IL131349A - Pharmaceuticals containing kinazolinone for the prevention of neovascularization and for the treatment of tumors - Google Patents
Pharmaceuticals containing kinazolinone for the prevention of neovascularization and for the treatment of tumorsInfo
- Publication number
- IL131349A IL131349A IL13134998A IL13134998A IL131349A IL 131349 A IL131349 A IL 131349A IL 13134998 A IL13134998 A IL 13134998A IL 13134998 A IL13134998 A IL 13134998A IL 131349 A IL131349 A IL 131349A
- Authority
- IL
- Israel
- Prior art keywords
- group
- halofuginone
- hydrogen
- compound
- tumor
- Prior art date
Links
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- 230000000381 tumorigenic effect Effects 0.000 description 1
- 230000003827 upregulation Effects 0.000 description 1
- 210000003932 urinary bladder Anatomy 0.000 description 1
- 210000005167 vascular cell Anatomy 0.000 description 1
- 210000004509 vascular smooth muscle cell Anatomy 0.000 description 1
- 210000005166 vasculature Anatomy 0.000 description 1
- 230000004862 vasculogenesis Effects 0.000 description 1
- 210000000264 venule Anatomy 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/797,703 US6028075A (en) | 1997-02-11 | 1997-02-11 | Quinazolinone containing pharmaceutical compositions for prevention of neovascularization and for treating malignancies |
| PCT/IL1998/000070 WO1998034613A1 (en) | 1997-02-11 | 1998-02-11 | Quinazolinone-containing pharmaceutical compositions for prevention of neovascularization and for treating malignancies |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL131349A0 IL131349A0 (en) | 2001-03-19 |
| IL131349A true IL131349A (en) | 2004-08-31 |
Family
ID=25171574
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL13134998A IL131349A (en) | 1997-02-11 | 1998-02-11 | Pharmaceuticals containing kinazolinone for the prevention of neovascularization and for the treatment of tumors |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US6028075A (de) |
| EP (1) | EP1007044B1 (de) |
| JP (1) | JP2001518075A (de) |
| KR (1) | KR100518106B1 (de) |
| AT (1) | ATE367158T1 (de) |
| AU (1) | AU738516B2 (de) |
| CA (1) | CA2280850C (de) |
| DE (1) | DE69838099T2 (de) |
| ES (1) | ES2290983T3 (de) |
| IL (1) | IL131349A (de) |
| WO (1) | WO1998034613A1 (de) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6028075A (en) * | 1997-02-11 | 2000-02-22 | Pines; Mark | Quinazolinone containing pharmaceutical compositions for prevention of neovascularization and for treating malignancies |
| EP0991411A4 (de) * | 1997-03-31 | 2000-05-31 | Agricultural Res Org | Behandlung von lungenfibrose |
| WO2000009070A2 (en) * | 1998-08-13 | 2000-02-24 | Hadasit Medical Research Services And Development Company Ltd. | Inhibition of pathogenic processes related to tissue trauma |
| AU764435B2 (en) * | 1999-09-09 | 2003-08-21 | Hadasit Medical Research Services & Development Company Ltd | Promotion of wound healing |
| US7230000B1 (en) | 1999-10-27 | 2007-06-12 | Cytokinetics, Incorporated | Methods and compositions utilizing quinazolinones |
| US6545004B1 (en) | 1999-10-27 | 2003-04-08 | Cytokinetics, Inc. | Methods and compositions utilizing quinazolinones |
| CN1518447A (zh) * | 2001-04-23 | 2004-08-04 | �������Ǵ�ѧר������� | 作为抗血管生成剂的新的苯邻二甲酰亚胺模拟物的合成和评估 |
| EP2329822A1 (de) * | 2001-09-05 | 2011-06-08 | Minerva Biotechnologies Corporation | Zusammensetzungen und deren Verwendung zur Behandlung von Krebs |
| WO2003020280A2 (en) * | 2001-09-05 | 2003-03-13 | Minerva Biotechnologies Corporation | Compositions and use thereof in the treatment of cancer |
| IL147416A (en) * | 2001-12-31 | 2008-11-26 | Israel State | Combined modalities for improved cancer treatment |
| JP2005529076A (ja) | 2002-02-15 | 2005-09-29 | サイトキネティクス・インコーポレーテッド | キナゾリノンの合成 |
| IL148292A (en) * | 2002-02-21 | 2008-08-07 | Shai Yarkoni | Stable preparations of lupoginone and other quinazolinone derivatives |
| EP1553931A4 (de) | 2002-05-09 | 2006-08-30 | Cytokinetics Inc | Verbindungen, zusammensetzungen und verfahren |
| RU2004135554A (ru) | 2002-05-09 | 2006-01-20 | Цитокинетикс, Инк. (Us) | Пиримидиноны, композиции на их основе и способы их использования |
| EP1513820A4 (de) | 2002-05-23 | 2006-09-13 | Cytokinetics Inc | Verbindungen, zusammensetzungen und verfahren |
| CA2489367A1 (en) | 2002-06-14 | 2003-12-24 | Cytokinetics, Inc. | Compounds, compositions, and methods |
| EP1537089A4 (de) | 2002-07-23 | 2008-04-16 | Cytokinetics Inc | Verbindungen, zusammenstellungen und verfahren |
| WO2004034972A2 (en) | 2002-09-30 | 2004-04-29 | Cytokinetics, Inc. | Compounds, compositions, and methods |
| US20060258692A1 (en) * | 2002-10-31 | 2006-11-16 | Mark Pines | Quinazolinone compositions for regulation of gene expression related to pathological processes |
| EP1692112A4 (de) | 2003-12-08 | 2008-09-24 | Cytokinetics Inc | Verbindungen, zusammensetzungen und verfahren |
| RU2410118C2 (ru) * | 2004-12-15 | 2011-01-27 | Зольвай Фармасьютиклз Гмбх | ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ, ВКЛЮЧАЮЩИЕ ИНГИБИТОРЫ НЭП (НЕЙТРАЛЬНОЙ ЭНДОПЕПТИДАЗЫ), ИНГИБИТОРЫ ЭНДОГЕННОЙ ПРОДУЦИРУЮЩЕЙ ЭНДОТЕЛИН СИСТЕМЫ И ИНГИБИТОРЫ ГМГ (ГИДРОКСИМЕТИЛГЛУТАРИЛ)СоА РЕДУКТАЗЫ |
| US20080255165A1 (en) * | 2005-02-23 | 2008-10-16 | Mordechai Erez | Pharmaceutical Compositions of the Isolated D-Enantiomer of the Quinazolinone Derivative Halofuginone |
| ES2435774T3 (es) * | 2005-07-07 | 2013-12-23 | Yissum Research Development Company, Of The Hebrew University Of Jerusalem | Agentes de ácido nucleico para la regulación negativa de H19, y métodos de uso del mismo |
| US20070160640A1 (en) * | 2006-01-12 | 2007-07-12 | Eun-Hyun Jang | Halofuginone delivering vascular medical devices |
| US20080025917A1 (en) * | 2006-04-10 | 2008-01-31 | Malcolm Whitman | Methods for modulating formation and progression of cellulite |
| US8883190B2 (en) * | 2006-12-01 | 2014-11-11 | Wake Forest University Health Sciences | Urologic devices incorporating collagen inhibitors |
| WO2008087641A2 (en) | 2007-01-16 | 2008-07-24 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | H19 silencing nucleic acid agents for treating rheumatoid arthritis |
| WO2008087650A2 (en) | 2007-01-21 | 2008-07-24 | Agricultural Research Organization | Composition and method for treating or preventing skeletal muscle fibrosis |
| KR20100024494A (ko) | 2007-06-22 | 2010-03-05 | 아르퀼 인코포레이티드 | 퀴나졸리논 화합물 및 이의 사용 방법 |
| WO2009023267A2 (en) * | 2007-08-15 | 2009-02-19 | President And Fellows Of Harvard College | Methods for modulating development and expansion of il-17 expressing cells |
| AU2009282480B2 (en) | 2008-08-11 | 2015-05-07 | Children's Medical Center Corporation | Halofuginone analogs for inhibition of tRNA synthetases and uses thereof |
| US8357692B2 (en) | 2010-06-20 | 2013-01-22 | Washington University | Methods of treatment of bone degenerative diseases |
| US10155742B2 (en) | 2012-01-13 | 2018-12-18 | President And Fellows Of Harvard College | Halofuginol derivatives and their use in cosmetic and pharmaceutical compositions |
| WO2015034330A1 (ko) * | 2013-09-09 | 2015-03-12 | 가톨릭대학교 산학협력단 | 헬로퓨지농을 유효성분으로 포함하는 골질환 치료 또는 예방용 조성물 |
| CN105497091B (zh) * | 2016-01-05 | 2020-01-24 | 香港浸会大学 | 一种用于抗癌的常山酮青蒿倍半萜内酯类化合物的组合物及其应用 |
| EP3801525A4 (de) | 2018-06-08 | 2022-03-23 | The General Hospital Corporation | Inhibitoren der prolyl-trna-synthetase |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3320124A (en) | 1964-07-20 | 1967-05-16 | American Cyanamid Co | Method for treating coccidiosis with quinazolinones |
| DE2934069A1 (de) * | 1979-08-23 | 1981-03-12 | Hoechst Ag, 6000 Frankfurt | Mittel gegen theileriosen und seine verwendung. |
| CA2113229C (en) * | 1994-01-11 | 1999-04-20 | Mark Pines | Anti-fibrotic quinazolinone-containing compositions and methods for the use thereof |
| IL110831A (en) | 1994-08-31 | 1998-12-27 | Hadasit Med Res Service | Pharmaceutical compositions containing quinazolinone derivatives for preventing restenosis |
| IL114951A (en) * | 1995-08-15 | 1999-08-17 | Hadasit Med Res Service | Quinazolinone-containing pharmaceutical compositions for prevention of neovascularization |
| US6028075A (en) * | 1997-02-11 | 2000-02-22 | Pines; Mark | Quinazolinone containing pharmaceutical compositions for prevention of neovascularization and for treating malignancies |
-
1997
- 1997-02-11 US US08/797,703 patent/US6028075A/en not_active Expired - Lifetime
-
1998
- 1998-02-11 CA CA002280850A patent/CA2280850C/en not_active Expired - Fee Related
- 1998-02-11 DE DE69838099T patent/DE69838099T2/de not_active Expired - Fee Related
- 1998-02-11 JP JP53407798A patent/JP2001518075A/ja active Pending
- 1998-02-11 EP EP98903275A patent/EP1007044B1/de not_active Expired - Lifetime
- 1998-02-11 IL IL13134998A patent/IL131349A/en not_active IP Right Cessation
- 1998-02-11 AU AU60049/98A patent/AU738516B2/en not_active Ceased
- 1998-02-11 KR KR10-1999-7007262A patent/KR100518106B1/ko not_active Expired - Fee Related
- 1998-02-11 WO PCT/IL1998/000070 patent/WO1998034613A1/en not_active Ceased
- 1998-02-11 AT AT98903275T patent/ATE367158T1/de not_active IP Right Cessation
- 1998-02-11 ES ES98903275T patent/ES2290983T3/es not_active Expired - Lifetime
-
2000
- 2000-01-10 US US09/479,660 patent/US6420371B1/en not_active Expired - Fee Related
- 2000-12-20 US US09/742,993 patent/USRE39574E1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE69838099D1 (de) | 2007-08-30 |
| AU6004998A (en) | 1998-08-26 |
| KR100518106B1 (ko) | 2005-10-04 |
| KR20000070996A (ko) | 2000-11-25 |
| CA2280850C (en) | 2004-01-13 |
| DE69838099T2 (de) | 2008-04-30 |
| EP1007044B1 (de) | 2007-07-18 |
| ES2290983T3 (es) | 2008-02-16 |
| ATE367158T1 (de) | 2007-08-15 |
| USRE39574E1 (en) | 2007-04-17 |
| CA2280850A1 (en) | 1998-08-13 |
| JP2001518075A (ja) | 2001-10-09 |
| IL131349A0 (en) | 2001-03-19 |
| WO1998034613A1 (en) | 1998-08-13 |
| AU738516B2 (en) | 2001-09-20 |
| EP1007044A1 (de) | 2000-06-14 |
| US6028075A (en) | 2000-02-22 |
| US6420371B1 (en) | 2002-07-16 |
| EP1007044A4 (de) | 2001-03-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |