IL121748A0 - Vanadium complexes of hydroxamates and pharmaceutical compositions comprising them - Google Patents

Vanadium complexes of hydroxamates and pharmaceutical compositions comprising them

Info

Publication number
IL121748A0
IL121748A0 IL12174897A IL12174897A IL121748A0 IL 121748 A0 IL121748 A0 IL 121748A0 IL 12174897 A IL12174897 A IL 12174897A IL 12174897 A IL12174897 A IL 12174897A IL 121748 A0 IL121748 A0 IL 121748A0
Authority
IL
Israel
Prior art keywords
hydroxamates
pharmaceutical compositions
vanadium complexes
vanadium
complexes
Prior art date
Application number
IL12174897A
Other languages
English (en)
Original Assignee
Yeda Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yeda Res & Dev filed Critical Yeda Res & Dev
Priority to IL12174897A priority Critical patent/IL121748A0/xx
Publication of IL121748A0 publication Critical patent/IL121748A0/xx
Priority to CA002303444A priority patent/CA2303444A1/en
Priority to US09/508,411 priority patent/US6414029B1/en
Priority to PCT/IL1998/000441 priority patent/WO1999012875A1/en
Priority to IL13495198A priority patent/IL134951A0/xx
Priority to AU90939/98A priority patent/AU748278B2/en
Priority to JP2000510690A priority patent/JP2001515874A/ja
Priority to KR1020007002553A priority patent/KR20010023870A/ko
Priority to BR9812640-7A priority patent/BR9812640A/pt
Priority to CN98810940A priority patent/CN1278785A/zh
Priority to EP98942991A priority patent/EP1023251A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C9/00—Aliphatic saturated hydrocarbons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/005—Compounds of elements of Group 5 of the Periodic Table without metal-carbon linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
IL12174897A 1997-09-11 1997-09-11 Vanadium complexes of hydroxamates and pharmaceutical compositions comprising them IL121748A0 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
IL12174897A IL121748A0 (en) 1997-09-11 1997-09-11 Vanadium complexes of hydroxamates and pharmaceutical compositions comprising them
EP98942991A EP1023251A1 (en) 1997-09-11 1998-09-10 Vanadium complexes of monohydroxamates and pharmaceutical compositions comprising them
IL13495198A IL134951A0 (en) 1997-09-11 1998-09-10 Vanadium complexes of hydroxamates and pharmaceutical compositions comprising them
US09/508,411 US6414029B1 (en) 1997-09-11 1998-09-10 Vanadium complexes of monohydroxamates and pharmaceutical compositions comprising them
PCT/IL1998/000441 WO1999012875A1 (en) 1997-09-11 1998-09-10 Vanadium complexes of monohydroxamates and pharmaceutical compositions comprising them
CA002303444A CA2303444A1 (en) 1997-09-11 1998-09-10 Vanadium complexes of monohydroxamates and pharmaceutical compositions comprising them
AU90939/98A AU748278B2 (en) 1997-09-11 1998-09-10 Vanadium complexes of monohydroxamates and pharmaceutical compositions comprising them
JP2000510690A JP2001515874A (ja) 1997-09-11 1998-09-10 モノヒドロキサム酸塩のバナジウム錯体及び当該錯体で構成される医薬品組成物
KR1020007002553A KR20010023870A (ko) 1997-09-11 1998-09-10 모노히드록사메이트의 바나듐 착물 및 이를 포함하는 약제조성물
BR9812640-7A BR9812640A (pt) 1997-09-11 1998-09-10 Complexos de monoidroxamatos de vanádio e composições farmacêuticas compreendendo os mesmos
CN98810940A CN1278785A (zh) 1997-09-11 1998-09-10 单异羟肟酯酯的钒络合物和含其的药用组合物

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL12174897A IL121748A0 (en) 1997-09-11 1997-09-11 Vanadium complexes of hydroxamates and pharmaceutical compositions comprising them

Publications (1)

Publication Number Publication Date
IL121748A0 true IL121748A0 (en) 1998-02-22

Family

ID=11070622

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12174897A IL121748A0 (en) 1997-09-11 1997-09-11 Vanadium complexes of hydroxamates and pharmaceutical compositions comprising them

Country Status (10)

