IL128928A0 - Tricyclic inhibitors of farnesyl protein transferase - Google Patents
Tricyclic inhibitors of farnesyl protein transferaseInfo
- Publication number
- IL128928A0 IL128928A0 IL12892897A IL12892897A IL128928A0 IL 128928 A0 IL128928 A0 IL 128928A0 IL 12892897 A IL12892897 A IL 12892897A IL 12892897 A IL12892897 A IL 12892897A IL 128928 A0 IL128928 A0 IL 128928A0
- Authority
- IL
- Israel
- Prior art keywords
- protein transferase
- farnesyl protein
- tricyclic inhibitors
- compounds
- formula
- Prior art date
Links
- 102000004357 Transferases Human genes 0.000 title abstract 2
- 108090000992 Transferases Proteins 0.000 title abstract 2
- 125000004030 farnesyl group Chemical group [H]C([*])([H])C([H])=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 230000002159 abnormal effect Effects 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Dental Preparations (AREA)
- Cereal-Derived Products (AREA)
- Enzymes And Modification Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71332396A | 1996-09-13 | 1996-09-13 | |
| PCT/US1997/015907 WO1998011093A1 (en) | 1996-09-13 | 1997-09-11 | Tricyclic inhibitors of farnesyl protein transferase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL128928A0 true IL128928A0 (en) | 2000-02-17 |
Family
ID=24865689
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12892897A IL128928A0 (en) | 1996-09-13 | 1997-09-11 | Tricyclic inhibitors of farnesyl protein transferase |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP0929545B1 (OSRAM) |
| JP (1) | JP2001500510A (OSRAM) |
| KR (1) | KR20000036120A (OSRAM) |
| CN (1) | CN1104427C (OSRAM) |
| AT (1) | ATE286046T1 (OSRAM) |
| AU (1) | AU4337997A (OSRAM) |
| BR (1) | BR9712831A (OSRAM) |
| CA (1) | CA2266016C (OSRAM) |
| CZ (1) | CZ84399A3 (OSRAM) |
| DE (1) | DE69732120T2 (OSRAM) |
| ES (1) | ES2235252T3 (OSRAM) |
| HU (1) | HUP0000121A2 (OSRAM) |
| ID (1) | ID21699A (OSRAM) |
| IL (1) | IL128928A0 (OSRAM) |
| NO (1) | NO991234L (OSRAM) |
| NZ (1) | NZ334453A (OSRAM) |
| PL (1) | PL332242A1 (OSRAM) |
| SK (1) | SK33899A3 (OSRAM) |
| TR (1) | TR199901276T2 (OSRAM) |
| WO (1) | WO1998011093A1 (OSRAM) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT3962B (en) | 1993-12-21 | 1996-05-27 | Albright & Wilson | Funcional fluids |
| US5939416A (en) * | 1997-06-17 | 1999-08-17 | Schering Corporation | Benzo (5,6) cycloheptapyridine compounds useful as farnesyl protein transferase inhibitors |
| AU2335699A (en) | 1998-01-21 | 1999-08-09 | Kyowa Hakko Kogyo Co. Ltd. | Chemokine receptor antagonists and methods of use therefor |
| US6509346B2 (en) | 1998-01-21 | 2003-01-21 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| ATE309249T1 (de) | 1998-01-21 | 2005-11-15 | Millennium Pharm Inc | Chemokin rezeptor antagonisten und verwndung |
| US6613905B1 (en) | 1998-01-21 | 2003-09-02 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| US6288083B1 (en) | 1998-09-04 | 2001-09-11 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| US7271176B2 (en) | 1998-09-04 | 2007-09-18 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use thereof |
| US6503926B2 (en) | 1998-09-04 | 2003-01-07 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| US7541365B2 (en) | 2001-11-21 | 2009-06-02 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| TWI291467B (en) | 2002-11-13 | 2007-12-21 | Millennium Pharm Inc | CCR1 antagonists and methods of use therefor |
| US8679096B2 (en) | 2007-06-21 | 2014-03-25 | Board Of Regents Of The University Of Nebraska | Multifunctional operational component for robotic devices |
| US9579088B2 (en) | 2007-02-20 | 2017-02-28 | Board Of Regents Of The University Of Nebraska | Methods, systems, and devices for surgical visualization and device manipulation |
| TW200902007A (en) * | 2007-05-25 | 2009-01-16 | Astrazeneca Ab | Spirocyclopropyl piperidine derivatives |
| EP2170564A4 (en) | 2007-07-12 | 2015-10-07 | Univ Nebraska | ACTUATING PROCESSES AND SYSTEMS IN ROBOTIC EQUIPMENT |
| US20090076536A1 (en) | 2007-08-15 | 2009-03-19 | Board Of Regents Of The University Of Nebraska | Medical inflation, attachment, and delivery devices and related methods |
| CA2838637C (en) | 2011-06-10 | 2020-11-17 | Board Of Regents Of The University Of Nebraska | Methods, systems, and devices relating to surgical end effectors |
| EP2732344B1 (en) | 2011-07-11 | 2019-06-05 | Board of Regents of the University of Nebraska | Robotic surgical system |
| JP6502848B2 (ja) | 2011-10-03 | 2019-04-17 | ボード オブ リージェンツ オブ ザ ユニバーシティ オブ ネブラスカ | モジュール式手術用ロボットシステム |
| US20140058205A1 (en) | 2012-01-10 | 2014-02-27 | Board Of Regents Of The University Of Nebraska | Methods, Systems, and Devices for Surgical Access and Insertion |
| WO2014011238A2 (en) | 2012-05-01 | 2014-01-16 | Board Of Regents Of The University Of Nebraska | Single site robotic device and related systems and methods |
| EP3680071B1 (en) | 2012-06-22 | 2021-09-01 | Board of Regents of the University of Nebraska | Local control robotic surgical devices |
| CA2880622C (en) | 2012-08-08 | 2021-01-12 | Board Of Regents Of The University Of Nebraska | Robotic surgical devices, systems and related methods |
| US9770305B2 (en) | 2012-08-08 | 2017-09-26 | Board Of Regents Of The University Of Nebraska | Robotic surgical devices, systems, and related methods |
| WO2014152418A1 (en) | 2013-03-14 | 2014-09-25 | Board Of Regents Of The University Of Nebraska | Methods, systems, and devices relating to force control surgical systems |
| US9743987B2 (en) | 2013-03-14 | 2017-08-29 | Board Of Regents Of The University Of Nebraska | Methods, systems, and devices relating to robotic surgical devices, end effectors, and controllers |
| EP4628042A3 (en) | 2013-03-15 | 2025-12-31 | Virtual Incision Corporation | ROBOTIC SURGICAL DEVICES AND SYSTEMS |
| WO2015009949A2 (en) | 2013-07-17 | 2015-01-22 | Board Of Regents Of The University Of Nebraska | Robotic surgical devices, systems and related methods |
| WO2016040946A1 (en) | 2014-09-12 | 2016-03-17 | Board Of Regents Of University Of Nebraska | Quick-release end effectors and related systems and methods |
| CA2967593C (en) | 2014-11-11 | 2024-02-27 | Board Of Regents Of The University Of Nebraska | Robotic device with compact joint design and related systems and methods |
| EP3331453B1 (en) | 2015-08-03 | 2025-05-14 | Virtual Incision Corporation | Robotic surgical devices and systems |
| CN109715081B (zh) | 2016-05-18 | 2021-11-09 | 虚拟切割有限公司 | 机器人外科装置、系统及相关方法 |
| EP3503829A4 (en) | 2016-08-25 | 2020-04-15 | Board of Regents of the University of Nebraska | Quick-release tool coupler and related systems and methods |
| EP3507065B1 (en) | 2016-08-30 | 2025-02-12 | Board of Regents of the University of Nebraska | Robotic device with compact joint design and an additional degree of freedom |
| CN110139620B (zh) | 2016-11-22 | 2022-09-20 | 内布拉斯加大学董事会 | 改进的粗定位装置及相关系统和方法 |
| JP7099728B2 (ja) | 2016-11-29 | 2022-07-12 | バーチャル インシジョン コーポレイション | ユーザの存在検出機能を備えたユーザコントローラ、関連システムおよび方法 |
| US10722319B2 (en) | 2016-12-14 | 2020-07-28 | Virtual Incision Corporation | Releasable attachment device for coupling to medical devices and related systems and methods |
| EP3687370B1 (en) | 2017-09-27 | 2024-11-20 | Virtual Incision Corporation | Robotic surgical devices with tracking camera technology and related systems |
| CN117140580A (zh) | 2018-01-05 | 2023-12-01 | 内布拉斯加大学董事会 | 具有紧凑型关节设计的单臂机器人装置及相关系统和方法 |
| CN114302665B (zh) | 2019-01-07 | 2025-12-19 | 虚拟切割有限公司 | 机器人辅助手术系统以及相关装置和方法 |
| CA3186863A1 (en) | 2020-07-06 | 2022-01-13 | Virtual Incision Corporation | Surgical robot positioning system and related devices and methods |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4826853A (en) * | 1986-10-31 | 1989-05-02 | Schering Corporation | 6,11-Dihydro-11-(N-substituted-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines and compositions and methods of use |
| US5089496A (en) * | 1986-10-31 | 1992-02-18 | Schering Corporation | Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies |
| JPH0676403B2 (ja) * | 1991-01-18 | 1994-09-28 | エスエス製薬株式会社 | 新規なベンゾ［５，６ シクロヘプタ［１，２−ｂ ピリジン誘導体及びこれを含有する抗アレルギー剤 |
| IL111235A (en) * | 1993-10-15 | 2001-03-19 | Schering Plough Corp | Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them |
| US5719148A (en) * | 1993-10-15 | 1998-02-17 | Schering Corporation | Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases |
| ZA947969B (en) * | 1993-10-15 | 1996-07-12 | Schering Corp | Tricyclic sulfonamide compounds useful for inhibition of g-protein function and for treatment of proliferative diseases |
| ATE210652T1 (de) * | 1993-10-15 | 2001-12-15 | Schering Corp | Tricyclische carbamat-derivate zur inhibierung der g-protein funktion und für die behandlung von proliferativen erkrankungen |
| US5700806A (en) * | 1995-03-24 | 1997-12-23 | Schering Corporation | Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
| IL117798A (en) * | 1995-04-07 | 2001-11-25 | Schering Plough Corp | Tricyclic compounds useful for inhibiting the function of protein - G and for the treatment of malignant diseases, and pharmaceutical preparations containing them |
| CA2240846C (en) * | 1995-12-22 | 2002-07-16 | Schering Corporation | Tricyclic amides useful for inhibition of g-protein function and for treatment of proliferative diseases |
-
1997
- 1997-09-11 NZ NZ334453A patent/NZ334453A/xx unknown
- 1997-09-11 KR KR1019997002149A patent/KR20000036120A/ko not_active Withdrawn
- 1997-09-11 BR BR9712831-7A patent/BR9712831A/pt unknown
- 1997-09-11 AT AT97941480T patent/ATE286046T1/de not_active IP Right Cessation
- 1997-09-11 CN CN97199598A patent/CN1104427C/zh not_active Expired - Fee Related
- 1997-09-11 EP EP97941480A patent/EP0929545B1/en not_active Expired - Lifetime
- 1997-09-11 PL PL97332242A patent/PL332242A1/xx unknown
- 1997-09-11 JP JP10513765A patent/JP2001500510A/ja not_active Ceased
- 1997-09-11 CZ CZ99843A patent/CZ84399A3/cs unknown
- 1997-09-11 IL IL12892897A patent/IL128928A0/xx unknown
- 1997-09-11 ES ES97941480T patent/ES2235252T3/es not_active Expired - Lifetime
- 1997-09-11 AU AU43379/97A patent/AU4337997A/en not_active Abandoned
- 1997-09-11 SK SK338-99A patent/SK33899A3/sk unknown
- 1997-09-11 DE DE69732120T patent/DE69732120T2/de not_active Expired - Fee Related
- 1997-09-11 HU HU0000121A patent/HUP0000121A2/hu unknown
- 1997-09-11 TR TR1999/01276T patent/TR199901276T2/xx unknown
- 1997-09-11 CA CA002266016A patent/CA2266016C/en not_active Expired - Fee Related
- 1997-09-11 WO PCT/US1997/015907 patent/WO1998011093A1/en not_active Ceased
- 1997-11-09 ID IDW990086A patent/ID21699A/id unknown
-
1999
- 1999-03-12 NO NO991234A patent/NO991234L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2001500510A (ja) | 2001-01-16 |
| EP0929545B1 (en) | 2004-12-29 |
| AU4337997A (en) | 1998-04-02 |
| CN1237165A (zh) | 1999-12-01 |
| NZ334453A (en) | 2000-08-25 |
| NO991234L (no) | 1999-05-12 |
| CN1104427C (zh) | 2003-04-02 |
| PL332242A1 (en) | 1999-08-30 |
| CA2266016A1 (en) | 1998-03-19 |
| NO991234D0 (no) | 1999-03-12 |
| TR199901276T2 (xx) | 1999-09-21 |
| SK33899A3 (en) | 2000-02-14 |
| HUP0000121A2 (hu) | 2001-04-28 |
| BR9712831A (pt) | 1999-11-16 |
| CZ84399A3 (cs) | 1999-11-17 |
| ID21699A (id) | 1999-07-15 |
| ES2235252T3 (es) | 2005-07-01 |
| WO1998011093A1 (en) | 1998-03-19 |
| CA2266016C (en) | 2004-06-01 |
| DE69732120D1 (de) | 2005-02-03 |
| DE69732120T2 (de) | 2005-12-08 |
| ATE286046T1 (de) | 2005-01-15 |
| EP0929545A1 (en) | 1999-07-21 |
| KR20000036120A (ko) | 2000-06-26 |
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