IL108429A - Manufacture of anticoagulant based on lithium paraffin modified by heavy metal salt - Google Patents
Manufacture of anticoagulant based on lithium paraffin modified by heavy metal saltInfo
- Publication number
- IL108429A IL108429A IL108429A IL10842994A IL108429A IL 108429 A IL108429 A IL 108429A IL 108429 A IL108429 A IL 108429A IL 10842994 A IL10842994 A IL 10842994A IL 108429 A IL108429 A IL 108429A
- Authority
- IL
- Israel
- Prior art keywords
- solution
- heavy metal
- grams
- heparin
- zinc
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 39
- 239000003146 anticoagulant agent Substances 0.000 title claims abstract description 31
- 229940127219 anticoagulant drug Drugs 0.000 title claims abstract description 31
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 10
- 229920000669 heparin Polymers 0.000 title claims description 48
- 229910001385 heavy metal Inorganic materials 0.000 title claims description 16
- 239000008280 blood Substances 0.000 title abstract description 39
- 210000004369 blood Anatomy 0.000 title abstract description 39
- 150000003839 salts Chemical class 0.000 title description 8
- 229910052744 lithium Inorganic materials 0.000 title description 7
- -1 lithium heparinate Chemical class 0.000 title description 4
- 238000000034 method Methods 0.000 claims abstract description 40
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical class OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims description 36
- 239000000243 solution Substances 0.000 claims description 35
- WMFOQBRAJBCJND-UHFFFAOYSA-M Lithium hydroxide Chemical group [Li+].[OH-] WMFOQBRAJBCJND-UHFFFAOYSA-M 0.000 claims description 18
- ZFGMDIBRIDKWMY-PASTXAENSA-N heparin Chemical compound CC(O)=N[C@@H]1[C@@H](O)[C@H](O)[C@@H](COS(O)(=O)=O)O[C@@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O[C@H]2[C@@H]([C@@H](OS(O)(=O)=O)[C@@H](O[C@@H]3[C@@H](OC(O)[C@H](OS(O)(=O)=O)[C@H]3O)C(O)=O)O[C@@H]2O)CS(O)(=O)=O)[C@H](O)[C@H]1O ZFGMDIBRIDKWMY-PASTXAENSA-N 0.000 claims description 13
- YZYKBQUWMPUVEN-UHFFFAOYSA-N zafuleptine Chemical compound OC(=O)CCCCCC(C(C)C)NCC1=CC=C(F)C=C1 YZYKBQUWMPUVEN-UHFFFAOYSA-N 0.000 claims description 10
- 230000002378 acidificating effect Effects 0.000 claims description 9
- 239000007864 aqueous solution Substances 0.000 claims description 9
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 claims description 8
- 239000003456 ion exchange resin Substances 0.000 claims description 8
- 229920003303 ion-exchange polymer Polymers 0.000 claims description 8
- 150000001875 compounds Chemical class 0.000 claims description 7
- 239000011347 resin Substances 0.000 claims description 7
- 229920005989 resin Polymers 0.000 claims description 7
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 6
- 229910052725 zinc Inorganic materials 0.000 claims description 6
- 239000011701 zinc Substances 0.000 claims description 6
- 229910052788 barium Inorganic materials 0.000 claims description 4
- DSAJWYNOEDNPEQ-UHFFFAOYSA-N barium atom Chemical compound [Ba] DSAJWYNOEDNPEQ-UHFFFAOYSA-N 0.000 claims description 4
- 238000005342 ion exchange Methods 0.000 claims description 4
- 229910003002 lithium salt Inorganic materials 0.000 claims description 4
- 159000000002 lithium salts Chemical class 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 3
- 150000001879 copper Chemical class 0.000 claims description 2
- OPQARKPSCNTWTJ-UHFFFAOYSA-L copper(ii) acetate Chemical compound [Cu+2].CC([O-])=O.CC([O-])=O OPQARKPSCNTWTJ-UHFFFAOYSA-L 0.000 claims description 2
- 239000011148 porous material Substances 0.000 claims description 2
- TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 claims 2
- 238000001914 filtration Methods 0.000 claims 2
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 1
- ITHZDDVSAWDQPZ-UHFFFAOYSA-L barium acetate Chemical compound [Ba+2].CC([O-])=O.CC([O-])=O ITHZDDVSAWDQPZ-UHFFFAOYSA-L 0.000 claims 1
- WDIHJSXYQDMJHN-UHFFFAOYSA-L barium chloride Chemical compound [Cl-].[Cl-].[Ba+2] WDIHJSXYQDMJHN-UHFFFAOYSA-L 0.000 claims 1