Country Link
US (1) US6414029B1 (zh)
EP (1) EP1023251A1 (zh)
JP (1) JP2001515874A (zh)
KR (1) KR20010023870A (zh)
CN (1) CN1278785A (zh)
AU (1) AU748278B2 (zh)
BR (1) BR9812640A (zh)
CA (1) CA2303444A1 (zh)
IL (1) IL121748A0 (zh)
WO (1) WO1999012875A1 (zh)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002214222A1 (en) * 2000-11-01 2002-05-15 Yeda Research And Development Co..Ltd. Pharmaceutical compositions comprising organic vanadium complexes for treatment of ischemia
WO2007043606A1 (ja) * 2005-10-12 2007-04-19 Genolac Bl Corporation アニオン性ポリアミノ酸／金属複合体からなる抗糖尿病薬剤
WO2009032591A1 (en) * 2007-08-28 2009-03-12 Akesis Pharmaceuticals Inc. Food effect in treatment of diabetes with vanadium salts
CN101947238B (zh) * 2010-06-24 2011-12-21 攀枝花兴辰钒钛有限公司 治疗癌症的药物组合物及其用途
CN101972273B (zh) * 2010-10-29 2011-12-21 攀枝花兴辰钒钛有限公司 一种药物在制备治疗糖尿病的药物中的用途
CN102134738B (zh) * 2010-12-24 2012-11-28 华东师范大学 一种有生物活性的草酸羟胺钒配合物晶体的制备方法
CN103561733A (zh) * 2011-03-07 2014-02-05 Cfm医药控股有限公司 用于维持哺乳动物体内血糖量正常的钒化合物的用途
US20140018340A1 (en) 2011-03-25 2014-01-16 Mihir K. Chaudhuri Insulin Mimetic Active Comprising Oxodiperoxo Vanadates and a Pharmaceutical Composition Obtained Thereof
PL231079B1 (pl) 2012-11-07 2019-01-31 Univ Jagiellonski Kompleksy wanadu z hydrazydohydrazonami, preparaty farmaceutyczne oraz zastosowanie kompleksów wanadu z hydrazydohydrazonami
CN107873023B (zh) 2015-02-02 2021-07-23 福马治疗股份有限公司 作为hdac抑制剂的3-烷基-4-酰氨基-双环[4，5，0]异羟肟酸
WO2016126726A1 (en) 2015-02-02 2016-08-11 Forma Therapeutics, Inc. Bicyclic [4,6,0] hydroxamic acids as hdac6 inhibitors
US10555935B2 (en) 2016-06-17 2020-02-11 Forma Therapeutics, Inc. 2-spiro-5- and 6-hydroxamic acid indanes as HDAC inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2619382B1 (fr) * 1987-08-11 1990-05-04 Lazaro Rene Compose organo-mineral de vanadyle, procede d'obtention d'un tel compose, composition pharmaceutique contenant ce compose organo-mineral
IL99666A (en) * 1991-10-07 1996-09-12 Yeda Res & Dev Vanadyl complexes of hydroxamate chelators and pharmaceutical compositions comprising them
US5338758A (en) * 1992-04-03 1994-08-16 Schering Corporation Bicyclic diterpene PAF antagonist compounds
US5804601A (en) * 1995-04-10 1998-09-08 Takeda Chemical Industries, Ltd. Aromatic hydroxamic acid compounds, their production and use

Also Published As

Publication number Publication date
AU748278B2 (en) 2002-05-30
KR20010023870A (ko) 2001-03-26
CN1278785A (zh) 2001-01-03
EP1023251A1 (en) 2000-08-02
CA2303444A1 (en) 1999-03-18
JP2001515874A (ja) 2001-09-25
AU9093998A (en) 1999-03-29
BR9812640A (pt) 2000-08-22
US6414029B1 (en) 2002-07-02
WO1999012875A1 (en) 1999-03-18

Similar Documents

Publication Publication Date Title
HUS1200028I1 (hu) 4"-Szubsztituált-9-dezoxo-9a-aza-9a-homoeritromicin-származékok és ezeket tartalmazó gyógyszerek
IL114622A0 (en) Heteroaryl-oxazolidinones and pharmaceutical compositions containing them
PT1213020E (pt) Compostos e composições farmacêuticas com actividade supressora do apetite
HUP0004318A3 (en) Pharmaceutical composition comprising atorvastatin and an antihypertensive agent
EP0950665A4 (en) PHYSIOLOGICALLY ACTIVE MODIFIED PROTEINS AND DRUG COMPOSITIONS CONTAINING THEM
HUP0100178A3 (en) Tetrahydro-naphtiridinyl-imidazolydinyl-carboxylic acid derivatives and pharmaceutical compositions thereof
HUP0001309A3 (en) 1-phenyl-4-benzylpiperazines and pharmaceutical compositions containing them
IL117727A (en) Synergistic combinations having anti-hiv activity and pharmaceutical compositions containing them
HUP9701299A3 (en) Insuline derivatives of enhanced zinc-binding activity, complexes and pharmaceutical compositions comprising thereof and their proinsulines
HUP0100149A3 (en) Antipicornaviral peptide derivatives pharmaceutical compositions comprising thereof and their use
AU5613999A (en) Pharmaceutical compositions of vanadium biguanide complexes and their use
HU9800147D0 (en) Isoxasol-and crotonoil-amide derivatives and pharmaceutical and diagnostical compositions containing them
LT99141A (en) Pharmaceutical compositions of tizoxanide and nitazoxanide
IL121748A0 (en) Vanadium complexes of hydroxamates and pharmaceutical compositions comprising them
ZA967800B (en) Heteroaryllsubstituted acryloylguanidine derivatives and pharmaceutical compositions comprising them
HUP0100085A3 (en) Biphenylamidine derivatives and pharmaceutical compositions containing them
HUP0101701A3 (en) Substituted betha-alanines and pharmaceutical compositions comprising them
HUP0002331A3 (en) 20-aralkyl-5alpha-pregnane derivatives and pharmaceutical compositions thereof
IL120669A0 (en) Benzylamine derivatives and pharmaceutical compositions containing them
HUP0000460A3 (en) Imidazopyridazines and pharmaceutical compositions thereof
IL123040A0 (en) Manganese complexes pharmaceutical compositions containg them and their use
IL126734A0 (en) Cosmetic and/or pharmaceutical and/or dermatological compositions
IL132516A (en) Pharmaceutical compositions of tizoxanide and nitazoxanide
GB9501286D0 (en) Pharmaceutical compositions and preparations thereof
HUP9601526A3 (en) Peptidyl-arginin-aldehyde derivatives of anticoagulant activity and pharmaceutical compositions containing them