IL131677A0 - Variants of ciliary neurotrophic factor with enhanced receptor selectivity and method for their selection - Google Patents
Variants of ciliary neurotrophic factor with enhanced receptor selectivity and method for their selectionInfo
- Publication number
- IL131677A0 IL131677A0 IL13167798A IL13167798A IL131677A0 IL 131677 A0 IL131677 A0 IL 131677A0 IL 13167798 A IL13167798 A IL 13167798A IL 13167798 A IL13167798 A IL 13167798A IL 131677 A0 IL131677 A0 IL 131677A0
- Authority
- IL
- Israel
- Prior art keywords
- cntf
- variants
- cntfr
- reduced
- neurotrophic factor
- Prior art date
Links
- 108010005939 Ciliary Neurotrophic Factor Proteins 0.000 title abstract 4
- 102100031614 Ciliary neurotrophic factor Human genes 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- 101000993364 Homo sapiens Ciliary neurotrophic factor Proteins 0.000 abstract 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 abstract 1
- 102000016989 Ciliary Neurotrophic Factor Receptor Human genes 0.000 abstract 1
- 108010000063 Ciliary Neurotrophic Factor Receptor Proteins 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 208000037765 diseases and disorders Diseases 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
- 208000005264 motor neuron disease Diseases 0.000 abstract 1
- 210000003205 muscle Anatomy 0.000 abstract 1
- 230000001537 neural effect Effects 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Plant Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- Public Health (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT97RM000156A IT1291114B1 (it) | 1997-03-20 | 1997-03-20 | Varianti del fattore neurotrofico ciliare (cntf) con migliorata selettivita' al recettore, e metodo per la loro selezione |
| PCT/IT1998/000064 WO1998041625A1 (en) | 1997-03-20 | 1998-03-20 | Variants of ciliary neurotrophic factor with enhanced receptor selectivity and method for their selection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL131677A0 true IL131677A0 (en) | 2001-03-19 |
Family
ID=11404878
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL13167798A IL131677A0 (en) | 1997-03-20 | 1998-03-20 | Variants of ciliary neurotrophic factor with enhanced receptor selectivity and method for their selection |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6660467B1 (de) |
| EP (1) | EP0970211B1 (de) |
| JP (1) | JP3200442B2 (de) |
| KR (1) | KR20010005503A (de) |
| CN (1) | CN1251132A (de) |
| AT (1) | ATE310084T1 (de) |
| AU (1) | AU718998B2 (de) |
| CA (1) | CA2284077C (de) |
| DE (1) | DE69832371T2 (de) |
| IL (1) | IL131677A0 (de) |
| IT (1) | IT1291114B1 (de) |
| WO (1) | WO1998041625A1 (de) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080254451A1 (en) * | 2004-12-28 | 2008-10-16 | Ares Trading S.A. | Compositions and Methods for Treating Schizophrenia and Related Disorders |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1283046C (en) | 1986-05-29 | 1991-04-16 | Nandini Katre | Tumor necrosis factor formulation |
| US5154924A (en) * | 1989-09-07 | 1992-10-13 | Alkermes, Inc. | Transferrin receptor specific antibody-neuropharmaceutical agent conjugates |
| CA2123234A1 (en) | 1991-11-11 | 1993-05-27 | Lanfranco Callegaro | Synthesis and purification of truncated and mutein forms of human ciliary neuronotrophic factor |
| IT1284867B1 (it) | 1996-07-10 | 1998-05-22 | Angeletti P Ist Richerche Bio | Varianti del fattore neurotrofico ciliare umano (hcntf) con uno spettro di azione differente dalla molecola di tipo selvatico |
| IT1288388B1 (it) * | 1996-11-19 | 1998-09-22 | Angeletti P Ist Richerche Bio | Uso di sostanze che attivano il recettore del cntf ( fattore neurotrofico ciliare) per la preparazione di farmaci per la terapia |
-
1997
- 1997-03-20 IT IT97RM000156A patent/IT1291114B1/it active IP Right Grant
-
1998
- 1998-03-20 JP JP54029898A patent/JP3200442B2/ja not_active Expired - Lifetime
- 1998-03-20 DE DE69832371T patent/DE69832371T2/de not_active Expired - Lifetime
- 1998-03-20 CA CA002284077A patent/CA2284077C/en not_active Expired - Lifetime
- 1998-03-20 WO PCT/IT1998/000064 patent/WO1998041625A1/en not_active Ceased
- 1998-03-20 IL IL13167798A patent/IL131677A0/xx unknown
- 1998-03-20 CN CN98803484A patent/CN1251132A/zh active Pending
- 1998-03-20 KR KR1019997008560A patent/KR20010005503A/ko not_active Ceased
- 1998-03-20 AT AT98912699T patent/ATE310084T1/de active
- 1998-03-20 AU AU67458/98A patent/AU718998B2/en not_active Expired
- 1998-03-20 US US09/381,393 patent/US6660467B1/en not_active Expired - Lifetime
- 1998-03-20 EP EP98912699A patent/EP0970211B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU718998B2 (en) | 2000-05-04 |
| JP3200442B2 (ja) | 2001-08-20 |
| CA2284077A1 (en) | 1998-09-24 |
| US6660467B1 (en) | 2003-12-09 |
| DE69832371D1 (de) | 2005-12-22 |
| DE69832371T2 (de) | 2006-07-27 |
| JP2000511565A (ja) | 2000-09-05 |
| IT1291114B1 (it) | 1998-12-29 |
| EP0970211B1 (de) | 2005-11-16 |
| ITRM970156A1 (it) | 1998-09-20 |
| WO1998041625A1 (en) | 1998-09-24 |
| CN1251132A (zh) | 2000-04-19 |
| CA2284077C (en) | 2002-12-03 |
| WO1998041625A8 (en) | 1999-10-21 |
| AU6745898A (en) | 1998-10-12 |
| KR20010005503A (ko) | 2001-01-15 |
| ATE310084T1 (de) | 2005-12-15 |
| EP0970211A1 (de) | 2000-01-12 |
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