- 229910001626 barium chloride Inorganic materials 0.000 claims 1
- 229910000365 copper sulfate Inorganic materials 0.000 claims 1
- ORTQZVOHEJQUHG-UHFFFAOYSA-L copper(II) chloride Chemical compound Cl[Cu]Cl ORTQZVOHEJQUHG-UHFFFAOYSA-L 0.000 claims 1
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 claims 1
- 238000004108 freeze drying Methods 0.000 claims 1
- 125000000542 sulfonic acid group Chemical group 0.000 claims 1
- 239000011592 zinc chloride Substances 0.000 claims 1
- 235000005074 zinc chloride Nutrition 0.000 claims 1
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 claims 1
- 229910000368 zinc sulfate Inorganic materials 0.000 claims 1
- 229960001763 zinc sulfate Drugs 0.000 claims 1
- 238000004458 analytical method Methods 0.000 abstract description 9
- 239000003792 electrolyte Substances 0.000 abstract description 7
- 238000005070 sampling Methods 0.000 abstract 1
- 229960002897 heparin Drugs 0.000 description 24
- 229910052791 calcium Inorganic materials 0.000 description 15
- 239000011575 calcium Substances 0.000 description 15
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 14
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 8
- 229910001424 calcium ion Inorganic materials 0.000 description 8
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 5
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 5
- 239000011591 potassium Substances 0.000 description 5
- 239000011734 sodium Substances 0.000 description 5
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 4
- ZOIORXHNWRGPMV-UHFFFAOYSA-N acetic acid;zinc Chemical compound [Zn].CC(O)=O.CC(O)=O ZOIORXHNWRGPMV-UHFFFAOYSA-N 0.000 description 4
- 229910001414 potassium ion Inorganic materials 0.000 description 4
- 239000004246 zinc acetate Substances 0.000 description 4
- 238000010241 blood sampling Methods 0.000 description 3
- 150000001768 cations Chemical class 0.000 description 3
- 230000015271 coagulation Effects 0.000 description 3
- 238000005345 coagulation Methods 0.000 description 3
- 229910001415 sodium ion Inorganic materials 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- MYRTYDVEIRVNKP-UHFFFAOYSA-N 1,2-Divinylbenzene Chemical compound C=CC1=CC=CC=C1C=C MYRTYDVEIRVNKP-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 230000000996 additive effect Effects 0.000 description 2
- 125000002091 cationic group Chemical group 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 210000004877 mucosa Anatomy 0.000 description 2
- 235000015277 pork Nutrition 0.000 description 2
- 229910052700 potassium Inorganic materials 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 229950003937 tolonium Drugs 0.000 description 2
- HNONEKILPDHFOL-UHFFFAOYSA-M tolonium chloride Chemical compound [Cl-].C1=C(C)C(N)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 HNONEKILPDHFOL-UHFFFAOYSA-M 0.000 description 2
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical group OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- NPYPAHLBTDXSSS-UHFFFAOYSA-N Potassium ion Chemical compound [K+] NPYPAHLBTDXSSS-UHFFFAOYSA-N 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- 238000001479 atomic absorption spectroscopy Methods 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 235000015278 beef Nutrition 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000009920 chelation Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 150000001805 chlorine compounds Chemical class 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- XIXADJRWDQXREU-UHFFFAOYSA-M lithium acetate Chemical compound [Li+].CC([O-])=O XIXADJRWDQXREU-UHFFFAOYSA-M 0.000 description 1
- XGZVUEUWXADBQD-UHFFFAOYSA-L lithium carbonate Chemical compound [Li+].[Li+].[O-]C([O-])=O XGZVUEUWXADBQD-UHFFFAOYSA-L 0.000 description 1
- 229910052808 lithium carbonate Inorganic materials 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 150000003751 zinc Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/727—Heparin; Heparan
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
- Y10T436/108331—Preservative, buffer, anticoagulant or diluent
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Materials Engineering (AREA)
- Polymers & Plastics (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Materials For Medical Uses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Soil Conditioners And Soil-Stabilizing Materials (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL11888194A IL118881A (en) | 1993-01-27 | 1994-01-25 | A device for collecting blood and a device for using it |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US962793A | 1993-01-27 | 1993-01-27 | |
| US08/096,123 US5336620A (en) | 1993-01-27 | 1993-07-22 | Process for the production of an anticoagulant composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL108429A0 IL108429A0 (en) | 1994-04-12 |
| IL108429A true IL108429A (en) | 1998-06-15 |
Family
ID=26679701
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL108429A IL108429A (en) | 1993-01-27 | 1994-01-25 | Manufacture of anticoagulant based on lithium paraffin modified by heavy metal salt |
Country Status (15)
| Country | Link |
|---|---|
| US (4) | US5336620A (de) |
| EP (1) | EP0681590B1 (de) |
| JP (1) | JP3278661B2 (de) |
| KR (1) | KR960700276A (de) |
| AT (1) | ATE177434T1 (de) |
| AU (1) | AU679498B2 (de) |
| CA (1) | CA2154788C (de) |
| DE (1) | DE69417017T2 (de) |
| DK (1) | DK0681590T3 (de) |
| ES (1) | ES2131677T3 (de) |
| GR (1) | GR3030186T3 (de) |
| IL (1) | IL108429A (de) |
| LV (1) | LV12498B (de) |
| RU (1) | RU2148376C1 (de) |
| WO (1) | WO1994017108A1 (de) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5336620A (en) * | 1993-01-27 | 1994-08-09 | American Home Products Corporation | Process for the production of an anticoagulant composition |
| US20020055710A1 (en) | 1998-04-30 | 2002-05-09 | Ronald J. Tuch | Medical device for delivering a therapeutic agent and method of preparation |
| US5552323A (en) * | 1994-08-03 | 1996-09-03 | Mercereau; Steven F. | Method of blending an anticoagulant |
| US6238578B1 (en) * | 1996-12-09 | 2001-05-29 | Sherwood Services Ag | Method for dispensing separator gel in a blood collection tube |
| AU5532498A (en) * | 1996-12-27 | 1998-07-31 | Sherwood Medical Company | Anticoagulant composition |
| CA2286155A1 (en) * | 1997-04-08 | 1998-10-15 | Randall E. Ohnemus | Method and apparatus for collecting blood |
| US5900291A (en) * | 1997-05-19 | 1999-05-04 | Pebbles; Patricia J. | Non-light penetrating phlebotomy tube with temperature sensitive level indicator |
| US6203536B1 (en) * | 1997-06-17 | 2001-03-20 | Medtronic, Inc. | Medical device for delivering a therapeutic substance and method therefor |
| US6106454A (en) * | 1997-06-17 | 2000-08-22 | Medtronic, Inc. | Medical device for delivering localized radiation |
| US6013099A (en) | 1998-04-29 | 2000-01-11 | Medtronic, Inc. | Medical device for delivering a water-insoluble therapeutic salt or substance |
| US6206914B1 (en) | 1998-04-30 | 2001-03-27 | Medtronic, Inc. | Implantable system with drug-eluting cells for on-demand local drug delivery |
| US20030069601A1 (en) * | 1998-12-15 | 2003-04-10 | Closys Corporation | Clotting cascade initiating apparatus and methods of use |
| JP2001161668A (ja) * | 1999-12-07 | 2001-06-19 | Terumo Corp | 採血器具 |
| DK1389955T3 (da) * | 2001-05-10 | 2010-03-01 | Chempaq As | Indretning til at udtage prøve af små og præcise væskevolumener |
| US7648678B2 (en) * | 2002-12-20 | 2010-01-19 | Dako Denmark A/S | Method and system for pretreatment of tissue slides |
| CN100335506C (zh) * | 2004-05-20 | 2007-09-05 | 汕头市金丰医疗器械科技有限公司 | 一种肝素化合物及其制备方法和应用 |
| CN1308351C (zh) * | 2005-11-21 | 2007-04-04 | 武汉理工大学 | 离子平衡交换法制备肝素锂 |
| US20090036841A1 (en) * | 2007-08-01 | 2009-02-05 | Mckale James M | Coatings for blood and bone marrow-contacting devices |
| US11517232B1 (en) * | 2014-11-07 | 2022-12-06 | Labrador Dlagnostics LLC | Systems and methods for mobile sample collection |
| CN109232773A (zh) * | 2018-11-29 | 2019-01-18 | 淮安麦德森制药有限公司 | 肝素锂的制备方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3337409A (en) * | 1963-11-20 | 1967-08-22 | Rexall Drug Chemical | Process for the recovery of heparin |
| US3817831A (en) * | 1973-01-10 | 1974-06-18 | Wilson Pharm & Chem Corp | Process for production of alkali metal salt of heparin |
| FR2495935A1 (fr) * | 1980-12-15 | 1982-06-18 | Choay Sa | Fractions mucopolysaccharidiques possedant des proprietes biologiques, leur procede de preparation et leur application en tant que medicaments |
| US4521975A (en) * | 1981-05-04 | 1985-06-11 | Marquest Medical Products, Inc. | Lyophilizing and forming biologicals having a predetermined unit dosage |
| US4479799A (en) * | 1981-05-21 | 1984-10-30 | Riker Laboratories, Inc. | Hypodermic syringe containing microfibers of an amorphous heparin salt |
| JPS58138441A (ja) * | 1982-02-15 | 1983-08-17 | テルモ株式会社 | 血液採取器 |
| WO1983003830A1 (en) * | 1982-04-28 | 1983-11-10 | Charles Richardson White Gray | Blood products and processes for their production |
| DK150403C (da) * | 1983-07-15 | 1987-07-13 | Radiometer As | Blodproevetagningsudstyr |
| EP0356435B1 (de) * | 1987-03-19 | 1995-10-18 | Arthropharm Pty. Limited | Antientzündungsmittel und zusammensetzungen |
| SE8702254D0 (sv) * | 1987-05-29 | 1987-05-29 | Kabivitrum Ab | Novel heparin derivatives |
| IT1234826B (it) * | 1989-01-30 | 1992-05-29 | Alfa Wassermann Spa | Derivati eparinici e procedimento per la loro preparazione |
| JP2540649B2 (ja) * | 1990-04-27 | 1996-10-09 | テルモ株式会社 | 採血管 |
| US5336620A (en) * | 1993-01-27 | 1994-08-09 | American Home Products Corporation | Process for the production of an anticoagulant composition |
-
1993
- 1993-07-22 US US08/096,123 patent/US5336620A/en not_active Expired - Lifetime
-
1994
- 1994-01-25 JP JP51729594A patent/JP3278661B2/ja not_active Expired - Fee Related
- 1994-01-25 KR KR1019950703082A patent/KR960700276A/ko not_active Abandoned
- 1994-01-25 CA CA002154788A patent/CA2154788C/en not_active Expired - Fee Related
- 1994-01-25 EP EP94907324A patent/EP0681590B1/de not_active Expired - Lifetime
- 1994-01-25 DK DK94907324T patent/DK0681590T3/da active
- 1994-01-25 RU RU95117107A patent/RU2148376C1/ru not_active IP Right Cessation
- 1994-01-25 WO PCT/US1994/000914 patent/WO1994017108A1/en not_active Ceased
- 1994-01-25 ES ES94907324T patent/ES2131677T3/es not_active Expired - Lifetime
- 1994-01-25 AU AU60958/94A patent/AU679498B2/en not_active Ceased
- 1994-01-25 IL IL108429A patent/IL108429A/en not_active IP Right Cessation
- 1994-01-25 AT AT94907324T patent/ATE177434T1/de not_active IP Right Cessation
- 1994-01-25 DE DE69417017T patent/DE69417017T2/de not_active Expired - Lifetime
- 1994-05-02 US US08/236,283 patent/US5399318A/en not_active Expired - Lifetime
-
1995
- 1995-06-07 US US08/482,995 patent/US5580789A/en not_active Expired - Lifetime
-
1996
- 1996-09-11 US US08/712,249 patent/US6340675B1/en not_active Expired - Fee Related
-
1999
- 1999-05-11 GR GR990401274T patent/GR3030186T3/el unknown
-
2000
- 2000-02-23 LV LVP-00-25A patent/LV12498B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US6340675B1 (en) | 2002-01-22 |
| JPH08506184A (ja) | 1996-07-02 |
| LV12498B (en) | 2000-09-20 |
| DE69417017T2 (de) | 2001-01-11 |
| DK0681590T3 (da) | 1999-09-27 |
| KR960700276A (ko) | 1996-01-19 |
| CA2154788C (en) | 2006-06-06 |
| LV12498A (en) | 2000-06-20 |
| ES2131677T3 (es) | 1999-08-01 |
| EP0681590B1 (de) | 1999-03-10 |
| GR3030186T3 (en) | 1999-08-31 |
| JP3278661B2 (ja) | 2002-04-30 |
| US5580789A (en) | 1996-12-03 |
| RU2148376C1 (ru) | 2000-05-10 |
| US5399318A (en) | 1995-03-21 |
| CA2154788A1 (en) | 1994-08-04 |
| US5336620A (en) | 1994-08-09 |
| WO1994017108A1 (en) | 1994-08-04 |
| EP0681590A1 (de) | 1995-11-15 |
| IL108429A0 (en) | 1994-04-12 |
| DE69417017D1 (de) | 1999-04-15 |
| AU6095894A (en) | 1994-08-15 |
| AU679498B2 (en) | 1997-07-03 |
| ATE177434T1 (de) | 1999-03-15 |
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| MM9K | Patent not in force due to non-payment of renewal fees |