IL130880A - Method of identifying modulators of cell surface membrane receptors useful in the treatment of disease - Google Patents

Method of identifying modulators of cell surface membrane receptors useful in the treatment of disease

Info

Publication number
IL130880A
IL130880A IL13088098A IL13088098A IL130880A IL 130880 A IL130880 A IL 130880A IL 13088098 A IL13088098 A IL 13088098A IL 13088098 A IL13088098 A IL 13088098A IL 130880 A IL130880 A IL 130880A
Authority
IL
Israel
Prior art keywords
receptor
receptors
compound
protein
human
Prior art date
Application number
IL13088098A
Other languages
English (en)
Other versions
IL130880A0 (en
Original Assignee
Arena Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arena Pharm Inc filed Critical Arena Pharm Inc
Publication of IL130880A0 publication Critical patent/IL130880A0/xx
Publication of IL130880A publication Critical patent/IL130880A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70571—Assays involving receptors, cell surface antigens or cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Neurology (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL13088098A 1997-04-14 1998-04-14 Method of identifying modulators of cell surface membrane receptors useful in the treatment of disease IL130880A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83944997A 1997-04-14 1997-04-14
PCT/US1998/007496 WO1998046995A1 (fr) 1997-04-14 1998-04-14 Procede pour identifier les modulateurs des recepteurs membranaires de surfaces cellulaires utiles dans le traitement de maladies

Publications (2)

Publication Number Publication Date
IL130880A0 IL130880A0 (en) 2001-01-28
IL130880A true IL130880A (en) 2004-03-28

Family

ID=25279763

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13088098A IL130880A (en) 1997-04-14 1998-04-14 Method of identifying modulators of cell surface membrane receptors useful in the treatment of disease

Country Status (11)

Country Link
US (1) US20060240523A1 (fr)
EP (1) EP0965041B1 (fr)
AT (1) ATE423313T1 (fr)
AU (1) AU743259B2 (fr)
CA (1) CA2279881C (fr)
DE (2) DE965041T1 (fr)
DK (1) DK0965041T3 (fr)
ES (1) ES2147167T1 (fr)
IL (1) IL130880A (fr)
NZ (1) NZ336479A (fr)
WO (1) WO1998046995A1 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6555339B1 (en) * 1997-04-14 2003-04-29 Arena Pharmaceuticals, Inc. Non-endogenous, constitutively activated human protein-coupled receptors
US7119190B2 (en) 1997-04-14 2006-10-10 Arena Pharmaceuticals, Inc. Endogenous and non-endogenous versions of human G protein-coupled receptors
US6653086B1 (en) 1998-04-14 2003-11-25 Arena Pharmaceuticals, Inc. Endogenous constitutively activated G protein-coupled orphan receptors
DK1095275T3 (da) * 1998-07-31 2009-09-28 Arena Pharm Inc Endogen, konstitutivt aktiverede G-protein-koblede orphan-receptorer
USRE42190E1 (en) 1998-11-20 2011-03-01 Arena Pharmaceuticals, Inc. Method of identifying a compound for inhibiting or stimulating human G protein-coupled receptors
US7816492B2 (en) 1998-11-20 2010-10-19 Arena Pharmaceuticals, Inc. Human G protein-coupled receptors
US20030017528A1 (en) 1998-11-20 2003-01-23 Ruoping Chen Human orphan G protein-coupled receptors
US6991908B1 (en) * 1998-12-28 2006-01-31 Takeda Chemical Industries, Ltd. Antiobestic agents methods for screening antiobestic agents and kits comprising same
AU5787901A (en) * 1999-12-10 2001-07-09 Astrazeneca Ab Compound
EP1290449A1 (fr) * 2000-05-03 2003-03-12 AstraZeneca AB Utilisation du recepteur couple a la proteine g gpr3 dans l'identification d'agents de regulation de l'appetit
DE10123958A1 (de) * 2001-05-17 2002-11-28 Aventis Pharma Gmbh Verfahren zur Identifizierung von Liganden für G protein coupled receptors
US6902902B2 (en) 2001-11-27 2005-06-07 Arena Pharmaceuticals, Inc. Human G protein-coupled receptors and modulators thereof for the treatment of metabolic-related disorders
EP1625159B1 (fr) 2003-05-20 2011-03-02 The University Court Of The University Of Glasgow Substances et methodes associees aux oligomeres des recepteurs couples a une proteine g
WO2014139884A2 (fr) 2013-03-14 2014-09-18 Galapagos Nv Cibles et composés moléculaires destinés au traitement de la fibrose, et méthodes utilisées pour les identifier
US20190216891A1 (en) 2016-03-06 2019-07-18 Yeda Research And Development Co., Ltd. Method for modulating myelination
GB201803079D0 (en) * 2018-02-26 2018-04-11 Autolus Ltd Cell

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2076386C (fr) * 1990-02-26 2003-04-22 David S. Hogness Identification et expression d'une sequence d'adn d'insecte ayant les caracteristiques des recepteurs steroides d'insecte
AU655850B2 (en) * 1991-10-01 1995-01-12 United States Of America, Represented By The Secretary, Department Of Health And Human Services, The A method of identifying ligands and antagonists of ligands
JPH08505044A (ja) * 1992-09-25 1996-06-04 シナプティック・ファーマスーティカル・コーポレーション ヒトα▲下１▼アドレナリン作動性受容体をコードするＤＮＡおよびその使用
AU1173995A (en) * 1993-11-10 1995-05-29 Arch Development Corporation Ubiquitous nuclear receptor: compositions and methods
US5573944A (en) * 1994-07-22 1996-11-12 President And Fellows Of Harvard College Yeast cell expressing heterologous receptor kinase
WO1997011159A1 (fr) * 1995-09-20 1997-03-27 Molecular Geriatrics Corporation Recepteur de levure et proteine de fusion de proteine g
US5750353A (en) * 1995-12-11 1998-05-12 New England Medical Center Hospitals, Inc. Assay for non-peptide agonists to peptide hormone receptors
JP4442930B2 (ja) * 1995-12-11 2010-03-31 タフツ メディカル センター インコーポレイテッド ペプチドホルモンレセプターリガンドに関するアッセイ法およびその使用
ATE284972T1 (de) * 1996-09-24 2005-01-15 Cadus Pharmaceutical Corp Verfahren und zusammensetzungen für die identifizierung von receptor effectoren
US5891720A (en) * 1997-04-17 1999-04-06 Millennium Pharmaceuticals, Inc. Isolated DNA encoding a novel human G-protein coupled receptor
US5955308A (en) * 1997-06-18 1999-09-21 Smithkline Beecham Corporation cDNA clone HEAOD54 that encodes a human 7-transmembrane receptor
AU1450900A (en) * 1998-10-21 2000-05-08 Arch Development Corporation Methods of treatment of type 2 diabetes

Also Published As

Publication number Publication date
US20060240523A1 (en) 2006-10-26
WO1998046995A1 (fr) 1998-10-22
AU7116698A (en) 1998-11-11
ES2147167T1 (es) 2000-09-01
IL130880A0 (en) 2001-01-28
EP0965041A4 (fr) 2003-01-02
NZ336479A (en) 2001-10-26
AU743259B2 (en) 2002-01-24
EP0965041B1 (fr) 2009-02-18
CA2279881A1 (fr) 1998-10-22
DE965041T1 (de) 2000-11-09
DK0965041T3 (da) 2009-05-25
CA2279881C (fr) 2009-12-22
DE69840568D1 (de) 2009-04-02
ATE423313T1 (de) 2009-03-15
EP0965041A1 (fr) 1999-12-22

Similar Documents

Publication Publication Date Title
WO2000021987A9 (fr) Methode d'identification de modulateurs de recepteurs de membranes de surface cellulaire s'utilisant dans le traitement de maladies
AU743259B2 (en) A method of identifying modulators of cell surface membrane receptors useful in the treatment of disease
JP3657602B2 (ja) ソマトスタチン受容体
US6806054B2 (en) Non-endogenous, constitutively activated known G protein-coupled receptors
Hermans Biochemical and pharmacological control of the multiplicity of coupling at G-protein-coupled receptors
Zlotos et al. MT1 and MT2 melatonin receptors: ligands, models, oligomers, and therapeutic potential
Raymond Multiple mechanisms of receptor-G protein signaling specificity
AU2005244540B2 (en) Endogenous and non-endogenous versions of human G protein-coupled receptors
WO1998046995A9 (fr) Procede pour identifier les modulateurs des recepteurs membranaires de surfaces cellulaires utiles dans le traitement de maladies
JP2011200229A (ja) レポーター酵素変異体相補作用の利用によるｇタンパク共役受容体およびオーファン受容体機能の高感度検知のための改良システム
Liebmann G protein-coupled receptors and their signaling pathways: classical therapeutical targets susceptible to novel therapeutic concepts
US20030191114A1 (en) Assay for and uses of peptide hormone receptor agonists
Schöneberg et al. A novel subgroup of class I G-protein-coupled receptors
US20130165633A1 (en) Endogenous and Non-Endogenous Versions of Human G Protein-Coupled Receptors
US20040091946A1 (en) Methods of screening compositions for G protein -coupled receptor desensitization inhibitory activity
Dutta Mechanism of store-operated calcium entry
JP3813156B2 (ja) オピオイド受容体と、その組成物および製造方法
Spada et al. G-proteins and hormonal signalling in human pituitary tumors: genetic mutations and functional alterations
KR20000070545A (ko) 질병 치료에 유용한 세포 표면막 수용체 조절제의 확인 방법
Pincas et al. G protein-coupled receptors
Caron The guanine nucleotide regulatory protein-coupled receptors for nucleosides, nucleotides, amino acids and amine neurotransmitters
US20050042720A1 (en) Novel promiscuous G alpha protein mutants and their use
WO1993005073A1 (fr) RECEPTEURS D'ANGIOTENSINE IIcAMP/VASOPRESSINEV2 ET MOLECULES ET PROCEDES ASSOCIES
Bullock Molecular characterization of a constitutively active mutant dopamine D2 receptor and two prokineticin receptors
Celver Molecular mechanisms of opioid receptor regulation by GRK and arrestin

Legal Events

Date Code Title Description
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees