IL116577A - 6-¬triazolyl¬3-(trifluoromethyl)phenyl¾methyl¾-2-quinolinones and-quinolinethiones their preparation and pharmaceutical compositions containing them - Google Patents
6-¬triazolyl¬3-(trifluoromethyl)phenyl¾methyl¾-2-quinolinones and-quinolinethiones their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL116577A IL116577A IL11657795A IL11657795A IL116577A IL 116577 A IL116577 A IL 116577A IL 11657795 A IL11657795 A IL 11657795A IL 11657795 A IL11657795 A IL 11657795A IL 116577 A IL116577 A IL 116577A
- Authority
- IL
- Israel
- Prior art keywords
- quinolinethiones
- quinolinones
- triazolyl
- trifluoromethyl
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP94203773 | 1994-12-28 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL116577A0 IL116577A0 (en) | 1996-03-31 |
| IL116577A true IL116577A (en) | 2000-02-29 |
Family
ID=8217501
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL11657795A IL116577A (en) | 1994-12-28 | 1995-12-27 | 6-¬triazolyl¬3-(trifluoromethyl)phenyl¾methyl¾-2-quinolinones and-quinolinethiones their preparation and pharmaceutical compositions containing them |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US5922734A (da) |
| EP (1) | EP0800524B1 (da) |
| JP (1) | JPH10511654A (da) |
| CN (1) | CN1085668C (da) |
| AR (1) | AR002264A1 (da) |
| AT (1) | ATE207924T1 (da) |
| AU (1) | AU698199B2 (da) |
| BR (1) | BR9510504A (da) |
| CA (1) | CA2207268A1 (da) |
| DE (1) | DE69523629T2 (da) |
| DK (1) | DK0800524T3 (da) |
| ES (1) | ES2166838T3 (da) |
| FI (1) | FI972794A0 (da) |
| HR (1) | HRP950616A2 (da) |
| IL (1) | IL116577A (da) |
| MY (1) | MY131690A (da) |
| NO (1) | NO311220B1 (da) |
| NZ (1) | NZ298789A (da) |
| PL (1) | PL182956B1 (da) |
| PT (1) | PT800524E (da) |
| RU (1) | RU2165419C2 (da) |
| TR (1) | TR199501688A2 (da) |
| TW (1) | TW316902B (da) |
| WO (1) | WO1996020200A1 (da) |
| ZA (1) | ZA9510989B (da) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW591030B (en) | 1997-03-10 | 2004-06-11 | Janssen Pharmaceutica Nv | Farnesyl transferase inhibiting 1,8-annelated quinolinone derivatives substituted with N- or C-linked imidazoles |
| CA2335435A1 (en) * | 1998-06-16 | 1999-12-23 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R | Imidazolyl derivatives |
| US6420555B1 (en) | 1998-06-16 | 2002-07-16 | Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. | Imidazolyl derivatives |
| EP1420015A1 (en) * | 1999-06-11 | 2004-05-19 | Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. | Imidazolyl derivatives |
| ES2328225T3 (es) * | 2000-11-21 | 2009-11-11 | Janssen Pharmaceutica Nv | Derivados benzoheterociclicos inhibidores de la farnesil-transferasa. |
| DK1339407T3 (da) * | 2000-11-28 | 2006-08-14 | Janssen Pharmaceutica Nv | Farnesylproteintransferaseinhibitorer til behandling af inflammatorisk tarmsygdom |
| ATE319704T1 (de) * | 2000-12-27 | 2006-03-15 | Janssen Pharmaceutica Nv | Farnesyltransferase hemmende, in der 4-stellung substituierte chinolin- und chinazolinderivate |
| DE60119383T2 (de) * | 2000-12-27 | 2007-04-19 | Janssen Pharmaceutica N.V. | Farnesyltransferasehemmende 4-heterocyclylchinolin- und chinazolinderivate |
| US8232402B2 (en) * | 2008-03-12 | 2012-07-31 | Link Medicine Corporation | Quinolinone farnesyl transferase inhibitors for the treatment of synucleinopathies and other indications |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4792561A (en) * | 1986-05-29 | 1988-12-20 | Syntex (U.S.A.) Inc. | Carbostyril derivatives as combined thromboxane synthetase and cyclic-AMP phosphodiesterase inhibitors |
| US4859684A (en) * | 1986-09-15 | 1989-08-22 | Janssen Pharmaceutica N.V. | (1H-imidazol-1-ylmethyl) substituted benzimidazole derivatives and use thereof in treating androgen dependent disorders |
| NZ221729A (en) * | 1986-09-15 | 1989-07-27 | Janssen Pharmaceutica Nv | Imidazolyl methyl-substituted benzimidazole derivatives and pharmaceutical compositions |
| CA2002864C (en) * | 1988-11-29 | 1999-11-16 | Eddy J. E. Freyne | (1h-azol-1-ylmethyl) substituted quinoline, quinazoline or quinoxaline derivatives |
| GB8827822D0 (en) * | 1988-11-29 | 1988-12-29 | Janssen Pharmaceutica Nv | (1h-azol-1-ylmethyl)substituted quinoline derivatives |
| US5185346A (en) * | 1988-11-29 | 1993-02-09 | Hanssen Pharmaceutica | (1H-azol-1-ylmethyl)substituted quinoline derivatives |
| US5157046A (en) * | 1988-11-29 | 1992-10-20 | Janssen Pharmaceutica N.V. | Method of treating epithelial disorders |
| CA2002859C (en) * | 1988-11-29 | 1998-12-29 | Jean P. F. Van Wauwe | Method of treating epithelial disorders |
-
1995
- 1995-12-20 TW TW084113605A patent/TW316902B/zh active
- 1995-12-21 AT AT95943237T patent/ATE207924T1/de not_active IP Right Cessation
- 1995-12-21 AU AU44362/96A patent/AU698199B2/en not_active Ceased
- 1995-12-21 CA CA002207268A patent/CA2207268A1/en not_active Abandoned
- 1995-12-21 BR BR9510504A patent/BR9510504A/pt not_active Application Discontinuation
- 1995-12-21 JP JP8520222A patent/JPH10511654A/ja active Pending
- 1995-12-21 US US08/860,239 patent/US5922734A/en not_active Expired - Fee Related
- 1995-12-21 EP EP95943237A patent/EP0800524B1/en not_active Expired - Lifetime
- 1995-12-21 PT PT95943237T patent/PT800524E/pt unknown
- 1995-12-21 CN CN95197162A patent/CN1085668C/zh not_active Expired - Fee Related
- 1995-12-21 PL PL95321041A patent/PL182956B1/pl unknown
- 1995-12-21 ES ES95943237T patent/ES2166838T3/es not_active Expired - Lifetime
- 1995-12-21 NZ NZ298789A patent/NZ298789A/xx unknown
- 1995-12-21 WO PCT/EP1995/005173 patent/WO1996020200A1/en not_active Application Discontinuation
- 1995-12-21 DK DK95943237T patent/DK0800524T3/da active
- 1995-12-21 DE DE69523629T patent/DE69523629T2/de not_active Expired - Fee Related
- 1995-12-21 RU RU97112898/04A patent/RU2165419C2/ru not_active IP Right Cessation
- 1995-12-22 HR HR94203773.0A patent/HRP950616A2/hr not_active Application Discontinuation
- 1995-12-27 ZA ZA9510989A patent/ZA9510989B/xx unknown
- 1995-12-27 IL IL11657795A patent/IL116577A/xx not_active IP Right Cessation
- 1995-12-27 AR ARP950100795A patent/AR002264A1/es unknown
- 1995-12-27 TR TR95/01688A patent/TR199501688A2/xx unknown
- 1995-12-28 MY MYPI95004141A patent/MY131690A/en unknown
-
1997
- 1997-06-27 FI FI972794A patent/FI972794A0/fi unknown
- 1997-06-27 NO NO19973029A patent/NO311220B1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MY131690A (en) | 2007-08-30 |
| NO973029D0 (no) | 1997-06-27 |
| FI972794A (fi) | 1997-06-27 |
| IL116577A0 (en) | 1996-03-31 |
| NZ298789A (en) | 1999-07-29 |
| EP0800524B1 (en) | 2001-10-31 |
| PL321041A1 (en) | 1997-11-24 |
| ATE207924T1 (de) | 2001-11-15 |
| NO973029L (no) | 1997-06-27 |
| AU698199B2 (en) | 1998-10-29 |
| MX9704667A (es) | 1997-09-30 |
| TW316902B (da) | 1997-10-01 |
| US5922734A (en) | 1999-07-13 |
| CN1171789A (zh) | 1998-01-28 |
| HRP950616A2 (en) | 1997-10-31 |
| PT800524E (pt) | 2002-04-29 |
| AR002264A1 (es) | 1998-03-11 |
| TR199501688A2 (tr) | 1996-07-21 |
| PL182956B1 (pl) | 2002-05-31 |
| DK0800524T3 (da) | 2002-03-25 |
| BR9510504A (pt) | 1999-06-01 |
| CN1085668C (zh) | 2002-05-29 |
| ES2166838T3 (es) | 2002-05-01 |
| CA2207268A1 (en) | 1996-07-04 |
| NO311220B1 (no) | 2001-10-29 |
| AU4436296A (en) | 1996-07-19 |
| EP0800524A1 (en) | 1997-10-15 |
| DE69523629T2 (de) | 2002-07-18 |
| JPH10511654A (ja) | 1998-11-10 |
| WO1996020200A1 (en) | 1996-07-04 |
| DE69523629D1 (de) | 2001-12-06 |
| ZA9510989B (en) | 1997-06-27 |
| FI972794A0 (fi) | 1997-06-27 |
| RU2165419C2 (ru) | 2001-04-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL121236A0 (en) | Cycloalkano-pyridines their preparation and pharmaceutical compositions containing them | |
| IL115039A (en) | Spiroazabicyclic compounds, their preparation and pharmaceutical compositions containing them | |
| IL110834A0 (en) | Carboxamides, their preparation and pharmaceutical compositions containing them | |
| IL117860A0 (en) | Substituted 1-phenyl-3-pyrazolecarboxamides their preparation and pharmaceutical compositions containing them | |
| IL119995A0 (en) | Pyrido-fused thienyl - and furanyl-oxazolidinones their preparation and pharmaceutical compositions containing them | |
| IL121235A0 (en) | Bicyclic-fused pyridines their preparation and pharmaceutical compositions containing them | |
| HUP0202338A2 (en) | Pharmaceutical composition containing fenofibrate and preparation method | |
| IL122618A0 (en) | Substituted imidazolylacetonitrile compounds their preparation and pharmaceutical compositions containing them | |
| IL122293A0 (en) | Substituted 4-phenylaminothiazoles their preparation and pharmaceutical compositions containing them | |
| IL125710A0 (en) | Arylglycinamide derivatives their preparation and pharmaceutical compositions containing them | |
| IL115905A0 (en) | Sordarin derivatives their preparation and pharmaceutical compositions containing them | |
| IL119559A0 (en) | Purin -6- one derivatives their preparation and pharmaceutical compositions containing them | |
| HUP0002272A3 (en) | Aroyl-piperazine derivatives, their preparation pharmaceutical compositions containing them and their use | |
| IL122705A (en) | 2-(4-Susbstituted)-benzylamino-2-methyl-propanamide derivatives their preparation and pharmaceutical compositions containing them | |
| IL117554A0 (en) | Imidazoquinazolines their preparation and pharmaceutical compositions containing them | |
| ZA984266B (en) | Pharmaceutical composition and process of preparation | |
| IL112443A0 (en) | Heterocyclic compounds, their preparation and pharmaceutical compositions containing them | |
| IL117981A0 (en) | Compositions containing 2-oxetanones their preparation and use | |
| IL123322A0 (en) | Tetrahydroquinolines their preparation and pharmaceutical compositions containing them | |
| HUP9801386A3 (en) | Indazolecarboxamide derivatives, preparation thereof and pharmaceutical compositions containing them | |
| IL117067A (en) | Anti-neurodegeneratively active 10-aminoaliphatyl-dibenz¬b,f¾oxepines their preparation and pharmaceutical compositions containing them | |
| IL116577A (en) | 6-¬triazolyl¬3-(trifluoromethyl)phenyl¾methyl¾-2-quinolinones and-quinolinethiones their preparation and pharmaceutical compositions containing them | |
| IL114623A0 (en) | Substituted triazolylmethylphenylnaph-thyridones their preparation and pharmaceutical compositions containing them | |
| IL119371A0 (en) | Sulfonylaminopyrimidines their preparation and pharmaceutical compositions containing them | |
| IL118672A0 (en) | Benzisothiazolyl-substituted aminomethylchromans their preparation and pharmaceutical compositions containing them |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |