IL124871A - Naphthyl glyoxamides and medicinal preparations containing them, as inhibitors of sPLA2 - Google Patents
Naphthyl glyoxamides and medicinal preparations containing them, as inhibitors of sPLA2Info
- Publication number
- IL124871A IL124871A IL12487196A IL12487196A IL124871A IL 124871 A IL124871 A IL 124871A IL 12487196 A IL12487196 A IL 12487196A IL 12487196 A IL12487196 A IL 12487196A IL 124871 A IL124871 A IL 124871A
- Authority
- IL
- Israel
- Prior art keywords
- compound
- formula
- medicament
- compounds
- naphthyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/72—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
- C07C235/76—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
- C07C235/78—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US855795P | 1995-12-13 | 1995-12-13 | |
GBGB9602268.6A GB9602268D0 (en) | 1996-02-05 | 1996-02-05 | Naphthyl glyoxamides as sPLA2 inhibitors |
PCT/US1996/019529 WO1997021716A1 (fr) | 1995-12-13 | 1996-12-09 | NAPHTYLGLYOXAMIDES EN TANT QU'INHIBITEURS DE sPLA¿2? |
Publications (2)
Publication Number | Publication Date |
---|---|
IL124871A0 IL124871A0 (en) | 1999-01-26 |
IL124871A true IL124871A (en) | 2002-04-21 |
Family
ID=26308608
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL12487196A IL124871A (en) | 1995-12-13 | 1996-12-09 | Naphthyl glyoxamides and medicinal preparations containing them, as inhibitors of sPLA2 |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0779273B1 (fr) |
JP (1) | JP2000502083A (fr) |
KR (1) | KR19990072111A (fr) |
AU (1) | AU1149797A (fr) |
ES (1) | ES2174034T3 (fr) |
HU (1) | HUP9902120A3 (fr) |
IL (1) | IL124871A (fr) |
MX (1) | MX9804750A (fr) |
WO (1) | WO1997021716A1 (fr) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20010042307A (ko) | 1998-03-31 | 2001-05-25 | 시오노 요시히코 | 피롤로[1,2-a]피라진 sPLA2 억제제 |
JP4544446B2 (ja) | 1998-05-21 | 2010-09-15 | 塩野義製薬株式会社 | sPLA2阻害作用を有するピロロ[1,2−b]ピリダジン誘導体 |
DE69931963D1 (de) | 1998-10-14 | 2006-07-27 | Shionogi & Co | Spla2-inhibitoren zur behandlung von ischämischen reperfusionsschäden |
WO2001005789A1 (fr) | 1999-07-19 | 2001-01-25 | Shionogi & Co., Ltd. | Composes tricycliques a action inhibitrice a l'encontre de spla¿2? |
AU6023200A (en) | 1999-08-02 | 2001-02-19 | Shionogi & Co., Ltd. | Tricyclic compounds having spla2-inhibitory activities |
WO2001014378A1 (fr) | 1999-08-23 | 2001-03-01 | Shionogi & Co., Ltd. | DERIVES DE PYRROLOTRIAZINE A ACTIVITES INHIBANT sPLA¿2? |
US6756376B1 (en) | 1999-11-15 | 2004-06-29 | Shionogi & Co., Ltd. | Tricyclic azaindolizine derivatives having an sPLA2-inhibitory activities |
US6967200B2 (en) | 2000-06-29 | 2005-11-22 | Shionogi & Co., Ltd. | Remedies for cirrhosis |
WO2002000621A1 (fr) | 2000-06-29 | 2002-01-03 | Shionogi & Co., Ltd. | Composes inhibiteurs de la spla2 de type x |
TWI314457B (fr) | 2001-03-19 | 2009-09-11 | Shionogi & Co |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2658818B1 (fr) * | 1990-02-27 | 1993-12-31 | Adir Cie | Nouveaux derives a structure naphtalenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
US5436369A (en) * | 1993-06-16 | 1995-07-25 | Bristol-Myers Squibb Company | Alicyclic phospholipase A2 inhibitors |
-
1996
- 1996-12-09 AU AU11497/97A patent/AU1149797A/en not_active Abandoned
- 1996-12-09 JP JP9522135A patent/JP2000502083A/ja not_active Withdrawn
- 1996-12-09 EP EP96308901A patent/EP0779273B1/fr not_active Expired - Lifetime
- 1996-12-09 WO PCT/US1996/019529 patent/WO1997021716A1/fr not_active Application Discontinuation
- 1996-12-09 IL IL12487196A patent/IL124871A/en not_active IP Right Cessation
- 1996-12-09 ES ES96308901T patent/ES2174034T3/es not_active Expired - Lifetime
- 1996-12-09 KR KR1019980704426A patent/KR19990072111A/ko not_active Application Discontinuation
- 1996-12-09 HU HU9902120A patent/HUP9902120A3/hu unknown
-
1998
- 1998-06-12 MX MX9804750A patent/MX9804750A/es not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
JP2000502083A (ja) | 2000-02-22 |
EP0779273A1 (fr) | 1997-06-18 |
KR19990072111A (ko) | 1999-09-27 |
HUP9902120A2 (hu) | 1999-11-29 |
HUP9902120A3 (en) | 1999-12-28 |
EP0779273B1 (fr) | 2002-03-20 |
WO1997021716A1 (fr) | 1997-06-19 |
IL124871A0 (en) | 1999-01-26 |
MX9804750A (es) | 1998-10-31 |
AU1149797A (en) | 1997-07-03 |
ES2174034T3 (es) | 2002-11-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FF | Patent granted | ||
KB | Patent renewed | ||
RH1 | Patent not in force |