IL112039A - Derivatives of benzothiophines and their use in inhibiting breast diseases - Google Patents
Derivatives of benzothiophines and their use in inhibiting breast diseasesInfo
- Publication number
- IL112039A IL112039A IL11203994A IL11203994A IL112039A IL 112039 A IL112039 A IL 112039A IL 11203994 A IL11203994 A IL 11203994A IL 11203994 A IL11203994 A IL 11203994A IL 112039 A IL112039 A IL 112039A
- Authority
- IL
- Israel
- Prior art keywords
- compound
- formula
- medicament
- breast
- pharmaceutically acceptable
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/171,955 US5593987A (en) | 1993-12-21 | 1993-12-21 | Methods of inhibiting breast disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL112039A0 IL112039A0 (en) | 1995-03-15 |
| IL112039A true IL112039A (en) | 1999-03-12 |
Family
ID=22625779
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL11203994A IL112039A (en) | 1993-12-21 | 1994-12-19 | Derivatives of benzothiophines and their use in inhibiting breast diseases |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5593987A (fr) |
| EP (1) | EP0659419A1 (fr) |
| JP (1) | JPH07196501A (fr) |
| KR (1) | KR950016729A (fr) |
| CN (1) | CN1108100A (fr) |
| AU (1) | AU701701B2 (fr) |
| CA (1) | CA2138501A1 (fr) |
| CZ (1) | CZ321294A3 (fr) |
| HU (1) | HUT71480A (fr) |
| IL (1) | IL112039A (fr) |
| NO (1) | NO944933L (fr) |
| NZ (1) | NZ270170A (fr) |
| PH (1) | PH31326A (fr) |
| RU (1) | RU2126251C1 (fr) |
| ZA (1) | ZA9410088B (fr) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6515009B1 (en) | 1991-09-27 | 2003-02-04 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| US5811447A (en) | 1993-01-28 | 1998-09-22 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| US6491938B2 (en) | 1993-05-13 | 2002-12-10 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| US5521214A (en) * | 1995-01-25 | 1996-05-28 | Eli Lilly And Company | Methods of inhibiting environmental estrogens |
| DE19604231A1 (de) * | 1996-01-29 | 1997-07-31 | Schering Ag | Pharmazeutisches Kombinationspräparat und seine Verwendung zur Behandlung von gynäkologischen Störungen |
| TW442286B (en) * | 1996-02-28 | 2001-06-23 | Pfizer | New therapeutic uses of estrogen agonists |
| IL120266A (en) | 1996-02-28 | 2005-05-17 | Pfizer | Use of estrogen antagonists and estrogen agonists in the preparation of medicaments for inhibiting pathological conditions |
| US6117911A (en) * | 1997-04-11 | 2000-09-12 | Neorx Corporation | Compounds and therapies for the prevention of vascular and non-vascular pathologies |
| US6054446A (en) | 1997-12-24 | 2000-04-25 | Sri International | Anti-estrogenic steroids, and associated pharmaceutical compositions and methods of use |
| HUP0200871A3 (en) | 1999-05-04 | 2004-04-28 | Strakan Int Ltd | Androgen glycosides and androgenic activity thereof |
| US20020016318A1 (en) * | 2000-07-06 | 2002-02-07 | American Home Products Corporation | Methods of treating breast disorders |
| ITMI20011495A1 (it) * | 2001-07-12 | 2003-01-12 | Pharmaproducts Uk Ltd | Sali di calcio ad attivita' citotossica |
| US7332525B2 (en) * | 2003-01-17 | 2008-02-19 | Castle Erik P | Method of treatment of prostate cancer and composition for treatment thereof |
| ITMI20041279A1 (it) * | 2004-06-24 | 2004-09-24 | Pharmaproducts Uk Ltd | Uso di calcio trifluoroacetato per la preparazione di medicamenti ad effetto anti-angiogenetico |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4001242A (en) * | 1974-08-02 | 1977-01-04 | Eli Lilly And Company | D-6-methyl-8-formyl-10α-alkoxy-8-ergolene |
| US4133814A (en) * | 1975-10-28 | 1979-01-09 | Eli Lilly And Company | 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents |
| US4418068A (en) * | 1981-04-03 | 1983-11-29 | Eli Lilly And Company | Antiestrogenic and antiandrugenic benzothiophenes |
| US4380635A (en) * | 1981-04-03 | 1983-04-19 | Eli Lilly And Company | Synthesis of acylated benzothiophenes |
| US4895715A (en) * | 1988-04-14 | 1990-01-23 | Schering Corporation | Method of treating gynecomastia |
| US5395842A (en) * | 1988-10-31 | 1995-03-07 | Endorecherche Inc. | Anti-estrogenic compounds and compositions |
| US5227375A (en) * | 1990-02-08 | 1993-07-13 | Endorecherche, Inc. | Aromatase inhibitors |
| FR2677027B1 (fr) * | 1991-05-27 | 1993-09-10 | Roussel Uclaf | Nouveaux produits sterouides substitues en position 6, et comportant, en position 10, un radical thioethyle, leur procede de preparation leurs intermediaires, leur application comme medicaments. |
| JP3157882B2 (ja) * | 1991-11-15 | 2001-04-16 | 帝国臓器製薬株式会社 | 新規なベンゾチオフエン誘導体 |
-
1993
- 1993-12-21 US US08/171,955 patent/US5593987A/en not_active Expired - Fee Related
-
1994
- 1994-12-16 RU RU94045280A patent/RU2126251C1/ru active
- 1994-12-19 NO NO944933A patent/NO944933L/no unknown
- 1994-12-19 HU HU9403666A patent/HUT71480A/hu unknown
- 1994-12-19 AU AU81560/94A patent/AU701701B2/en not_active Ceased
- 1994-12-19 NZ NZ270170A patent/NZ270170A/en unknown
- 1994-12-19 CZ CZ943212A patent/CZ321294A3/cs unknown
- 1994-12-19 CN CN94119732A patent/CN1108100A/zh active Pending
- 1994-12-19 JP JP6314547A patent/JPH07196501A/ja active Pending
- 1994-12-19 ZA ZA9410088A patent/ZA9410088B/xx unknown
- 1994-12-19 PH PH49579A patent/PH31326A/en unknown
- 1994-12-19 KR KR1019940034920A patent/KR950016729A/ko not_active Application Discontinuation
- 1994-12-19 IL IL11203994A patent/IL112039A/en not_active IP Right Cessation
- 1994-12-19 CA CA002138501A patent/CA2138501A1/fr not_active Abandoned
- 1994-12-19 EP EP94309477A patent/EP0659419A1/fr not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| NO944933D0 (no) | 1994-12-19 |
| KR950016729A (ko) | 1995-07-20 |
| AU8156094A (en) | 1995-06-29 |
| RU2126251C1 (ru) | 1999-02-20 |
| RU94045280A (ru) | 1996-10-10 |
| NZ270170A (en) | 1997-07-27 |
| PH31326A (en) | 1998-07-06 |
| IL112039A0 (en) | 1995-03-15 |
| CA2138501A1 (fr) | 1995-06-22 |
| HU9403666D0 (en) | 1995-02-28 |
| JPH07196501A (ja) | 1995-08-01 |
| CN1108100A (zh) | 1995-09-13 |
| EP0659419A1 (fr) | 1995-06-28 |
| AU701701B2 (en) | 1999-02-04 |
| NO944933L (no) | 1995-06-22 |
| HUT71480A (en) | 1995-11-28 |
| ZA9410088B (en) | 1996-06-19 |
| CZ321294A3 (en) | 1995-08-16 |
| US5593987A (en) | 1997-01-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |