IL107627A - Pharmaceutical compositions containing 3-substituted-2-amino-4- (hetero) arylpyrano (iso) quinoline derivatives, some new such derivatives and their preparation - Google Patents
Pharmaceutical compositions containing 3-substituted-2-amino-4- (hetero) arylpyrano (iso) quinoline derivatives, some new such derivatives and their preparationInfo
- Publication number
- IL107627A IL107627A IL107627A IL10762793A IL107627A IL 107627 A IL107627 A IL 107627A IL 107627 A IL107627 A IL 107627A IL 10762793 A IL10762793 A IL 10762793A IL 107627 A IL107627 A IL 107627A
- Authority
- IL
- Israel
- Prior art keywords
- phenyl
- alkyl
- optionally substituted
- substituted
- derivatives
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 125000002943 quinolinyl group Chemical class N1=C(C=CC2=CC=CC=C12)* 0.000 title abstract 2
- 229940027991 antiseptic and disinfectant quinoline derivative Drugs 0.000 title 1
- 125000005842 heteroatom Chemical group 0.000 title 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 9
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- -1 cyano, carboxy Chemical group 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 101100134927 Gallus gallus COR8 gene Proteins 0.000 abstract 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 abstract 1
- 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 abstract 1
- 150000001562 benzopyrans Chemical class 0.000 abstract 1
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 abstract 1
- 230000004663 cell proliferation Effects 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 125000004185 ester group Chemical group 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 208000026278 immune system disease Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB929224169A GB9224169D0 (en) | 1992-11-18 | 1992-11-18 | Pharmaceutical compounds |
| GB939302367A GB9302367D0 (en) | 1993-02-06 | 1993-02-06 | Pharmaceutical compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL107627A0 IL107627A0 (en) | 1994-02-27 |
| IL107627A true IL107627A (en) | 1997-04-15 |
Family
ID=26301995
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL107627A IL107627A (en) | 1992-11-18 | 1993-11-16 | Pharmaceutical compositions containing 3-substituted-2-amino-4- (hetero) arylpyrano (iso) quinoline derivatives, some new such derivatives and their preparation |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5434160A (de) |
| EP (2) | EP1004584A3 (de) |
| JP (1) | JPH06199862A (de) |
| KR (1) | KR940011465A (de) |
| CN (1) | CN1040982C (de) |
| AU (1) | AU668602B2 (de) |
| CA (1) | CA2103203A1 (de) |
| CO (1) | CO4130335A1 (de) |
| CZ (1) | CZ243493A3 (de) |
| FI (1) | FI103727B (de) |
| HU (1) | HU9303261D0 (de) |
| IL (1) | IL107627A (de) |
| NO (1) | NO304890B1 (de) |
| NZ (1) | NZ250195A (de) |
| PL (1) | PL301059A1 (de) |
| TW (1) | TW289755B (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9306062D0 (en) * | 1993-03-24 | 1993-05-12 | Lilly Industries Ltd | Pharmaceutical compounds |
| FR2795071B1 (fr) * | 1999-06-16 | 2001-07-27 | Adir | Nouveaux derives de carboxylate de 7-oxo-2,3,7,14- tetrahydro-1h-benzo[b]pyrano[3,2,h] acridine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| EP1230232B1 (de) * | 1999-11-05 | 2004-02-25 | Cytovia, Inc. | Substituierte 4h-chromene und ähnliche verbindungen als kaspasis aktivatoren und apoptosis induktoren und deren verwendung |
| US6858607B1 (en) | 2001-05-16 | 2005-02-22 | Cytovia, Inc. | 7,8-fused 4H-chromene and analogs as activators of caspases and inducers of apoptosis and the use thereof |
| WO2002092076A1 (en) | 2001-05-16 | 2002-11-21 | Cytovia, Inc. | Substituted coumarins and quinolines as caspases activators |
| CA2447010C (en) | 2001-05-16 | 2011-08-02 | Cytovia, Inc. | Substituted 4h-chromenes and analogs as activators of caspases and inducers of apoptosis and the use thereof |
| WO2003096982A2 (en) | 2002-05-16 | 2003-11-27 | Cytovia, Inc. | Substituted 4h-chromenes, 2h-chromenes, chromans and analogs as activators of caspases and inducers of apoptosis and the use thereof |
| CA2484702A1 (en) | 2002-05-16 | 2003-11-27 | Cytovia, Inc. | Substituted 4-aryl-4h-pyrrolo[2,3-h]chromenes and analogs as activators of caspases and inducers of apoptosis and the use thereof |
| JP5031567B2 (ja) * | 2004-09-09 | 2012-09-19 | ハワード・フローレイ・インスティテュート・オブ・イクスペリメンタル・フィジオロジー・アンド・メディスン | 酵素阻害剤およびその使用 |
| US7843312B2 (en) * | 2006-12-12 | 2010-11-30 | Honeywell International Inc. | Wireless control of security system with key-operated key fob |
| WO2009065169A1 (en) | 2007-11-19 | 2009-05-28 | Howard Florey Institute | Insulin-regulated aminopeptidase (irap) inhibitors and uses thereof |
| WO2012062905A2 (en) * | 2010-11-12 | 2012-05-18 | Deutsches Krebsforschungszentrum (Dkfz) | Chromene derivatives and their analoga as wnt pathway antagonists |
| JP2024543981A (ja) * | 2021-12-01 | 2024-11-26 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 炎症性疾患の処置に使用するためのｉｒａｐアミノペプチダーゼ阻害剤の使用 |
| CN115028643B (zh) * | 2022-06-10 | 2024-03-22 | 中国药科大学 | 吡喃并喹啉衍生物及其制备方法和应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4243674A (en) * | 1978-06-12 | 1981-01-06 | Pfizer Inc. | 9-Hydroxydibenzo[b,d]pyrans and intermediates therefore |
| EP0181351A4 (de) * | 1984-05-09 | 1989-06-21 | Univ Australian | Verfahren zur modulierung der immunologischen antwort. |
| JP2631710B2 (ja) * | 1988-08-16 | 1997-07-16 | 日本ヘキスト・マリオン・ルセル株式会社 | ピラノ〔ｆ〕キノリノン誘導体及び該化合物を有効成分とする医薬組成物 |
| US4931221A (en) * | 1988-12-30 | 1990-06-05 | Ppg Industries, Inc. | Photochromic spiropyran compounds |
| US5284868A (en) * | 1991-10-09 | 1994-02-08 | Eli Lilly And Company | Pharmaceutical compounds |
| GB9306062D0 (en) * | 1993-03-24 | 1993-05-12 | Lilly Industries Ltd | Pharmaceutical compounds |
-
1993
- 1993-11-11 EP EP99204310A patent/EP1004584A3/de not_active Withdrawn
- 1993-11-11 EP EP19930308999 patent/EP0599514A3/en not_active Ceased
- 1993-11-12 US US08/150,945 patent/US5434160A/en not_active Expired - Fee Related
- 1993-11-15 PL PL93301059A patent/PL301059A1/xx unknown
- 1993-11-15 TW TW082109528A patent/TW289755B/zh active
- 1993-11-15 AU AU50671/93A patent/AU668602B2/en not_active Ceased
- 1993-11-15 CZ CZ932434A patent/CZ243493A3/cs unknown
- 1993-11-15 NZ NZ250195A patent/NZ250195A/en unknown
- 1993-11-16 NO NO934145A patent/NO304890B1/no not_active IP Right Cessation
- 1993-11-16 IL IL107627A patent/IL107627A/xx not_active IP Right Cessation
- 1993-11-16 FI FI935065A patent/FI103727B/fi active
- 1993-11-16 CA CA002103203A patent/CA2103203A1/en not_active Abandoned
- 1993-11-16 KR KR1019930024262A patent/KR940011465A/ko not_active Ceased
- 1993-11-17 JP JP5287139A patent/JPH06199862A/ja active Pending
- 1993-11-17 HU HU9303261A patent/HU9303261D0/hu unknown
- 1993-11-17 CN CN93115028A patent/CN1040982C/zh not_active Expired - Fee Related
- 1993-11-17 CO CO93418738A patent/CO4130335A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FI935065L (fi) | 1994-05-19 |
| HU9303261D0 (en) | 1994-03-28 |
| AU668602B2 (en) | 1996-05-09 |
| FI935065A0 (fi) | 1993-11-16 |
| IL107627A0 (en) | 1994-02-27 |
| NO934145D0 (no) | 1993-11-16 |
| NO304890B1 (no) | 1999-03-01 |
| TW289755B (de) | 1996-11-01 |
| KR940011465A (ko) | 1994-06-21 |
| EP1004584A3 (de) | 2000-07-05 |
| CO4130335A1 (es) | 1995-02-13 |
| EP1004584A2 (de) | 2000-05-31 |
| CN1040982C (zh) | 1998-12-02 |
| US5434160A (en) | 1995-07-18 |
| EP0599514A3 (en) | 1994-07-06 |
| FI103727B1 (fi) | 1999-08-31 |
| NO934145L (no) | 1994-05-19 |
| CZ243493A3 (en) | 1994-06-15 |
| FI103727B (fi) | 1999-08-31 |
| EP0599514A2 (de) | 1994-06-01 |
| AU5067193A (en) | 1994-06-02 |
| PL301059A1 (en) | 1994-05-30 |
| JPH06199862A (ja) | 1994-07-19 |
| CA2103203A1 (en) | 1994-05-19 |
| NZ250195A (en) | 1995-12-21 |
| CN1092072A (zh) | 1994-09-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| HC | Change of name of proprietor(s) | ||
| KB | Patent renewed | ||
| RH1 | Patent not in force |