DE69434861D1 - Zusammenstellungen enthaltend C7 Taxane - Google Patents

Zusammenstellungen enthaltend C7 Taxane

Info

Publication number
DE69434861D1
DE69434861D1 DE69434861T DE69434861T DE69434861D1 DE 69434861 D1 DE69434861 D1 DE 69434861D1 DE 69434861 T DE69434861 T DE 69434861T DE 69434861 T DE69434861 T DE 69434861T DE 69434861 D1 DE69434861 D1 DE 69434861D1
Authority
DE
Germany
Prior art keywords
compilations
taxanes
acyloxy
hydroxy
alternative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69434861T
Other languages
English (en)
Other versions
DE69434861T2 (de
Inventor
Robert A Holton
Ki-Byung Chai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Florida State University
Original Assignee
Florida State University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/010,798 external-priority patent/US5399726A/en
Application filed by Florida State University filed Critical Florida State University
Publication of DE69434861D1 publication Critical patent/DE69434861D1/de
Application granted granted Critical
Publication of DE69434861T2 publication Critical patent/DE69434861T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/22Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from lactams, cyclic ketones or cyclic oximes, e.g. by reactions involving Beckmann rearrangement
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00Preparation of carboxylic acid amides
    • C07C231/12Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00Carboxylic acid amides
    • C07C233/64Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/81Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/82Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/87Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D205/00Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D305/00Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D407/00Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804Compounds having Si-O-C linkages
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14The ring being saturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00Systems containing at least three condensed rings
    • C07C2603/56Ring systems containing bridged rings
    • C07C2603/58Ring systems containing bridged rings containing three rings
    • C07C2603/60Ring systems containing bridged rings containing three rings containing at least one ring with less than six members
    • C07C2603/62Ring systems containing bridged rings containing three rings containing at least one ring with less than six members containing three- or four-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69434861T 1993-01-29 1994-01-28 C7-taxane enthaltende zusammensetzungen Expired - Fee Related DE69434861T2 (de)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US08/010,798 US5399726A (en) 1993-01-29 1993-01-29 Process for the preparation of baccatin III analogs bearing new C2 and C4 functional groups
US10798 1993-01-29
US3485293A 1993-03-22 1993-03-22
US34852 1993-03-22
US9516093A 1993-07-20 1993-07-20
US95160 1993-07-20

Publications (2)

Publication Number Publication Date
DE69434861D1 true DE69434861D1 (de) 2006-11-16
DE69434861T2 DE69434861T2 (de) 2007-04-26

Family

ID=27359310

Family Applications (3)

Application Number Title Priority Date Filing Date
DE69432835T Expired - Fee Related DE69432835T2 (de) 1993-01-29 1994-01-28 C7-taxan-derivate und diese enthaltende pharmazeutische zusammensetzungen
DE69432404T Expired - Fee Related DE69432404T2 (de) 1993-01-29 1994-01-28 C7-Taxan-Derivate sowie diese enthaltende Arzneimittel
DE69434861T Expired - Fee Related DE69434861T2 (de) 1993-01-29 1994-01-28 C7-taxane enthaltende zusammensetzungen

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DE69432835T Expired - Fee Related DE69432835T2 (de) 1993-01-29 1994-01-28 C7-taxan-derivate und diese enthaltende pharmazeutische zusammensetzungen
DE69432404T Expired - Fee Related DE69432404T2 (de) 1993-01-29 1994-01-28 C7-Taxan-Derivate sowie diese enthaltende Arzneimittel

Country Status (12)

Country Link
EP (3) EP1275389B1 (de)
JP (2) JPH08506324A (de)
AT (3) ATE243205T1 (de)
AU (1) AU689099B2 (de)
CA (1) CA2155018C (de)
DE (3) DE69432835T2 (de)
DK (3) DK0681574T3 (de)
ES (3) ES2191029T3 (de)
IL (1) IL108443A0 (de)
PT (3) PT681574E (de)
TW (1) TW492963B (de)
WO (1) WO1994017050A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5721268A (en) 1991-09-23 1998-02-24 Florida State University C7 taxane derivatives and pharmaceutical compositions containing them
US5710287A (en) 1991-09-23 1998-01-20 Florida State University Taxanes having an amino substituted side-chain and pharmaceutical compositions containing them
FR2712289B1 (fr) * 1993-11-08 1996-01-05 Rhone Poulenc Rorer Sa Nouveaux dérivés de taxicine, leur préparation et les compositions pharmaceutiques qui les contiennent.
US5677470A (en) * 1994-06-28 1997-10-14 Tanabe Seiyaku Co., Ltd. Baccatin derivatives and processes for preparing the same
WO1996013495A1 (en) * 1994-10-28 1996-05-09 The Research Foundation Of State University Of New York Taxoid derivatives, their preparation and their use as antitumor agents
US6500858B2 (en) 1994-10-28 2002-12-31 The Research Foundation Of The State University Of New York Taxoid anti-tumor agents and pharmaceutical compositions thereof
US6458976B1 (en) 1994-10-28 2002-10-01 The Research Foundation Of State University Of New York Taxoid anti-tumor agents, pharmaceutical compositions, and treatment methods
CA2162759A1 (en) * 1994-11-17 1996-05-18 Kenji Tsujihara Baccatin derivatives and processes for preparing the same
US5635531A (en) * 1996-07-08 1997-06-03 Bristol-Myers Squibb Company 3'-aminocarbonyloxy paclitaxels
WO1998013359A1 (de) * 1996-09-24 1998-04-02 Marigen S.A. Ultramikroemulsionen aus spontan dispergierbaren konzentraten mit antitumoral und antiviral wirksamen estern von baccatin-iii-verbindungen
ATE413397T1 (de) * 2000-02-02 2008-11-15 Univ Florida State Res Found Heterosubstituierte c7-taxanacetate als antitumormittel
EP1165553B1 (de) * 2000-02-02 2009-06-03 Florida State University Research Foundation, Inc. C10-taxanester als antitumormittel
AR030188A1 (es) * 2000-02-02 2003-08-13 Univ Florida State Res Found Compuestos de taxano sustituidos con esteres en el c7; composiciones farmaceuticas que los contienen y proceso para tratar un sujeto mamifero que sufre de una condicion que responde a los taxanos
US6362217B2 (en) 2000-03-17 2002-03-26 Bristol-Myers Squibb Company Taxane anticancer agents
KR20050032110A (ko) * 2002-08-02 2005-04-06 이뮤노젠 아이엔씨 신규의 효능을 갖는 탁산을 포함하는 세포독성제 및 그치료용도
US7390898B2 (en) 2002-08-02 2008-06-24 Immunogen Inc. Cytotoxic agents containing novel potent taxanes and their therapeutic use

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4960790A (en) * 1989-03-09 1990-10-02 University Of Kansas Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof
US5227400A (en) * 1991-09-23 1993-07-13 Florida State University Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them
KR100239201B1 (ko) * 1991-09-23 2000-02-01 로버트 엠 존슨 10-데스아세톡시탁솔 유도체
US5248796A (en) * 1992-06-18 1993-09-28 Bristol-Myers Squibb Company Taxol derivatives
CA2100808A1 (en) * 1992-10-01 1994-04-02 Vittorio Farina Deoxy paclitaxels
IL108316A (en) * 1993-01-15 2006-10-31 Univ Florida State History of C-10 Texan and pharmaceuticals containing them
IL108444A0 (en) * 1993-01-29 1994-04-12 Univ Florida State C2 taxane derivatives and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
ES2267921T3 (es) 2007-03-16
DK1275389T3 (da) 2007-02-12
PT681574E (pt) 2003-09-30
ATE243205T1 (de) 2003-07-15
PT1275389E (pt) 2006-12-29
EP1108717A3 (de) 2001-08-29
JP2004043499A (ja) 2004-02-12
AU6233794A (en) 1994-08-15
DE69432835D1 (de) 2003-07-24
WO1994017050A1 (en) 1994-08-04
ATE236142T1 (de) 2003-04-15
EP0681574A1 (de) 1995-11-15
JP3940392B2 (ja) 2007-07-04
EP1108717A2 (de) 2001-06-20
CA2155018C (en) 2006-11-28
TW492963B (en) 2002-07-01
DE69432404D1 (de) 2003-05-08
EP1275389A1 (de) 2003-01-15
ATE341321T1 (de) 2006-10-15
DE69432835T2 (de) 2004-04-22
EP1108717B1 (de) 2003-06-18
DE69432404T2 (de) 2003-10-30
ES2191029T3 (es) 2003-09-01
IL108443A0 (en) 1994-04-12
EP0681574B1 (de) 2003-04-02
EP0681574A4 (de) 1995-12-13
JPH08506324A (ja) 1996-07-09
DK0681574T3 (da) 2003-07-28
ES2199901T3 (es) 2004-03-01
CA2155018A1 (en) 1994-08-04
DE69434861T2 (de) 2007-04-26
EP1275389B1 (de) 2006-10-04
DK1108717T3 (da) 2003-10-13
PT1108717E (pt) 2003-11-28
AU689099B2 (en) 1998-03-26

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee