HK1033548A1 - Cd154 blockade therapy for pancreatic islet tissuetransplantation in primates - Google Patents

Cd154 blockade therapy for pancreatic islet tissuetransplantation in primates

Info

Publication number
HK1033548A1
HK1033548A1 HK01102744A HK01102744A HK1033548A1 HK 1033548 A1 HK1033548 A1 HK 1033548A1 HK 01102744 A HK01102744 A HK 01102744A HK 01102744 A HK01102744 A HK 01102744A HK 1033548 A1 HK1033548 A1 HK 1033548A1
Authority
HK
Hong Kong
Prior art keywords
graft
compositions
tissuetransplantation
primates
methods
Prior art date
Application number
HK01102744A
Other languages
English (en)
Inventor
Norma S Kenyon
Camillo Ricordi
David W Thomas
Linda Burkly
Original Assignee
Biogen Inc
Univ Miami
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogen Inc, Univ Miami filed Critical Biogen Inc
Publication of HK1033548A1 publication Critical patent/HK1033548A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Transplantation (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)
  • Steroid Compounds (AREA)
  • External Artificial Organs (AREA)
HK01102744A 1997-06-20 2001-04-18 Cd154 blockade therapy for pancreatic islet tissuetransplantation in primates HK1033548A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5026797P 1997-06-20 1997-06-20
US7726598P 1998-03-09 1998-03-09
PCT/US1998/012892 WO1998058669A2 (en) 1997-06-20 1998-06-19 Cd154 blockade therapy for pancreatic islet tissue transplantation

Publications (1)

Publication Number Publication Date
HK1033548A1 true HK1033548A1 (en) 2001-09-07

Family

ID=26728084

Family Applications (1)

Application Number Title Priority Date Filing Date
HK01102744A HK1033548A1 (en) 1997-06-20 2001-04-18 Cd154 blockade therapy for pancreatic islet tissuetransplantation in primates

Country Status (22)

Country Link
US (2) US20030072754A1 (ru)
EP (1) EP1051191B1 (ru)
JP (1) JP2002506446A (ru)
KR (1) KR100634847B1 (ru)
CN (2) CN1651919A (ru)
AT (1) ATE339966T1 (ru)
AU (1) AU730763B2 (ru)
BG (1) BG64976B1 (ru)
BR (1) BR9810620A (ru)
CA (1) CA2294154A1 (ru)
DE (1) DE69835965T2 (ru)
EA (1) EA002550B1 (ru)
EE (1) EE9900588A (ru)
HK (1) HK1033548A1 (ru)
HU (1) HUP0003160A3 (ru)
IL (1) IL133303A0 (ru)
IS (1) IS5273A (ru)
NO (1) NO996275L (ru)
NZ (1) NZ502052A (ru)
SK (1) SK180299A3 (ru)
TR (1) TR199903142T2 (ru)
WO (1) WO1998058669A2 (ru)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999045958A1 (en) * 1998-03-09 1999-09-16 Biogen, Inc. Cd154 blockade therapy for modulation of immune responses to implanted devices
WO2001079555A2 (en) 2000-04-14 2001-10-25 Millennium Pharmaceuticals, Inc. Roles of jak/stat family members in tolerance induction
CA2410786A1 (en) * 2000-06-02 2001-12-13 Regents Of The University Of Minnesota Immunotherapeutic method to prevent islet cell rejection
KR20030007899A (ko) * 2000-06-09 2003-01-23 브리스톨-마이어스스퀴브컴파니 림프구성 신호의 차단 및 ｌｆａ-1 매개 접착의 차단을통한 세포-매개 면역 반응의 조절 방법
NZ544486A (en) * 2003-06-13 2009-04-30 Biogen Idec Inc Aglycosyl anti-cd154 (cd40 ligand) antibodies and uses thereof
EP1791563A4 (en) 2004-07-26 2009-07-08 Biogen Idec Inc ANTI-CD154 ANTIBODIES
WO2006054305A2 (en) * 2004-11-22 2006-05-26 Ramot At Tel Aviv University Ltd. Populations of expanded and re-differentiated adult islet beta cells capable of producing insulin and methods of generating same
WO2007047539A2 (en) * 2005-10-14 2007-04-26 Medtronic, Inc. Localized delivery to the lymphatic system
US8636995B2 (en) 2006-08-31 2014-01-28 Cardiac Pacemakers, Inc. Methods and devices to regulate stem cell homing
US8372399B2 (en) 2006-08-31 2013-02-12 Cardiac Pacemakers, Inc. Bispecific antibodies and agents to enhance stem cell homing
US8911739B2 (en) 2009-02-10 2014-12-16 Trustees Of Columbia University In The City Of New York Methods of preventing rejection of transplanted tissue by administering anti-CD40L antibody and dendritic cells loaded with Hsp60sp peptide
WO2011146395A2 (en) 2010-05-17 2011-11-24 The Board Of Trustees Of The Leland Stanford Junior University Prevention of immunological rejection of transplanted stem cells by leukocyte costimulatory molecule blockade
GB201403775D0 (en) 2014-03-04 2014-04-16 Kymab Ltd Antibodies, uses & methods
US10147463B2 (en) 2014-12-10 2018-12-04 Nxp Usa, Inc. Video processing unit and method of buffering a source video stream
US9512229B2 (en) * 2015-03-03 2016-12-06 Kymab Limited Synergistic combinations of OX40L antibodies for the treatment of GVHD
KR101810778B1 (ko) * 2015-06-23 2017-12-20 서울대학교산학협력단 Cd154 결합 폴리펩타이드 및 그 용도
US10986309B2 (en) 2015-06-30 2021-04-20 Nxp Usa, Inc. Video buffering and frame rate doubling device and method
US11779604B2 (en) 2016-11-03 2023-10-10 Kymab Limited Antibodies, combinations comprising antibodies, biomarkers, uses and methods
KR20210095781A (ko) 2020-01-24 2021-08-03 주식회사 에이프릴바이오 항원결합 단편 및 생리활성 이펙터 모이어티로 구성된 융합 컨스트럭트를 포함하는 다중결합항체 및 이를 포함하는 약학조성물

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5227298A (en) * 1990-08-17 1993-07-13 The Trustees Of Columbia University In The City Of New York Method for microencapuslation of cells or tissue
US5474771A (en) * 1991-11-15 1995-12-12 The Trustees Of Columbia University In The City Of New York Murine monoclonal antibody (5c8) recognizes a human glycoprotein on the surface of T-lymphocytes, compositions containing same
US5683693A (en) * 1994-04-25 1997-11-04 Trustees Of Dartmouth College Method for inducing T cell unresponsiveness to a tissue or organ graft with anti-CD40 ligand antibody or soluble CD40
DK0892643T4 (da) * 1996-03-20 2009-12-14 Bristol Myers Squibb Co Fremgangsmåder til inhibering af et immunrespons ved blokering af GP39/CD40- og CTLA4/CD28/B7-banerne og præparater til anvendelse derved

Also Published As

Publication number Publication date
EA002550B1 (ru) 2002-06-27
SK180299A3 (en) 2000-06-12
CN1195546C (zh) 2005-04-06
BG104091A (en) 2000-10-31
KR100634847B1 (ko) 2006-10-17
DE69835965T2 (de) 2007-06-14
AU7983098A (en) 1999-01-04
IS5273A (is) 1999-11-26
IL133303A0 (en) 2001-04-30
CA2294154A1 (en) 1998-12-30
TR199903142T2 (xx) 2000-09-21
BR9810620A (pt) 2000-10-03
WO1998058669A3 (en) 1999-04-29
ATE339966T1 (de) 2006-10-15
HUP0003160A3 (en) 2002-09-30
WO1998058669A2 (en) 1998-12-30
CN1651919A (zh) 2005-08-10
NO996275L (no) 2000-02-21
NO996275D0 (no) 1999-12-17
AU730763B2 (en) 2001-03-15
US20030072754A1 (en) 2003-04-17
BG64976B1 (bg) 2006-11-30
EP1051191A2 (en) 2000-11-15
EE9900588A (et) 2000-08-15
NZ502052A (en) 2001-01-26
EP1051191B1 (en) 2006-09-20
JP2002506446A (ja) 2002-02-26
US20070292440A1 (en) 2007-12-20
KR20010013965A (ko) 2001-02-26
EA200000058A1 (ru) 2000-08-28
HUP0003160A2 (hu) 2001-01-29
CN1261286A (zh) 2000-07-26
DE69835965D1 (de) 2006-11-02

Similar Documents

Publication Publication Date Title
HK1033548A1 (en) Cd154 blockade therapy for pancreatic islet tissuetransplantation in primates
AU6039194A (en) Imidazopyridines and their use in treating gastrointestinal diseases
AU3173297A (en) Exendin analogues, processes for their preparation and medicaments containing them
IL113566A0 (en) Use of certain methanebisphosphonic acid derivatives to prevent prosthesis loosening and prosthesis migration
HK1044895A1 (en) Methods for treating diabetes.
SG49239A1 (en) Amylin and possibly insulin containing composition for the treatment of aneroxia and related states
HUT67008A (en) Preparation containing gamma interferon for the treatment of infections in transplant recipients
GB0209998D0 (en) Use
EP0971725A4 (en) METHOD FOR TREATING SCAR TISSUE
ZA905422B (en) Substituted 2-imidazolines and preparation and use thereof
EP1754490A3 (en) CD 154 blockage therapy for pancreatic islet tissue transplantation in primates
DE69231583D1 (de) Zusammensetzung zur Behandlung des Insulinmangels bei Säugetieren, die Amylin und Insulin enthält.
EP0886528A4 (en) USE OF COXIELLA BACTERIA TO TREAT AUTOIMMUNE DISEASES
ZA981558B (en) Inclusion complexes in aqueous solution
WO2001051093A3 (en) METHODS OF INCREASING THE GLUCOSE RESPONSIVENESS OF PANCREATIC β-CELLS
AU674909B2 (en) New triazoloquinazolines, their production and their use
IL117734A (en) Anellated beta-carbolines their preparation and pharmaceutical compositions containing them
UA39046A (ru) Способ лечения инсулинозависимого сахарного диабета

Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20100619