IL126581A - Biosensor for detecting a binding event between a ligand and ligand-binding receptor - Google Patents

Biosensor for detecting a binding event between a ligand and ligand-binding receptor

Info

Publication number
IL126581A
IL126581A IL12658197A IL12658197A IL126581A IL 126581 A IL126581 A IL 126581A IL 12658197 A IL12658197 A IL 12658197A IL 12658197 A IL12658197 A IL 12658197A IL 126581 A IL126581 A IL 126581A
Authority
IL
Israel
Prior art keywords
ligand
monolayer
receptor
binding
chains
Prior art date
Application number
IL12658197A
Other languages
English (en)
Other versions
IL126581A0 (en
Original Assignee
Pence Inc
Univ Mcgill
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pence Inc, Univ Mcgill filed Critical Pence Inc
Publication of IL126581A0 publication Critical patent/IL126581A0/xx
Publication of IL126581A publication Critical patent/IL126581A/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438—Electrodes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/002—Electrode membranes
    • C12Q1/003—Functionalisation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00653—Making arrays on substantially continuous surfaces the compounds being bound to electrodes embedded in or on the solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00702—Processes involving means for analysing and characterising the products
    • B01J2219/00704—Processes involving means for analysing and characterising the products integrated with the reactor apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00725—Peptides
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Peptides Or Proteins (AREA)
IL12658197A 1996-04-25 1997-04-25 Biosensor for detecting a binding event between a ligand and ligand-binding receptor IL126581A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US1619696P 1996-04-25 1996-04-25
US1638596P 1996-04-25 1996-04-25
US1638496P 1996-04-25 1996-04-25
PCT/CA1997/000276 WO1997041425A1 (fr) 1996-04-25 1997-04-25 Biocapteur et methode afferente

Publications (2)

Publication Number Publication Date
IL126581A0 IL126581A0 (en) 1999-08-17
IL126581A true IL126581A (en) 2004-03-28

Family

ID=27360510

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12658197A IL126581A (en) 1996-04-25 1997-04-25 Biosensor for detecting a binding event between a ligand and ligand-binding receptor

Country Status (9)

Country Link
EP (1) EP1005644B1 (fr)
JP (1) JP2000510233A (fr)
AT (1) ATE234462T1 (fr)
AU (1) AU711861B2 (fr)
CA (1) CA2251674C (fr)
DE (1) DE69719817T2 (fr)
DK (1) DK1005644T3 (fr)
IL (1) IL126581A (fr)
WO (1) WO1997041425A1 (fr)

Families Citing this family (64)

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US6071699A (en) 1996-06-07 2000-06-06 California Institute Of Technology Nucleic acid mediated electron transfer
US6165335A (en) 1996-04-25 2000-12-26 Pence And Mcgill University Biosensor device and method
US7381525B1 (en) 1997-03-07 2008-06-03 Clinical Micro Sensors, Inc. AC/DC voltage apparatus for detection of nucleic acids
US7393645B2 (en) 1996-11-05 2008-07-01 Clinical Micro Sensors, Inc. Compositions for the electronic detection of analytes utilizing monolayers
US7045285B1 (en) 1996-11-05 2006-05-16 Clinical Micro Sensors, Inc. Electronic transfer moieties attached to peptide nucleic acids
US7160678B1 (en) 1996-11-05 2007-01-09 Clinical Micro Sensors, Inc. Compositions for the electronic detection of analytes utilizing monolayers
US6306584B1 (en) * 1997-01-21 2001-10-23 President And Fellows Of Harvard College Electronic-property probing of biological molecules at surfaces
US6391558B1 (en) 1997-03-18 2002-05-21 Andcare, Inc. Electrochemical detection of nucleic acid sequences
DE19753056A1 (de) * 1997-11-29 1999-08-05 Wolfbeis Otto S Prof Dr Künstliche Oberfläche mit vorbestimmter Affinität
US6395480B1 (en) 1999-02-01 2002-05-28 Signature Bioscience, Inc. Computer program and database structure for detecting molecular binding events
US6485905B2 (en) 1998-02-02 2002-11-26 Signature Bioscience, Inc. Bio-assay device
US6338968B1 (en) 1998-02-02 2002-01-15 Signature Bioscience, Inc. Method and apparatus for detecting molecular binding events
US6287776B1 (en) 1998-02-02 2001-09-11 Signature Bioscience, Inc. Method for detecting and classifying nucleic acid hybridization
DE69918389T2 (de) * 1998-02-02 2005-10-06 Mds Sciex, Concord Verfahren und Vorrichtung zur Erkennung von Molekülbindungsreaktionen
US6287874B1 (en) 1998-02-02 2001-09-11 Signature Bioscience, Inc. Methods for analyzing protein binding events
US6472224B1 (en) 1998-04-17 2002-10-29 Franz Schleicher Biosensor with modified precious metal surface and process for the preparation thereof
DE19817180C2 (de) * 1998-04-17 2000-04-27 Biotul Bio Instr Gmbh Biosensor mit modifizierter Edelmetalloberfläche und Verfahren zu seiner Herstellung
WO1999066322A1 (fr) * 1998-06-15 1999-12-23 Biosensor Systems Design, Inc. (1998) Capteur de detection d'analytes
US6322963B1 (en) 1998-06-15 2001-11-27 Biosensor Systems Design., Inc. Sensor for analyte detection
US6761816B1 (en) 1998-06-23 2004-07-13 Clinical Micro Systems, Inc. Printed circuit boards with monolayers and capture ligands
US6406921B1 (en) 1998-07-14 2002-06-18 Zyomyx, Incorporated Protein arrays for high-throughput screening
US6576478B1 (en) 1998-07-14 2003-06-10 Zyomyx, Inc. Microdevices for high-throughput screening of biomolecules
US6682942B1 (en) 1998-07-14 2004-01-27 Zyomyx, Inc. Microdevices for screening biomolecules
AU749884B2 (en) 1998-08-28 2002-07-04 Febit Ferrarius Biotechnology Gmbh Support for a method for determining an analyte and a method for producing the support
US6740518B1 (en) 1998-09-17 2004-05-25 Clinical Micro Sensors, Inc. Signal detection techniques for the detection of analytes
AU1241000A (en) 1998-10-27 2000-05-15 Clinical Micro Sensors, Inc. Detection of target analytes using particles and electrodes
DE19860547C1 (de) 1998-12-23 2000-10-12 Genetrix B V I O Affinitätssensor für den Nachweis spezifischer molekularer Bindungsereignisse und dessen Verwendung
US6833267B1 (en) 1998-12-30 2004-12-21 Clinical Micro Sensors, Inc. Tissue collection devices containing biosensors
JP2002535656A (ja) * 1999-01-23 2002-10-22 ミナーヴァ・バイオテクノロジーズ・コーポレーション コロイド固定化種と非コロイド構造上の種との相互作用
EP1144677B1 (fr) * 1999-01-25 2006-07-26 Micronas Holding GmbH Immobilisation de molecules sur des surfaces par des brosses polymeres
EP1035218A1 (fr) * 1999-03-03 2000-09-13 BioChip Technologies GmbH Immobilisation des molécules sur des surfaces via des brosses de polymer
AU5251299A (en) * 1999-02-01 2000-08-18 Signature Bioscience Inc. Method and apparatus for detecting molecular binding events
US6787368B1 (en) 1999-03-02 2004-09-07 Helix Biopharma Corporation Biosensor method for detecting analytes in a liquid
AU5646800A (en) * 1999-03-02 2000-09-21 Helix Biopharma Corporation Card-based biosensor device
DE19916638C2 (de) * 1999-04-13 2002-11-07 Jandratek Gmbh Oberflächen zur Verbesserung des Bindungsverhaltens von Analytmolekülen auf der Basis kovalent gebundener hydrophiler Spacer an Hydrogelen
WO2002043864A2 (fr) * 2000-11-03 2002-06-06 Clinical Micro Sensors, Inc. Dispositifs et procedes de multiplexage de puces a adn
US6503701B1 (en) 1999-06-15 2003-01-07 Biosensor Systems Design, Inc. Analytic sensor apparatus and method
US6342347B1 (en) 1999-10-22 2002-01-29 Biosensor Systems Design., Inc. Electromagnetic sensor
EP1185868A1 (fr) * 1999-06-15 2002-03-13 Biosensor Systems Design, Inc. Dispositif et procede servant a detecter des substances a analyser
EP1208126B1 (fr) 1999-07-02 2006-04-12 Symyx Technologies, Inc. Brosses polymeres destinees a immobiliser des molecules sur une surface ou un substrat, dans lesquelles les polymeres presentent des segments dispersables ou solubles dans l'eau et capteurs y etant lies
CA2380258C (fr) 1999-07-26 2008-07-15 Clinical Micro Sensors, Inc. Determination de sequences d'acides nucleiques par detection electronique
AU772250B2 (en) * 2000-01-11 2004-04-22 Clinical Micro Sensors, Inc. Devices and methods for biochip multiplexing
ES2278757T3 (es) * 2000-01-11 2007-08-16 Clinical Micro Sensors, Inc. Cartucho que comprende un biochip.
US7455975B2 (en) 2000-04-14 2008-11-25 Esa Biosciences, Inc. Electrochemical detection of nucleic acid sequences
DE10051396A1 (de) 2000-10-17 2002-04-18 Febit Ferrarius Biotech Gmbh Verfahren und Vorrichtung zur integrierten Synthese und Analytbestimmung an einem Träger
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AU2002246978A1 (en) 2001-01-10 2002-07-24 Symyx Technologies, Inc. Polymer brushes for immobilizing molecules to a surface
DE10112505C1 (de) * 2001-03-15 2003-01-30 Iongate Biosciences Gmbh Sensoranordnung und Vorrichtung zur amperometrischen und/oder potentiometrischen, pharmakologischen Wirkort- und/oder Wirkstofftestung sowie Verfahren zur amperometrischen und/oder potentiometrischen, pharmakologischen Wirkort- und/oder Wirkstofftestung
EP1386158B1 (fr) * 2001-05-09 2008-05-14 Andreas Hofmann Objet a surface hydrogel fonctionnalisee non chargee
WO2003098661A2 (fr) * 2001-10-26 2003-11-27 Integrated Nano-Technologies, Llc Systeme de detection de risques chimiques et biologiques et leurs procedes
WO2004023128A1 (fr) * 2002-09-05 2004-03-18 Unisearch Limited Detection de molecules d'acide nucleique cibles par la modification de la reaction d'une espece redox apres l'hybridation avec des molecules d'acide nucleique de capture immobilisees
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WO2005016115A2 (fr) 2003-01-23 2005-02-24 Montana State University Biocapteurs faisant intervenir des ligands immobilises sur des dendrimeres et utilisation de ceux-ci
DE10320898A1 (de) * 2003-05-09 2004-12-02 Iongate Biosciences Gmbh Biokompatible Sensorelektrodenanordnung und Verfahren zu deren Herstellung
GB0323802D0 (en) * 2003-10-10 2003-11-12 Univ Cambridge Tech Detection of molecular interactions using a metal-insulator-semiconductor diode structure
WO2005093418A1 (fr) * 2004-03-26 2005-10-06 Toto, Ltd. Procede de detection specifique de substance de test a l'aide de courant photoelectrique et d'electrodes, cellule de mesure, dispositif de mesure et solution tampon destines a etre utilises a cet effet
JP2006133137A (ja) * 2004-11-08 2006-05-25 Eiichi Tamiya 被検物質の検出方法
GB2433506A (en) * 2005-12-20 2007-06-27 Sharp Kk A method of producing a multimeric capture agent
GB2433591A (en) * 2005-12-20 2007-06-27 Sharp Kk Method for functionalising a hydrophobic substrate
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US20090159458A1 (en) * 2006-04-07 2009-06-25 Bio Device Technology Ltd. Method for Determination of Test Substance
JP5447716B1 (ja) 2013-04-30 2014-03-19 国立大学法人 東京大学 バイオセンサ及び分子識別部材
JP5565783B1 (ja) 2013-08-08 2014-08-06 国立大学法人 東京大学 バイオセンサ
CN117999476A (zh) * 2021-09-16 2024-05-07 株式会社电装 离子传感器、以及被检测物质的检测方法

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JP2682859B2 (ja) * 1987-07-27 1997-11-26 コモンウェルス サイエンティフィック アンド インダストリアル リサーチ オーガニゼーション レセプター膜
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US5368712A (en) * 1989-11-02 1994-11-29 Synporin Technologies, Inc. Biologically mimetic synthetic ion channel transducers
IL93020A (en) * 1990-01-09 1995-06-29 Yeda Res & Dev Biosensors comprising a lipid bilayer doped with ion channels anchored to a recording electrode by bridging molecules
IT1275482B (it) * 1995-07-05 1997-08-07 Cooperativa Centro Ricerche Po Biosensori elettrochimici basati su trasduttori compositi

Also Published As

Publication number Publication date
WO1997041425A1 (fr) 1997-11-06
EP1005644A1 (fr) 2000-06-07
DE69719817D1 (de) 2003-04-17
EP1005644B1 (fr) 2003-03-12
CA2251674A1 (fr) 1997-11-06
CA2251674C (fr) 2004-12-14
AU2563997A (en) 1997-11-19
JP2000510233A (ja) 2000-08-08
DE69719817T2 (de) 2003-12-24
ATE234462T1 (de) 2003-03-15
DK1005644T3 (da) 2003-06-23
AU711861B2 (en) 1999-10-21
IL126581A0 (en) 1999-08-17

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