ATE511752T1 - Methode zur kontrolle der proliferation und differenzierung von stamm- und vorläuferzellen - Google Patents

Methode zur kontrolle der proliferation und differenzierung von stamm- und vorläuferzellen

Info

Publication number
ATE511752T1
ATE511752T1 AT99906799T AT99906799T ATE511752T1 AT E511752 T1 ATE511752 T1 AT E511752T1 AT 99906799 T AT99906799 T AT 99906799T AT 99906799 T AT99906799 T AT 99906799T AT E511752 T1 ATE511752 T1 AT E511752T1
Authority
AT
Austria
Prior art keywords
stem
stem cells
cells
progenicial
differentiation
Prior art date
Application number
AT99906799T
Other languages
English (en)
Inventor
Tony Peled
Eitan Fibach
Avi Treves
Mark Friedman
Original Assignee
Gamida Cell Ltd
Hadasit Med Res Service
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gamida Cell Ltd, Hadasit Med Res Service filed Critical Gamida Cell Ltd
Application granted granted Critical
Publication of ATE511752T1 publication Critical patent/ATE511752T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/20—Transition metals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/20—Transition metals
    • C12N2500/22—Zinc; Zn chelators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/125—Stem cell factor [SCF], c-kit ligand [KL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/145—Thrombopoietin [TPO]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/26—Flt-3 ligand (CD135L, flk-2 ligand)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Wood Science & Technology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
AT99906799T 1998-02-17 1999-02-08 Methode zur kontrolle der proliferation und differenzierung von stamm- und vorläuferzellen ATE511752T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2419598A 1998-02-17 1998-02-17
US13036798A 1998-08-07 1998-08-07
PCT/US1999/002664 WO1999040783A1 (en) 1998-02-17 1999-02-08 Method of controlling proliferation and differentiation of stem and progenitor cells

Publications (1)

Publication Number Publication Date
ATE511752T1 true ATE511752T1 (de) 2011-06-15

Family

ID=26698157

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99906799T ATE511752T1 (de) 1998-02-17 1999-02-08 Methode zur kontrolle der proliferation und differenzierung von stamm- und vorläuferzellen

Country Status (8)

Country Link
EP (2) EP1069821B1 (de)
JP (1) JP3810273B2 (de)
AT (1) ATE511752T1 (de)
AU (1) AU759522C (de)
CA (1) CA2320073C (de)
ES (1) ES2391055T3 (de)
IL (2) IL137757A0 (de)
WO (1) WO1999040783A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6962698B1 (en) 1998-02-17 2005-11-08 Gamida Cell Ltd. Methods of controlling proliferation and differentiation of stem and progenitor cells
BR9914465A (pt) 1998-09-29 2001-10-09 Gamida Cell Ltd Métodos para controlar a proliferação e a diferenciação de células-tronco e células progenitoras e uma composição farmacêutica para induzir a diferenciação em uma população de células
NL1017973C2 (nl) * 2000-05-10 2002-11-08 Tristem Trading Cyprus Ltd Inrichting.
IL152904A0 (en) * 2002-01-24 2003-06-24 Gamida Cell Ltd Utilization of retinoid and vitamin d receptor antagonists for expansion of renewable stem cell populations
EP1465982A4 (de) 2002-01-25 2006-06-07 Gamida Cell Ltd Verfahren zur expansion von stamm- und vorläuferzellen und damit erhaltene expandierte zellpopulationen
EP1601759A4 (de) * 2003-03-07 2007-02-14 Gamida Cell Ltd Expansion erneuerbarer stammzellpopulationen unter verwendung von modulatoren der pi-3-kinase
WO2005007799A2 (en) * 2003-07-17 2005-01-27 Gamida-Cell Ltd. Methods for ex-vivo expanding stem/progenitor cells
IL161903A0 (en) * 2003-07-17 2005-11-20 Gamida Cell Ltd Ex vivo progenitor and stem cell expansion for usein the treatment of disease of endodermally- deri ved organs
US20050069553A1 (en) 2003-08-13 2005-03-31 Yi Zheng Chimeric peptides for the regulation of GTPases
WO2005017160A2 (en) * 2003-08-13 2005-02-24 Children's Hospital Medical Center Mobilization of hematopoietic cells
WO2006030442A2 (en) 2004-09-16 2006-03-23 Gamida-Cell Ltd. Methods of ex vivo progenitor and stem cell expansion by co-culture with mesenchymal cells
US8846393B2 (en) 2005-11-29 2014-09-30 Gamida-Cell Ltd. Methods of improving stem cell homing and engraftment
WO2007108689A2 (en) * 2006-03-21 2007-09-27 Stichting Skeletal Tissue Engineering Method for induction of differentiation of stem and progenitor cells
US9115341B2 (en) 2007-12-05 2015-08-25 Nissan Chemical Industries, Ltd. Method for expanding hematopoietic stem cells using heterocyclic compound
US20100310536A1 (en) 2007-12-05 2010-12-09 Nissan Chemical Industries Limited Method for expanding hematopoietic stem cells using heterocyclic compound
WO2009072625A1 (ja) 2007-12-05 2009-06-11 Nissan Chemical Industries, Ltd. ヘテロ環化合物による造血幹細胞の増幅方法
BRPI0820915A8 (pt) 2007-12-06 2017-10-03 Reprocell Incorporated Método para expandir células-tronco hematopoéticas usando composto heterocíclico
US20120128640A1 (en) 2009-06-04 2012-05-24 Nissan Chemical Industries Ltd. Heterocyclic compounds and expansion agents for hematopoietic stem cells
WO2011158806A1 (ja) 2010-06-14 2011-12-22 日産化学工業株式会社 造血幹細胞の製造方法
EP2647697B1 (de) 2010-12-01 2016-08-24 Nissan Chemical Industries, Ltd. Verfahren zur herstellung hämatopoietischer stammzellen mithilfe einer pyrazolverbindung
US10047345B2 (en) 2012-02-13 2018-08-14 Gamida-Cell Ltd. Culturing of mesenchymal stem cells with FGF4 and nicotinamide
US9567569B2 (en) 2012-07-23 2017-02-14 Gamida Cell Ltd. Methods of culturing and expanding mesenchymal stem cells
US9175266B2 (en) 2012-07-23 2015-11-03 Gamida Cell Ltd. Enhancement of natural killer (NK) cell proliferation and activity
WO2021149127A1 (ja) * 2020-01-21 2021-07-29 オリンパス株式会社 赤血球分化モニタリング装置および赤血球分化モニタリング方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01222780A (ja) * 1988-03-02 1989-09-06 Tosoh Corp ウロキナーゼ前駆体様蛋白質のリフォールディング方法
US5631219A (en) * 1994-03-08 1997-05-20 Somatogen, Inc. Method of stimulating hematopoiesis with hemoglobin
WO1997031647A1 (en) * 1996-03-01 1997-09-04 Imclone Systems Incorporated Use of delta-like protein to inhibit the differentiation of stem cells
WO1997033978A1 (en) * 1996-03-12 1997-09-18 Life Technologies, Inc. Hematopoietic cell culture nutrient supplement
US6962698B1 (en) * 1998-02-17 2005-11-08 Gamida Cell Ltd. Methods of controlling proliferation and differentiation of stem and progenitor cells
BR9914465A (pt) * 1998-09-29 2001-10-09 Gamida Cell Ltd Métodos para controlar a proliferação e a diferenciação de células-tronco e células progenitoras e uma composição farmacêutica para induzir a diferenciação em uma população de células

Also Published As

Publication number Publication date
EP1069821A4 (de) 2001-11-21
AU759522C (en) 2005-05-12
JP3810273B2 (ja) 2006-08-16
EP1069821B1 (de) 2011-06-08
IL137757A (en) 2006-08-20
WO1999040783A1 (en) 1999-08-19
HK1034162A1 (en) 2001-10-19
CA2320073A1 (en) 1999-08-19
HK1057976A1 (en) 2004-04-30
EP1332673A1 (de) 2003-08-06
AU759522B2 (en) 2003-04-17
ES2391055T3 (es) 2012-11-21
EP1332673B1 (de) 2012-05-30
JP2002502617A (ja) 2002-01-29
AU2662499A (en) 1999-08-30
CA2320073C (en) 2011-11-01
EP1069821A1 (de) 2001-01-24
IL137757A0 (en) 2001-10-31

Similar Documents

Publication Publication Date Title
ATE511752T1 (de) Methode zur kontrolle der proliferation und differenzierung von stamm- und vorläuferzellen
DE69928678D1 (de) Verwendung von wachstumsfaktoren und hormonen zur vermehrung menschlicher chondrozyten und knorpelgewebeherstellung
IL163180A (en) Growing populations of renewable hematopoietic stem cells and their methods
DE69737949D1 (de) Isolierung, vermehrung und gezielte differenzierung von zäugetierstammzellen des zentralnervensystems
DK0904351T3 (da) Dyreceller og fremgangsmåder til replikationen af influenzavirus
MXPA99007026A (es) Metodo para proliferacion y diferenciacion de celulas hematopoieticas y mesenquimatosas.
DE69734766D1 (de) Hemmstoff und stimulator der proliferation haematopoietischer stammzellen und deren anwendungen
HUP0101547A2 (hu) Szilárd táptalajú fermentor, valamint fermentációs eljárás szilárd táptalajjal
DK0477290T3 (da) Fremgangsmåder, sammensætninger og indretninger til dyrkning af celler
ATE288481T1 (de) Verwendung von collagenase in der zubereitung von neuralen stammzellkulturen
NO20006096D0 (no) Medium for dyrking av dyreceller og fremgangsmåte for fremstilling av protein ved anvendelse av det samme
ATE513209T1 (de) Grenzflächen-patch-clamp-verfahren und -gerät
DE69806232D1 (de) Verfahren zur vermehrung von haaren
ATE309267T1 (de) Methode zur proliferation und differenzierung von b-zellen und verwendungen dafür
DK0954596T3 (da) Foröget produktion af taxaner ved celledyrkning af Taxus-art
WO2000070022A3 (en) Ex vivo expansion of mammalian hematopoietic stem cells
GB9825096D0 (en) Cells,culture methods and their uses
ATE449162T1 (de) Herstellung von tcr gamma delta t-zellen
ATE190654T1 (de) Verwendung von dna oligomeren zur hemmung von hiv durch reduktion ribosomaler leserasterverschichtung
FR2625221B1 (fr) Protoplastes stabilises et procede pour leur obtention
DK0755438T3 (da) Fremgangsmåde til bekæmpelse af metallophosphatpræcipitation i fermenteringer med høj celledensitet
ATE374243T1 (de) Knorpelzell-kulturmedium und verwendung desselben
DK1238057T3 (da) Fremgangsmåde til produktion af vedhæftende dyreceller
ATE290067T1 (de) Verfahren zur erhöhung der wachstumsrate von zellen in statischen flüssigmedien
GB9828624D0 (en) Production of proteins

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties