IL103353A - ליגנד תצמידי מתכת שלו תכשיר אבחון ותהליכים להכנתם - Google Patents
ליגנד תצמידי מתכת שלו תכשיר אבחון ותהליכים להכנתםInfo
- Publication number
- IL103353A IL103353A IL10335392A IL10335392A IL103353A IL 103353 A IL103353 A IL 103353A IL 10335392 A IL10335392 A IL 10335392A IL 10335392 A IL10335392 A IL 10335392A IL 103353 A IL103353 A IL 103353A
- Authority
- IL
- Israel
- Prior art keywords
- complex
- alkyl
- formula
- hypoxia
- aryl
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/32—Oximes
- C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/32—Oximes
- C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C251/36—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atoms of the oxyimino groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C251/38—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atoms of the oxyimino groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of a saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/91—Nitro radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Furan Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Inorganic Compounds Of Heavy Metals (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78448691A | 1991-10-29 | 1991-10-29 | |
| CN93103893A CN1093084A (zh) | 1991-10-29 | 1993-03-31 | 包含缺氧定位部分的铼和锝络合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL103353A0 IL103353A0 (en) | 1993-03-15 |
| IL103353A true IL103353A (he) | 1999-01-26 |
Family
ID=36809246
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL10335392A IL103353A (he) | 1991-10-29 | 1992-10-05 | ליגנד תצמידי מתכת שלו תכשיר אבחון ותהליכים להכנתם |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP0544412B1 (he) |
| JP (1) | JP3385048B2 (he) |
| CN (2) | CN1071928A (he) |
| AT (1) | ATE155691T1 (he) |
| AU (1) | AU662361B2 (he) |
| CA (1) | CA2081637C (he) |
| DE (1) | DE69221084T2 (he) |
| DK (1) | DK0544412T3 (he) |
| ES (1) | ES2104848T3 (he) |
| FI (1) | FI924914A (he) |
| GR (1) | GR3024895T3 (he) |
| HU (1) | HUT74804A (he) |
| IL (1) | IL103353A (he) |
| MX (1) | MX9206070A (he) |
| NO (1) | NO304466B1 (he) |
| NZ (1) | NZ244613A (he) |
| PL (1) | PL296409A1 (he) |
| ZA (1) | ZA927692B (he) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5808091A (en) | 1991-10-29 | 1998-09-15 | Bracco International B.V. | Rhenium and technetium complexes containing a hypoxia localizing moiety |
| US5608110A (en) * | 1993-06-15 | 1997-03-04 | Bracco International B.V. | Heteroatom-bearing ligands and metal complexes thereof |
| HUT73672A (en) * | 1993-08-04 | 1996-09-30 | Amersham Int Plc | Radiometal complexes that localise in hypoxic tissue |
| IL111592A0 (en) * | 1993-12-14 | 1995-01-24 | Bracco Int Bv | Stable multilayer lyophile |
| ATE164833T1 (de) * | 1994-01-12 | 1998-04-15 | Bracco Int Bv | Liganden und deren metallkomplexe |
| US5700825A (en) * | 1995-03-31 | 1997-12-23 | Florida State University | Radiosensitizing diamines and their pharmaceutical preparations |
| US6060604A (en) * | 1995-03-31 | 2000-05-09 | Florida State University | Pharmaceutical compounds comprising polyamines substituted with electron-affinic groups |
| AU5570898A (en) | 1997-01-21 | 1998-08-07 | Nycomed Amersham Plc | Labelled factor xiiia substrates |
| AU5676398A (en) * | 1997-01-31 | 1998-08-25 | University Of Alberta, The | Method for detecting exogenous gene expression |
| RU2498798C2 (ru) * | 2008-01-09 | 2013-11-20 | Моликьюлар Инсайт Фармасьютикалз, Инк. | Ингибиторы карбоангидразы iх |
| EP2706057B1 (en) | 2008-12-05 | 2016-04-20 | Molecular Insight Pharmaceuticals, Inc. | Bis(imidazolyl)compounds and radionuclide complexes |
| AU2010260195B2 (en) | 2009-06-15 | 2014-11-20 | Molecular Insight Pharmaceuticals, Inc. | Process for production of heterodimers of glutamic acid |
| CN102612511A (zh) * | 2009-09-28 | 2012-07-25 | 肯塔基大学研究基金会 | 用于从污染的环境中去除元素的含巯基化合物及其使用方法 |
| AU2013207486A1 (en) | 2012-01-06 | 2014-08-21 | Molecular Insight Pharmaceuticals | Metal complexes of poly(carboxyl)amine-containing ligands having an affinity for carbonic anhydrase IX |
| ES2648096T3 (es) | 2013-01-14 | 2017-12-28 | Molecular Insight Pharmaceuticals, Inc. | Radiofármacos a base de triazina y agentes de radioformación de imágenes |
| EP3684781A4 (en) * | 2017-09-19 | 2022-06-29 | The Governors of the University of Alberta | Bioreductively-activated compounds, their prodrugs, radiopharmaceuticals, the compositions, and their applications in multimodal theranostic management of hypoxia diseases including cancer |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2093451B (en) * | 1981-02-24 | 1984-10-31 | May & Baker Ltd | Nitroimidazole derivatives |
| US4615876A (en) * | 1983-04-25 | 1986-10-07 | Curators Of The University Of Missouri | Macrocyclic complexes of technetium-99m for use as diagnostic radionuclides |
| US4638051A (en) * | 1984-04-30 | 1987-01-20 | The Johns Hopkins University | Brain imaging radiopharmaceuticals |
| DE3687467T2 (de) * | 1985-03-11 | 1993-04-29 | Amersham Int Plc | Komplexe von technetium-99m mit propylen-amin-oximen. |
| WO1989010759A1 (en) * | 1988-04-29 | 1989-11-16 | Mallinckrodt, Inc. | Diaminedithiol chelating agents for radiopharmaceuticals |
| US4988496A (en) * | 1988-05-31 | 1991-01-29 | Neorx Corporation | Metal radionuclide chelating compounds for improved chelation kinetics |
| US4925650A (en) * | 1988-11-16 | 1990-05-15 | Mallinckrodt, Inc. | Technetium -99m complex for examining the renal function |
| US4986979A (en) * | 1989-03-14 | 1991-01-22 | Neorx Corporation | Imaging tissue sites of inflammation |
| DE3930674A1 (de) * | 1989-09-11 | 1991-03-21 | Diagnostikforschung Inst | Bifunktionelle chelatbildner zur komplexierung von tc- und re-isotopen, verfahren zu ihrer herstellung und darstellung von konjugaten daraus sowie deren verwendung in diagnostik und therapie |
-
1992
- 1992-10-05 IL IL10335392A patent/IL103353A/he not_active IP Right Cessation
- 1992-10-05 NZ NZ244613A patent/NZ244613A/en unknown
- 1992-10-06 ZA ZA927692A patent/ZA927692B/xx unknown
- 1992-10-22 MX MX9206070A patent/MX9206070A/es unknown
- 1992-10-28 HU HU9203389A patent/HUT74804A/hu unknown
- 1992-10-28 NO NO924157A patent/NO304466B1/no not_active IP Right Cessation
- 1992-10-28 AU AU27373/92A patent/AU662361B2/en not_active Ceased
- 1992-10-28 CA CA002081637A patent/CA2081637C/en not_active Expired - Fee Related
- 1992-10-29 CN CN92112552A patent/CN1071928A/zh active Pending
- 1992-10-29 DE DE69221084T patent/DE69221084T2/de not_active Expired - Fee Related
- 1992-10-29 ES ES92309922T patent/ES2104848T3/es not_active Expired - Lifetime
- 1992-10-29 FI FI924914A patent/FI924914A/fi unknown
- 1992-10-29 JP JP29120492A patent/JP3385048B2/ja not_active Expired - Fee Related
- 1992-10-29 EP EP92309922A patent/EP0544412B1/en not_active Expired - Lifetime
- 1992-10-29 AT AT92309922T patent/ATE155691T1/de active
- 1992-10-29 DK DK92309922.0T patent/DK0544412T3/da active
- 1992-10-29 PL PL29640992A patent/PL296409A1/xx unknown
-
1993
- 1993-03-31 CN CN93103893A patent/CN1093084A/zh active Pending
-
1997
- 1997-10-01 GR GR970402542T patent/GR3024895T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX9206070A (es) | 1993-04-01 |
| CN1093084A (zh) | 1994-10-05 |
| HU9203389D0 (en) | 1993-01-28 |
| DE69221084T2 (de) | 1998-02-26 |
| ATE155691T1 (de) | 1997-08-15 |
| CA2081637C (en) | 2000-05-16 |
| AU2737392A (en) | 1993-05-06 |
| FI924914A0 (fi) | 1992-10-29 |
| JP3385048B2 (ja) | 2003-03-10 |
| ES2104848T3 (es) | 1997-10-16 |
| AU662361B2 (en) | 1995-08-31 |
| IL103353A0 (en) | 1993-03-15 |
| CN1071928A (zh) | 1993-05-12 |
| FI924914A (fi) | 1993-04-30 |
| NO924157D0 (no) | 1992-10-28 |
| NO304466B1 (no) | 1998-12-21 |
| CA2081637A1 (en) | 1993-12-15 |
| EP0544412A3 (en) | 1993-08-25 |
| EP0544412A2 (en) | 1993-06-02 |
| NO924157L (no) | 1993-04-30 |
| GR3024895T3 (en) | 1998-01-30 |
| HUT74804A (en) | 1997-02-28 |
| DE69221084D1 (de) | 1997-08-28 |
| DK0544412T3 (da) | 1998-03-02 |
| ZA927692B (en) | 1993-04-15 |
| EP0544412B1 (en) | 1997-07-23 |
| NZ244613A (en) | 1996-05-28 |
| PL296409A1 (en) | 1993-11-29 |
| JPH05239046A (ja) | 1993-09-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| RH1 | Patent not in force |