DE69525757D1 - Ein wachstumshormon und leucin enthaltende pharmazeutische formulierung - Google Patents
Ein wachstumshormon und leucin enthaltende pharmazeutische formulierungInfo
- Publication number
- DE69525757D1 DE69525757D1 DE69525757T DE69525757T DE69525757D1 DE 69525757 D1 DE69525757 D1 DE 69525757D1 DE 69525757 T DE69525757 T DE 69525757T DE 69525757 T DE69525757 T DE 69525757T DE 69525757 D1 DE69525757 D1 DE 69525757D1
- Authority
- DE
- Germany
- Prior art keywords
- growth hormone
- leucine
- pharmaceutical formulation
- formulation containing
- containing growth
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000018997 Growth Hormone Human genes 0.000 title abstract 2
- 108010051696 Growth Hormone Proteins 0.000 title abstract 2
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 title abstract 2
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 title abstract 2
- 239000000122 growth hormone Substances 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 238000003776 cleavage reaction Methods 0.000 abstract 1
- 230000006240 deamidation Effects 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 230000007017 scission Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32283894A | 1994-10-13 | 1994-10-13 | |
| US08/455,886 US5654278A (en) | 1994-10-13 | 1995-05-31 | Composition and method comprising growth hormone and leucine |
| PCT/DK1995/000410 WO1996011704A1 (en) | 1994-10-13 | 1995-10-13 | A pharmaceutical formulation comprising a growth hormone and leucine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69525757D1 true DE69525757D1 (de) | 2002-04-11 |
| DE69525757T2 DE69525757T2 (de) | 2002-10-17 |
Family
ID=26983636
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69525757T Expired - Lifetime DE69525757T2 (de) | 1994-10-13 | 1995-10-13 | Ein wachstumshormon und leucin enthaltende pharmazeutische formulierung |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP0785797B1 (de) |
| JP (1) | JP4064455B2 (de) |
| AT (1) | ATE213953T1 (de) |
| AU (1) | AU699369B2 (de) |
| DE (1) | DE69525757T2 (de) |
| ES (1) | ES2172594T3 (de) |
| IL (1) | IL115592A (de) |
| WO (1) | WO1996011704A1 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070179096A1 (en) | 1996-04-24 | 2007-08-02 | Novo Nordisk A/S | Pharmaceutical Formulation |
| AUPQ387599A0 (en) * | 1999-11-05 | 1999-12-02 | Metabolic Pharmaceuticals Limited | Product and method for control of obesity |
| JP4711520B2 (ja) | 2000-03-21 | 2011-06-29 | 日本ケミカルリサーチ株式会社 | 生理活性ペプチド含有粉末 |
| EP1309312A2 (de) | 2000-08-07 | 2003-05-14 | Inhale Therapeutic Systems, Inc. | Inhalierbare sprühgetrocknete pulver aus proteinen die bündel aus 4 helices ausbilden mit minimierter aggregation |
| BRPI0917807A2 (pt) * | 2008-08-15 | 2019-11-19 | Forest Laboratories Holdings Ltd | formulação sólida estável de um polipeptídeo agonista de recepto gc-c adequada para administração oral |
| EP2464373A1 (de) * | 2009-08-13 | 2012-06-20 | Ironwood Pharmaceuticals, Inc. | Verfahren zur modulation der pharmakodynamischen wirkung von oral verabreichten guanylat-cyclase-rezeptoragonisten |
| EP2613794A1 (de) * | 2010-09-11 | 2013-07-17 | Ironwood Pharmaceuticals, Inc. | Behandlung von verstopfungsprädominantem reizdarmsyndrom |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5967228A (ja) * | 1982-10-07 | 1984-04-16 | Green Cross Corp:The | 寒冷不溶性グロブリンの凍結乾燥方法 |
| ATE82506T1 (de) * | 1987-08-21 | 1992-12-15 | Imcera Group Inc | Stabilisierung von wachstumshormonen. |
| DE10399015I1 (de) * | 1991-12-20 | 2012-05-03 | Novo Nordisk As | Stabilisierte pharmazeutische formulierung, die wachstumshormon und histidin enthält |
| SE9201073D0 (sv) * | 1992-04-03 | 1992-04-03 | Kabi Pharmacia Ab | Protein formulation |
-
1995
- 1995-10-12 IL IL11559295A patent/IL115592A/xx not_active IP Right Cessation
- 1995-10-13 WO PCT/DK1995/000410 patent/WO1996011704A1/en active IP Right Grant
- 1995-10-13 EP EP95933347A patent/EP0785797B1/de not_active Expired - Lifetime
- 1995-10-13 ES ES95933347T patent/ES2172594T3/es not_active Expired - Lifetime
- 1995-10-13 DE DE69525757T patent/DE69525757T2/de not_active Expired - Lifetime
- 1995-10-13 AU AU36054/95A patent/AU699369B2/en not_active Ceased
- 1995-10-13 JP JP51286396A patent/JP4064455B2/ja not_active Expired - Fee Related
- 1995-10-13 AT AT95933347T patent/ATE213953T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0785797B1 (de) | 2002-03-06 |
| JPH10507183A (ja) | 1998-07-14 |
| EP0785797A1 (de) | 1997-07-30 |
| AU699369B2 (en) | 1998-12-03 |
| DE69525757T2 (de) | 2002-10-17 |
| AU3605495A (en) | 1996-05-06 |
| WO1996011704A1 (en) | 1996-04-25 |
| ES2172594T3 (es) | 2002-10-01 |
| ATE213953T1 (de) | 2002-03-15 |
| IL115592A (en) | 2000-07-26 |
| IL115592A0 (en) | 1996-01-19 |
| JP4064455B2 (ja) | 2008-03-19 |
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