KR20000036120A - 파르네실 단백질 트랜스퍼라제에 대한 트리사이클릭 저해제 - Google Patents

파르네실 단백질 트랜스퍼라제에 대한 트리사이클릭 저해제 Download PDF

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Publication number
KR20000036120A
KR20000036120A KR1019997002149A KR19997002149A KR20000036120A KR 20000036120 A KR20000036120 A KR 20000036120A KR 1019997002149 A KR1019997002149 A KR 1019997002149A KR 19997002149 A KR19997002149 A KR 19997002149A KR 20000036120 A KR20000036120 A KR 20000036120A
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KR
South Korea
Prior art keywords
formula
compound
group
mmol
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
KR1019997002149A
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English (en)
Korean (ko)
Inventor
타버라스아더지
말람스알란케이
아폰소아드리아노
Original Assignee
둘락 노먼 씨.
쉐링 코포레이션
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Application filed by 둘락 노먼 씨., 쉐링 코포레이션 filed Critical 둘락 노먼 씨.
Publication of KR20000036120A publication Critical patent/KR20000036120A/ko
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Dental Preparations (AREA)
  • Cereal-Derived Products (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1019997002149A 1996-09-13 1997-09-11 파르네실 단백질 트랜스퍼라제에 대한 트리사이클릭 저해제 Withdrawn KR20000036120A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71332396A 1996-09-13 1996-09-13
US8/713,323 1996-09-13

Publications (1)

Publication Number Publication Date
KR20000036120A true KR20000036120A (ko) 2000-06-26

Family

ID=24865689

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019997002149A Withdrawn KR20000036120A (ko) 1996-09-13 1997-09-11 파르네실 단백질 트랜스퍼라제에 대한 트리사이클릭 저해제

Country Status (20)

Country Link
EP (1) EP0929545B1 (OSRAM)
JP (1) JP2001500510A (OSRAM)
KR (1) KR20000036120A (OSRAM)
CN (1) CN1104427C (OSRAM)
AT (1) ATE286046T1 (OSRAM)
AU (1) AU4337997A (OSRAM)
BR (1) BR9712831A (OSRAM)
CA (1) CA2266016C (OSRAM)
CZ (1) CZ84399A3 (OSRAM)
DE (1) DE69732120T2 (OSRAM)
ES (1) ES2235252T3 (OSRAM)
HU (1) HUP0000121A2 (OSRAM)
ID (1) ID21699A (OSRAM)
IL (1) IL128928A0 (OSRAM)
NO (1) NO991234L (OSRAM)
NZ (1) NZ334453A (OSRAM)
PL (1) PL332242A1 (OSRAM)
SK (1) SK33899A3 (OSRAM)
TR (1) TR199901276T2 (OSRAM)
WO (1) WO1998011093A1 (OSRAM)

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LT3962B (en) 1993-12-21 1996-05-27 Albright & Wilson Funcional fluids
US5939416A (en) * 1997-06-17 1999-08-17 Schering Corporation Benzo (5,6) cycloheptapyridine compounds useful as farnesyl protein transferase inhibitors
US6613905B1 (en) 1998-01-21 2003-09-02 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
US6509346B2 (en) 1998-01-21 2003-01-21 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
US6433165B1 (en) 1998-01-21 2002-08-13 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
WO1999037651A1 (en) 1998-01-21 1999-07-29 Millenium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
US6503926B2 (en) 1998-09-04 2003-01-07 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
US6288083B1 (en) 1998-09-04 2001-09-11 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
US7271176B2 (en) 1998-09-04 2007-09-18 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use thereof
US7541365B2 (en) 2001-11-21 2009-06-02 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
TWI291467B (en) 2002-11-13 2007-12-21 Millennium Pharm Inc CCR1 antagonists and methods of use therefor
US8679096B2 (en) 2007-06-21 2014-03-25 Board Of Regents Of The University Of Nebraska Multifunctional operational component for robotic devices
US9579088B2 (en) 2007-02-20 2017-02-28 Board Of Regents Of The University Of Nebraska Methods, systems, and devices for surgical visualization and device manipulation
TW200902007A (en) * 2007-05-25 2009-01-16 Astrazeneca Ab Spirocyclopropyl piperidine derivatives
JP5591696B2 (ja) 2007-07-12 2014-09-17 ボード オブ リージェンツ オブ ザ ユニバーシティ オブ ネブラスカ 生検要素、アーム装置、および医療装置
EP2178431A4 (en) 2007-08-15 2017-01-18 Board of Regents of the University of Nebraska Medical inflation, attachment, and delivery devices and related methods
EP3714821A1 (en) 2011-06-10 2020-09-30 Board of Regents of the University of Nebraska Surgical end effector
CA2841459C (en) 2011-07-11 2020-07-28 Board Of Regents Of The University Of Nebraska Robotic surgical devices, systems, and related methods
EP3730031A1 (en) 2011-10-03 2020-10-28 Board of Regents of the University of Nebraska Robotic surgical devices and systems
WO2013106569A2 (en) 2012-01-10 2013-07-18 Board Of Regents Of The University Of Nebraska Methods, systems, and devices for surgical access and insertion
WO2014011238A2 (en) 2012-05-01 2014-01-16 Board Of Regents Of The University Of Nebraska Single site robotic device and related systems and methods
EP3943255B1 (en) 2012-06-22 2023-06-14 Board of Regents of the University of Nebraska Local control robotic surgical devices
US9770305B2 (en) 2012-08-08 2017-09-26 Board Of Regents Of The University Of Nebraska Robotic surgical devices, systems, and related methods
WO2014025399A1 (en) 2012-08-08 2014-02-13 Board Of Regents Of The University Of Nebraska Robotic surgical devices, systems, and related methods
US9888966B2 (en) 2013-03-14 2018-02-13 Board Of Regents Of The University Of Nebraska Methods, systems, and devices relating to force control surgical systems
CA2905948C (en) 2013-03-14 2022-01-11 Board Of Regents Of The University Of Nebraska Methods, systems, and devices relating to robotic surgical devices, end effectors, and controllers
CA2906772C (en) 2013-03-15 2021-09-21 Board Of Regents Of The University Of Nebraska Robotic surgical devices, systems and related methods
US10966700B2 (en) 2013-07-17 2021-04-06 Virtual Incision Corporation Robotic surgical devices, systems and related methods
WO2016040946A1 (en) 2014-09-12 2016-03-17 Board Of Regents Of University Of Nebraska Quick-release end effectors and related systems and methods
EP4286104A3 (en) 2014-11-11 2024-02-14 Board of Regents of the University of Nebraska Robotic device with compact joint design and related systems and methods
CN114027986B (zh) 2015-08-03 2024-06-14 内布拉斯加大学董事会 机器人手术装置系统及相关方法
JP7176757B2 (ja) 2016-05-18 2022-11-22 バーチャル インシジョン コーポレイション ロボット手術装置、システム及び関連する方法
EP3503829A4 (en) 2016-08-25 2020-04-15 Board of Regents of the University of Nebraska Quick-release tool coupler and related systems and methods
EP3507065B1 (en) 2016-08-30 2025-02-12 Board of Regents of the University of Nebraska Robotic device with compact joint design and an additional degree of freedom
EP3544539A4 (en) 2016-11-22 2020-08-05 Board of Regents of the University of Nebraska ENHANCED COARSE POSITIONING DEVICE AND RELATED SYSTEMS AND PROCESSES
JP7099728B2 (ja) 2016-11-29 2022-07-12 バーチャル インシジョン コーポレイション ユーザの存在検出機能を備えたユーザコントローラ、関連システムおよび方法
WO2018112199A1 (en) 2016-12-14 2018-06-21 Virtual Incision Corporation Releasable attachment device for coupling to medical devices and related systems and methods
JP7405432B2 (ja) 2017-09-27 2023-12-26 バーチャル インシジョン コーポレイション 追跡カメラ技術を有するロボット手術デバイスならびに関連するシステムおよび方法
WO2019136360A1 (en) 2018-01-05 2019-07-11 Board Of Regents Of The University Of Nebraska Single-arm robotic device with compact joint design and related systems and methods
US11903658B2 (en) 2019-01-07 2024-02-20 Virtual Incision Corporation Robotically assisted surgical system and related devices and methods
WO2022010887A1 (en) 2020-07-06 2022-01-13 Virtual Incision Corporation Surgical Robot Positioning System and Related Devices and Methods

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5089496A (en) * 1986-10-31 1992-02-18 Schering Corporation Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies
US4826853A (en) * 1986-10-31 1989-05-02 Schering Corporation 6,11-Dihydro-11-(N-substituted-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines and compositions and methods of use
KR920014799A (ko) * 1991-01-18 1992-08-25 나오가따 다이도 신규벤조[5,6]시클로헵타[1,2-b]피리딘 유도체 및 이를 함유하는 항알레르기제
IL111257A0 (en) * 1993-10-15 1994-12-29 Schering Corp Tricyclic sulfonamide compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
AU699043B2 (en) * 1993-10-15 1998-11-19 Schering Corporation Tricyclic carbamate compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
IL111235A (en) * 1993-10-15 2001-03-19 Schering Plough Corp Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them
US5719148A (en) * 1993-10-15 1998-02-17 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
US5700806A (en) * 1995-03-24 1997-12-23 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
IL117798A (en) * 1995-04-07 2001-11-25 Schering Plough Corp Tricyclic compounds useful for inhibiting the function of protein - G and for the treatment of malignant diseases, and pharmaceutical preparations containing them
TW350844B (en) * 1995-12-22 1999-01-21 Schering Corp Tricyclic amides useful to inhibition of G-protein function and for treatment of proliferative diseases

Also Published As

Publication number Publication date
CZ84399A3 (cs) 1999-11-17
NO991234L (no) 1999-05-12
BR9712831A (pt) 1999-11-16
WO1998011093A1 (en) 1998-03-19
NO991234D0 (no) 1999-03-12
IL128928A0 (en) 2000-02-17
DE69732120D1 (de) 2005-02-03
ATE286046T1 (de) 2005-01-15
CA2266016A1 (en) 1998-03-19
NZ334453A (en) 2000-08-25
ES2235252T3 (es) 2005-07-01
EP0929545A1 (en) 1999-07-21
CN1237165A (zh) 1999-12-01
JP2001500510A (ja) 2001-01-16
PL332242A1 (en) 1999-08-30
CA2266016C (en) 2004-06-01
AU4337997A (en) 1998-04-02
HUP0000121A2 (hu) 2001-04-28
TR199901276T2 (xx) 1999-09-21
DE69732120T2 (de) 2005-12-08
SK33899A3 (en) 2000-02-14
ID21699A (id) 1999-07-15
CN1104427C (zh) 2003-04-02
EP0929545B1 (en) 2004-12-29

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Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 19990313

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
PC1203 Withdrawal of no request for examination
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid