IL117996A0 - Antithrombotic amidinotetrahydro pyridylalanine derivatives - Google Patents
Antithrombotic amidinotetrahydro pyridylalanine derivativesInfo
- Publication number
- IL117996A0 IL117996A0 IL11799696A IL11799696A IL117996A0 IL 117996 A0 IL117996 A0 IL 117996A0 IL 11799696 A IL11799696 A IL 11799696A IL 11799696 A IL11799696 A IL 11799696A IL 117996 A0 IL117996 A0 IL 117996A0
- Authority
- IL
- Israel
- Prior art keywords
- optionally substituted
- alkyl
- conr5r6
- alkoxy
- aryl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9508622.9A GB9508622D0 (en) | 1995-04-28 | 1995-04-28 | Therapeutic agants |
Publications (1)
Publication Number | Publication Date |
---|---|
IL117996A0 true IL117996A0 (en) | 1996-08-04 |
Family
ID=10773652
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL11799696A IL117996A0 (en) | 1995-04-28 | 1996-04-22 | Antithrombotic amidinotetrahydro pyridylalanine derivatives |
Country Status (14)
Country | Link |
---|---|
US (1) | US5798352A (fr) |
EP (1) | EP0822934B1 (fr) |
JP (1) | JP2846963B2 (fr) |
AT (1) | ATE189679T1 (fr) |
AU (1) | AU5499796A (fr) |
CA (1) | CA2219261A1 (fr) |
DE (1) | DE69606632T2 (fr) |
DK (1) | DK0822934T3 (fr) |
ES (1) | ES2142057T3 (fr) |
GB (1) | GB9508622D0 (fr) |
GR (1) | GR3033070T3 (fr) |
IL (1) | IL117996A0 (fr) |
PT (1) | PT822934E (fr) |
WO (1) | WO1996033993A1 (fr) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999016752A1 (fr) * | 1997-09-30 | 1999-04-08 | Molecular Designs International, Inc. | AGONISTES DE β3-ADRENORECEPTEURS, COMPOSITIONS D'AGONISTES ET PROCEDES D'UTILISATION |
IL137517A0 (en) * | 1998-01-27 | 2001-07-24 | Aventis Pharm Prod Inc | Substituted oxoazaheterocyclyl factor xa inhibitors |
AU3127900A (en) | 1998-12-23 | 2000-07-31 | Du Pont Pharmaceuticals Company | Thrombin or factor xa inhibitors |
US6593341B2 (en) | 2001-03-29 | 2003-07-15 | Molecular Design International, Inc. | β3-adrenoreceptor agonists, agonist compositions and methods of making and using the same |
US6953787B2 (en) | 2002-04-12 | 2005-10-11 | Arena Pharmaceuticals, Inc. | 5HT2C receptor modulators |
US6596734B1 (en) | 2002-10-11 | 2003-07-22 | Molecular Design International, Inc. | Tetrahydroisoquinoline compounds for use as β3-adrenoreceptor agonists |
CN101792417A (zh) | 2003-06-17 | 2010-08-04 | 艾尼纳制药公司 | 用于治疗5ht2c受体相关疾病的苯并氮杂卓衍生物 |
EP2189448B1 (fr) | 2003-06-17 | 2014-01-29 | Arena Pharmaceuticals, Inc. | Procédés de séparation de racemates de 3-Benzazepines |
FR2870846B1 (fr) | 2004-05-25 | 2006-08-04 | Sanofi Synthelabo | Derives de tetrahydroisoquinolylsulfonamides, leur preparation et leur utilisation en therapeutique |
KR101281919B1 (ko) | 2004-12-21 | 2013-07-03 | 아레나 파마슈티칼스, 인크. | (r)-8-클로로-1-메틸-2,3,4,5-테트라히드로-1h-3-벤즈아제핀 히드로클로라이드의 결정질 형태 |
EP2001852A2 (fr) | 2006-04-03 | 2008-12-17 | Arena Pharmaceuticals, Inc. | Procédés de préparation de 8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine et produits intermédiaires associés |
CA2670285A1 (fr) | 2006-12-05 | 2008-06-12 | Arena Pharmaceuticals, Inc. | Procedes de preparation de (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine et intermediaires de celle-ci |
JP5491421B2 (ja) | 2008-03-04 | 2014-05-14 | アリーナ ファーマシューティカルズ, インコーポレイテッド | 5−ht2cアゴニストである(r)−8−クロロ−1−メチル−2,3,4,5−テトラヒドロ−1h−3−ベンゾアゼピンに関連する中間体の調製のためのプロセス |
CN102648170A (zh) | 2009-06-18 | 2012-08-22 | 艾尼纳制药公司 | 制备5-ht2c受体激动剂的方法 |
US9045431B2 (en) | 2010-06-02 | 2015-06-02 | Arena Pharmaceuticals, Inc. | Processes for the preparation of 5-HT2C receptor agonists |
CN103189360A (zh) | 2010-09-01 | 2013-07-03 | 艾尼纳制药公司 | 5-ht2c激动剂的非吸湿性盐 |
EP2939677A1 (fr) | 2010-09-01 | 2015-11-04 | Arena Pharmaceuticals, Inc. | Administration de lorcasérine à des individus avec une insuffisance rénale |
ES2704455T3 (es) | 2010-09-01 | 2019-03-18 | Arena Pharm Inc | Formas farmacéuticas de liberación modificada de agonistas de 5-HT2C útiles para la gestión del peso |
WO2012030938A1 (fr) | 2010-09-01 | 2012-03-08 | Arena Pharmaceuticals, Inc. | Sels de lorcasérine dotés d'acides optiquement actifs |
US9035059B2 (en) | 2011-03-14 | 2015-05-19 | Taisho Pharmaceutical Co., Ltd. | Nitrogen-containing condensed heterocyclic compound |
AU2012392187B2 (en) | 2012-10-09 | 2018-07-12 | Arena Pharmaceuticals, Inc. | Method of weight management |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IE48623B1 (en) * | 1978-08-31 | 1985-03-20 | Mitsubishi Chem Ind | Alpha-(n-arylsulfonyl-l-argininamides,processes for their preparation and pharmaceutical compositions containing these substances |
EP0511347A1 (fr) * | 1990-11-15 | 1992-11-04 | Pentapharm A.G. | Derives de la phenylalanine metasubstitues |
JPH06329627A (ja) * | 1993-05-03 | 1994-11-29 | Bristol Myers Squibb Co | グアニジニル−またはアミジニル−置換ヘテロ環トロンビンインヒビター |
-
1995
- 1995-04-28 GB GBGB9508622.9A patent/GB9508622D0/en active Pending
-
1996
- 1996-04-01 DE DE69606632T patent/DE69606632T2/de not_active Expired - Fee Related
- 1996-04-01 ES ES96911999T patent/ES2142057T3/es not_active Expired - Lifetime
- 1996-04-01 WO PCT/EP1996/001459 patent/WO1996033993A1/fr active IP Right Grant
- 1996-04-01 EP EP96911999A patent/EP0822934B1/fr not_active Expired - Lifetime
- 1996-04-01 PT PT96911999T patent/PT822934E/pt unknown
- 1996-04-01 US US08/930,596 patent/US5798352A/en not_active Expired - Fee Related
- 1996-04-01 JP JP8532121A patent/JP2846963B2/ja not_active Expired - Lifetime
- 1996-04-01 AU AU54997/96A patent/AU5499796A/en not_active Abandoned
- 1996-04-01 AT AT96911999T patent/ATE189679T1/de active
- 1996-04-01 DK DK96911999T patent/DK0822934T3/da active
- 1996-04-01 CA CA002219261A patent/CA2219261A1/fr not_active Abandoned
- 1996-04-22 IL IL11799696A patent/IL117996A0/xx unknown
-
2000
- 2000-03-27 GR GR20000400759T patent/GR3033070T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
EP0822934A1 (fr) | 1998-02-11 |
GB9508622D0 (en) | 1995-06-14 |
CA2219261A1 (fr) | 1996-10-31 |
GR3033070T3 (en) | 2000-08-31 |
DK0822934T3 (da) | 2000-05-15 |
JPH10507198A (ja) | 1998-07-14 |
DE69606632D1 (de) | 2000-03-16 |
EP0822934B1 (fr) | 2000-02-09 |
AU5499796A (en) | 1996-11-18 |
WO1996033993A1 (fr) | 1996-10-31 |
ES2142057T3 (es) | 2000-04-01 |
PT822934E (pt) | 2000-06-30 |
DE69606632T2 (de) | 2000-07-06 |
US5798352A (en) | 1998-08-25 |
ATE189679T1 (de) | 2000-02-15 |
JP2846963B2 (ja) | 1999-01-13 |
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