IL115592A - Stabilized pharmaceutical formulation comprising a growth hormone and leucine - Google Patents
Stabilized pharmaceutical formulation comprising a growth hormone and leucineInfo
- Publication number
- IL115592A IL115592A IL11559295A IL11559295A IL115592A IL 115592 A IL115592 A IL 115592A IL 11559295 A IL11559295 A IL 11559295A IL 11559295 A IL11559295 A IL 11559295A IL 115592 A IL115592 A IL 115592A
- Authority
- IL
- Israel
- Prior art keywords
- growth hormone
- leucine
- pharmaceutical formulation
- stabilized pharmaceutical
- dissolved
- Prior art date
Links
- 102000018997 Growth Hormone Human genes 0.000 title abstract 2
- 108010051696 Growth Hormone Proteins 0.000 title abstract 2
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 title abstract 2
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 title abstract 2
- 239000000122 growth hormone Substances 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 238000003776 cleavage reaction Methods 0.000 abstract 1
- 230000006240 deamidation Effects 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 230000007017 scission Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Endocrinology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32283894A | 1994-10-13 | 1994-10-13 | |
| US08/455,886 US5654278A (en) | 1994-10-13 | 1995-05-31 | Composition and method comprising growth hormone and leucine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL115592A0 IL115592A0 (en) | 1996-01-19 |
| IL115592A true IL115592A (en) | 2000-07-26 |
Family
ID=26983636
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL11559295A IL115592A (en) | 1994-10-13 | 1995-10-12 | Stabilized pharmaceutical formulation comprising a growth hormone and leucine |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP0785797B1 (de) |
| JP (1) | JP4064455B2 (de) |
| AT (1) | ATE213953T1 (de) |
| AU (1) | AU699369B2 (de) |
| DE (1) | DE69525757T2 (de) |
| ES (1) | ES2172594T3 (de) |
| IL (1) | IL115592A (de) |
| WO (1) | WO1996011704A1 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070179096A1 (en) | 1996-04-24 | 2007-08-02 | Novo Nordisk A/S | Pharmaceutical Formulation |
| AUPQ387599A0 (en) * | 1999-11-05 | 1999-12-02 | Metabolic Pharmaceuticals Limited | Product and method for control of obesity |
| JP4711520B2 (ja) | 2000-03-21 | 2011-06-29 | 日本ケミカルリサーチ株式会社 | 生理活性ペプチド含有粉末 |
| MXPA03001092A (es) | 2000-08-07 | 2003-09-25 | Nektar Therapeutics Al Corp | Polvos de proteina de haz de 4 helices secados por rocio, inhalables, que tienen agregacion minimizada. |
| CN109010254A (zh) * | 2008-08-15 | 2018-12-18 | 硬木药品公司 | 适合口服给药的鸟苷酸环化酶-c受体激动剂多肽的稳定的固体制剂 |
| US20130045239A1 (en) * | 2009-08-13 | 2013-02-21 | Ironwood Pharmaceuticals, Inc. | Method for Modulating the Pharmacodynamic Effect of Orally Administered Guanylate Cyclase Receptor Agonists |
| JP2013540732A (ja) * | 2010-09-11 | 2013-11-07 | アイロンウッド ファーマシューティカルズ， インコーポレイテッド | 便秘型過敏性腸症候群の処置 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5967228A (ja) * | 1982-10-07 | 1984-04-16 | Green Cross Corp:The | 寒冷不溶性グロブリンの凍結乾燥方法 |
| ES2044941T5 (es) * | 1987-08-21 | 1999-02-16 | Mallinckrodt Group Inc | Estabilizador de hormonas promotoras del crecimiento. |
| ES2185625T3 (es) * | 1991-12-20 | 2003-05-01 | Novo Nordisk As | Formulacion farmaceutica estabilizada que incluye hormona de crecimiento e histidina. |
| SE9201073D0 (sv) * | 1992-04-03 | 1992-04-03 | Kabi Pharmacia Ab | Protein formulation |
-
1995
- 1995-10-12 IL IL11559295A patent/IL115592A/xx not_active IP Right Cessation
- 1995-10-13 JP JP51286396A patent/JP4064455B2/ja not_active Expired - Fee Related
- 1995-10-13 ES ES95933347T patent/ES2172594T3/es not_active Expired - Lifetime
- 1995-10-13 AT AT95933347T patent/ATE213953T1/de not_active IP Right Cessation
- 1995-10-13 DE DE69525757T patent/DE69525757T2/de not_active Expired - Lifetime
- 1995-10-13 AU AU36054/95A patent/AU699369B2/en not_active Ceased
- 1995-10-13 WO PCT/DK1995/000410 patent/WO1996011704A1/en active IP Right Grant
- 1995-10-13 EP EP95933347A patent/EP0785797B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE69525757D1 (de) | 2002-04-11 |
| ATE213953T1 (de) | 2002-03-15 |
| JPH10507183A (ja) | 1998-07-14 |
| AU699369B2 (en) | 1998-12-03 |
| IL115592A0 (en) | 1996-01-19 |
| WO1996011704A1 (en) | 1996-04-25 |
| EP0785797B1 (de) | 2002-03-06 |
| JP4064455B2 (ja) | 2008-03-19 |
| EP0785797A1 (de) | 1997-07-30 |
| DE69525757T2 (de) | 2002-10-17 |
| AU3605495A (en) | 1996-05-06 |
| ES2172594T3 (es) | 2002-10-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL115590A (en) | Pharmaceutical formulation comprising a growth hormone and isoleucine | |
| HU9401831D0 (en) | Stabilized pharmaceutical formulations comprising growth hormone and asparagine | |
| ZA958605B (en) | A pharmaceutical formulation | |
| CA2125855A1 (en) | A stabilized pharmaceutical formulation comprising growth hormone and histidine | |
| AU610636B2 (en) | Stabilised human protein preparations | |
| CA2155005A1 (en) | Pharmaceutical Compositions Containing Bactericidal Permeability Increasing Protein and a Surfactant | |
| IL137904A0 (en) | Peptide analogues of insulin and pharmaceutical compositions containing the same | |
| BG106046A (en) | Pharmaceutical compositions of ertythropoietin | |
| IL115592A (en) | Stabilized pharmaceutical formulation comprising a growth hormone and leucine | |
| AU2670495A (en) | Ifn-beta liquid formulations | |
| MX9800309A (es) | Formulacion farmaceutica estabilizada que comprende una hormona del crecimiento y un peptido que comprende al menos un residuo de aminoacido basico y al menos un residuo de aminoacido acido. | |
| NZ328402A (en) | Aprotinin variants having the amino acid arg in position 15 and optionally ala in position 17 and medicaments containing them | |
| MX9800358A (es) | Formulacion farmaceutica estabilizada que comprende una hormona del crecimiento pretratada con zinc y opcionalmente lisina o iones calcio. | |
| ZA9710254B (en) | LH-RH peptide analogues, their uses and pharmaceutical composition containing them. | |
| GR3022709T3 (en) | Aerosol composition containing fusafungine. | |
| WO2002079247A3 (en) | Intimins in the prevention or treatment of infections:ii | |
| AU1519399A (en) | Compositions providing for increased igf-i solubility | |
| AU1879097A (en) | Fragments of cr1 and their use | |
| IT1254453B (it) | Composizioni farmaceutiche per uso orale a base di glutatione ridotto | |
| IT1241459B (it) | Composizioni farmaceutiche per la somministrazione rettale di calcitonina |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |