IL114405A0 - Cascade polymer complexes pharmaceutical compositions containing the same and processes for the preparation thereof - Google Patents
Cascade polymer complexes pharmaceutical compositions containing the same and processes for the preparation thereofInfo
- Publication number
- IL114405A0 IL114405A0 IL11440595A IL11440595A IL114405A0 IL 114405 A0 IL114405 A0 IL 114405A0 IL 11440595 A IL11440595 A IL 11440595A IL 11440595 A IL11440595 A IL 11440595A IL 114405 A0 IL114405 A0 IL 114405A0
- Authority
- IL
- Israel
- Prior art keywords
- cascade
- reproduction
- stands
- stand
- independently
- Prior art date
Links
- 229920000642 polymer Polymers 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 150000001768 cations Chemical class 0.000 abstract 1
- 230000000536 complexating effect Effects 0.000 abstract 1
- 239000008139 complexing agent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 150000007529 inorganic bases Chemical class 0.000 abstract 1
- 150000002500 ions Chemical class 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 150000007530 organic bases Chemical class 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/12—Macromolecular compounds
- A61K49/124—Macromolecular compounds dendrimers, dendrons, hyperbranched compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- C07C237/12—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/54—Three nitrogen atoms
- C07D251/64—Condensation products of melamine with aldehydes; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/16—Dendrimers and dendritic polymers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Radiology & Medical Imaging (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4425857A DE4425857A1 (de) | 1994-07-07 | 1994-07-07 | Kaskaden-Polymer-Komplexe, Verfahren zur ihrer Herstellung und diese enthaltende pharmazeutische Mittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL114405A0 true IL114405A0 (en) | 1995-10-31 |
Family
ID=6523793
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL11440595A IL114405A0 (en) | 1994-07-07 | 1995-06-30 | Cascade polymer complexes pharmaceutical compositions containing the same and processes for the preparation thereof |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US6248306B1 (zh) |
| EP (1) | EP0768898B1 (zh) |
| JP (1) | JP3701678B2 (zh) |
| CN (1) | CN1151701A (zh) |
| AT (1) | ATE236658T1 (zh) |
| AU (1) | AU697203B2 (zh) |
| CA (1) | CA2194560A1 (zh) |
| CZ (1) | CZ3197A3 (zh) |
| DE (2) | DE4425857A1 (zh) |
| DK (1) | DK0768898T3 (zh) |
| ES (1) | ES2196068T3 (zh) |
| HU (1) | HUT76804A (zh) |
| IL (1) | IL114405A0 (zh) |
| NO (1) | NO970055L (zh) |
| NZ (1) | NZ289845A (zh) |
| PL (1) | PL318043A1 (zh) |
| PT (1) | PT768898E (zh) |
| SI (1) | SI9520068A (zh) |
| SK (1) | SK167496A3 (zh) |
| WO (1) | WO1996001655A1 (zh) |
| ZA (1) | ZA955682B (zh) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5863919A (en) * | 1994-07-25 | 1999-01-26 | University Of South Florida | Lock and key micelles and monomer building blocks therefor |
| DE19518222A1 (de) * | 1995-05-11 | 1996-11-14 | Schering Ag | Verwendung von polymeren Kontrastmittel mittleren Molekulargewichts zur Differenzierung von benignen und malignen Tumoren mittels moderner bildgebender Verfahren |
| US6166200A (en) * | 1995-07-04 | 2000-12-26 | Schering Aktiengesellschaft | Cascade polymer complexes, process for their production and pharmaceutical agents containing said complexes |
| DE19525924A1 (de) | 1995-07-04 | 1997-01-09 | Schering Ag | Kaskaden-Polymer-Komplexe, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel |
| AU726034B2 (en) * | 1995-12-22 | 2000-10-26 | Schering Aktiengesellschaft | Cascade polymer complexes, process for their production and pharmaceutical agents that contain the latter |
| DE19549286A1 (de) * | 1995-12-22 | 1997-06-26 | Schering Ag | Kaskaden-Polymer-Komplexe, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel |
| US5874061A (en) * | 1995-12-22 | 1999-02-23 | Schering Aktiengesellschaft | Cascade polymer complexes, process for their production and pharmaceutical agents containing said complexes |
| IL118657A0 (en) * | 1996-06-14 | 1996-10-16 | Arad Dorit | Inhibitors for picornavirus proteases |
| DE19652387A1 (de) * | 1996-12-04 | 1998-06-10 | Schering Ag | Macrocyclische Metallkomplexcarbonsäuren, ihre Verwendung sowie Verfahren zu ihrer Herstellung |
| DE19728954C1 (de) * | 1997-06-30 | 1999-04-22 | Schering Ag | Saccharid-Konjugate, diese enthaltende pharmazeutische Mittel, Verfahren zu ihrer Herstellung und ihre Verwendung |
| DE19744003B4 (de) * | 1997-09-26 | 2004-07-08 | Schering Ag | Kontrastmittel für das Infarkt- und Nekroseimaging |
| DE19758105A1 (de) * | 1997-12-18 | 1999-06-24 | Schering Ag | Dendritische Polymer-Saccharid-Konjugate, diese enthaltende pharmazeutische Mittel, Verfahren zu ihrer Herstellung und ihre Verwendung |
| US7405320B2 (en) * | 1998-06-22 | 2008-07-29 | Immunomedics, Inc. | Therapeutic and diagnostic conjugates for use with multispecific antibodies |
| AU6386000A (en) | 1999-07-29 | 2001-02-19 | Epix Pharmaceuticals, Inc. | Targeting multimeric imaging agents through multilocus binding |
| EP1401430A4 (en) | 2001-05-31 | 2005-10-19 | Miravant Pharm Inc | SUBSTITUTED PORPHYRIN AND AZAPORPHYRIN DERIVATIVES AND USE IN PHOTODYNAMIC THERAPY, RADIOIMAGING, AND MRI DIAGNOSIS |
| TWI221406B (en) * | 2001-07-30 | 2004-10-01 | Epix Medical Inc | Systems and methods for targeted magnetic resonance imaging of the vascular system |
| AR047692A1 (es) * | 2003-07-10 | 2006-02-08 | Epix Medical Inc | Imagenes de blancos estacionarios |
| US7223759B2 (en) * | 2003-09-15 | 2007-05-29 | Anadys Pharmaceuticals, Inc. | Antibacterial 3,5-diaminopiperidine-substituted aromatic and heteroaromatic compounds |
| US7199268B2 (en) | 2003-12-16 | 2007-04-03 | Schering Aktiengesellschaft | Process for the production of dendritic trimesic acid triamides |
| DE102007002726A1 (de) * | 2007-01-18 | 2008-07-31 | Bayer Schering Pharma Aktiengesellschaft | Neue Kaskaden-Polymer-Komplexe, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel |
| HUP0700782A3 (en) * | 2007-12-05 | 2009-11-30 | Biostatin Gyogyszerkutato Fejl | Novel peptides and amino acid derivatives, pharmaceutical compositions containing the same and use of the compounds |
| AU2010226434A1 (en) * | 2009-03-20 | 2011-10-13 | Egen, Inc. | Polyamine derivatives |
| US20120063976A1 (en) * | 2010-09-09 | 2012-03-15 | Battelle Energy Alliance, Llc | Methods of removing carbon dioxide and sorbents for same |
| EP3101012A1 (en) | 2015-06-04 | 2016-12-07 | Bayer Pharma Aktiengesellschaft | New gadolinium chelate compounds for use in magnetic resonance imaging |
| JP7034160B2 (ja) | 2016-11-28 | 2022-03-11 | バイエル・ファルマ・アクティエンゲゼルシャフト | 磁気共鳴画像法に使用するための高緩和度ガドリニウムキレート化合物 |
| PE20211471A1 (es) | 2018-11-23 | 2021-08-05 | Bayer Ag | Formulacion de medios de contraste y proceso para prepararlos |
| CN109867635A (zh) * | 2019-02-14 | 2019-06-11 | 华东师范大学 | 一种t1型胶束磁共振成像造影剂及其制备方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4587329A (en) * | 1984-08-17 | 1986-05-06 | The Dow Chemical Company | Dense star polymers having two dimensional molecular diameter |
| US5527524A (en) * | 1986-08-18 | 1996-06-18 | The Dow Chemical Company | Dense star polymer conjugates |
| US5135737A (en) * | 1986-11-10 | 1992-08-04 | The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon | Amplifier molecules for enhancement of diagnosis and therapy |
| US4863717A (en) * | 1986-11-10 | 1989-09-05 | The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon | Methods for circumventing the problem of free radial reduction associated with the use of stable nitroxide free radicals as contrast agents for magnetic reasonance imaging |
| US5364613A (en) * | 1989-04-07 | 1994-11-15 | Sieving Paul F | Polychelants containing macrocyclic chelant moieties |
| US5914095A (en) | 1989-04-07 | 1999-06-22 | Salutar, Inc. | Polychelants containg amide bonds |
