IL133303A0 - Use of a cd40: cd154 binding interruptor for inhibiting rejection of an insulin-producing tissue graft - Google Patents
Use of a cd40: cd154 binding interruptor for inhibiting rejection of an insulin-producing tissue graftInfo
- Publication number
- IL133303A0 IL133303A0 IL13330398A IL13330398A IL133303A0 IL 133303 A0 IL133303 A0 IL 133303A0 IL 13330398 A IL13330398 A IL 13330398A IL 13330398 A IL13330398 A IL 13330398A IL 133303 A0 IL133303 A0 IL 133303A0
- Authority
- IL
- Israel
- Prior art keywords
- insulin
- producing tissue
- graft
- compositions
- tissue graft
- Prior art date
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 6
- 102000004877 Insulin Human genes 0.000 title abstract 3
- 108090001061 Insulin Proteins 0.000 title abstract 3
- 229940125396 insulin Drugs 0.000 title abstract 3
- 230000002401 inhibitory effect Effects 0.000 title abstract 2
- 238000000034 method Methods 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 3
- 230000007547 defect Effects 0.000 abstract 2
- 206010012601 diabetes mellitus Diseases 0.000 abstract 2
- 206010052779 Transplant rejections Diseases 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 230000014101 glucose homeostasis Effects 0.000 abstract 1
- 230000001900 immune effect Effects 0.000 abstract 1
- 230000001771 impaired effect Effects 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 230000002503 metabolic effect Effects 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 230000004083 survival effect Effects 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Transplantation (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Orthopedics, Nursing, And Contraception (AREA)
- Steroid Compounds (AREA)
- External Artificial Organs (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5026797P | 1997-06-20 | 1997-06-20 | |
| US7726598P | 1998-03-09 | 1998-03-09 | |
| PCT/US1998/012892 WO1998058669A2 (en) | 1997-06-20 | 1998-06-19 | Cd154 blockade therapy for pancreatic islet tissue transplantation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL133303A0 true IL133303A0 (en) | 2001-04-30 |
Family
ID=26728084
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL13330398A IL133303A0 (en) | 1997-06-20 | 1998-06-19 | Use of a cd40: cd154 binding interruptor for inhibiting rejection of an insulin-producing tissue graft |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US20030072754A1 (ru) |
| EP (1) | EP1051191B1 (ru) |
| JP (1) | JP2002506446A (ru) |
| KR (1) | KR100634847B1 (ru) |
| CN (2) | CN1651919A (ru) |
| AT (1) | ATE339966T1 (ru) |
| AU (1) | AU730763B2 (ru) |
| BG (1) | BG64976B1 (ru) |
| BR (1) | BR9810620A (ru) |
| CA (1) | CA2294154A1 (ru) |
| DE (1) | DE69835965T2 (ru) |
| EA (1) | EA002550B1 (ru) |
| EE (1) | EE9900588A (ru) |
| HK (1) | HK1033548A1 (ru) |
| HU (1) | HUP0003160A3 (ru) |
| IL (1) | IL133303A0 (ru) |
| IS (1) | IS5273A (ru) |
| NO (1) | NO996275L (ru) |
| NZ (1) | NZ502052A (ru) |
| SK (1) | SK180299A3 (ru) |
| TR (1) | TR199903142T2 (ru) |
| WO (1) | WO1998058669A2 (ru) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999045958A1 (en) * | 1998-03-09 | 1999-09-16 | Biogen, Inc. | Cd154 blockade therapy for modulation of immune responses to implanted devices |
| AU2001251612A1 (en) | 2000-04-14 | 2001-10-30 | Millennium Pharmaceuticals, Inc. | Roles of jak/stat family members in tolerance induction |
| WO2001093908A1 (en) * | 2000-06-02 | 2001-12-13 | Regents Of The University Of Minnesota | Immunotherapeutic method to prevent islet cell rejection |
| US20020039577A1 (en) * | 2000-06-09 | 2002-04-04 | Townsend Robert M. | Methods for regulating a lymphocyte-mediated immune response by blocking costimulatory signals and blocking LFA-1 mediated adhesion in lymphocytes |
| DE602004029252D1 (de) * | 2003-06-13 | 2010-11-04 | Biogen Idec Inc | Aglycosyl-anti-cd154 (cd40-ligand) antikörper und deren verwendungen |
| GEP20105059B (en) | 2004-07-26 | 2010-08-10 | Biogen Idec Inc | Anti-cd154 antibodies |
| EP1814980B1 (en) * | 2004-11-22 | 2015-03-25 | Ramot at Tel-Aviv University Ltd. | Populations of expanded and re-differentiated adult islet beta cells capable of producing insulin and methods of generating same |
| US20070087029A1 (en) * | 2005-10-14 | 2007-04-19 | Pakala Syamasundar V | Localized delivery to the lymphatic system |
| US8372399B2 (en) | 2006-08-31 | 2013-02-12 | Cardiac Pacemakers, Inc. | Bispecific antibodies and agents to enhance stem cell homing |
| US8636995B2 (en) | 2006-08-31 | 2014-01-28 | Cardiac Pacemakers, Inc. | Methods and devices to regulate stem cell homing |
| EP2396348B1 (en) * | 2009-02-10 | 2015-04-08 | The Trustees of Columbia University in the City of New York | Compositions comprising hla-e for use in methods for inducing transplantation tolerance |
| WO2011146395A2 (en) | 2010-05-17 | 2011-11-24 | The Board Of Trustees Of The Leland Stanford Junior University | Prevention of immunological rejection of transplanted stem cells by leukocyte costimulatory molecule blockade |
| GB201403775D0 (en) | 2014-03-04 | 2014-04-16 | Kymab Ltd | Antibodies, uses & methods |
| US10147463B2 (en) | 2014-12-10 | 2018-12-04 | Nxp Usa, Inc. | Video processing unit and method of buffering a source video stream |
| US9512229B2 (en) | 2015-03-03 | 2016-12-06 | Kymab Limited | Synergistic combinations of OX40L antibodies for the treatment of GVHD |
| KR101810778B1 (ko) * | 2015-06-23 | 2017-12-20 | 서울대학교산학협력단 | Cd154 결합 폴리펩타이드 및 그 용도 |
| US10986309B2 (en) | 2015-06-30 | 2021-04-20 | Nxp Usa, Inc. | Video buffering and frame rate doubling device and method |
| EP3534947A1 (en) | 2016-11-03 | 2019-09-11 | Kymab Limited | Antibodies, combinations comprising antibodies, biomarkers, uses & methods |
| KR20210095781A (ko) | 2020-01-24 | 2021-08-03 | 주식회사 에이프릴바이오 | 항원결합 단편 및 생리활성 이펙터 모이어티로 구성된 융합 컨스트럭트를 포함하는 다중결합항체 및 이를 포함하는 약학조성물 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5227298A (en) * | 1990-08-17 | 1993-07-13 | The Trustees Of Columbia University In The City Of New York | Method for microencapuslation of cells or tissue |
| US5474771A (en) * | 1991-11-15 | 1995-12-12 | The Trustees Of Columbia University In The City Of New York | Murine monoclonal antibody (5c8) recognizes a human glycoprotein on the surface of T-lymphocytes, compositions containing same |
| US5683693A (en) * | 1994-04-25 | 1997-11-04 | Trustees Of Dartmouth College | Method for inducing T cell unresponsiveness to a tissue or organ graft with anti-CD40 ligand antibody or soluble CD40 |
| AU710998B2 (en) * | 1996-03-20 | 1999-10-07 | Bristol-Myers Squibb Company | Methods for inhibiting an immune response by blocking the GP39/CD40 and CTLA4 /CD28/B7 pathways and compositions for use therewith |
-
1998
- 1998-06-19 TR TR1999/03142T patent/TR199903142T2/xx unknown
- 1998-06-19 AU AU79830/98A patent/AU730763B2/en not_active Ceased
- 1998-06-19 DE DE69835965T patent/DE69835965T2/de not_active Expired - Fee Related
- 1998-06-19 CA CA002294154A patent/CA2294154A1/en not_active Abandoned
- 1998-06-19 EA EA200000058A patent/EA002550B1/ru not_active IP Right Cessation
- 1998-06-19 EP EP98930436A patent/EP1051191B1/en not_active Expired - Lifetime
- 1998-06-19 NZ NZ502052A patent/NZ502052A/xx unknown
- 1998-06-19 HU HU0003160A patent/HUP0003160A3/hu unknown
- 1998-06-19 CN CNA2005100079419A patent/CN1651919A/zh active Pending
- 1998-06-19 KR KR1019997011991A patent/KR100634847B1/ko not_active IP Right Cessation
- 1998-06-19 EE EEP199900588A patent/EE9900588A/xx unknown
- 1998-06-19 AT AT98930436T patent/ATE339966T1/de not_active IP Right Cessation
- 1998-06-19 JP JP50490799A patent/JP2002506446A/ja not_active Ceased
- 1998-06-19 IL IL13330398A patent/IL133303A0/xx unknown
- 1998-06-19 SK SK1802-99A patent/SK180299A3/sk unknown
- 1998-06-19 BR BR9810620-1A patent/BR9810620A/pt not_active Application Discontinuation
- 1998-06-19 CN CNB988064413A patent/CN1195546C/zh not_active Expired - Fee Related
- 1998-06-19 WO PCT/US1998/012892 patent/WO1998058669A2/en active IP Right Grant
-
1999
- 1999-11-26 IS IS5273A patent/IS5273A/is unknown
- 1999-12-17 NO NO996275A patent/NO996275L/no unknown
-
2000
- 2000-01-18 BG BG104091A patent/BG64976B1/bg unknown
-
2001
- 2001-04-18 HK HK01102744A patent/HK1033548A1/xx not_active IP Right Cessation
-
2002
- 2002-10-11 US US10/270,783 patent/US20030072754A1/en not_active Abandoned
-
2006
- 2006-12-13 US US11/638,244 patent/US20070292440A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| BG64976B1 (bg) | 2006-11-30 |
| AU7983098A (en) | 1999-01-04 |
| SK180299A3 (en) | 2000-06-12 |
| TR199903142T2 (xx) | 2000-09-21 |
| NZ502052A (en) | 2001-01-26 |
| EA002550B1 (ru) | 2002-06-27 |
| CN1195546C (zh) | 2005-04-06 |
| US20030072754A1 (en) | 2003-04-17 |
| KR100634847B1 (ko) | 2006-10-17 |
| CN1651919A (zh) | 2005-08-10 |
| WO1998058669A3 (en) | 1999-04-29 |
| NO996275L (no) | 2000-02-21 |
| CN1261286A (zh) | 2000-07-26 |
| ATE339966T1 (de) | 2006-10-15 |
| HUP0003160A2 (hu) | 2001-01-29 |
| NO996275D0 (no) | 1999-12-17 |
| HUP0003160A3 (en) | 2002-09-30 |
| KR20010013965A (ko) | 2001-02-26 |
| EE9900588A (et) | 2000-08-15 |
| DE69835965T2 (de) | 2007-06-14 |
| CA2294154A1 (en) | 1998-12-30 |
| WO1998058669A2 (en) | 1998-12-30 |
| DE69835965D1 (de) | 2006-11-02 |
| JP2002506446A (ja) | 2002-02-26 |
| AU730763B2 (en) | 2001-03-15 |
| US20070292440A1 (en) | 2007-12-20 |
| IS5273A (is) | 1999-11-26 |
| EP1051191A2 (en) | 2000-11-15 |
| BR9810620A (pt) | 2000-10-03 |
| BG104091A (en) | 2000-10-31 |
| EA200000058A1 (ru) | 2000-08-28 |
| EP1051191B1 (en) | 2006-09-20 |
| HK1033548A1 (en) | 2001-09-07 |
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