび方法
US6638716B2 (en) * 1998-08-24 2003-10-28 Therasense, Inc. Rapid amperometric verification of PCR amplification of DNA
US6361671B1 (en) * 1999-01-11 2002-03-26 The Regents Of The University Of California Microfabricated capillary electrophoresis chip and method for simultaneously detecting multiple redox labels

Also Published As

Publication number Publication date
WO2002020838A2 (fr) 2002-03-14
US20040023258A1 (en) 2004-02-05
CA2421204A1 (fr) 2002-03-14
EP1379684A2 (fr) 2004-01-14
MXPA03001879A (es) 2004-04-20
NZ524956A (en) 2005-01-28
AU2001282491A1 (en) 2002-03-22
IL138229A0 (en) 2001-10-31
JP2004526409A (ja) 2004-09-02
WO2002020838A3 (fr) 2003-10-23

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