IL117396A - Benzofuran derivatives and pharmaceutical compositions containing them - Google Patents

Benzofuran derivatives and pharmaceutical compositions containing them

Info

Publication number
IL117396A
IL117396A IL11739696A IL11739696A IL117396A IL 117396 A IL117396 A IL 117396A IL 11739696 A IL11739696 A IL 11739696A IL 11739696 A IL11739696 A IL 11739696A IL 117396 A IL117396 A IL 117396A
Authority
IL
Israel
Prior art keywords
alkyl
pharmaceutical compositions
compositions containing
benzofuran derivatives
dimethylpyrrolidino
Prior art date
Application number
IL11739696A
Other languages
English (en)
Other versions
IL117396A0 (en
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of IL117396A0 publication Critical patent/IL117396A0/xx
Publication of IL117396A publication Critical patent/IL117396A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL11739696A 1995-03-10 1996-03-07 Benzofuran derivatives and pharmaceutical compositions containing them IL117396A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/402,285 US5523309A (en) 1995-03-10 1995-03-10 Benzofuran pharmaceutical compounds

Publications (2)

Publication Number Publication Date
IL117396A0 IL117396A0 (en) 1996-07-23
IL117396A true IL117396A (en) 2000-01-31

Family

ID=23591296

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11739696A IL117396A (en) 1995-03-10 1996-03-07 Benzofuran derivatives and pharmaceutical compositions containing them

Country Status (15)

Country Link
US (1) US5523309A (pt)
EP (1) EP0731097B1 (pt)
JP (1) JP2000510814A (pt)
AT (1) ATE189678T1 (pt)
AU (1) AU692690B2 (pt)
BR (1) BR9607774A (pt)
CA (1) CA2214450A1 (pt)
DE (1) DE69606566T2 (pt)
DK (1) DK0731097T3 (pt)
ES (1) ES2142021T3 (pt)
GR (1) GR3033326T3 (pt)
IL (1) IL117396A (pt)
PT (1) PT731097E (pt)
WO (1) WO1996028152A1 (pt)
ZA (1) ZA961882B (pt)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6703407B1 (en) * 1994-09-20 2004-03-09 Eli Lilly And Company Benzofuran compounds, compositions, and methods
US6417199B1 (en) * 1995-03-10 2002-07-09 Eli Lilly And Company 3-benzyl-benzothiophenes
US6653328B1 (en) * 1995-03-10 2003-11-25 Eli Lilly And Company 3-benzyl-benzothiophenes
US6395755B1 (en) * 1995-03-10 2002-05-28 Eli Lilly And Company Benzothiophene pharmaceutical compounds
US5567828A (en) * 1995-06-07 1996-10-22 Eli Lilly And Company Compounds and compositions with nitrogen-containing non-basic side
US6444688B1 (en) * 1995-06-07 2002-09-03 Eli Lilly And Company Compounds and compositions with nitrogen-containing non-basic side chains
DE69634045T2 (de) 1995-10-31 2005-05-19 Eli Lilly And Co., Indianapolis Antithrombotische diamine
CA2214919A1 (en) * 1996-09-24 1998-03-24 Kenneth Lee Hauser Benzothiophene compounds, intermediates, processes, compositions, and methods
US5965573A (en) * 1996-10-23 1999-10-12 Zymogenetics, Inc. Compositions and methods for treating bone deficit conditions
US5939444A (en) * 1996-10-23 1999-08-17 Zymogenetic, Inc. Compositions and methods for treating bone deficit conditions
US5948776A (en) * 1996-10-23 1999-09-07 Zymogenetic, Inc. Compositions and methods for treating bone deficit conditions
US5919808A (en) * 1996-10-23 1999-07-06 Zymogenetics, Inc. Compositions and methods for treating bone deficit conditions
US6153631A (en) * 1996-10-23 2000-11-28 Zymogenetics, Inc. Compositions and methods for treating bone deficit conditions
US6251901B1 (en) 1996-10-23 2001-06-26 Zymogenetics, Inc. Compositions and methods for treating bone deficit conditions
US6342514B1 (en) 1996-10-23 2002-01-29 Zymogenetics, Inc. Compositions and methods for treating bone deficit conditions
AU4988997A (en) * 1996-10-23 1998-05-15 Osteoscreen, Inc. Compositions and methods for treating bone deficit conditions
US6017940A (en) * 1996-10-23 2000-01-25 Zymogenetics, Inc. Compositions and methods for treating bone deficit conditions
US5922753A (en) * 1996-10-23 1999-07-13 Zymogenetics, Inc. Methods for treating bone deficit conditions with benzothiazole
US5990169A (en) * 1996-10-23 1999-11-23 Zymogenetics, Inc. Compositions and methods for treating bone deficit conditions
AU7470098A (en) 1997-04-30 1998-11-24 Eli Lilly And Company Antithrombotic agents
AU7274198A (en) 1997-04-30 1998-11-24 Eli Lilly And Company Antithrombotic agents
JP2002513415A (ja) 1997-04-30 2002-05-08 イーライ・リリー・アンド・カンパニー 抗血栓剤
CA2288144A1 (en) 1997-04-30 1998-11-05 Eli Lilly And Company Antithrombotic agents
FR2764800B1 (fr) * 1997-06-23 1999-09-10 Sanofi Sa Composition pharmaceutique solide contenant des derives de benzofuranne
US6649631B1 (en) 1997-10-23 2003-11-18 The Board Of Regents Of The University Of Texas System Compositions and methods for treating bone deficit conditions
US6284756B1 (en) 1998-04-30 2001-09-04 Eli Lilly And Company Antithrombotic agents
US7005428B1 (en) 1998-06-11 2006-02-28 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
US6465445B1 (en) 1998-06-11 2002-10-15 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
CA2287549A1 (en) * 1998-10-28 2000-04-28 Jefferson Ray Mccowan Antithrombotic agents
FR2813306B1 (fr) * 2000-08-23 2005-10-21 Sanofi Synthelabo Aminoalkybenzoyl-benzofurannes ou benzothiophenes, leur procede de preparation et les compositions les contenant
FR2813307B1 (fr) * 2000-08-23 2002-11-08 Sanofi Synthelabo Aminoalkenylbenzoyl-benzofurannes ou benzothiophenes, leur procede de preparation et les compositions les contenant
ATE420869T1 (de) * 2000-10-05 2009-01-15 Takeda Pharmaceutical Promotoren zur proliferation und differenzierung von stammzellen und/oder vorstufen von neuronenzellen
EP1395563B1 (en) * 2001-05-22 2006-03-29 Eli Lilly And Company 2-substituted 1,2,3,4-tetrahydroquinolines and derivatives thereof, compositions and methods
US6962928B2 (en) * 2001-05-22 2005-11-08 Eli Lilly And Company Tetrahydroquinoline derivatives for the inhibition of osteoporosis, estrogen dependent breast cancer, endometriosis and uterine fibrosis
WO2004100998A2 (en) * 2003-05-07 2004-11-25 General Electric Company Compositions and methods for non-invasive imaging of soluble beta-amyloid
US20040223912A1 (en) * 2003-05-07 2004-11-11 Montalto Michael Christopher Compositions and methods for non-invasive imaging of soluble beta-amyloid
US7420066B2 (en) 2003-08-07 2008-09-02 Bayer Pharmaceuticals Corporation Benzofuran derivatives useful for treating hyper-proliferative disorders
CN114315774B (zh) * 2022-01-04 2023-05-09 山东第一医科大学(山东省医学科学院) Psf蛋白抑制剂、药物组合物及其应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4133814A (en) * 1975-10-28 1979-01-09 Eli Lilly And Company 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents
US4418068A (en) * 1981-04-03 1983-11-29 Eli Lilly And Company Antiestrogenic and antiandrugenic benzothiophenes
US4380635A (en) * 1981-04-03 1983-04-19 Eli Lilly And Company Synthesis of acylated benzothiophenes
US4851554A (en) * 1987-04-06 1989-07-25 University Of Tennessee Research Corporation Certain 3-substituted 2-alkyl benzofuran derivatives
TW366342B (en) * 1992-07-28 1999-08-11 Lilly Co Eli The use of 2-phenyl-3-aroylbenzothiophenes in inhibiting bone loss
US5354861A (en) * 1992-11-04 1994-10-11 National University Of Singapore 2-(benzyl)-3-arylbenzofurans as antitumour and hypocholesterolemic agents
US5482949A (en) * 1993-03-19 1996-01-09 Eli Lilly And Company Sulfonate derivatives of 3-aroylbenzo[b]thiophenes

Also Published As

Publication number Publication date
PT731097E (pt) 2000-07-31
AU692690B2 (en) 1998-06-11
DE69606566D1 (de) 2000-03-16
IL117396A0 (en) 1996-07-23
DE69606566T2 (de) 2000-06-29
MX9706738A (es) 1997-11-29
DK0731097T3 (da) 2000-05-15
CA2214450A1 (en) 1996-09-19
ZA961882B (en) 1997-09-08
ES2142021T3 (es) 2000-04-01
EP0731097A1 (en) 1996-09-11
WO1996028152A1 (en) 1996-09-19
EP0731097B1 (en) 2000-02-09
AU5187396A (en) 1996-10-02
BR9607774A (pt) 1998-07-07
JP2000510814A (ja) 2000-08-22
ATE189678T1 (de) 2000-02-15
GR3033326T3 (en) 2000-09-29
US5523309A (en) 1996-06-04

Similar Documents

Publication Publication Date Title
IL117396A (en) Benzofuran derivatives and pharmaceutical compositions containing them
MX9603508A (es) Analogos de la doxiciclina.
PL301579A1 (en) Pharmaceutical preparation
ATE236185T1 (de) Makrozyklische derivate von erythromycin a und b mit 13 ringatomen
DE59511110D1 (de) Estra-1,3,5(10)-trien-3-sulfamat Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
YU4198A (sh) Karbapenem antibiotik, kompozicija i postupak za dobijanje
ATE113943T1 (de) Bestimmte 3-substituierte 2-alkyl-benzofuran- derivate.
EP0214600A3 (en) Cephalosporin derivatives
CA2071669A1 (en) Aminophenoxyalkyl derivatives of benzodioxan
EP0461574A3 (en) Medicines containing 3,7-diazabicyclo(3,3,1)nonanes
ATE62244T1 (de) Pyrrolo(1,2-a>(4,1>benzoxazepine, verfahren zur ihrer herstellung, pharmazeutische praeparate enthaltend diese verbindungen, sowie therapeutische verwendung.
DE59712053D1 (de) 4-Amino-2-ureido-pyrimidin-5-carbonsäureamide, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
KR910000785A (ko) 9-r-아자사이클릭 에리트로마이신 항생제
PT84328A (en) Heterocyclic compounds and their preparation and pharmaceutical formulation
DE68918071D1 (de) Antibiotikum A80915 und Verfahren zu seiner Herstellung.
IT1204458B (it) Derivati eterociclici
HUT48873A (en) Process for producing dihydropyridine derivatives and pharmaceutical compositions comprising these compounds as active ingredient
IT1201455B (it) Derivati piridinici sostituiti
DE3369322D1 (en) Tricyclic triazino compounds, their use and formulation as pharmaceuticals and processes for their production
ATE111465T1 (de) Imidazobenzodiazepine und ihre salze, verfahren zur herstellung, verwendung als arzneimittel und diese substanzen enthaltende zusammensetzungen.
GR3030692T3 (en) Erythromycin derivatives
BG95629A (en) Derivatives of 10, 11, 12, 13 - tetrahytdrodesmicozine, method for preparing them, and their use as pharmaceutical preparations
GR3033457T3 (en) Enolethers and their use as a fungicide
IT1098327B (it) Esaidro-1-idrossi-9-idrossimetil-6h-dibenzo aperta parentesi quadra b,d chiusa parentesi quadra pirani sostituiti in posizione 3 come agenti analgesici
HUP9901882A2 (hu) Benzotiofénszármazékok és e vegyületeket tartalmazó gyógyászati készítmények és alkalmazásuk

Legal Events

Date Code Title Description
FF Patent granted
MM9K Patent not in force due to non-payment of renewal fees