IL110992A0 - n-substituted 5'-deoxy adenosine derivatives and pharmaceutical compositions containing them - Google Patents
n-substituted 5'-deoxy adenosine derivatives and pharmaceutical compositions containing themInfo
- Publication number
- IL110992A0 IL110992A0 IL11099294A IL11099294A IL110992A0 IL 110992 A0 IL110992 A0 IL 110992A0 IL 11099294 A IL11099294 A IL 11099294A IL 11099294 A IL11099294 A IL 11099294A IL 110992 A0 IL110992 A0 IL 110992A0
- Authority
- IL
- Israel
- Prior art keywords
- substituted
- pharmaceutical compositions
- compositions containing
- adenosine derivatives
- deoxy adenosine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Neurosurgery (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK104393A DK104393D0 (da) | 1993-09-17 | 1993-09-17 | Kemiske forbindelser, deres fremstilling og anvendelse |
DK31094 | 1994-03-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
IL110992A0 true IL110992A0 (en) | 1994-11-28 |
Family
ID=26063751
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL11099294A IL110992A0 (en) | 1993-09-17 | 1994-09-18 | n-substituted 5'-deoxy adenosine derivatives and pharmaceutical compositions containing them |
Country Status (10)
Country | Link |
---|---|
US (1) | US5589467A (xx) |
EP (1) | EP0719275A1 (xx) |
JP (1) | JPH11511436A (xx) |
AU (1) | AU678053B2 (xx) |
CA (1) | CA2171940A1 (xx) |
FI (1) | FI961219A (xx) |
IL (1) | IL110992A0 (xx) |
NO (1) | NO961071L (xx) |
NZ (1) | NZ273284A (xx) |
WO (1) | WO1995007921A1 (xx) |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2022597A (en) * | 1996-03-13 | 1997-10-01 | Novo Nordisk A/S | A method of treating disorders related to cytokines in mammals |
WO1997033590A1 (en) * | 1996-03-13 | 1997-09-18 | Novo Nordisk A/S | A method of treating disorders related to cytokines in mammals |
GB9610031D0 (en) * | 1996-05-14 | 1996-07-17 | Glaxo Group Ltd | Chemical compounds |
AU4377397A (en) * | 1996-10-14 | 1998-05-11 | Novo Nordisk A/S | Novel therapeutically active adenosine derivatives |
US6110902A (en) * | 1997-06-23 | 2000-08-29 | Moehler; Hanns | Method for the inhibition of neuronal activity leading to a focal epileptic seizure by local delivery of adenosine |
GB9723590D0 (en) * | 1997-11-08 | 1998-01-07 | Glaxo Group Ltd | Chemical compounds |
GB9723589D0 (en) * | 1997-11-08 | 1998-01-07 | Glaxo Group Ltd | Chemical compounds |
AU4138601A (en) * | 1999-12-03 | 2001-06-12 | Cv Therapeutics, Inc. | Method of identifying partial adenosine a1 receptor agonists and their use in the treatment of arrhythmias |
US6605597B1 (en) * | 1999-12-03 | 2003-08-12 | Cv Therapeutics, Inc. | Partial or full A1agonists-N-6 heterocyclic 5′-thio substituted adenosine derivatives |
GB2372742A (en) * | 2001-03-03 | 2002-09-04 | Univ Leiden | C2,5'-Disubstituted and N6,C2,5'-trisubstituted adenosine derivatives and their different uses |
US7414036B2 (en) | 2002-01-25 | 2008-08-19 | Muscagen Limited | Compounds useful as A3 adenosine receptor agonists |
US7265111B2 (en) | 2002-06-27 | 2007-09-04 | Sanofi-Aventis Deutschland Gmbh | Adenosine analogues and their use as pharmaceutical agents |
RU2340623C2 (ru) * | 2002-08-15 | 2008-12-10 | Си Ви Терапьютикс, Инк. | Частичные и полные агонисты аденозиновых рецепторов a1 |
US7423144B2 (en) * | 2004-05-26 | 2008-09-09 | Inotek Pharmaceuticals Corporation | Purine Derivatives as adenosine A1 receptor agonists and methods of use thereof |
JP5011112B2 (ja) * | 2004-09-20 | 2012-08-29 | イノテック ファーマシューティカルズ コーポレイション | プリン誘導体を含有する炎症性疾患の治療用医薬 |
EP1962597A4 (en) * | 2005-11-30 | 2008-12-17 | Inotek Pharmaceuticals Corp | PURINE DERIVATIVES AND METHOD OF USE |
CN101857622B (zh) * | 2009-04-07 | 2014-12-03 | 中国医学科学院药物研究所 | 一种腺苷衍生物及其制备方法和应用 |
ME02608B (me) | 2010-01-11 | 2017-06-20 | Inotek Pharmaceuticals Corp | Kombinacija, komplet i postupak snižavanja intraokularnog pritiska |
JP2013523739A (ja) | 2010-03-26 | 2013-06-17 | イノテック ファーマシューティカルズ コーポレイション | N6−シクロペンチルアデノシン(cpa)、cpa誘導体またはそれらのプロドラッグを用いてヒトにおける眼内圧を低下させる方法 |
GB2494851A (en) | 2011-07-07 | 2013-03-27 | Kalvista Pharmaceuticals Ltd | Plasma kallikrein inhibitors |
RS56150B1 (sr) | 2012-01-26 | 2017-11-30 | Inotek Pharmaceuticals Corp | Anhidrovani polimorfi (2r,3s,4r,5r)-5-(6-(ciklopentilamino)-9h-purin-9-yl)-3,4-dihidroksitetrahidrofuran-2-yl)} metil-nitrata i postupak njegove pripreme |
GB201212081D0 (en) | 2012-07-06 | 2012-08-22 | Kalvista Pharmaceuticals Ltd | New polymorph |
PH12015501492A1 (en) | 2013-01-08 | 2015-09-28 | Kalvista Pharmaceuticals Ltd | Benzylamine derivatives |
GB201300304D0 (en) | 2013-01-08 | 2013-02-20 | Kalvista Pharmaceuticals Ltd | Benzylamine derivatives |
GB2510407A (en) | 2013-02-04 | 2014-08-06 | Kalvista Pharmaceuticals Ltd | Aqueous suspensions of kallikrein inhibitors for parenteral administration |
JP2016513706A (ja) | 2013-03-15 | 2016-05-16 | イノテック ファーマシューティカルズ コーポレイション | 点眼用製剤 |
WO2014188211A1 (en) | 2013-05-23 | 2014-11-27 | Kalvista Pharmaceuticals Limited | Heterocyclic derivates |
CN105683179B (zh) | 2013-08-14 | 2018-10-26 | 卡尔维斯塔制药有限公司 | 血浆激肽释放酶的抑制剂 |
TWI636047B (zh) | 2013-08-14 | 2018-09-21 | 英商卡爾維斯塔製藥有限公司 | 雜環衍生物 |
GB2517908A (en) | 2013-08-14 | 2015-03-11 | Kalvista Pharmaceuticals Ltd | Bicyclic inhibitors |
GB201421085D0 (en) | 2014-11-27 | 2015-01-14 | Kalvista Pharmaceuticals Ltd | New enzyme inhibitors |
GB201421088D0 (en) | 2014-11-27 | 2015-01-14 | Kalvista Pharmaceuticals Ltd | New enzyme inhibitors |
GB201421083D0 (en) | 2014-11-27 | 2015-01-14 | Kalvista Pharmaceuticals Ltd | Enzyme inhibitors |
SG11201809922YA (en) | 2016-05-31 | 2018-12-28 | Kalvista Pharmaceuticals Ltd | Pyrazole derivatives as plasma kallikrein inhibitors |
GB201609607D0 (en) | 2016-06-01 | 2016-07-13 | Kalvista Pharmaceuticals Ltd | Polymorphs of N-(3-Fluoro-4-methoxypyridin-2-yl)methyl)-3-(methoxymethyl)-1-({4-((2-oxopy ridin-1-yl)methyl)phenyl}methyl)pyrazole-4-carboxamide and salts |
GB201609603D0 (en) | 2016-06-01 | 2016-07-13 | Kalvista Pharmaceuticals Ltd | Polymorphs of N-[(6-cyano-2-fluoro-3-methoxyphenyl)Methyl]-3-(methoxymethyl)-1-({4-[(2-ox opyridin-1-YL)Methyl]phenyl}methyl)pyrazole-4-carboxamide |
LT3716952T (lt) | 2017-11-29 | 2022-04-11 | Kalvista Pharmaceuticals Limited | Vaisto formos, apimančios plazmos kalikreino inhibitorių |
GB201719881D0 (en) | 2017-11-29 | 2018-01-10 | Kalvista Pharmaceuticals Ltd | Solid forms of plasma kallikrein inhibitor and salts thereof |
GB201910116D0 (en) | 2019-07-15 | 2019-08-28 | Kalvista Pharmaceuticals Ltd | Treatments of hereditary angioedema |
GB201910125D0 (en) | 2019-07-15 | 2019-08-28 | Kalvista Pharmaceuticals Ltd | Treatments of angioedema |
EP4010333A1 (en) | 2019-08-09 | 2022-06-15 | Kalvista Pharmaceuticals Limited | Plasma kallikrein inhibitors |
GB201918994D0 (en) | 2019-12-20 | 2020-02-05 | Kalvista Pharmaceuticals Ltd | Treatments of diabetic macular edema and impaired visual acuity |
GB2591730A (en) | 2019-12-09 | 2021-08-11 | Kalvista Pharmaceuticals Ltd | New polymorphs |
WO2022079446A1 (en) | 2020-10-15 | 2022-04-21 | Kalvista Pharmaceuticals Limited | Treatments of angioedema |
WO2022084693A1 (en) | 2020-10-23 | 2022-04-28 | Kalvista Pharmaceuticals Limited | Treatments of angioedema |
US20240122909A1 (en) | 2021-02-09 | 2024-04-18 | Kalvista Pharmaceuticals Limited | Treatments of hereditary angioedema |
WO2023002219A1 (en) | 2021-07-23 | 2023-01-26 | Kalvista Pharmaceuticals Limited | Treatments of hereditary angioedema |
LT4288036T (lt) | 2022-04-27 | 2024-09-25 | Kalvista Pharmaceuticals Limited | Farmacinės plazmos kalikreino inhibitoriaus formos |
WO2024180100A1 (en) | 2023-02-27 | 2024-09-06 | Kalvista Pharmaceuticals Limited | New solid form of a plasma kallikrein inhibitor |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB131501A (xx) * | ||||
DE1545645A1 (de) * | 1965-12-06 | 1969-08-21 | Boehringer Mannheim Gmbh | Verfahren zur Herstellung von disubstituierten Adenosin-Derivaten |
JPS4935635B1 (xx) * | 1970-12-28 | 1974-09-25 | ||
US3910885A (en) * | 1974-03-12 | 1975-10-07 | Syntex Inc | 4-Alkoxy nucleosides and intermediates therefore |
DE3406533A1 (de) * | 1984-02-23 | 1985-08-29 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verwendung von adenosin-derivaten als antiallergica und arzneimittel, die diese enthalten |
EP0300144A3 (en) * | 1984-04-18 | 1989-09-27 | Whitby Research Incorporated | N-6 alkyl substituted adenosine derivatives as cardiac vasodilators |
AU575438B2 (en) * | 1984-10-26 | 1988-07-28 | Warner-Lambert Company | N6 - substituted deoxyribose analogues of adenosines |
CA1254888A (en) * | 1984-10-26 | 1989-05-30 | Bharat Trivedi | N.sup.6-bicycloadenosines |
US4755594A (en) * | 1986-01-31 | 1988-07-05 | Warner-Lambert Company | N6 -substituted adenosines |
JPH0696534B2 (ja) * | 1986-04-25 | 1994-11-30 | ヘキストジヤパン株式会社 | 抗痴呆剤 |
AU8276187A (en) * | 1986-10-31 | 1988-05-25 | Warner-Lambert Company | Selected n6-substituted adenosines having selective a2 binding activity |
US4962194A (en) * | 1987-04-02 | 1990-10-09 | Warner-Lambert Company | Method of preparing 51,N6-disubstituted adenosines from inosines |
KR0137786B1 (ko) * | 1988-11-15 | 1998-05-15 | 하마구찌 미찌오 | 심장 또는 뇌의 허혈성 질환의 치료, 예방제 |
US5017578A (en) * | 1989-06-09 | 1991-05-21 | Hoechst-Roussel Pharmaceuticals Inc. | N-heteroaryl-purin-6-amines useful as analgesic and anticonvulsant agents |
JPH05506842A (ja) * | 1989-09-15 | 1993-10-07 | ジェンシア・ファーマシュウティカルズ・インコーポレイテッド | 神経変性状態の処置方法 |
EP0423777A3 (en) * | 1989-10-19 | 1991-09-25 | G.D. Searle & Co. | Method of treating gastrointestinal motility disorders |
IL99124A (en) * | 1990-08-10 | 1998-02-22 | Gensia Pharma | Substituted imidazole analogs of aica riboside |
US5308837A (en) * | 1990-08-22 | 1994-05-03 | Merrell Dow Pharmaceuticals Inc. | 5'-amine substituted adenosine analogs as immunosuppressants |
HUT61567A (en) * | 1990-12-07 | 1993-01-28 | Sandoz Ag | Process for producing new pharmaceutical compositions comprising 2'-o-alkyladenosine derivatives and for producing 6-cyclohexyl-2'-o-methyladenosinehydrate |
US5432164A (en) * | 1991-10-24 | 1995-07-11 | Novo Nordisk A/S | C2,N6 -disubstituted adenosine derivatives |
DK62692D0 (xx) * | 1992-05-14 | 1992-05-14 | Novo Nordisk As | |
DK62592D0 (xx) * | 1992-05-14 | 1992-05-14 | Novo Nordisk As | |
WO1994002497A1 (en) * | 1992-07-15 | 1994-02-03 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Sulfo-derivatives of adenosine |
AU4845193A (en) * | 1992-09-11 | 1994-04-12 | Regents Of The University Of California, The | Adenosine analogues and method of increasing adenosine release |
-
1994
- 1994-09-14 US US08/306,232 patent/US5589467A/en not_active Expired - Fee Related
- 1994-09-15 CA CA002171940A patent/CA2171940A1/en not_active Abandoned
- 1994-09-15 NZ NZ273284A patent/NZ273284A/en unknown
- 1994-09-15 JP JP7508922A patent/JPH11511436A/ja active Pending
- 1994-09-15 WO PCT/DK1994/000344 patent/WO1995007921A1/en not_active Application Discontinuation
- 1994-09-15 EP EP94926815A patent/EP0719275A1/en not_active Withdrawn
- 1994-09-15 AU AU76519/94A patent/AU678053B2/en not_active Ceased
- 1994-09-18 IL IL11099294A patent/IL110992A0/xx unknown
-
1996
- 1996-03-15 FI FI961219A patent/FI961219A/fi not_active Application Discontinuation
- 1996-03-15 NO NO961071A patent/NO961071L/no unknown
Also Published As
Publication number | Publication date |
---|---|
FI961219A (fi) | 1996-05-15 |
EP0719275A1 (en) | 1996-07-03 |
AU7651994A (en) | 1995-04-03 |
NO961071D0 (no) | 1996-03-15 |
FI961219A0 (fi) | 1996-03-15 |
NO961071L (no) | 1996-05-15 |
WO1995007921A1 (en) | 1995-03-23 |
JPH11511436A (ja) | 1999-10-05 |
AU678053B2 (en) | 1997-05-15 |
CA2171940A1 (en) | 1995-03-23 |
NZ273284A (en) | 1997-03-24 |
US5589467A (en) | 1996-12-31 |
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