IL115245A - Tumor necrosis factor inhibiting pharmaceuticals - Google Patents

Tumor necrosis factor inhibiting pharmaceuticals

Info

Publication number
IL115245A
IL115245A IL11524595A IL11524595A IL115245A IL 115245 A IL115245 A IL 115245A IL 11524595 A IL11524595 A IL 11524595A IL 11524595 A IL11524595 A IL 11524595A IL 115245 A IL115245 A IL 115245A
Authority
IL
Israel
Prior art keywords
tnf
use according
lps
compound
alkyl
Prior art date
Application number
IL11524595A
Other languages
English (en)
Other versions
IL115245A0 (en
Inventor
Esther Shohami
Ruth Gallily
Raphael Mechoulam
Original Assignee
Yissum Res Dev Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yissum Res Dev Co filed Critical Yissum Res Dev Co
Priority to IL11524595A priority Critical patent/IL115245A/en
Publication of IL115245A0 publication Critical patent/IL115245A0/xx
Priority to US08/952,660 priority patent/US5932610A/en
Priority to CA002231764A priority patent/CA2231764A1/fr
Priority to DE69636308T priority patent/DE69636308T2/de
Priority to AT96930337T priority patent/ATE331503T1/de
Priority to JP9513269A priority patent/JP2000500737A/ja
Priority to EP96930337A priority patent/EP0876143B1/fr
Priority to AU69420/96A priority patent/AU708886B2/en
Priority to PCT/IL1996/000108 priority patent/WO1997011668A2/fr
Priority to US09/318,774 priority patent/US6331560B1/en
Priority to US09/971,821 priority patent/US6545041B2/en
Publication of IL115245A publication Critical patent/IL115245A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
IL11524595A 1995-09-11 1995-09-11 Tumor necrosis factor inhibiting pharmaceuticals IL115245A (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
IL11524595A IL115245A (en) 1995-09-11 1995-09-11 Tumor necrosis factor inhibiting pharmaceuticals
PCT/IL1996/000108 WO1997011668A2 (fr) 1995-09-11 1996-09-10 PRODUITS PHARMACEUTIQUES INHIBITEURS DU FACTEUR DE NECROSE TUMORALE ALPHA (TNF-α)
AT96930337T ATE331503T1 (de) 1995-09-11 1996-09-10 Tumornekrosefaktor alpha (tnf-alpha) hemmende arzneistoffe
CA002231764A CA2231764A1 (fr) 1995-09-11 1996-09-10 Produits pharmaceutiques inhibiteurs du facteur de necrose tumorale alpha (tnf-.alpha.)
DE69636308T DE69636308T2 (de) 1995-09-11 1996-09-10 Tumornekrosefaktor alpha (tnf-alpha) hemmende arzneistoffe
US08/952,660 US5932610A (en) 1995-09-11 1996-09-10 Tumor necrosis factor α (TNF-α) inhibiting pharmaceuticals
JP9513269A JP2000500737A (ja) 1995-09-11 1996-09-10 腫瘍壊死因子α（ＴＮＦ−α）阻害性医薬品
EP96930337A EP0876143B1 (fr) 1995-09-11 1996-09-10 Produits pharmaceutiques inhibiteurs du facteur de necrose tumorale alpha (tnf-alpha)
AU69420/96A AU708886B2 (en) 1995-09-11 1996-09-10 Tumor necrosis factor (TNF) inhibiting pharmaceuticals
US09/318,774 US6331560B1 (en) 1995-09-11 1999-05-26 Tumor necrosis factor alpha (TNF-α) inhibiting pharmaceuticals
US09/971,821 US6545041B2 (en) 1995-09-11 2001-10-04 Tumor necrosis factor alpha (TNF-α) inhibiting pharmaceuticals

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL11524595A IL115245A (en) 1995-09-11 1995-09-11 Tumor necrosis factor inhibiting pharmaceuticals

Publications (2)

Publication Number Publication Date
IL115245A0 IL115245A0 (en) 1995-12-31
IL115245A true IL115245A (en) 2002-12-01

Family

ID=11067971

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11524595A IL115245A (en) 1995-09-11 1995-09-11 Tumor necrosis factor inhibiting pharmaceuticals

Country Status (9)

Country Link
US (3) US5932610A (fr)
EP (1) EP0876143B1 (fr)
JP (1) JP2000500737A (fr)
AT (1) ATE331503T1 (fr)
AU (1) AU708886B2 (fr)
CA (1) CA2231764A1 (fr)
DE (1) DE69636308T2 (fr)
IL (1) IL115245A (fr)
WO (1) WO1997011668A2 (fr)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9726916D0 (en) * 1997-12-19 1998-02-18 Danbiosyst Uk Nasal formulation
ATE247097T1 (de) * 1998-05-04 2003-08-15 Univ Connecticut Analgetische und immunomodulierende cannabinoiden
US7589220B2 (en) * 1998-06-09 2009-09-15 University Of Connecticut Inhibitors of the anandamide transporter
US7897598B2 (en) * 1998-06-09 2011-03-01 Alexandros Makriyannis Inhibitors of the anandamide transporter
US7161016B1 (en) 1998-11-24 2007-01-09 University Of Connecticut Cannabimimetic lipid amides as useful medications
US7276613B1 (en) 1998-11-24 2007-10-02 University Of Connecticut Retro-anandamides, high affinity and stability cannabinoid receptor ligands
US6274635B1 (en) 1999-03-22 2001-08-14 Immugen Pharmaceuticals Inc. Alkylated resorcinol derivatives for the treatment of immune diseases
US6566560B2 (en) 1999-03-22 2003-05-20 Immugen Pharmaceuticals, Inc. Resorcinolic compounds
US6900236B1 (en) 1999-10-18 2005-05-31 University Of Connecticut Cannabimimetic indole derivatives
US8084467B2 (en) * 1999-10-18 2011-12-27 University Of Connecticut Pyrazole derivatives as cannabinoid receptor antagonists
US6943266B1 (en) * 1999-10-18 2005-09-13 University Of Connecticut Bicyclic cannabinoid agonists for the cannabinoid receptor
US7393842B2 (en) * 2001-08-31 2008-07-01 University Of Connecticut Pyrazole analogs acting on cannabinoid receptors
MXPA02005103A (es) 1999-10-18 2003-09-25 Alexipharma Inc Ligandos selectivos del receptor de canabinoide (cb2) perifericos.
US7119108B1 (en) 1999-10-18 2006-10-10 University Of Connecticut Pyrazole derivatives as cannabinoid receptor antagonists
US7741365B2 (en) * 1999-10-18 2010-06-22 University Of Connecticut Peripheral cannabinoid receptor (CB2) selective ligands
US6808902B1 (en) 1999-11-12 2004-10-26 Amgen Inc. Process for correction of a disulfide misfold in IL-1Ra Fc fusion molecules
US6531128B1 (en) * 2000-02-08 2003-03-11 Pharmacia Corporation Methods for treating glaucoma
AU2001237939A1 (en) * 2000-02-08 2001-08-20 Gulgun Tezel Methods for treating glaucoma
CN100494182C (zh) 2000-05-12 2009-06-03 基酶有限公司 肿瘤坏死α因子信号的调节因子
CA2411585A1 (fr) * 2000-06-22 2001-12-27 Pharmos Corporation Nouveaux cannabinoides non psychotropes
US7235584B2 (en) * 2000-06-22 2007-06-26 Pharmos Corporation Non-psychotropic cannabinoids
EP1785417A3 (fr) * 2000-06-22 2007-08-01 Pharmos Corporation Cannabinoïdes non-psychotropes originaux
WO2002026224A2 (fr) * 2000-09-28 2002-04-04 Immugen Pharmaceuticals, Inc. Procedes et composes pour inhiber le metabolisme des eicosanoides et l'agregation plaquettaire
US6541510B2 (en) * 2000-09-28 2003-04-01 Immugen Pharmaceuticals, Inc. Antiviral methods and compounds
EP1361876A4 (fr) * 2001-01-26 2004-03-31 Univ Connecticut Nouveaux ligands cannabimimetiques
US7173027B2 (en) 2001-01-29 2007-02-06 University Of Connecticut Receptor selective cannabimimetic aminoalkylindoles
CN1547486A (zh) 2001-06-26 2004-11-17 抗opgl抗体
CA2452881C (fr) * 2001-07-13 2012-03-06 University Of Connecticut Nouveaux cannabinoides bicycliques et tricycliques
JP2005510492A (ja) * 2001-10-26 2005-04-21 ユニバーシティ オブ コネチカット 新規な種類の効力のあるカンナビミメティックリガンド
IL148736A0 (en) * 2002-03-18 2002-09-12 Pharmos Corp Dexanabinol and dexanabinol analogs which regulate inflammation related genes
US20050137251A1 (en) * 2002-03-18 2005-06-23 Aaron Garzon Dexanabinol and dexanabinol analogs regulate inflammation related genes
CN1652766A (zh) * 2002-03-18 2005-08-10 免疫力药品有限公司 间苯二酚和大麻素的局部制剂及其施用方法
CA2496097A1 (fr) 2002-08-23 2004-03-04 University Of Connecticut Ceto-cannabinoides possedant des indications therapeutiques
US20050192341A1 (en) * 2002-09-05 2005-09-01 Seth Kindler Non-psychotropic cannabinoids for prevention of cognitive impairment
ATE493980T1 (de) * 2002-11-21 2011-01-15 Genzyme Corp Verwendung eines diamidderivats zur verhinderung der chronischen transplantatabstossung
WO2004047826A1 (fr) * 2002-11-21 2004-06-10 Genzyme Corporation Combinaison de derives de diamide et agents immunosuppresseurs pour l'induction de la tolerance immunitaire
JP2006509038A (ja) * 2002-12-04 2006-03-16 ファーモス コーポレイション 医薬組成物用の高エナンチオマー純度を有するデキサナビノール
EP2578561A1 (fr) 2005-09-29 2013-04-10 Albany Molecular Research, Inc. Procédés pour la production de dérivés de cannabidiol et leurs intermédiaires
WO2009059277A1 (fr) * 2007-11-02 2009-05-07 University Of South Florida Modulation synergique de l'activation de la microglie par la nicotine et le thc
GB0915877D0 (en) 2009-09-10 2009-10-14 E Therapeutics Plc Cancer cell apoptosis
GB201207305D0 (en) 2012-04-26 2012-06-13 E Therapeutics Plc Therapy
US10610512B2 (en) 2014-06-26 2020-04-07 Island Breeze Systems Ca, Llc MDI related products and methods of use
US9585867B2 (en) 2015-08-06 2017-03-07 Charles Everett Ankner Cannabinod formulation for the sedation of a human or animal
WO2017068349A1 (fr) * 2015-10-23 2017-04-27 E-Therapeutics Plc Cannabinoïde pour utilisation en immunothérapie

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL80411A (en) * 1986-10-24 1991-08-16 Raphael Mechoulam Preparation of dibenzopyranol derivatives and pharmaceutical compositions containing them
US5284867A (en) * 1989-11-07 1994-02-08 Yissum Research Development Company Of The Hebrew University In Jerusalem NMDA-blocking pharmaceutical compositions
US5338753A (en) * 1992-07-14 1994-08-16 Sumner H. Burstein (3R,4R)-Δ6 -tetrahydrocannabinol-7-oic acids useful as antiinflammatory agents and analgesics
WO1994012667A1 (fr) * 1992-11-27 1994-06-09 The United States Department Of The Army Inhibiteurs de metabolites d'acide arachidonique destine a la prevention de deteriorations neurologiques

Also Published As

Publication number Publication date
ATE331503T1 (de) 2006-07-15
AU708886B2 (en) 1999-08-12
WO1997011668A3 (fr) 1997-05-15
IL115245A0 (en) 1995-12-31
EP0876143A4 (fr) 2001-06-27
EP0876143A2 (fr) 1998-11-11
US5932610A (en) 1999-08-03
AU6942096A (en) 1997-04-17
EP0876143B1 (fr) 2006-06-28
DE69636308D1 (de) 2006-08-10
JP2000500737A (ja) 2000-01-25
CA2231764A1 (fr) 1997-04-03
US6331560B1 (en) 2001-12-18
US6545041B2 (en) 2003-04-08
WO1997011668A2 (fr) 1997-04-03
DE69636308T2 (de) 2007-05-31
US20020049245A1 (en) 2002-04-25

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Legal Events

Date Code Title Description
FF Patent granted
FF Patent granted
NE Application for restoration - patent lapsed through non-payment of renewal fees (section 60, patents law, 5727-1967)
MM9K Patent not in force due to non-payment of renewal fees