IL127942A0 - 1,4-Di-substituted piperidines as muscarinic antagonists - Google Patents

1,4-Di-substituted piperidines as muscarinic antagonists

Info

Publication number
IL127942A0
IL127942A0 IL12794297A IL12794297A IL127942A0 IL 127942 A0 IL127942 A0 IL 127942A0 IL 12794297 A IL12794297 A IL 12794297A IL 12794297 A IL12794297 A IL 12794297A IL 127942 A0 IL127942 A0 IL 127942A0
Authority
IL
Israel
Prior art keywords
alkyl
cycloalkyl
heteroaryl
aryl
alkylheteroaryl
Prior art date
Application number
IL12794297A
Other languages
English (en)
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of IL127942A0 publication Critical patent/IL127942A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL12794297A 1996-07-10 1997-07-08 1,4-Di-substituted piperidines as muscarinic antagonists IL127942A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67861896A 1996-07-10 1996-07-10
PCT/US1997/011176 WO1998001425A1 (en) 1996-07-10 1997-07-08 1,4-di-sustituted piperidines as muscarinic antagonists

Publications (1)

Publication Number Publication Date
IL127942A0 true IL127942A0 (en) 1999-11-30

Family

ID=24723553

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12794297A IL127942A0 (en) 1996-07-10 1997-07-08 1,4-Di-substituted piperidines as muscarinic antagonists

Country Status (14)

Country Link
EP (1) EP0912515B1 (xx)
JP (1) JP3068206B2 (xx)
KR (1) KR20000023599A (xx)
AT (1) ATE227708T1 (xx)
AU (1) AU728592B2 (xx)
CA (1) CA2259655C (xx)
DE (1) DE69717109T2 (xx)
DK (1) DK0912515T3 (xx)
ES (1) ES2182104T3 (xx)
HU (1) HUP9904622A3 (xx)
IL (1) IL127942A0 (xx)
NZ (1) NZ333513A (xx)
PT (1) PT912515E (xx)
WO (1) WO1998001425A1 (xx)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1600599A (en) * 1998-02-27 1999-09-15 Warner-Lambert Company Heterocyclic substituted aniline calcium channel blockers
TR200402496T2 (tr) * 1999-05-04 2005-01-24 Schering Corporation CCR5 antagonistleri olarak yararlı piperidin türevleri.
US6387930B1 (en) 1999-05-04 2002-05-14 Schering Corporation Piperidine derivatives useful as CCR5 antagonists
US6635646B1 (en) 1999-05-04 2003-10-21 Schering Corporation Pegylated interferon alfa-CCR5 antagonist combination HIV therapy
AR033517A1 (es) 2000-04-08 2003-12-26 Astrazeneca Ab Derivados de piperidina, proceso para su preparacion y uso de estos derivados en la fabricacion de medicamentos
AU6589801A (en) 2000-04-28 2001-11-12 F. Hoffmann-La Roche Ag P-(sulfonyl)aryl and heteroaryls
US6640155B2 (en) 2000-08-22 2003-10-28 Lam Research Corporation Chemical mechanical polishing apparatus and methods with central control of polishing pressure applied by polishing head
RU2004100839A (ru) 2001-07-02 2005-06-20 Астразенека Аб (Se) Производные пиперидина полезные в качестве модуляторов активности рецепторов хемокинов
GB0120461D0 (en) 2001-08-22 2001-10-17 Astrazeneca Ab Novel compounds
AR036366A1 (es) 2001-08-29 2004-09-01 Schering Corp Derivados de piperidina utiles como antagonistas de ccr5, composiciones farmaceuticas, el uso de dichos derivados para la fabricación de un medicamento y un kit
GB0122503D0 (en) 2001-09-18 2001-11-07 Astrazeneca Ab Chemical compounds
EP1453806B1 (en) * 2001-12-03 2007-12-19 F. Hoffmann-La Roche Ag Aminotetralin derivatives as muscarinic receptor antagonist
SE0200843D0 (sv) 2002-03-19 2002-03-19 Astrazeneca Ab Chemical compounds
SE0200844D0 (sv) 2002-03-19 2002-03-19 Astrazeneca Ab Chemical compounds
CN100375619C (zh) * 2002-06-14 2008-03-19 富山化学工业株式会社 改善脑功能的药物组合物及其用途
SE0202838D0 (sv) * 2002-09-24 2002-09-24 Astrazeneca Ab Chemical compounds
GB0223223D0 (en) * 2002-10-07 2002-11-13 Novartis Ag Organic compounds
SE0300957D0 (sv) 2003-04-01 2003-04-01 Astrazeneca Ab Chemical compounds
JP2009501793A (ja) 2005-07-21 2009-01-22 アストラゼネカ・アクチエボラーグ 新規ピペリジン誘導体
CA2617413A1 (en) 2005-08-02 2007-02-08 Lexicon Pharmaceuticals, Inc. 2-aminoaryl pyridines as protein kinases inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2151930T3 (es) * 1993-07-28 2001-01-16 Santen Pharmaceutical Co Ltd Nuevos derivados de 1,4-(difenilalquil)piperazina.
IL117149A0 (en) * 1995-02-23 1996-06-18 Schering Corp Muscarinic antagonists

Also Published As

Publication number Publication date
AU3581097A (en) 1998-02-02
DK0912515T3 (da) 2003-03-10
JPH11514671A (ja) 1999-12-14
HUP9904622A2 (hu) 2000-06-28
ES2182104T3 (es) 2003-03-01
AU728592B2 (en) 2001-01-11
KR20000023599A (ko) 2000-04-25
JP3068206B2 (ja) 2000-07-24
CA2259655A1 (en) 1998-01-15
DE69717109T2 (de) 2003-04-30
NZ333513A (en) 2000-04-28
EP0912515A1 (en) 1999-05-06
HUP9904622A3 (en) 2001-07-30
ATE227708T1 (de) 2002-11-15
EP0912515B1 (en) 2002-11-13
DE69717109D1 (de) 2002-12-19
CA2259655C (en) 2003-05-13
WO1998001425A1 (en) 1998-01-15
PT912515E (pt) 2003-03-31

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