IL114562A - Alpha-(4-chlorophenyl)-4-((4-fluorophenyl)-methyl) piperidine-1-ethanol esters their preparation and pharmaceutical compositions containing them - Google Patents

Alpha-(4-chlorophenyl)-4-((4-fluorophenyl)-methyl) piperidine-1-ethanol esters their preparation and pharmaceutical compositions containing them

Info

Publication number
IL114562A
IL114562A IL11456295A IL11456295A IL114562A IL 114562 A IL114562 A IL 114562A IL 11456295 A IL11456295 A IL 11456295A IL 11456295 A IL11456295 A IL 11456295A IL 114562 A IL114562 A IL 114562A
Authority
IL
Israel
Prior art keywords
fluorophenyl
chlorophenyl
piperidine
alpha
methyl
Prior art date
Application number
IL11456295A
Other languages
English (en)
Other versions
IL114562A0 (en
Original Assignee
Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo filed Critical Synthelabo
Publication of IL114562A0 publication Critical patent/IL114562A0/xx
Publication of IL114562A publication Critical patent/IL114562A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Ophthalmology & Optometry (AREA)
  • Immunology (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL11456295A 1994-07-13 1995-07-12 Alpha-(4-chlorophenyl)-4-((4-fluorophenyl)-methyl) piperidine-1-ethanol esters their preparation and pharmaceutical compositions containing them IL114562A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9408711A FR2722497B1 (fr) 1994-07-13 1994-07-13 Esters de alpha-4-chlorophenyl)-4-(4-fluorophenyl)methyl) piperidine-1-ethanol, leur preparation et leur application en therapeutique

Publications (2)

Publication Number Publication Date
IL114562A0 IL114562A0 (en) 1995-11-27
IL114562A true IL114562A (en) 1999-11-30

Family

ID=9465359

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11456295A IL114562A (en) 1994-07-13 1995-07-12 Alpha-(4-chlorophenyl)-4-((4-fluorophenyl)-methyl) piperidine-1-ethanol esters their preparation and pharmaceutical compositions containing them

Country Status (19)

Country Link
US (1) US5620990A (ko)
EP (1) EP0692472A1 (ko)
JP (1) JPH0859616A (ko)
KR (1) KR960004322A (ko)
CN (1) CN1120038A (ko)
AU (1) AU695312B2 (ko)
CA (1) CA2153726A1 (ko)
CZ (1) CZ180795A3 (ko)
FI (1) FI953410A (ko)
FR (1) FR2722497B1 (ko)
HU (1) HU215599B (ko)
IL (1) IL114562A (ko)
NO (1) NO304427B1 (ko)
NZ (1) NZ272552A (ko)
PL (1) PL309589A1 (ko)
RU (1) RU95113144A (ko)
SK (1) SK88795A3 (ko)
TW (1) TW374084B (ko)
ZA (1) ZA955801B (ko)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2197451C (en) * 1994-08-18 2001-01-23 Bertrand L. Chenard Neuroprotective 3-(piperidinyl-1)-chroman-4,7-diol and 1-(4-hydrophenyl)-2-(piperidinyl-1)-alkanol derivatives
EP1034783B1 (en) * 1997-10-27 2004-12-15 Sumitomo Pharmaceuticals Company, Limited Amide derivatives for the treatment of retinal neurodegenerative disorders

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2534580A1 (fr) * 1982-10-13 1984-04-20 Synthelabo Derives de phenyl-1 piperidino-2 propanol, leur preparation, et medicaments qui les contiennent
FR2628740B3 (fr) * 1989-04-12 1990-01-19 Synthelabo Procede de preparation des enantiomeres du (chloro-4 phenyl)-1 (((fluoro-4 phenyl)methyl)-4 piperidyl-1)-2 ethanol
ES2060547B1 (es) * 1992-06-04 1995-06-16 Ferrer Int Mejoras en el objeto de la patente de invencion n/ 9201158 que se refiere a "procedimiento de obtencion de nuevos derivados de la 4-bencilpiperidina".
FR2694555A1 (fr) * 1992-08-05 1994-02-11 Synthelabo Procédé de péparation des énantiomères du 1-(4-chloro-2-hydroxyphényl)-2-[4-[(4-fluorophényl)méthyl]-piperidin-1-yl]éthanol.
US5434171A (en) * 1993-12-08 1995-07-18 Eli Lilly And Company Preparation of 3,4,4-trisubstituted-piperidinyl-N-alkylcarboxylates and intermediates

Also Published As

Publication number Publication date
ZA955801B (en) 1996-04-25
HU9502113D0 (en) 1995-09-28
NO952761L (no) 1996-01-15
CZ180795A3 (en) 1996-01-17
AU2492295A (en) 1996-01-25
NZ272552A (en) 1996-06-25
RU95113144A (ru) 1997-06-27
FI953410A (fi) 1996-01-14
HUT73137A (en) 1996-06-28
US5620990A (en) 1997-04-15
EP0692472A1 (fr) 1996-01-17
SK88795A3 (en) 1996-02-07
AU695312B2 (en) 1998-08-13
FI953410A0 (fi) 1995-07-12
CA2153726A1 (en) 1996-01-14
NO952761D0 (no) 1995-07-12
HU215599B (hu) 1999-01-28
FR2722497B1 (fr) 1996-08-14
JPH0859616A (ja) 1996-03-05
KR960004322A (ko) 1996-02-23
TW374084B (en) 1999-11-11
CN1120038A (zh) 1996-04-10
FR2722497A1 (fr) 1996-01-19
NO304427B1 (no) 1998-12-14
IL114562A0 (en) 1995-11-27
PL309589A1 (en) 1996-01-22

Similar Documents

Publication Publication Date Title
IL119995A0 (en) Pyrido-fused thienyl - and furanyl-oxazolidinones their preparation and pharmaceutical compositions containing them
IL124994A0 (en) Taxoids preparation thereof and pharmaceutical compositions containing same
IL121236A0 (en) Cycloalkano-pyridines their preparation and pharmaceutical compositions containing them
AP9701093A0 (en) Novel taxoids preparation thereof and pharmaceutical compositions containing same
IL114622A (en) 5-membered heteroaryl-oxazolidinones and pharmaceutical compositions containing them
IL114626A0 (en) 6-membered nitrogen-containing heteroaryl-oxazolidinones their preparation and pharmaceutical compositions containing them
HUT75648A (en) 3-(5-tetrazolyl-benzyl)amino-piperidine derivatives and pharmaceutical compositions containing them
IL110834A0 (en) Carboxamides, their preparation and pharmaceutical compositions containing them
ZA942804B (en) Oral drug delivery compositions and methods
HUP0202338A2 (en) Pharmaceutical composition containing fenofibrate and preparation method
IL120998A (en) Xanthine alkynols their preparation and pharmaceutical compositions containing them
IL117554A0 (en) Imidazoquinazolines their preparation and pharmaceutical compositions containing them
HUP0100470A3 (en) Oxazolidinone derivatives and pharmaceutical compositions containing them
IL117817A0 (en) N-subsituted azaheterocyclic compounds their preparation and pharmaceutical compositions containing them
IL116480A0 (en) Acetic acid deriratives their preparation and pharmaceutical compositions containing them
IL128096A0 (en) Arylcycloalkane carboxylic esters their use pharmaceutical compositions and preparation
IL125998A0 (en) Taxoids preparation thereof and pharmaceutical compositions containing them
IL116930A (en) 4-(1H-indol-1-YL)-1-piperidinyl derivatives their preparation and pharmaceutical compositions containing them
ZA963397B (en) Esters and pharmaceutical compositions
AP9701094A0 (en) Novel taxoids preparation thereof and pharmaceutical compositions containing same
IL114623A0 (en) Substituted triazolylmethylphenylnaph-thyridones their preparation and pharmaceutical compositions containing them
IL118672A0 (en) Benzisothiazolyl-substituted aminomethylchromans their preparation and pharmaceutical compositions containing them
IL119371A0 (en) Sulfonylaminopyrimidines their preparation and pharmaceutical compositions containing them
IL116577A (en) 6-¬triazolyl¬3-(trifluoromethyl)phenyl¾methyl¾-2-quinolinones and-quinolinethiones their preparation and pharmaceutical compositions containing them
HUP9801751A3 (en) Benzopyrans their preparation and use and pharmaceutical compositions containing them

Legal Events

Date Code Title Description
FF Patent granted