IL105901A0 - Novel estradiol derivative-chlorambucil conjugate,process for preparing the same,and pharmaceutical compositions - Google Patents
Novel estradiol derivative-chlorambucil conjugate,process for preparing the same,and pharmaceutical compositionsInfo
- Publication number
- IL105901A0 IL105901A0 IL105901A IL10590193A IL105901A0 IL 105901 A0 IL105901 A0 IL 105901A0 IL 105901 A IL105901 A IL 105901A IL 10590193 A IL10590193 A IL 10590193A IL 105901 A0 IL105901 A0 IL 105901A0
- Authority
- IL
- Israel
- Prior art keywords
- same
- preparing
- pharmaceutical compositions
- estradiol derivative
- conjugate
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
- C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
- C07J1/0074—Esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0044—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an estrane or gonane skeleton, including 18-substituted derivatives and derivatives where position 17-beta is substituted by a carbon atom not directly bonded to another carbon atom and not being part of an amide group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
- C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0072—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the A ring of the steroid being aromatic
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Transplantation (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4177363A JP2520074B2 (ja) | 1992-06-11 | 1992-06-11 | 新規なエストラジオ―ル誘導体−クロラムブチル結合体、その製造方法、及び医薬製剤 |
Publications (1)
Publication Number | Publication Date |
---|---|
IL105901A0 true IL105901A0 (en) | 1993-10-20 |
Family
ID=16029655
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL105901A IL105901A0 (en) | 1992-06-11 | 1993-06-03 | Novel estradiol derivative-chlorambucil conjugate,process for preparing the same,and pharmaceutical compositions |
Country Status (11)
Country | Link |
---|---|
US (3) | US5354745A (fi) |
EP (1) | EP0573977B1 (fi) |
JP (1) | JP2520074B2 (fi) |
KR (1) | KR970001532B1 (fi) |
AT (1) | ATE166060T1 (fi) |
AU (1) | AU649180B2 (fi) |
CA (1) | CA2097137A1 (fi) |
DE (1) | DE69318474T2 (fi) |
FI (1) | FI932641A (fi) |
IL (1) | IL105901A0 (fi) |
ZA (1) | ZA933993B (fi) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH07101977A (ja) * | 1993-10-05 | 1995-04-18 | Kureha Chem Ind Co Ltd | ホルモン作用を軽減した新規なエストラジオール誘導体及びその増殖因子阻害剤 |
US6500669B1 (en) * | 1994-05-04 | 2002-12-31 | Massachusetts Institute Of Technology | Programmable genotoxic agents and uses therefor |
US5882941A (en) * | 1994-05-04 | 1999-03-16 | Massachusette Institute Of Technology | Programmable genotoxic agents and uses therefor |
US20030129194A1 (en) * | 1997-02-13 | 2003-07-10 | Bone Care International, Inc. | Targeted therapeutic delivery of vitamin D compounds |
AU750451B2 (en) * | 1997-02-13 | 2002-07-18 | Bone Care International, Inc. | Targeted therapeutic delivery of vitamin D compounds |
US6534037B1 (en) | 1998-01-21 | 2003-03-18 | Neorx Corporation | Non-steroidal compounds for steroid receptors and uses relating thereto |
US7138502B2 (en) * | 2000-09-28 | 2006-11-21 | Yale University | Antibodies to the propeptide of Candida albicans and methods of use |
US20120225849A1 (en) * | 2011-03-01 | 2012-09-06 | The University Of Kansas | 2-Methoxyestradiol (2-ME2) Prodrug with Enhanced Bioavailability for Prophylaxis or Treatment of Cancerous or Non-Cancerous Condition |
CN103772463B (zh) * | 2013-12-30 | 2016-06-22 | 郑州大学 | 2-甲氧基雌二醇类似物及其制备方法与用途 |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2950292A (en) * | 1959-06-29 | 1960-08-23 | Searle & Co | 3-alkoxy-16-alkyl-16-hydroxy-1, 3, 5(10)-estratrien-17-ones, their ethers and esters |
US3086033A (en) * | 1960-03-11 | 1963-04-16 | Merck Ag E | 1-methyl-17-alkyl-11-oxygenated delta1, 3, 5 (10)-estrogenic compounds |
US3031469A (en) * | 1961-10-24 | 1962-04-24 | American Cyanamid Co | New 15, 17-disubstituted-1, 3, 5(10)-estratriens and method of preparing the same |
NL6405462A (fi) * | 1963-05-17 | 1964-11-18 | ||
FR4339M (fi) * | 1965-03-29 | 1966-08-08 | ||
US3449383A (en) * | 1967-02-16 | 1969-06-10 | Searle & Co | 17-oxygenated estra-1,3,5(10)-triene-3,11beta,16-triols,ethers and esters thereof |
US3496168A (en) * | 1967-09-12 | 1970-02-17 | Smithkline Corp | 4-alkoxyestradiols |
DE2402482C2 (de) * | 1974-01-16 | 1982-07-15 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Verfahren zur Herstellung von 3-Ketosteroiden durch elektrochemische Reduktion von α,β -ungesättigten 3-Ketosteroiden |
US4096253A (en) * | 1976-07-06 | 1978-06-20 | Ortho Pharmaceutical Corporation | 1-Oxygenated steroids |
US4260736A (en) * | 1978-08-14 | 1981-04-07 | Kureha Kagaku Kogyo Kabushiki Kaisha | Steroid hormone-antitumor derivatives |
US4261910A (en) * | 1978-08-14 | 1981-04-14 | Kureha Kagaku Kogyo Kabushiki Kaisha | Process for the preparation of Chlorambucil derivatives |
JPS56110700A (en) * | 1980-02-08 | 1981-09-01 | Kureha Chem Ind Co Ltd | Estradiol-17alphaderivative and ist antitumor agent |
SE8305596D0 (sv) * | 1983-10-12 | 1983-10-12 | Leo Ab | A selective acylation method |
DE3510555A1 (de) * | 1985-03-21 | 1986-09-25 | Schering AG, 1000 Berlin und 4709 Bergkamen | Estriolester |
JPS61293993A (ja) * | 1985-06-21 | 1986-12-24 | Kureha Chem Ind Co Ltd | 新規な螢光物質,その製造方法及び薬剤 |
US4882439A (en) * | 1985-09-19 | 1989-11-21 | The University Of Sheffield | Steroid intermediates |
EP0240717A3 (en) * | 1986-03-04 | 1990-05-16 | Board of Regents of the University of Nebraska | Prevention of mammary carcinoma |
JPH0621072B2 (ja) * | 1986-11-12 | 1994-03-23 | 呉羽化学工業株式会社 | エストラジオ−ル誘導体よりなる免疫調節剤 |
JPH0794377B2 (ja) * | 1987-07-22 | 1995-10-11 | 呉羽化学工業株式会社 | エストラジオール誘導体を含有する注射剤 |
JPS6445393A (en) * | 1987-08-13 | 1989-02-17 | Toa Nenryo Kogyo Kk | Estradiol derivative |
JPS6445392A (en) * | 1987-08-13 | 1989-02-17 | Toa Nenryo Kogyo Kk | Production of estradiol derivative |
SE8802402D0 (sv) * | 1988-06-28 | 1988-06-28 | Pharmacia Ab | Novel esters |
US5031469A (en) * | 1988-11-30 | 1991-07-16 | Blackburn Robert E | Fluid sampler |
CA2123472C (en) * | 1994-05-12 | 2005-07-05 | Craig W. Renwick | Injection molding manifold and method with the heating element extending between the plates |
-
1992
- 1992-06-11 JP JP4177363A patent/JP2520074B2/ja not_active Expired - Fee Related
-
1993
- 1993-05-27 CA CA002097137A patent/CA2097137A1/en not_active Abandoned
- 1993-06-03 US US08/070,797 patent/US5354745A/en not_active Expired - Fee Related
- 1993-06-03 IL IL105901A patent/IL105901A0/xx unknown
- 1993-06-07 ZA ZA933993A patent/ZA933993B/xx unknown
- 1993-06-09 AT AT93109281T patent/ATE166060T1/de not_active IP Right Cessation
- 1993-06-09 FI FI932641A patent/FI932641A/fi unknown
- 1993-06-09 EP EP93109281A patent/EP0573977B1/en not_active Expired - Lifetime
- 1993-06-09 AU AU40116/93A patent/AU649180B2/en not_active Ceased
- 1993-06-09 DE DE69318474T patent/DE69318474T2/de not_active Expired - Fee Related
- 1993-06-10 KR KR1019930010560A patent/KR970001532B1/ko active IP Right Grant
-
1995
- 1995-05-15 US US08/440,839 patent/US5576309A/en not_active Expired - Fee Related
- 1995-05-15 US US08/440,838 patent/US5578589A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DE69318474T2 (de) | 1998-10-15 |
KR970001532B1 (ko) | 1997-02-11 |
EP0573977B1 (en) | 1998-05-13 |
CA2097137A1 (en) | 1993-12-12 |
KR940005662A (ko) | 1994-03-22 |
ATE166060T1 (de) | 1998-05-15 |
FI932641A (fi) | 1993-12-12 |
FI932641A0 (fi) | 1993-06-09 |
AU649180B2 (en) | 1994-05-12 |
ZA933993B (en) | 1994-01-05 |
US5576309A (en) | 1996-11-19 |
JP2520074B2 (ja) | 1996-07-31 |
DE69318474D1 (de) | 1998-06-18 |
US5354745A (en) | 1994-10-11 |
EP0573977A3 (en) | 1996-01-31 |
JPH05339285A (ja) | 1993-12-21 |
US5578589A (en) | 1996-11-26 |
AU4011693A (en) | 1993-12-16 |
EP0573977A2 (en) | 1993-12-15 |
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