IL117989A - N-(1-(3,5-bisfluoromethylbenzoyl)-2- benzyl-piperidin-4-YL)-4-oxo-4H-1- benzopyran-2 carboxamides their preparation and pharmaceutical compositions comprising them - Google Patents
N-(1-(3,5-bisfluoromethylbenzoyl)-2- benzyl-piperidin-4-YL)-4-oxo-4H-1- benzopyran-2 carboxamides their preparation and pharmaceutical compositions comprising themInfo
- Publication number
- IL117989A IL117989A IL11798996A IL11798996A IL117989A IL 117989 A IL117989 A IL 117989A IL 11798996 A IL11798996 A IL 11798996A IL 11798996 A IL11798996 A IL 11798996A IL 117989 A IL117989 A IL 117989A
- Authority
- IL
- Israel
- Prior art keywords
- bisfluoromethylbenzoyl
- benzopyran
- carboxamides
- piperidin
- oxo
- Prior art date
Links
- GKDBZOXVCRGYDK-UHFFFAOYSA-N N-[2-benzyl-1-[3,5-bis(fluoromethyl)benzoyl]piperidin-4-yl]-4-oxochromene-2-carboxamide Chemical class FCC1=CC(CF)=CC(C(=O)N2C(CC(CC2)NC(=O)C=2OC3=CC=CC=C3C(=O)C=2)CC=2C=CC=CC=2)=C1 GKDBZOXVCRGYDK-UHFFFAOYSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/08—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing alicyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH115795 | 1995-04-24 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL117989A0 IL117989A0 (en) | 1996-08-04 |
| IL117989A true IL117989A (en) | 2000-01-31 |
Family
ID=4203819
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL11798996A IL117989A (en) | 1995-04-24 | 1996-04-21 | N-(1-(3,5-bisfluoromethylbenzoyl)-2- benzyl-piperidin-4-YL)-4-oxo-4H-1- benzopyran-2 carboxamides their preparation and pharmaceutical compositions comprising them |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US5604247A (xx) |
| EP (1) | EP0739892B1 (xx) |
| JP (1) | JP3068458B2 (xx) |
| KR (1) | KR100416674B1 (xx) |
| CN (1) | CN1063176C (xx) |
| AR (1) | AR001813A1 (xx) |
| AT (1) | ATE224891T1 (xx) |
| AU (1) | AU714523B2 (xx) |
| BR (1) | BR9602025A (xx) |
| CA (1) | CA2174707C (xx) |
| DE (1) | DE59609707D1 (xx) |
| DK (1) | DK0739892T3 (xx) |
| ES (1) | ES2183923T3 (xx) |
| HU (1) | HUP9601062A3 (xx) |
| IL (1) | IL117989A (xx) |
| NO (1) | NO309813B1 (xx) |
| NZ (1) | NZ286422A (xx) |
| PT (1) | PT739892E (xx) |
| RU (1) | RU2156250C2 (xx) |
| TW (1) | TW475930B (xx) |
| ZA (1) | ZA963211B (xx) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997044035A1 (en) * | 1996-05-24 | 1997-11-27 | Eli Lilly And Company | Methods of treating hypertension |
| TW426667B (en) * | 1997-11-19 | 2001-03-21 | Pfizer | Piperidinylaminomethyl trifluoromethyl cyclic ether compounds as substance P antagonists |
| BR9913201A (pt) * | 1998-08-25 | 2001-05-08 | Novartis Ag | Uso de antagonista da substância p para o tratamento da sìndrome da fadiga crÈnica e/ou fibromialgia e uso de antagonistas do recptor de nk-1 para tratamento da sìndrome da fadiga crÈnica |
| DE60001736T2 (de) * | 1999-05-21 | 2003-09-18 | Pfizer Prod Inc | 1-trifluorotmethyl-4-hydroxy-7-piperidinyl-aminomethylchroman-derivate |
| GB0220953D0 (en) * | 2002-09-10 | 2002-10-23 | Novartis Ag | Organic compounds |
| GB2394417A (en) * | 2002-10-24 | 2004-04-28 | Novartis Ag | Solid dispersion comprising a piperidine substance P antagonist and a carrier |
| DE10256174A1 (de) * | 2002-12-02 | 2004-06-09 | Merck Patent Gmbh | 2-Benzoylchromonderivate |
| DE10256182A1 (de) * | 2002-12-02 | 2004-06-24 | Merck Patent Gmbh | 2-Oxadiazolchromonderivate |
| US20050209274A1 (en) * | 2004-02-26 | 2005-09-22 | Lynch John K | Antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor |
| CN1300163C (zh) * | 2004-06-23 | 2007-02-14 | 南京大学 | 3－羟基色原酮糖苷及其制法和用途 |
| JP2009534399A (ja) * | 2006-04-18 | 2009-09-24 | アボット・ラボラトリーズ | バニロイド受容体サブタイプ１型（ｖｒ１）の拮抗薬およびその使用 |
| GB0701365D0 (en) * | 2007-01-24 | 2007-03-07 | Glaxo Group Ltd | Novel pharmaceutical compositions |
| UA105182C2 (ru) | 2008-07-03 | 2014-04-25 | Ньюрексон, Інк. | Бензоксазины, бензотиазины и родственные соединения, которые имеют ингибирующую nos активность |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3117389A1 (de) * | 1981-05-02 | 1982-11-18 | Boehringer Mannheim Gmbh, 6800 Mannheim | Benzopyranylether, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel |
| MY110227A (en) * | 1991-08-12 | 1998-03-31 | Ciba Geigy Ag | 1-acylpiperindine compounds. |
| AU7856194A (en) * | 1993-10-26 | 1995-05-22 | Ciba-Geigy Ag | N-benzoyl-4-oxy/thio-2-substituted piperidines as substance-p receptor antagonists |
| ES2172595T3 (es) * | 1994-09-30 | 2002-10-01 | Novartis Ag | Compuestos de 1-acil-4-alifatilaminopiperidina. |
| TW397825B (en) * | 1994-10-14 | 2000-07-11 | Novartis Ag | Aroyl-piperidine derivatives |
-
1996
- 1996-04-11 TW TW085104270A patent/TW475930B/zh not_active IP Right Cessation
- 1996-04-11 RU RU96107121/04A patent/RU2156250C2/ru not_active IP Right Cessation
- 1996-04-16 DE DE59609707T patent/DE59609707D1/de not_active Expired - Lifetime
- 1996-04-16 DK DK96810237T patent/DK0739892T3/da active
- 1996-04-16 PT PT96810237T patent/PT739892E/pt unknown
- 1996-04-16 AT AT96810237T patent/ATE224891T1/de not_active IP Right Cessation
- 1996-04-16 US US08/632,971 patent/US5604247A/en not_active Expired - Lifetime
- 1996-04-16 ES ES96810237T patent/ES2183923T3/es not_active Expired - Lifetime
- 1996-04-16 EP EP96810237A patent/EP0739892B1/de not_active Expired - Lifetime
- 1996-04-21 IL IL11798996A patent/IL117989A/xx active IP Right Grant
- 1996-04-22 NZ NZ286422A patent/NZ286422A/en unknown
- 1996-04-22 CA CA002174707A patent/CA2174707C/en not_active Expired - Fee Related
- 1996-04-22 AU AU50805/96A patent/AU714523B2/en not_active Ceased
- 1996-04-23 JP JP8101568A patent/JP3068458B2/ja not_active Expired - Fee Related
- 1996-04-23 CN CN96106111A patent/CN1063176C/zh not_active Expired - Fee Related
- 1996-04-23 ZA ZA963211A patent/ZA963211B/xx unknown
- 1996-04-23 HU HU9601062A patent/HUP9601062A3/hu unknown
- 1996-04-23 KR KR1019960012355A patent/KR100416674B1/ko not_active IP Right Cessation
- 1996-04-23 NO NO961616A patent/NO309813B1/no unknown
- 1996-04-24 BR BR9602025A patent/BR9602025A/pt not_active IP Right Cessation
- 1996-04-24 AR AR33626596A patent/AR001813A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUP9601062A2 (en) | 1997-10-28 |
| NZ286422A (en) | 1998-01-26 |
| AU714523B2 (en) | 2000-01-06 |
| TW475930B (en) | 2002-02-11 |
| NO961616L (no) | 1996-10-25 |
| NO961616D0 (no) | 1996-04-23 |
| AR001813A1 (es) | 1997-12-10 |
| IL117989A0 (en) | 1996-08-04 |
| JPH093066A (ja) | 1997-01-07 |
| JP3068458B2 (ja) | 2000-07-24 |
| NO309813B1 (no) | 2001-04-02 |
| US5604247A (en) | 1997-02-18 |
| MX9601515A (es) | 1997-09-30 |
| ATE224891T1 (de) | 2002-10-15 |
| HUP9601062A3 (en) | 1998-10-28 |
| BR9602025A (pt) | 1998-10-06 |
| HU9601062D0 (en) | 1996-06-28 |
| CN1141921A (zh) | 1997-02-05 |
| ZA963211B (en) | 1996-10-24 |
| DK0739892T3 (da) | 2003-01-20 |
| PT739892E (pt) | 2003-01-31 |
| ES2183923T3 (es) | 2003-04-01 |
| CA2174707A1 (en) | 1996-10-25 |
| CA2174707C (en) | 2008-03-25 |
| KR960037680A (ko) | 1996-11-19 |
| KR100416674B1 (ko) | 2004-06-11 |
| RU2156250C2 (ru) | 2000-09-20 |
| CN1063176C (zh) | 2001-03-14 |
| AU5080596A (en) | 1996-11-07 |
| EP0739892A3 (de) | 1997-01-22 |
| DE59609707D1 (de) | 2002-10-31 |
| EP0739892B1 (de) | 2002-09-25 |
| EP0739892A2 (de) | 1996-10-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed |