IL108443A0 - C7 taxane derivatives and pharmaceutical compositions containing them - Google Patents
C7 taxane derivatives and pharmaceutical compositions containing themInfo
- Publication number
- IL108443A0 IL108443A0 IL10844394A IL10844394A IL108443A0 IL 108443 A0 IL108443 A0 IL 108443A0 IL 10844394 A IL10844394 A IL 10844394A IL 10844394 A IL10844394 A IL 10844394A IL 108443 A0 IL108443 A0 IL 108443A0
- Authority
- IL
- Israel
- Prior art keywords
- pharmaceutical compositions
- compositions containing
- taxane derivatives
- derivatives
- taxane
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 title abstract 2
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 230000000719 anti-leukaemic effect Effects 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/22—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from lactams, cyclic ketones or cyclic oximes, e.g. by reactions involving Beckmann rearrangement
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/87—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/58—Ring systems containing bridged rings containing three rings
- C07C2603/60—Ring systems containing bridged rings containing three rings containing at least one ring with less than six members
- C07C2603/62—Ring systems containing bridged rings containing three rings containing at least one ring with less than six members containing three- or four-membered rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/010,798 US5399726A (en) | 1993-01-29 | 1993-01-29 | Process for the preparation of baccatin III analogs bearing new C2 and C4 functional groups |
| US3485293A | 1993-03-22 | 1993-03-22 | |
| US9516093A | 1993-07-20 | 1993-07-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL108443A0 true IL108443A0 (en) | 1994-04-12 |
Family
ID=27359310
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL10844394A IL108443A0 (en) | 1993-01-29 | 1994-01-26 | C7 taxane derivatives and pharmaceutical compositions containing them |
Country Status (12)
| Country | Link |
|---|---|
| EP (3) | EP1275389B1 (fr) |
| JP (2) | JPH08506324A (fr) |
| AT (3) | ATE243205T1 (fr) |
| AU (1) | AU689099B2 (fr) |
| CA (1) | CA2155018C (fr) |
| DE (3) | DE69432835T2 (fr) |
| DK (3) | DK0681574T3 (fr) |
| ES (3) | ES2191029T3 (fr) |
| IL (1) | IL108443A0 (fr) |
| PT (3) | PT681574E (fr) |
| TW (1) | TW492963B (fr) |
| WO (1) | WO1994017050A1 (fr) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5721268A (en) | 1991-09-23 | 1998-02-24 | Florida State University | C7 taxane derivatives and pharmaceutical compositions containing them |
| US5710287A (en) | 1991-09-23 | 1998-01-20 | Florida State University | Taxanes having an amino substituted side-chain and pharmaceutical compositions containing them |
| FR2712289B1 (fr) * | 1993-11-08 | 1996-01-05 | Rhone Poulenc Rorer Sa | Nouveaux dérivés de taxicine, leur préparation et les compositions pharmaceutiques qui les contiennent. |
| US5677470A (en) * | 1994-06-28 | 1997-10-14 | Tanabe Seiyaku Co., Ltd. | Baccatin derivatives and processes for preparing the same |
| WO1996013495A1 (fr) * | 1994-10-28 | 1996-05-09 | The Research Foundation Of State University Of New York | Derives taxoides, leur preparation et leur utilisation en tant qu'agents antitumoraux |
| US6500858B2 (en) | 1994-10-28 | 2002-12-31 | The Research Foundation Of The State University Of New York | Taxoid anti-tumor agents and pharmaceutical compositions thereof |
| US6458976B1 (en) | 1994-10-28 | 2002-10-01 | The Research Foundation Of State University Of New York | Taxoid anti-tumor agents, pharmaceutical compositions, and treatment methods |
| CA2162759A1 (fr) * | 1994-11-17 | 1996-05-18 | Kenji Tsujihara | Derives de la baccatine et methodes de preparation |
| US5635531A (en) * | 1996-07-08 | 1997-06-03 | Bristol-Myers Squibb Company | 3'-aminocarbonyloxy paclitaxels |
| WO1998013359A1 (fr) * | 1996-09-24 | 1998-04-02 | Marigen S.A. | Ultramicroemulsions constituees de concentres pouvant etre disperses de façon spontanne, renfermant des esters de composes de baccatine-iii a effet antitumoral et antiviral |
| ATE413397T1 (de) * | 2000-02-02 | 2008-11-15 | Univ Florida State Res Found | Heterosubstituierte c7-taxanacetate als antitumormittel |
| EP1165553B1 (fr) * | 2000-02-02 | 2009-06-03 | Florida State University Research Foundation, Inc. | Taxanes substitues par un ester en c10 comme agents antitumoraux |
| AR030188A1 (es) * | 2000-02-02 | 2003-08-13 | Univ Florida State Res Found | Compuestos de taxano sustituidos con esteres en el c7; composiciones farmaceuticas que los contienen y proceso para tratar un sujeto mamifero que sufre de una condicion que responde a los taxanos |
| US6362217B2 (en) | 2000-03-17 | 2002-03-26 | Bristol-Myers Squibb Company | Taxane anticancer agents |
| KR20050032110A (ko) * | 2002-08-02 | 2005-04-06 | 이뮤노젠 아이엔씨 | 신규의 효능을 갖는 탁산을 포함하는 세포독성제 및 그치료용도 |
| US7390898B2 (en) | 2002-08-02 | 2008-06-24 | Immunogen Inc. | Cytotoxic agents containing novel potent taxanes and their therapeutic use |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4960790A (en) * | 1989-03-09 | 1990-10-02 | University Of Kansas | Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof |
| US5227400A (en) * | 1991-09-23 | 1993-07-13 | Florida State University | Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them |
| KR100239201B1 (ko) * | 1991-09-23 | 2000-02-01 | 로버트 엠 존슨 | 10-데스아세톡시탁솔 유도체 |
| US5248796A (en) * | 1992-06-18 | 1993-09-28 | Bristol-Myers Squibb Company | Taxol derivatives |
| CA2100808A1 (fr) * | 1992-10-01 | 1994-04-02 | Vittorio Farina | Desoxytaxols |
| IL108316A (en) * | 1993-01-15 | 2006-10-31 | Univ Florida State | History of C-10 Texan and pharmaceuticals containing them |
| IL108444A0 (en) * | 1993-01-29 | 1994-04-12 | Univ Florida State | C2 taxane derivatives and pharmaceutical compositions containing them |
-
1994
- 1994-01-26 IL IL10844394A patent/IL108443A0/xx unknown
- 1994-01-28 EP EP02023352A patent/EP1275389B1/fr not_active Expired - Lifetime
- 1994-01-28 PT PT94909514T patent/PT681574E/pt unknown
- 1994-01-28 AT AT01102160T patent/ATE243205T1/de not_active IP Right Cessation
- 1994-01-28 ES ES94909514T patent/ES2191029T3/es not_active Expired - Lifetime
- 1994-01-28 AT AT94909514T patent/ATE236142T1/de not_active IP Right Cessation
- 1994-01-28 AT AT02023352T patent/ATE341321T1/de not_active IP Right Cessation
- 1994-01-28 DK DK94909514T patent/DK0681574T3/da active
- 1994-01-28 WO PCT/US1994/001059 patent/WO1994017050A1/fr active IP Right Grant
- 1994-01-28 DK DK02023352T patent/DK1275389T3/da active
- 1994-01-28 PT PT01102160T patent/PT1108717E/pt unknown
- 1994-01-28 PT PT02023352T patent/PT1275389E/pt unknown
- 1994-01-28 DE DE69432835T patent/DE69432835T2/de not_active Expired - Fee Related
- 1994-01-28 DE DE69432404T patent/DE69432404T2/de not_active Expired - Fee Related
- 1994-01-28 DK DK01102160T patent/DK1108717T3/da active
- 1994-01-28 EP EP94909514A patent/EP0681574B1/fr not_active Expired - Lifetime
- 1994-01-28 AU AU62337/94A patent/AU689099B2/en not_active Ceased
- 1994-01-28 ES ES01102160T patent/ES2199901T3/es not_active Expired - Lifetime
- 1994-01-28 CA CA002155018A patent/CA2155018C/fr not_active Expired - Fee Related
- 1994-01-28 DE DE69434861T patent/DE69434861T2/de not_active Expired - Fee Related
- 1994-01-28 EP EP01102160A patent/EP1108717B1/fr not_active Expired - Lifetime
- 1994-01-28 JP JP6517370A patent/JPH08506324A/ja active Pending
- 1994-01-28 ES ES02023352T patent/ES2267921T3/es not_active Expired - Lifetime
- 1994-04-18 TW TW083103420A patent/TW492963B/zh not_active IP Right Cessation
-
2003
- 2003-10-08 JP JP2003349865A patent/JP3940392B2/ja not_active Expired - Fee Related
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL108443A0 (en) | C7 taxane derivatives and pharmaceutical compositions containing them | |
| IL110660A0 (en) | Phosphonooxymethyl ethers of taxane derivatives | |
| DE69716135D1 (en) | In 6-position durch thio substituierte paclitaxele | |
| BG102172A (en) | New stable medicamentous compositions for the preparation of propellant-free aerosols | |
| NZ514409A (en) | C7 ester substituted taxanes as antitumor agents | |
| MY113806A (en) | Antiparasitic marcfortines and paraherquamides | |
| AP2004003103A0 (en) | Controlled synthesis of ziprasidone and compositions thereof | |
| CY2431B1 (en) | Novel phenanthridines substituted in the 6 position. | |
| DE69715173D1 (en) | Bisarylcyclobutenderivate als cyclooxygenasehemmer | |
| IL107555A0 (en) | Taxanes having an alkyl substituted side-chain and pharmaceutical compositions containing them | |
| DK0688212T3 (da) | C9-taxanderivater og farmaceutiske præparater indeholdende disse | |
| ES2110258T3 (es) | Derivados de 1,3,5(10)-estratrieno activos por via oral. | |
| ATE223427T1 (de) | Modifizierte kojibioside analoge | |
| EP1108716A3 (fr) | Dérivés de taxanne en C7 et compositions pharmaceutiques les contenant | |
| TW374764B (en) | Antitumor and antileukaemic compounds, their preparation and pharmaceutical composition containing them | |
| TWI226833B (en) | Pharmaceutical composition for inhibiting bone resorption | |
| CA2156908A1 (fr) | Derives c9 du taxane; compositions pharmaceutiques a base de ces derives |