| US5446145A (en) * | 1990-01-19 | 1995-08-29 | Nycomed Salutar, Inc. | Polychelant compounds |
| GB8923843D0 (en) * | 1989-10-23 | 1989-12-13 | Salutar Inc | Compounds |
| DE3938992A1 (de) * | 1989-11-21 | 1991-05-23 | Schering Ag | Kaskadenpolymer-gebundene komplexbildner, deren komplexe und konjugate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
| GB9024208D0 (en) * | 1990-11-07 | 1990-12-19 | Salutar Inc | Compounds |
| US5385719A (en) * | 1991-09-24 | 1995-01-31 | Unger; Evan C. | Copolymers and their use as contrast agents in magnetic resonance imaging and in other applications |
| US5405601A (en) * | 1993-07-02 | 1995-04-11 | Mallinckrodt Medical Inc. | Functionalized tripodal ligands for imaging applications |
| US5449761A (en) * | 1993-09-28 | 1995-09-12 | Cytogen Corporation | Metal-binding targeted polypeptide constructs |
| DE4344460A1 (de) | 1993-12-22 | 1995-06-29 | Schering Ag | Metallkomplexe von dendrimeren Makromolekülen, diese enthaltende diagnostische Mittel sowie Verfahren zur Herstellung der Komplexe und Mittel |
| DE4344464A1 (de) * | 1993-12-22 | 1995-06-29 | Schering Ag | Kaskadenpolymere mit Iodaromaten |
| DE19525924A1 (de) * | 1995-07-04 | 1997-01-09 | Schering Ag | Kaskaden-Polymer-Komplexe, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel |
| US5874061A (en) * | 1995-12-22 | 1999-02-23 | Schering Aktiengesellschaft | Cascade polymer complexes, process for their production and pharmaceutical agents containing said complexes |
-
1994
- 1994-07-07 DE DE4425857A patent/DE4425857A1/de not_active Withdrawn
-
1995
- 1995-06-06 US US08/485,558 patent/US6248306B1/en not_active Expired - Fee Related
- 1995-06-30 IL IL11440595A patent/IL114405A0/xx unknown
- 1995-07-04 JP JP50410096A patent/JP3701678B2/ja not_active Expired - Fee Related
- 1995-07-04 PT PT95925817T patent/PT768898E/pt unknown
- 1995-07-04 NZ NZ289845A patent/NZ289845A/xx unknown
- 1995-07-04 AT AT95925817T patent/ATE236658T1/de not_active IP Right Cessation
- 1995-07-04 CN CN95193803A patent/CN1151701A/zh active Pending
- 1995-07-04 DE DE59510632T patent/DE59510632D1/de not_active Expired - Fee Related
- 1995-07-04 SK SK1674-96A patent/SK167496A3/sk unknown
- 1995-07-04 WO PCT/EP1995/002577 patent/WO1996001655A1/de not_active Application Discontinuation
- 1995-07-04 EP EP95925817A patent/EP0768898B1/de not_active Expired - Lifetime
- 1995-07-04 HU HU9700025A patent/HUT76804A/hu unknown
- 1995-07-04 ES ES95925817T patent/ES2196068T3/es not_active Expired - Lifetime
- 1995-07-04 CA CA002194560A patent/CA2194560A1/en not_active Abandoned
- 1995-07-04 DK DK95925817T patent/DK0768898T3/da active
- 1995-07-04 CZ CZ9731A patent/CZ3197A3/cs unknown
- 1995-07-04 PL PL95318043A patent/PL318043A1/xx unknown
- 1995-07-04 AU AU29808/95A patent/AU697203B2/en not_active Ceased
- 1995-07-04 SI SI9520068A patent/SI9520068A/sl unknown
- 1995-07-07 ZA ZA955682A patent/ZA955682B/xx unknown
-
1997
- 1997-01-07 NO NO970055A patent/NO970055L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUT76804A (en) | 1997-11-28 |
| NZ289845A (en) | 1999-03-29 |
| SK167496A3 (en) | 1997-07-09 |
| EP0768898A1 (de) | 1997-04-23 |
| DK0768898T3 (da) | 2003-08-04 |
| SI9520068A (en) | 1997-10-31 |
| DE59510632D1 (de) | 2003-05-15 |
| PL318043A1 (en) | 1997-05-12 |
| DE4425857A1 (de) | 1996-01-11 |
| AU697203B2 (en) | 1998-10-01 |
| EP0768898B1 (de) | 2003-04-09 |
| JP3701678B2 (ja) | 2005-10-05 |
| ATE236658T1 (de) | 2003-04-15 |
| JPH10502679A (ja) | 1998-03-10 |
| CZ3197A3 (en) | 1997-07-16 |
| CA2194560A1 (en) | 1996-01-25 |
| ES2196068T3 (es) | 2003-12-16 |
| WO1996001655A1 (de) | 1996-01-25 |
| HU9700025D0 (en) | 1997-02-28 |
| US6248306B1 (en) | 2001-06-19 |
| NO970055L (no) | 1997-03-06 |
| AU2980895A (en) | 1996-02-09 |
| NO970055D0 (no) | 1997-01-07 |
| CN1151701A (zh) | 1997-06-11 |
| PT768898E (pt) | 2003-08-29 |
| ZA955682B (en) | 1996-02-22 |
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