IL110969A - Process for purification-N-) S] -1 (- ethoxycarbonyl (-3- phenylpropyl) - - N (6-trifluoroacetyl [- L-lysyl-L-proline) - Google Patents

Process for purification-N-) S] -1 (- ethoxycarbonyl (-3- phenylpropyl) - - N (6-trifluoroacetyl [- L-lysyl-L-proline)

Info

Publication number
IL110969A
IL110969A IL11096994A IL11096994A IL110969A IL 110969 A IL110969 A IL 110969A IL 11096994 A IL11096994 A IL 11096994A IL 11096994 A IL11096994 A IL 11096994A IL 110969 A IL110969 A IL 110969A
Authority
IL
Israel
Prior art keywords
process according
crystallisation
tert
methyl
butyl ether
Prior art date
Application number
IL11096994A
Other languages
English (en)
Hebrew (he)
Other versions
IL110969A0 (en
Original Assignee
Degussa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Degussa filed Critical Degussa
Publication of IL110969A0 publication Critical patent/IL110969A0/xx
Publication of IL110969A publication Critical patent/IL110969A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)
IL11096994A 1993-09-17 1994-09-14 Process for purification-N-) S] -1 (- ethoxycarbonyl (-3- phenylpropyl) - - N (6-trifluoroacetyl [- L-lysyl-L-proline) IL110969A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4331540A DE4331540A1 (de) 1993-09-17 1993-09-17 Verfahren zur Reinigung von 1-[N·2·-((S)-Ethoxycarbonyl)-3-phenylpropyl)-N·6·-trifluoracetyl]-L-lysyl-L-prolin (Lisinopril(Tfa)ethylester)
US08/616,885 US5616727A (en) 1993-09-17 1996-03-18 Process for purifying 1-[N2 -((S)-ethoxycarbonyl)-3-phenylpropyl)-N6 -trifluoroacetyl]-l-lysyl-l-proline (lisinopril (TFA) ethyl ester

Publications (2)

Publication Number Publication Date
IL110969A0 IL110969A0 (en) 1994-11-28
IL110969A true IL110969A (en) 1998-07-15

Family

ID=25929624

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11096994A IL110969A (en) 1993-09-17 1994-09-14 Process for purification-N-) S] -1 (- ethoxycarbonyl (-3- phenylpropyl) - - N (6-trifluoroacetyl [- L-lysyl-L-proline)

Country Status (13)

Country Link
US (1) US5616727A (fr)
EP (1) EP0719279B1 (fr)
JP (1) JP2752520B2 (fr)
AT (1) ATE160355T1 (fr)
CZ (1) CZ285157B6 (fr)
DE (2) DE4331540A1 (fr)
DK (1) DK0719279T3 (fr)
ES (1) ES2111324T3 (fr)
GR (1) GR3025570T3 (fr)
HU (1) HU219596B (fr)
IL (1) IL110969A (fr)
SG (1) SG46623A1 (fr)
WO (1) WO1995007928A1 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994015957A1 (fr) * 1993-01-08 1994-07-21 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Procede de cristallisation de n2-((s)-1-ethoxycarbonyl-3-phenylpropyl)-n6-trifluoroacetyl-l-lysyl-l-proline
US5614609A (en) * 1994-10-20 1997-03-25 Carlos F. Ibanez Serine threonine kinase receptor
US5962696A (en) * 1997-06-23 1999-10-05 Degussa Aktiengesellschaft Process for the preparation of 1-(N 2-(S)-ethoxycarbonyl)--3 phenylpropyl-N6-trifluoracetyl))-L-lysyl-L-prolin (Lisinopril(Tfa) ethylester, LPE))
US5907044A (en) * 1997-07-30 1999-05-25 Degussa Aktiengellschaft Method of isolating 1- N2 -((S)-ethoxycarbonyl)-3-phenylpropyl)-N6 -trifluoroacetyl!-L-lysyl-L-proline (lisinopril (TFA) ethyl ester, LPE)
CA2311407A1 (fr) * 1998-09-22 2000-03-30 Kaneka Corporation Procede de preparation de n2-(1(s)-carboxy-3-phenylpropyl)-l-lysyl-l-proline
US6458769B1 (en) 2001-06-25 2002-10-01 Astrazeneca Ab Amorphous compound
US6627760B1 (en) 2001-06-25 2003-09-30 Astrazeneca Ab Amorphous compound
US6462174B1 (en) 2001-06-25 2002-10-08 Astrazeneca Ab Amorphous compound
US7373857B2 (en) * 2002-07-29 2008-05-20 William Engineering Llc Composite metal article and method of making
CN101985462A (zh) * 2010-10-29 2011-03-16 浙江工业大学 一种赖诺普利酯的分离方法
CN104045687B (zh) * 2014-05-21 2016-08-24 丽珠医药集团股份有限公司 一种赖诺普利的提纯方法
CN109422702B (zh) * 2017-08-30 2023-04-18 上海科胜药物研发有限公司 赖诺普利中间体及其纯化方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01254651A (ja) * 1988-04-04 1989-10-11 Kanegafuchi Chem Ind Co Ltd Ｎ↑２−（１−カルボキシ−３−フエニルプロピル）−ｌ−リジン誘導体及び該化合物を用いるリジノプリルの製造法
DE4123248C2 (de) * 1991-07-13 1996-03-07 Degussa Verfahren zur Herstellung von N-substituierten alpha-Aminosäuren und alpha-Aminosäure-Derivaten
WO1994015957A1 (fr) * 1993-01-08 1994-07-21 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Procede de cristallisation de n2-((s)-1-ethoxycarbonyl-3-phenylpropyl)-n6-trifluoroacetyl-l-lysyl-l-proline

Also Published As

Publication number Publication date
ATE160355T1 (de) 1997-12-15
DE4331540A1 (de) 1995-03-23
CZ79996A3 (en) 1996-06-12
JPH09501697A (ja) 1997-02-18
ES2111324T3 (es) 1998-03-01
JP2752520B2 (ja) 1998-05-18
HU9600675D0 (en) 1996-05-28
HUT75536A (en) 1997-05-28
HU219596B (hu) 2001-05-28
DE59404646D1 (de) 1998-01-02
GR3025570T3 (en) 1998-03-31
DK0719279T3 (da) 1998-07-27
EP0719279B1 (fr) 1997-11-19
EP0719279A1 (fr) 1996-07-03
CZ285157B6 (cs) 1999-05-12
IL110969A0 (en) 1994-11-28
SG46623A1 (en) 1998-02-20
US5616727A (en) 1997-04-01
WO1995007928A1 (fr) 1995-03-23

Similar Documents

Publication Publication Date Title
US5936104A (en) Process for producing 1,2-epoxy-3-amino-4-phenylbutane derivatives
EP0903337B1 (fr) Procede de preparation de derives de 1-alcoxycarbonyl-3-phenylpropyle
IL110969A (en) Process for purification-N-) S] -1 (- ethoxycarbonyl (-3- phenylpropyl) - - N (6-trifluoroacetyl [- L-lysyl-L-proline)
EP0594099A1 (fr) Procédé pour la purification d'acide clavulanique cru
US20160090352A1 (en) Process for the purification of melphalan
US6335453B1 (en) Process for preparing pharmacologically acceptable salt of N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanyl amino acids
WO2005019173A1 (fr) Procede de production de sel de tert-butylamine de perindopril pur
AU1125197A (en) Novel process for preparing N-acetyl(L)-4-cyanophenylalanine Ac-(l)-Phe(4-CN)-OH and N-Acetyl-(L)-p-amidinophenylalanine -cyclohexylglycine-beta-(3-N-methylpyridinium)-alanine Ac- (L)-pAph-Cgh-PalMe(3)-NH2
US6316657B1 (en) Process for purification or recovery of sweetener
FR2547816A1 (fr) Procede de synthese de l'aspartame
US6455705B1 (en) 1-[N2-((S)-ethoxycarbonyl)-3-phenylproply)-N6-trifluoroacetyl]-L-ysyl-L-proline (lisinopril (TFA) ethyl ester, LPE)
US6187932B1 (en) Simple process for producing high quality captopril
US5756812A (en) Process for the preparation of pure (S,S)-N-(1-ethoxycarbonyl-3-phenylpropyl) alanine
BE1004449A4 (fr) Procede ameliore pour la preparation de tripeptide aldehydes.
IE61522B1 (en) Improved process for the prepartion of tripeptide aldehydes

Legal Events

Date Code Title Description
KB Patent renewed
KB Patent renewed
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees