IL105404A - Heterocyclic dipeptides, processes for their preparation and pharmaceutical preparations containing them - Google Patents

Heterocyclic dipeptides, processes for their preparation and pharmaceutical preparations containing them

Info

Publication number
IL105404A
IL105404A IL10540493A IL10540493A IL105404A IL 105404 A IL105404 A IL 105404A IL 10540493 A IL10540493 A IL 10540493A IL 10540493 A IL10540493 A IL 10540493A IL 105404 A IL105404 A IL 105404A
Authority
IL
Israel
Prior art keywords
compound
salt
solution
preparation
acid
Prior art date
Application number
IL10540493A
Other languages
English (en)
Hebrew (he)
Other versions
IL105404A0 (en
Original Assignee
Fujisawa Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co
Publication of IL105404A0 publication Critical patent/IL105404A0/xx
Publication of IL105404A publication Critical patent/IL105404A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Detergent Compositions (AREA)
IL10540493A 1992-04-21 1993-04-15 Heterocyclic dipeptides, processes for their preparation and pharmaceutical preparations containing them IL105404A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/871,723 US5420297A (en) 1990-10-24 1992-04-21 Peptides having substance P antagonistic activity

Publications (2)

Publication Number Publication Date
IL105404A0 IL105404A0 (en) 1993-08-18
IL105404A true IL105404A (en) 1999-11-30

Family

ID=25357987

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10540493A IL105404A (en) 1992-04-21 1993-04-15 Heterocyclic dipeptides, processes for their preparation and pharmaceutical preparations containing them

Country Status (17)

Country Link
US (2) US5420297A (ko)
EP (1) EP0640099B1 (ko)
JP (1) JPH07505879A (ko)
KR (1) KR100250921B1 (ko)
CN (1) CN1041830C (ko)
AT (1) ATE205852T1 (ko)
AU (1) AU674512B2 (ko)
CA (1) CA2118503A1 (ko)
DE (1) DE69330788T2 (ko)
ES (1) ES2160103T3 (ko)
HU (2) HUT71397A (ko)
IL (1) IL105404A (ko)
MX (1) MX9302178A (ko)
RU (1) RU2119922C1 (ko)
TW (1) TW314525B (ko)
WO (1) WO1993021215A1 (ko)
ZA (1) ZA932728B (ko)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5654400A (en) * 1991-10-04 1997-08-05 Fujisawa Pharmaceutical Co., Ltd. Process for making peptide compounds having tachykinin antagonistic activity
WO1994020126A1 (en) * 1993-03-03 1994-09-15 Fujisawa Pharmaceutical Co., Ltd. Use of peptides for the manufacture of a medicament
WO1995000536A1 (en) * 1993-06-22 1995-01-05 Fujisawa Pharmaceutical Co., Ltd. Peptide compounds
DE69519182T2 (de) * 1994-03-17 2001-05-17 Fujirebio Kk Azapeptid-Derivate
DE19512484A1 (de) 1995-04-04 1996-10-17 Bayer Ag Kohlenhydratmodifizierte Cytostatika
EP0966958A4 (en) * 1997-03-14 2001-10-10 Fujisawa Pharmaceutical Co AEROSOL PREPARATION
AU1600599A (en) 1998-02-27 1999-09-15 Warner-Lambert Company Heterocyclic substituted aniline calcium channel blockers
US6166052A (en) * 1998-03-11 2000-12-26 Warner-Lambert Company Heteroaryl alkyl alpha substituted peptidylamine calcium channel blockers
US6399629B1 (en) 1998-06-01 2002-06-04 Microcide Pharmaceuticals, Inc. Efflux pump inhibitors
WO2001019848A1 (fr) * 1999-09-14 2001-03-22 Fujisawa Pharmaceutical Co., Ltd. Nouveaux procedes de production de composes peptidiques
US6437093B1 (en) * 2000-11-28 2002-08-20 Milkhaus Laboratory, Inc. Methods of treatment comprising administration of Substance P
GB0223077D0 (en) * 2002-10-04 2002-11-13 Univ Reading The Treatment of vascular diseases
TW200500341A (en) * 2002-11-12 2005-01-01 Astrazeneca Ab Novel compounds
CA2628179A1 (en) 2005-11-15 2007-05-24 Vertex Pharmaceuticals Incorporated Azaindazoles useful as inhibitors of kinases
EA008737B1 (ru) * 2005-12-07 2007-08-31 Леонид Андреевич Кожемякин Средство для профилактики и лечения конъюнктивитов и кератитов различной этиологии (варианты), способ его применения
UA105182C2 (ru) 2008-07-03 2014-04-25 Ньюрексон, Інк. Бензоксазины, бензотиазины и родственные соединения, которые имеют ингибирующую nos активность
DE202011000090U1 (de) 2011-01-14 2011-04-21 E-LEAD ELECTRONIC CO., LTD., Shengang Shiang Fahrzeug-Audiosystem mit auswechselbarem Plug-In-Computer
IT1403659B1 (it) * 2011-01-28 2013-10-31 Kerakoll S P A Stucco epossidico a base acquosa
NO2729147T3 (ko) 2011-07-04 2018-02-03
EP2757924B1 (en) * 2011-09-24 2016-12-28 EnE Holdings Ltd Beverage system with aeration
WO2019162519A1 (en) 2018-02-26 2019-08-29 Ospedale San Raffaele S.R.L. Nk-1 antagonists for use in the treatment of ocular pain
EP4117673A1 (en) 2020-03-11 2023-01-18 Ospedale San Raffaele S.r.l. Treatment of stem cell deficiency

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5187156A (en) * 1988-03-16 1993-02-16 Fujisawa Pharmaceutical Co., Ltd. Peptide compounds, processes for preparation thereof and pharmaceutical composition comprising the same
US5164372A (en) * 1989-04-28 1992-11-17 Fujisawa Pharmaceutical Company, Ltd. Peptide compounds having substance p antagonism, processes for preparation thereof and pharmaceutical composition comprising the same
GB8929070D0 (en) * 1989-12-22 1990-02-28 Fujisawa Pharmaceutical Co Peptide compounds,processes for preparation thereof and pharmaceutical composition comprising the same
EP0515681A4 (en) * 1990-02-15 1993-12-29 Fujisawa Pharmaceutical Co., Ltd. Peptide compound
GB9023116D0 (en) * 1990-10-24 1990-12-05 Fujisawa Pharmaceutical Co Peptide compounds,processes for preparation thereof and pharmaceutical composition comprising the same

Also Published As

Publication number Publication date
ATE205852T1 (de) 2001-10-15
HUT71397A (en) 1995-11-28
US5420297A (en) 1995-05-30
JPH07505879A (ja) 1995-06-29
KR950700928A (ko) 1995-02-20
MX9302178A (es) 1994-06-30
CN1083074A (zh) 1994-03-02
IL105404A0 (en) 1993-08-18
CA2118503A1 (en) 1993-10-28
HU211831A9 (en) 1995-12-28
EP0640099A1 (en) 1995-03-01
AU3904593A (en) 1993-11-18
AU674512B2 (en) 1997-01-02
DE69330788D1 (de) 2001-10-25
ZA932728B (en) 1993-10-28
KR100250921B1 (ko) 2000-04-01
HU9403062D0 (en) 1994-12-28
RU94045881A (ru) 1996-09-10
CN1041830C (zh) 1999-01-27
RU2119922C1 (ru) 1998-10-10
WO1993021215A1 (en) 1993-10-28
TW314525B (ko) 1997-09-01
ES2160103T3 (es) 2001-11-01
US5633232A (en) 1997-05-27
DE69330788T2 (de) 2002-05-29
EP0640099B1 (en) 2001-09-19

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WO1992022569A1 (en) Peptides with tachykinin antagonist activity
WO1993014113A1 (en) Peptides with tachykinin antagonist activity
US5654400A (en) Process for making peptide compounds having tachykinin antagonistic activity
WO1995000536A1 (en) Peptide compounds
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JPH0881494A (ja) 新規な化合物およびその製造法

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
RH1 Patent not in force