ES2104848T3 - Complejos de renio y tecnecio que contienen un resto localizador de hipoxia. - Google Patents

Complejos de renio y tecnecio que contienen un resto localizador de hipoxia.

Info

Publication number
ES2104848T3
ES2104848T3 ES92309922T ES92309922T ES2104848T3 ES 2104848 T3 ES2104848 T3 ES 2104848T3 ES 92309922 T ES92309922 T ES 92309922T ES 92309922 T ES92309922 T ES 92309922T ES 2104848 T3 ES2104848 T3 ES 2104848T3
Authority
ES
Spain
Prior art keywords
aryl
alkyl
coor3
hydrogen
hypoxia
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92309922T
Other languages
English (en)
Inventor
Karen Linder
Kondareddiar Ramalingam
John P Pirro
Adrian D Nunn
Rocco Richard J Di
David P Nowotnik
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bracco International BV
Original Assignee
Bracco International BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco International BV filed Critical Bracco International BV
Application granted granted Critical
Publication of ES2104848T3 publication Critical patent/ES2104848T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32—Oximes
    • C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32—Oximes
    • C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C251/36—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atoms of the oxyimino groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C251/38—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atoms of the oxyimino groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Furan Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

UN COMPUESTO CON LA FORMULA EN DONDE, AL MENOS, UNA R ES -(A)P-R2, EN DONDE (A)P ES UN GRUPO ENLAZANTE Y R2 ES UN SISTEMA LOCALIZANTE DE HIPOXIA; Y EN DONDE LOS OTROS GRUPOS R SON LO MISMO O ALGO DISTINTO Y SE SELECCIONAN INDEPENDIENTEMENTE A PARTIR DE HIDROGENO, HALOGENO, HIDROXILO, ALQUILO, ALQUENILO, ALQUINILO, ALCOXI, ARILO, -COOR3, -NH2, HIDROXIALQUILO, ALCOXIALQUILO, HALOALQUILO, ARALQUILO, ALQUIL-COOR3, -ALQUIL-CON(R3)2, ALQUIL-N(R3)2, -ARIL-COOR3, ARIL-CON(R3)2, -ARIL-N(R3)2, NITROGENO DE 5 O 6 ELEMENTOS O HETEROCICLO QUE CONTIENE OXIGENO; O DOS GRUPOS R JUNTO CON UNO O MAS ATOMOS A LOS QUE ESTAN UNIDOS FORMAN UN ANILLO CONDENSADO O ESPIRO CARBOCICLICO O HETEROCICLICO, SATURADO O NO SATURADO QUE SE PUEDE SUSTITUIR POR LOS GRUPOS R; R1 ES HIDROGENO, UN GRUPO TIOL O -(A)P-R2; R3 ES HIDROGENO, ALQUILO O ARILO; M = 2 A 5; P = 0 A 20
ES92309922T 1991-10-29 1992-10-29 Complejos de renio y tecnecio que contienen un resto localizador de hipoxia. Expired - Lifetime ES2104848T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78448691A 1991-10-29 1991-10-29
CN93103893A CN1093084A (zh) 1991-10-29 1993-03-31 包含缺氧定位部分的铼和锝络合物

Publications (1)

Publication Number Publication Date
ES2104848T3 true ES2104848T3 (es) 1997-10-16

Family

ID=36809246

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92309922T Expired - Lifetime ES2104848T3 (es) 1991-10-29 1992-10-29 Complejos de renio y tecnecio que contienen un resto localizador de hipoxia.

Country Status (18)

Country Link
EP (1) EP0544412B1 (es)
JP (1) JP3385048B2 (es)
CN (2) CN1071928A (es)
AT (1) ATE155691T1 (es)
AU (1) AU662361B2 (es)
CA (1) CA2081637C (es)
DE (1) DE69221084T2 (es)
DK (1) DK0544412T3 (es)
ES (1) ES2104848T3 (es)
FI (1) FI924914A (es)
GR (1) GR3024895T3 (es)
HU (1) HUT74804A (es)
IL (1) IL103353A (es)
MX (1) MX9206070A (es)
NO (1) NO304466B1 (es)
NZ (1) NZ244613A (es)
PL (1) PL296409A1 (es)
ZA (1) ZA927692B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5808091A (en) * 1991-10-29 1998-09-15 Bracco International B.V. Rhenium and technetium complexes containing a hypoxia localizing moiety
US5608110A (en) * 1993-06-15 1997-03-04 Bracco International B.V. Heteroatom-bearing ligands and metal complexes thereof
WO1995004552A2 (en) * 1993-08-04 1995-02-16 Amersham International Plc Radiometal complexes that localise in hypoxic tissue
IL111592A0 (en) * 1993-12-14 1995-01-24 Bracco Int Bv Stable multilayer lyophile
CA2156605A1 (en) * 1994-01-12 1995-07-20 David Nowotnik Ligands and metal complexes thereof
US5700825A (en) * 1995-03-31 1997-12-23 Florida State University Radiosensitizing diamines and their pharmaceutical preparations
US6060604A (en) * 1995-03-31 2000-05-09 Florida State University Pharmaceutical compounds comprising polyamines substituted with electron-affinic groups
ES2244042T3 (es) 1997-01-21 2005-12-01 Ge Healthcare Limited Sustratos del factor xiiia marcados.
AU5676398A (en) * 1997-01-31 1998-08-25 University Of Alberta, The Method for detecting exogenous gene expression
JP2011509304A (ja) * 2008-01-09 2011-03-24 モレキュラ インサイト ファーマシューティカルズ インコーポレイテッド 炭酸脱水酵素ｉｘの阻害剤
WO2010065899A2 (en) 2008-12-05 2010-06-10 Molecular Insight Pharmaceuticals, Inc. Technetium-and rhenium-bis(heteroaryl)complexes and methods of use thereof
US8465725B2 (en) 2009-06-15 2013-06-18 Molecular Insight Pharmaceuticlas, Inc. Process for production of heterodimers of glutamic acid
IN2012DN02586A (es) * 2009-09-28 2015-08-28 Univ Kentucky Res Found
US9120837B2 (en) 2012-01-06 2015-09-01 Molecular Insight Pharmaceuticals Metal complexes of poly(carboxyl)amine-containing ligands having an affinity for carbonic anhydrase IX
CN105025933B (zh) 2013-01-14 2019-03-26 分子制药洞察公司 三嗪类放射性药物和放射性显影剂
CN111372940A (zh) * 2017-09-19 2020-07-03 阿尔伯塔大学理事会 生物还原活化的化合物、其前药、放射性药物、组合物及其在包括癌症在内的低氧疾病的多模式治疗控制中的应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2093451B (en) * 1981-02-24 1984-10-31 May & Baker Ltd Nitroimidazole derivatives
US4615876A (en) * 1983-04-25 1986-10-07 Curators Of The University Of Missouri Macrocyclic complexes of technetium-99m for use as diagnostic radionuclides
US4638051A (en) * 1984-04-30 1987-01-20 The Johns Hopkins University Brain imaging radiopharmaceuticals
EP0194843B1 (en) * 1985-03-11 1993-01-13 AMERSHAM INTERNATIONAL plc Complexes of technetium-99m with propylene amine oximes
WO1989010759A1 (en) * 1988-04-29 1989-11-16 Mallinckrodt, Inc. Diaminedithiol chelating agents for radiopharmaceuticals
US4988496A (en) * 1988-05-31 1991-01-29 Neorx Corporation Metal radionuclide chelating compounds for improved chelation kinetics
US4925650A (en) * 1988-11-16 1990-05-15 Mallinckrodt, Inc. Technetium -99m complex for examining the renal function
US4986979A (en) * 1989-03-14 1991-01-22 Neorx Corporation Imaging tissue sites of inflammation
DE3930674A1 (de) * 1989-09-11 1991-03-21 Diagnostikforschung Inst Bifunktionelle chelatbildner zur komplexierung von tc- und re-isotopen, verfahren zu ihrer herstellung und darstellung von konjugaten daraus sowie deren verwendung in diagnostik und therapie

Also Published As

Publication number Publication date
FI924914A0 (fi) 1992-10-29
CA2081637C (en) 2000-05-16
AU662361B2 (en) 1995-08-31
NO304466B1 (no) 1998-12-21
IL103353A (en) 1999-01-26
NO924157L (no) 1993-04-30
EP0544412A2 (en) 1993-06-02
DE69221084D1 (de) 1997-08-28
ATE155691T1 (de) 1997-08-15
EP0544412A3 (en) 1993-08-25
NO924157D0 (no) 1992-10-28
NZ244613A (en) 1996-05-28
JP3385048B2 (ja) 2003-03-10
HUT74804A (en) 1997-02-28
PL296409A1 (en) 1993-11-29
GR3024895T3 (en) 1998-01-30
IL103353A0 (en) 1993-03-15
FI924914A (fi) 1993-04-30
DE69221084T2 (de) 1998-02-26
JPH05239046A (ja) 1993-09-17
AU2737392A (en) 1993-05-06
ZA927692B (en) 1993-04-15
CN1093084A (zh) 1994-10-05
MX9206070A (es) 1993-04-01
DK0544412T3 (da) 1998-03-02
EP0544412B1 (en) 1997-07-23
HU9203389D0 (en) 1993-01-28
CA2081637A1 (en) 1993-12-15
CN1071928A (zh) 1993-05-12

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