IL118427A - N-acyl-2 aryl cycloalkylmethylamine derivatives as melatonergics and pharmaceutical compositions comprising them - Google Patents

N-acyl-2 aryl cycloalkylmethylamine derivatives as melatonergics and pharmaceutical compositions comprising them

Info

Publication number
IL118427A
IL118427A IL11842796A IL11842796A IL118427A IL 118427 A IL118427 A IL 118427A IL 11842796 A IL11842796 A IL 11842796A IL 11842796 A IL11842796 A IL 11842796A IL 118427 A IL118427 A IL 118427A
Authority
IL
Israel
Prior art keywords
melatonergics
acyl
aryl
pharmaceutical compositions
cycloalkylmethylamine derivatives
Prior art date
Application number
IL11842796A
Other languages
English (en)
Other versions
IL118427A0 (en
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/487,306 external-priority patent/US5596019A/en
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of IL118427A0 publication Critical patent/IL118427A0/xx
Publication of IL118427A publication Critical patent/IL118427A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C211/03—Monoamines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
    • C07C233/13—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/60—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/08—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
    • C07C255/60—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton at least one of the singly-bound nitrogen atoms being acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/20—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C07C275/24—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/26—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
IL11842796A 1995-06-07 1996-05-27 N-acyl-2 aryl cycloalkylmethylamine derivatives as melatonergics and pharmaceutical compositions comprising them IL118427A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48663395A 1995-06-07 1995-06-07
US08/487,306 US5596019A (en) 1995-06-07 1995-06-07 N-acyl-cycloalkylamine derivatives as melatonergics

Publications (2)

Publication Number Publication Date
IL118427A0 IL118427A0 (en) 1996-09-12
IL118427A true IL118427A (en) 2000-10-31

Family

ID=27048750

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11842796A IL118427A (en) 1995-06-07 1996-05-27 N-acyl-2 aryl cycloalkylmethylamine derivatives as melatonergics and pharmaceutical compositions comprising them

Country Status (23)

Country Link
EP (1) EP0747346B1 (fr)
JP (1) JPH08333314A (fr)
KR (1) KR100385360B1 (fr)
CN (1) CN1068583C (fr)
AR (1) AR003139A1 (fr)
AT (1) ATE189807T1 (fr)
AU (1) AU697028B2 (fr)
CA (1) CA2176854A1 (fr)
CY (1) CY2221B1 (fr)
CZ (1) CZ291380B6 (fr)
DE (1) DE69606665T2 (fr)
DK (1) DK0747346T3 (fr)
ES (1) ES2144666T3 (fr)
GR (1) GR3033414T3 (fr)
HK (1) HK1014704A1 (fr)
HU (1) HUP9601565A3 (fr)
IL (1) IL118427A (fr)
NO (1) NO311211B1 (fr)
NZ (1) NZ286640A (fr)
PL (1) PL314671A1 (fr)
PT (1) PT747346E (fr)
RU (1) RU2162076C2 (fr)
TW (1) TW350836B (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9713690B1 (pt) * 1996-12-10 2009-08-11 agentes melatoninérgicos benzodioxola, benzofurano, diidrobenzofurano e benzodioxano.
US6028112A (en) * 1997-05-23 2000-02-22 Bristol-Myers Squibb Company Spirocyclopropyl fluorenes as melatonergic agents
US6214869B1 (en) * 1998-06-05 2001-04-10 Bristol-Myers Squibb Heterocyclic cis cyclopropane derivatives as melatonergic agents
JP4593782B2 (ja) * 1998-06-29 2010-12-08 田辺三菱製薬株式会社 光学活性なトランス−シクロヘキシルアミン化合物の製造法
FR2784375B1 (fr) * 1998-10-12 2000-11-24 Adir Nouveaux derives cycliques a chaine cycloalkylenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO2000021910A2 (fr) * 1998-10-14 2000-04-20 Ortho-Mcneil Pharmaceutical, Inc. Cyclopropanes a disubstitution en position 1 et 2
UY26780A1 (es) 2000-06-15 2002-01-31 Pharmacia Corp Cicloalquil avb3 antagonistas
US7541055B2 (en) * 2004-09-10 2009-06-02 International Flavors & Fragrances Inc. Saturated and unsaturated N-alkamides exhibiting taste and flavor enhancement effect in flavor compositions
WO2007025144A1 (fr) * 2005-08-24 2007-03-01 University Of Illinois - Chicago Agonistes de recepteur 5-ht2c utilises en tant qu'agents anorexigenes
TWI402261B (zh) 2006-06-19 2013-07-21 Takeda Pharmaceutical 三環化合物及其醫藥組成物
US8835472B2 (en) * 2010-09-02 2014-09-16 Boehringer Ingelheim International Gmbh Compounds, pharmaceutical compositions and uses thereof
CA2872324C (fr) 2012-05-18 2017-06-06 Vanda Pharmaceuticals Inc. Metabolites de (1r-trans)-n-[[2-(2,3-dihydro-4-benzofuranyl)cyclopropyl]methyl]- propanamide
CN102863341B (zh) * 2012-10-22 2014-05-07 南通大学 一种（1r,2s）-2-芳基环丙胺衍生物的化学合成方法
DK3250549T3 (da) * 2015-01-29 2021-09-20 The Board Of Trustees Of The Univ Of Illionis Cyclopropylmethanaminer som selektive 5-HT(2C)-receptoragonister
CN105949153B (zh) * 2016-05-10 2018-03-02 浙江工业大学 一种他司美琼的合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1415997A (fr) * 1963-11-05 1965-10-29 Whitefin Holding Sa Dérivés de phénylcyclopropane et procédés de préparation
US5071875A (en) * 1989-09-25 1991-12-10 Northwestern University Substituted 2-amidotetralins as melatonin agonists and antagonists
JP3007138B2 (ja) * 1990-11-27 2000-02-07 ファイザー製薬株式会社 新規なヒドロキサム酸とｎ―ヒドロキシ尿素誘導体およびそれらの組成物
FR2680366B1 (fr) * 1991-08-13 1995-01-20 Adir Nouveaux derives d'arylethylamines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
AU2807192A (en) * 1991-10-02 1993-05-03 Smithkline Beecham Corporation Cyclopentane and cyclopentene derivatives with antiallergic antiinflammatory and tumor necrosis factor inhibiting activity
US5541228A (en) * 1994-10-14 1996-07-30 Bristol-Myers Squibb Co. Melatonergic agents

Also Published As

Publication number Publication date
NO962364L (no) 1996-12-09
AU5475996A (en) 1996-12-19
ATE189807T1 (de) 2000-03-15
AU697028B2 (en) 1998-09-24
CN1068583C (zh) 2001-07-18
AR003139A1 (es) 1998-07-08
CA2176854A1 (fr) 1996-12-08
ES2144666T3 (es) 2000-06-16
EP0747346A3 (fr) 1997-11-05
HUP9601565A3 (en) 1998-03-02
CN1143628A (zh) 1997-02-26
CZ291380B6 (cs) 2003-02-12
CY2221B1 (en) 2003-04-18
NZ286640A (en) 1998-06-26
EP0747346A2 (fr) 1996-12-11
HUP9601565A2 (en) 1997-05-28
DE69606665T2 (de) 2000-09-21
NO962364D0 (no) 1996-06-06
PT747346E (pt) 2000-06-30
KR100385360B1 (ko) 2003-08-25
HU9601565D0 (en) 1996-08-28
DE69606665D1 (de) 2000-03-23
PL314671A1 (en) 1996-12-09
RU2162076C2 (ru) 2001-01-20
GR3033414T3 (en) 2000-09-29
DK0747346T3 (da) 2000-06-05
IL118427A0 (en) 1996-09-12
NO311211B1 (no) 2001-10-29
HK1014704A1 (en) 1999-09-30
KR970001306A (ko) 1997-01-24
TW350836B (en) 1999-01-21
EP0747346B1 (fr) 2000-02-16
CZ163196A3 (en) 1997-06-11
JPH08333314A (ja) 1996-12-17

Similar Documents

Publication Publication Date Title
IL116851A (en) 3-arylidene-2-oxindole derivatives and pharmaceutical compositions containing them
IL119078A (en) Substituted benzylaminopiperidine compounds and pharmaceutical compositions comprising them
NZ304982A (en) Pyridinyloxy- or pyridinylamino-acetamide derivatives; pharmaceutical compositions
IL116917A0 (en) Piperidine derivatives and pharmaceutical compositions containing the same
HUP9900424A2 (hu) Tiazolil-benzfurán-származékok és a vegyületeket tartalmazó gyógyászati készítmények
IL119559A0 (en) Purin -6- one derivatives their preparation and pharmaceutical compositions containing them
IL125710A0 (en) Arylglycinamide derivatives their preparation and pharmaceutical compositions containing them
IL115905A0 (en) Sordarin derivatives their preparation and pharmaceutical compositions containing them
HUP9802290A3 (en) Pyrrole derivatives and pharmaceutical compositions containing them
ZA967827B (en) Pharmaceutical compositions
AU5856898A (en) Heteroarylsulfonamide derivatives and pharmaceutical compositions containing them
ZA967800B (en) Heteroaryllsubstituted acryloylguanidine derivatives and pharmaceutical compositions comprising them
IL118427A (en) N-acyl-2 aryl cycloalkylmethylamine derivatives as melatonergics and pharmaceutical compositions comprising them
HUP0100085A3 (en) Biphenylamidine derivatives and pharmaceutical compositions containing them
HUP9602196A3 (en) Sulfonyl- and sulfinyl-benzoyl-guanidine derivatives and pharmaceutical compositions thereof
HUP0002331A3 (en) 20-aralkyl-5alpha-pregnane derivatives and pharmaceutical compositions thereof
EG24294A (en) Pharmaceutical compositions
IL117397A (en) Substituted naphthyl compounds and pharmaceutical compositions comprising them
GB9506382D0 (en) Pharmaceutical compositions
GB9513972D0 (en) Pharmaceutical compositions
IL136045A0 (en) Pyridylpyrrole derivatives and pharmaceutical compositions containing the same
HUP9802291A3 (en) Penicillaminamide derivatives and pharmaceutical compositions containing them
IL115982A (en) Cyclolignan derivatives and pharmaceutical compositions containing them
IL123000A (en) Aza-anthracylinone derivatives their preparation and pharmaceutical compositions containing them
AU3710695A (en) Quinolonylcarboxyerythromycin derivatives and pharmaceutical compositions containing them

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees