IL118158A - Sequence of nucleotides capable of inhibiting -6IL - Google Patents
Sequence of nucleotides capable of inhibiting -6ILInfo
- Publication number
- IL118158A IL118158A IL11815896A IL11815896A IL118158A IL 118158 A IL118158 A IL 118158A IL 11815896 A IL11815896 A IL 11815896A IL 11815896 A IL11815896 A IL 11815896A IL 118158 A IL118158 A IL 118158A
- Authority
- IL
- Israel
- Prior art keywords
- plasmid
- nucleotide sequence
- apre
- inhibitor
- sequence
- Prior art date
Links
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Toxicology (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP1995/001778 WO1996035782A1 (en) | 1995-05-11 | 1995-05-11 | Il-6 activity inhibitor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL118158A0 IL118158A0 (en) | 1996-09-12 |
| IL118158A true IL118158A (en) | 2004-07-25 |
Family
ID=8166014
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL11815896A IL118158A (en) | 1995-05-11 | 1996-05-06 | Sequence of nucleotides capable of inhibiting -6IL |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US6004813A (ru) |
| EP (1) | EP0824588B1 (ru) |
| JP (1) | JP4173539B2 (ru) |
| KR (1) | KR100449677B1 (ru) |
| AT (1) | ATE271128T1 (ru) |
| AU (1) | AU715125B2 (ru) |
| CA (1) | CA2220433C (ru) |
| DE (1) | DE69533264T2 (ru) |
| DK (1) | DK0824588T3 (ru) |
| ES (1) | ES2220929T3 (ru) |
| HK (1) | HK1016213A1 (ru) |
| IL (1) | IL118158A (ru) |
| MX (1) | MX9708663A (ru) |
| RU (1) | RU2205874C2 (ru) |
| UA (1) | UA63888C2 (ru) |
| WO (1) | WO1996035782A1 (ru) |
| ZA (1) | ZA963593B (ru) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6727230B1 (en) | 1994-03-25 | 2004-04-27 | Coley Pharmaceutical Group, Inc. | Immune stimulation by phosphorothioate oligonucleotide analogs |
| US6429199B1 (en) | 1994-07-15 | 2002-08-06 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules for activating dendritic cells |
| US6239116B1 (en) | 1994-07-15 | 2001-05-29 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| EP0869176A4 (en) * | 1995-11-07 | 2000-09-20 | Kaneka Corp | AUTOANTIGENS |
| EP0855184A1 (en) * | 1997-01-23 | 1998-07-29 | Grayson B. Dr. Lipford | Pharmaceutical composition comprising a polynucleotide and an antigen especially for vaccination |
| JP2001513776A (ja) | 1997-02-28 | 2001-09-04 | ユニバーシティ オブ アイオワ リサーチ ファウンデーション | ＬＰＳ関連障害の処置における非メチル化ＣｐＧジヌクレオチドを含む核酸の使用 |
| US6406705B1 (en) | 1997-03-10 | 2002-06-18 | University Of Iowa Research Foundation | Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant |
| ATE370740T1 (de) | 1997-05-20 | 2007-09-15 | Ottawa Health Research Inst | Verfahren zur herstellung von nukleinsäurekonstrukten |
| ES2284247T3 (es) | 1998-04-03 | 2007-11-01 | University Of Iowa Research Foundation | Metodos y productos para estimular el sistema inmunitario usando oligonucleotidos y citoquinas inmunoterapeuticos. |
| EP0972780A1 (en) * | 1998-05-18 | 2000-01-19 | Applied Research Systems ARS Holding N.V. | Il-6 antagonist peptides |
| JP4748338B2 (ja) | 1998-09-11 | 2011-08-17 | 味の素株式会社 | ベンゼン誘導体及びその医薬用途 |
| WO2001016166A2 (en) | 1999-08-27 | 2001-03-08 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Polypeptides, comprising il-6 ligand-binding receptor domains, and related nucleic acids, antibodies, compositions, and methods of use |
| US6949520B1 (en) | 1999-09-27 | 2005-09-27 | Coley Pharmaceutical Group, Inc. | Methods related to immunostimulatory nucleic acid-induced interferon |
| US20030232813A1 (en) * | 2002-04-10 | 2003-12-18 | Orchid Chemicals & Pharmaceuticals Limited | Novel amino substituted pyrimidinone derivatives |
| US7521465B2 (en) * | 2003-01-17 | 2009-04-21 | Bexel Pharmaceuticals, Inc. | Diphenyl ether derivatives |
| US6794401B2 (en) * | 2003-01-17 | 2004-09-21 | Bexel Pharmaceuticals, Inc. | Amino acid phenoxy ethers |
| US7781464B2 (en) * | 2003-01-17 | 2010-08-24 | Bexel Pharmaceuticals, Inc. | Heterocyclic diphenyl ethers |
| US7087576B2 (en) * | 2003-10-07 | 2006-08-08 | Bexel Pharmaceuticals, Inc. | Dipeptide phenyl ethers |
| SI2511297T1 (sl) * | 2004-02-06 | 2015-07-31 | Morphosys Ag | Proti -CD38 humana protitelesa in njihova uporaba |
| JP2008533122A (ja) * | 2005-03-18 | 2008-08-21 | オーキッド ケミカルズ アンド ファーマシューティカルズ リミテッド | 新規なチロシン誘導体 |
| US20080267888A1 (en) * | 2005-05-26 | 2008-10-30 | Pandey Surendrakumar Satyanara | Heterocyclic Derivatives |
| WO2007000655A2 (en) * | 2005-06-28 | 2007-01-04 | Orchid Research Laboratories Limited | Novel pyrazolopyrimidinone derivatives |
| RS56677B1 (sr) | 2005-10-12 | 2018-03-30 | Morphosys Ag | Proizvodnja i karakterizacija potpuno humanih terapeutskih antitela dobijenih hucal gold tehnologijom, specifičnih za humani cd38 |
| US7863446B2 (en) * | 2006-01-19 | 2011-01-04 | Orchid Research Laboratories Limited | Heterocycles |
| WO2007083182A2 (en) * | 2006-01-19 | 2007-07-26 | Orchid Research Laboratories Limited | Novel heterocycles |
| US20080221103A1 (en) * | 2007-03-09 | 2008-09-11 | Orchid Research Laboratories Ltd. | New heterocyclic compounds |
| JP5646320B2 (ja) * | 2007-05-11 | 2014-12-24 | アダイニクス， インコーポレイテッド | 遺伝子発現と疼痛 |
| JP5704924B2 (ja) | 2008-02-01 | 2015-04-22 | オーキッド リサーチ ラボラトリーズ リミティド | 新規複素環化合物 |
| SG171914A1 (en) | 2008-12-02 | 2011-07-28 | Chiralgen Ltd | Method for the synthesis of phosphorus atom modified nucleic acids |
| AU2010270714B2 (en) | 2009-07-06 | 2015-08-13 | Wave Life Sciences Ltd. | Novel nucleic acid prodrugs and methods use thereof |
| US10428019B2 (en) | 2010-09-24 | 2019-10-01 | Wave Life Sciences Ltd. | Chiral auxiliaries |
| DK2734208T3 (en) | 2011-07-19 | 2017-06-19 | Wave Life Sciences Ltd | PROCEDURES FOR SYNTHESIS OF FUNCTIONALIZED NUCLEIC ACIDS |
| WO2013170086A2 (en) | 2012-05-10 | 2013-11-14 | Adynxx, Inc. | Formulations for the delivery of active ingredients |
| JP6246121B2 (ja) | 2012-07-13 | 2017-12-13 | 株式会社新日本科学 | キラル核酸アジュバント |
| US9598458B2 (en) | 2012-07-13 | 2017-03-21 | Wave Life Sciences Japan, Inc. | Asymmetric auxiliary group |
| SG11201500232UA (en) | 2012-07-13 | 2015-04-29 | Wave Life Sciences Pte Ltd | Chiral control |
| EP3095460A4 (en) | 2014-01-15 | 2017-08-23 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent |
| JPWO2015108048A1 (ja) | 2014-01-15 | 2017-03-23 | 株式会社新日本科学 | 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤 |
| JPWO2015108047A1 (ja) | 2014-01-15 | 2017-03-23 | 株式会社新日本科学 | 免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤 |
| US10160969B2 (en) | 2014-01-16 | 2018-12-25 | Wave Life Sciences Ltd. | Chiral design |
| ES2750689T3 (es) | 2014-08-15 | 2020-03-26 | Adynxx Inc | Señuelos oligonucleotídicos para el tratamiento del dolor |
-
1995
- 1995-05-11 US US08/945,726 patent/US6004813A/en not_active Expired - Lifetime
- 1995-05-11 MX MX9708663A patent/MX9708663A/es unknown
- 1995-05-11 CA CA2220433A patent/CA2220433C/en not_active Expired - Lifetime
- 1995-05-11 KR KR1019970708022A patent/KR100449677B1/ko not_active IP Right Cessation
- 1995-05-11 EP EP95919438A patent/EP0824588B1/en not_active Expired - Lifetime
- 1995-05-11 JP JP53368396A patent/JP4173539B2/ja not_active Expired - Lifetime
- 1995-05-11 ES ES95919438T patent/ES2220929T3/es not_active Expired - Lifetime
- 1995-05-11 WO PCT/EP1995/001778 patent/WO1996035782A1/en active IP Right Grant
- 1995-05-11 DE DE69533264T patent/DE69533264T2/de not_active Expired - Lifetime
- 1995-05-11 DK DK95919438T patent/DK0824588T3/da active
- 1995-05-11 AU AU25267/95A patent/AU715125B2/en not_active Expired
- 1995-05-11 AT AT95919438T patent/ATE271128T1/de active
- 1995-05-11 RU RU97120584/13A patent/RU2205874C2/ru active
- 1995-11-05 UA UA97126018A patent/UA63888C2/uk unknown
-
1996
- 1996-05-06 IL IL11815896A patent/IL118158A/en not_active IP Right Cessation
- 1996-05-07 ZA ZA963593A patent/ZA963593B/xx unknown
-
1998
- 1998-11-09 HK HK98111831A patent/HK1016213A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0824588A1 (en) | 1998-02-25 |
| JPH11504816A (ja) | 1999-05-11 |
| RU2205874C2 (ru) | 2003-06-10 |
| AU2526795A (en) | 1996-11-29 |
| DE69533264D1 (de) | 2004-08-19 |
| HK1016213A1 (en) | 1999-10-29 |
| EP0824588B1 (en) | 2004-07-14 |
| WO1996035782A1 (en) | 1996-11-14 |
| JP4173539B2 (ja) | 2008-10-29 |
| US6004813A (en) | 1999-12-21 |
| MX9708663A (es) | 1998-02-28 |
| UA63888C2 (en) | 2004-02-16 |
| CA2220433C (en) | 2010-02-16 |
| KR19990014681A (ko) | 1999-02-25 |
| CA2220433A1 (en) | 1996-11-14 |
| AU715125B2 (en) | 2000-01-20 |
| IL118158A0 (en) | 1996-09-12 |
| DE69533264T2 (de) | 2004-11-25 |
| KR100449677B1 (ko) | 2004-11-20 |
| ATE271128T1 (de) | 2004-07-15 |
| ZA963593B (en) | 1996-11-25 |
| DK0824588T3 (da) | 2004-08-16 |
| ES2220929T3 (es) | 2004-12-16 |
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