IL137757A0 - Method of controlling proliferation and differentiation of stem and progenitor cells - Google Patents

Method of controlling proliferation and differentiation of stem and progenitor cells

Info

Publication number
IL137757A0
IL137757A0 IL13775799A IL13775799A IL137757A0 IL 137757 A0 IL137757 A0 IL 137757A0 IL 13775799 A IL13775799 A IL 13775799A IL 13775799 A IL13775799 A IL 13775799A IL 137757 A0 IL137757 A0 IL 137757A0
Authority
IL
Israel
Prior art keywords
stem
stem cells
differentiation
progenitor cells
expanded
Prior art date
Application number
IL13775799A
Other languages
English (en)
Original Assignee
Gamida Cell Ltd
Hadasit Med Res Service
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gamida Cell Ltd, Hadasit Med Res Service filed Critical Gamida Cell Ltd
Publication of IL137757A0 publication Critical patent/IL137757A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/20—Transition metals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/20—Transition metals
    • C12N2500/22—Zinc; Zn chelators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/125—Stem cell factor [SCF], c-kit ligand [KL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/145—Thrombopoietin [TPO]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/26—Flt-3 ligand (CD135L, flk-2 ligand)
IL13775799A 1998-02-17 1999-02-08 Method of controlling proliferation and differentiation of stem and progenitor cells IL137757A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2419598A 1998-02-17 1998-02-17
US13036798A 1998-08-07 1998-08-07
PCT/US1999/002664 WO1999040783A1 (fr) 1998-02-17 1999-02-08 Procede de lutte contre la proliferation et la differenciation de cellules souches et parentes

Publications (1)

Publication Number Publication Date
IL137757A0 true IL137757A0 (en) 2001-10-31

Family

ID=26698157

Family Applications (2)

Application Number Title Priority Date Filing Date
IL13775799A IL137757A0 (en) 1998-02-17 1999-02-08 Method of controlling proliferation and differentiation of stem and progenitor cells
IL137757A IL137757A (en) 1998-02-17 2000-08-08 Method of controlling proliferation and differentiation of stem and progenitor cells

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL137757A IL137757A (en) 1998-02-17 2000-08-08 Method of controlling proliferation and differentiation of stem and progenitor cells

Country Status (9)

Country Link
EP (2) EP1332673B1 (fr)
JP (1) JP3810273B2 (fr)
AT (1) ATE511752T1 (fr)
AU (1) AU759522C (fr)
CA (1) CA2320073C (fr)
ES (1) ES2391055T3 (fr)
HK (2) HK1034162A1 (fr)
IL (2) IL137757A0 (fr)
WO (1) WO1999040783A1 (fr)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6962698B1 (en) 1998-02-17 2005-11-08 Gamida Cell Ltd. Methods of controlling proliferation and differentiation of stem and progenitor cells
IL142094A0 (en) 1998-09-29 2002-03-10 Gamida Cell Ltd Methods of controlling proliferation and differentiation of stem and progenitor cells
NL1017973C2 (nl) * 2000-05-10 2002-11-08 Tristem Trading Cyprus Ltd Inrichting.
IL152904A0 (en) * 2002-01-24 2003-06-24 Gamida Cell Ltd Utilization of retinoid and vitamin d receptor antagonists for expansion of renewable stem cell populations
EP1465982A4 (fr) * 2002-01-25 2006-06-07 Gamida Cell Ltd Methodes de developpement de cellules souches et de cellules precurseurs, populations de cellules multipliees obtenues a l'aide de ces methodes
US20050054103A1 (en) * 2003-03-07 2005-03-10 Tony Peled Expansion of renewable stem cell populations using modulators of PI 3-kinase
WO2005007799A2 (fr) * 2003-07-17 2005-01-27 Gamida-Cell Ltd. Procedes de multiplication ex-vivo de cellules souches / progenitrices
IL161903A0 (en) * 2003-07-17 2005-11-20 Gamida Cell Ltd Ex vivo progenitor and stem cell expansion for usein the treatment of disease of endodermally- deri ved organs
US20050069553A1 (en) 2003-08-13 2005-03-31 Yi Zheng Chimeric peptides for the regulation of GTPases
US7417026B2 (en) 2003-08-13 2008-08-26 Children's Hospital Medical Center Mobilization of hematopoietic cells
WO2006030442A2 (fr) 2004-09-16 2006-03-23 Gamida-Cell Ltd. Methodes de culture ex vivo de cellules souches et de precurseur par co-culture avec des cellules mesenchymales
US8846393B2 (en) 2005-11-29 2014-09-30 Gamida-Cell Ltd. Methods of improving stem cell homing and engraftment
WO2007108689A2 (fr) * 2006-03-21 2007-09-27 Stichting Skeletal Tissue Engineering Nouveau procede d'induction de la differenciation de cellules souches et progenitrices
EP2228435A4 (fr) 2007-12-05 2013-01-23 Nissan Chemical Ind Ltd Procédé d'amplification d'une cellule souche hématopoïétique utilisant un composé hétérocyclique
JP5573160B2 (ja) 2007-12-05 2014-08-20 日産化学工業株式会社 ヘテロ環化合物による造血幹細胞の増幅方法
EP2233561A4 (fr) 2007-12-05 2013-01-16 Nissan Chemical Ind Ltd Procédé d'amplification d'une cellule souche hématopoïétique utilisant un composé hétérocyclique
WO2009072635A1 (fr) 2007-12-06 2009-06-11 Nissan Chemical Industries, Ltd. Procédé pour amplifier des cellules souches hématopoïétiques utilisant un composé hétérocyclique
WO2010140685A1 (fr) 2009-06-04 2010-12-09 日産化学工業株式会社 Composé hétérocyclique et amplificateur de cellules souches hématopoïétiques
EP2581442A4 (fr) 2010-06-14 2013-11-06 Nissan Chemical Ind Ltd Procédé de production de cellules souches hématopoïétiques
EP2647697B1 (fr) 2010-12-01 2016-08-24 Nissan Chemical Industries, Ltd. Procédé de production de cellules souches hématopoïétiques à l'aide d'un composé pyrazole
IN2014MN01680A (fr) 2012-02-13 2015-07-03 Gamida Cell Ltd
US9175266B2 (en) 2012-07-23 2015-11-03 Gamida Cell Ltd. Enhancement of natural killer (NK) cell proliferation and activity
US9567569B2 (en) 2012-07-23 2017-02-14 Gamida Cell Ltd. Methods of culturing and expanding mesenchymal stem cells
WO2021149127A1 (fr) * 2020-01-21 2021-07-29 オリンパス株式会社 Dispositif de surveillance de la différenciation érythroïde et procédé de surveillance de la différenciation érythroïde

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01222780A (ja) * 1988-03-02 1989-09-06 Tosoh Corp ウロキナーゼ前駆体様蛋白質のリフォールディング方法
US5631219A (en) * 1994-03-08 1997-05-20 Somatogen, Inc. Method of stimulating hematopoiesis with hemoglobin
CA2247926A1 (fr) * 1996-03-01 1997-09-04 Imclone Systems Incorporated Utilisation de proteines de type delta afin d'inhiber la differentiation de cellules souches
AU2260097A (en) * 1996-03-12 1997-10-01 Life Technologies, Inc. Hematopoietic cell culture nutrient supplement
US6962698B1 (en) * 1998-02-17 2005-11-08 Gamida Cell Ltd. Methods of controlling proliferation and differentiation of stem and progenitor cells
IL142094A0 (en) * 1998-09-29 2002-03-10 Gamida Cell Ltd Methods of controlling proliferation and differentiation of stem and progenitor cells

Also Published As

Publication number Publication date
EP1069821A4 (fr) 2001-11-21
CA2320073C (fr) 2011-11-01
HK1034162A1 (en) 2001-10-19
AU2662499A (en) 1999-08-30
IL137757A (en) 2006-08-20
JP3810273B2 (ja) 2006-08-16
EP1332673B1 (fr) 2012-05-30
AU759522B2 (en) 2003-04-17
EP1069821A1 (fr) 2001-01-24
HK1057976A1 (en) 2004-04-30
EP1069821B1 (fr) 2011-06-08
AU759522C (en) 2005-05-12
JP2002502617A (ja) 2002-01-29
EP1332673A1 (fr) 2003-08-06
ATE511752T1 (de) 2011-06-15
WO1999040783A1 (fr) 1999-08-19
CA2320073A1 (fr) 1999-08-19
ES2391055T3 (es) 2012-11-21

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