IL101819A - Amidinophenylalanine derivatives, a process for the preparation thereof, and pharmaceutical compositions containing these as anticoagulants - Google Patents
Amidinophenylalanine derivatives, a process for the preparation thereof, and pharmaceutical compositions containing these as anticoagulantsInfo
- Publication number
- IL101819A IL101819A IL101819A IL10181992A IL101819A IL 101819 A IL101819 A IL 101819A IL 101819 A IL101819 A IL 101819A IL 10181992 A IL10181992 A IL 10181992A IL 101819 A IL101819 A IL 101819A
- Authority
- IL
- Israel
- Prior art keywords
- carbon atoms
- group
- alkyl groups
- ring
- derivatized
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4115468A DE4115468A1 (de) | 1991-05-11 | 1991-05-11 | Amidinophenylalaninderivate, verfahren zu deren herstellung, deren verwendung und diese enthaltende mittel als antikoagulantien |
Publications (2)
Publication Number | Publication Date |
---|---|
IL101819A0 IL101819A0 (en) | 1992-12-30 |
IL101819A true IL101819A (en) | 1997-04-15 |
Family
ID=6431497
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL101819A IL101819A (en) | 1991-05-11 | 1992-05-10 | Amidinophenylalanine derivatives, a process for the preparation thereof, and pharmaceutical compositions containing these as anticoagulants |
Country Status (20)
Country | Link |
---|---|
US (2) | US5457114A (zh) |
EP (1) | EP0513543B1 (zh) |
JP (1) | JPH089634B2 (zh) |
KR (1) | KR920021503A (zh) |
CN (1) | CN1039125C (zh) |
AT (1) | ATE129503T1 (zh) |
AU (1) | AU651196B2 (zh) |
CA (1) | CA2068263A1 (zh) |
CY (1) | CY2121B1 (zh) |
DE (2) | DE4115468A1 (zh) |
DK (1) | DK0513543T3 (zh) |
ES (1) | ES2079719T3 (zh) |
GR (1) | GR3018182T3 (zh) |
HK (1) | HK1006717A1 (zh) |
IE (1) | IE68884B1 (zh) |
IL (1) | IL101819A (zh) |
MX (1) | MX9202166A (zh) |
NO (1) | NO921835L (zh) |
NZ (1) | NZ242668A (zh) |
RU (1) | RU2088591C1 (zh) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4206858A1 (de) * | 1992-03-05 | 1993-09-09 | Behringwerke Ag | Glycopeptid-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische mittel |
AU675981B2 (en) * | 1992-12-02 | 1997-02-27 | Bristol-Myers Squibb Company | Guanidinyl-substituted heterocyclic thrombin inhibitors |
SE9301916D0 (sv) * | 1993-06-03 | 1993-06-03 | Ab Astra | New peptides derivatives |
US5783563A (en) * | 1993-06-03 | 1998-07-21 | Astra Aktiebolag | Method for treatment or prophylaxis of venous thrombosis |
US6984627B1 (en) | 1993-06-03 | 2006-01-10 | Astrazeneca Ab | Peptide derivatives |
DE4342154A1 (de) * | 1993-12-10 | 1995-06-14 | Behringwerke Ag | Amidinophenylalaninderivate, Verfahren zu deren Herstellung, deren Verwendung und diese enthaltende Mittel als Antikoagulantien |
DE4344919A1 (de) * | 1993-12-30 | 1995-07-06 | Behringwerke Ag | Verfahren zur Bestimmung der Thrombozytenaggregation |
DE4421052A1 (de) * | 1994-06-17 | 1995-12-21 | Basf Ag | Neue Thrombininhibitoren, ihre Herstellung und Verwendung |
SE9404196D0 (sv) * | 1994-12-02 | 1994-12-02 | Astra Ab | New antithrombotic formulation |
DE19514104C2 (de) * | 1995-04-13 | 1997-05-28 | Behringwerke Ag | Beschichtung für in den Blutstrom oder in das Gewebe des menschlichen Körpers einbringbares Biomaterial |
KR0173034B1 (ko) * | 1995-04-28 | 1999-03-30 | 성재갑 | 선택적 트롬빈 억제제 |
ATE206702T1 (de) * | 1995-06-06 | 2001-10-15 | Pfizer | Substituierte n-(indol-2-carbonyl)-glycinamide und derivate als glycogen phosphorylase inhibitoren |
US5766932A (en) * | 1995-12-20 | 1998-06-16 | Hoechst Marion Roussel, Inc. | Process for preparing N-acetyl(L)-4-cyanophenylalanine from a mixture of the corresponding D,L ethyl esters using subtilisin |
RU2170764C2 (ru) * | 1995-12-20 | 2001-07-20 | Авентис Фармасьютикалз Инк. | НОВЫЙ СПОСОБ ПОЛУЧЕНИЯ N-АЦЕТИЛ-(L)-4-ЦИАНОФЕНИЛАЛАНИНА АС-(L)-PHE(4-CN)-OH И N-АЦЕТИЛ-(L)-N-АМИДИНОФЕНИЛАЛАНИН-ЦИКЛОГЕКСИЛ-ГЛИЦИН-β-(3-N-МЕТИЛПИРИДИН ИЯ)-АЛАНИНА АС-(L)-PАPH-СHG-РAL МE(3)-NH2 |
AR005245A1 (es) | 1995-12-21 | 1999-04-28 | Astrazeneca Ab | Prodrogas de inhibidores de trombina, una formulación farmaceutica que las comprende, el uso de dichas prodrogas para la manufactura de un medicamento y un procedimiento para su preparacion |
US5840733A (en) * | 1996-07-01 | 1998-11-24 | Redcell, Canada, Inc. | Methods and compositions for producing novel conjugates of thrombin inhibitors and endogenous carriers resulting in anti-thrombins with extended lifetimes |
KR19990074598A (ko) * | 1998-03-12 | 1999-10-05 | 성재갑 | 고체상 반응을 이용한 벤즈아미딘 유도체의 신규한 제조방법 |
ES2312210T3 (es) | 1998-06-17 | 2009-02-16 | N.V. Organon | Composiciones antitromboticas. |
US6307090B1 (en) | 1999-01-22 | 2001-10-23 | The United States Of America As Represented By The Department Of Health And Human Services | Acylated oligopeptide derivatives having cell signal inhibiting activity |
US7226991B1 (en) * | 1999-03-23 | 2007-06-05 | United States Of America, Represented By The Secretary, Department Of Health And Human Services | Phenylalanine derivatives |
WO2000056760A1 (en) * | 1999-03-23 | 2000-09-28 | The United States Of America, Represented By Secretary, Department Of Health And Human Services | Phenylalanine derivatives |
ATE362767T1 (de) | 1999-10-22 | 2007-06-15 | Us Gov Health & Human Serv | Hemmung der zellmotilität und angiogenese mit grb2 sh2-domäne inhibitoren |
US7871981B2 (en) * | 1999-10-22 | 2011-01-18 | The United States Of America As Represented By The Department Of Health And Human Services | Inhibition of cell motility, angiogenesis, and metastasis |
TWI289566B (en) * | 1999-12-07 | 2007-11-11 | N.V.Organon | Antithrombotic compound |
US6277877B1 (en) | 2000-08-15 | 2001-08-21 | Pfizer, Inc. | Substituted n-(indole-2-carbonyl)glycinamides and derivates as glycogen phosphorylase inhibitors |
AU2001285133A1 (en) * | 2000-08-22 | 2002-03-04 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | SH2 domain binding inhibitors |
US7425537B2 (en) * | 2000-08-22 | 2008-09-16 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | SH2 domain binding inhibitors |
DE10049937A1 (de) * | 2000-10-06 | 2002-04-11 | Knoll Ag | Niedermolekulare Inhibitoren von Serinproteasen mit Polyhydroxyalkyl- und Polyhydroxycycloalkylresten |
US20040138104A1 (en) * | 2003-01-14 | 2004-07-15 | The Government Of The United States Of America Represented By The Secretary, | Peptides |
AU2003226582A1 (en) * | 2003-04-18 | 2004-11-04 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Use of beta-aminoisobutyric acid for the treatment of diseases linked to the accumulation of triglycerides and cholesterol |
DE10330900B4 (de) * | 2003-07-01 | 2006-09-14 | Leibniz-Institut Für Polymerforschung Dresden E.V. | Biomaterial mit einem modularen Beschichtungssystem zur Anwendung in Medizinprodukten mit direktem Blutkontakt |
US20050119163A1 (en) | 2003-09-18 | 2005-06-02 | The Government Of The United States Of America, As Represented By The Secretary, | SH2 domain binding inhibitors |
GB0507577D0 (en) | 2005-04-14 | 2005-05-18 | Novartis Ag | Organic compounds |
TWI389899B (zh) * | 2006-08-08 | 2013-03-21 | Msd Oss Bv | 具口服活性之凝血酶抑制劑 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE155954C (zh) * | ||||
DE235866C (zh) * | ||||
SE8203887D0 (sv) * | 1982-06-23 | 1982-06-23 | Kabivitrum Ab | Nya trombininhiberande foreningar |
PT84171B (pt) * | 1986-01-24 | 1989-03-30 | Sanofi Sa | Processo para a preparacao de derivados das n alfa-aril-sulfonilamiminoacil-p- -amidinofenil-alaninamidas, bem como dos seus derivados de sintese e das composicoes farmaceuticas que os contem |
PT84170B (pt) * | 1986-01-24 | 1989-03-30 | Sanofi Sa | Processo para a preparacao de derivados n alfa-substituidos das n alfa-aril-sulfonilaminoacil d-amidinofenil-alaninamidas |
DE4111394A1 (de) * | 1991-04-09 | 1992-10-15 | Behringwerke Ag | Amidinophenylalaninderivate, verfahren zu deren herstellung, deren verwendung und diese enthaltende mittel |
US5220050A (en) * | 1991-05-17 | 1993-06-15 | G. D. Searle & Co. | Peptide mimetic compounds useful as platelet aggregation inhibitors |
-
1991
- 1991-05-11 DE DE4115468A patent/DE4115468A1/de not_active Ceased
-
1992
- 1992-04-16 ES ES92106584T patent/ES2079719T3/es not_active Expired - Lifetime
- 1992-04-16 EP EP92106584A patent/EP0513543B1/de not_active Expired - Lifetime
- 1992-04-16 AT AT92106584T patent/ATE129503T1/de not_active IP Right Cessation
- 1992-04-16 DE DE59204094T patent/DE59204094D1/de not_active Expired - Fee Related
- 1992-04-16 DK DK92106584.3T patent/DK0513543T3/da active
- 1992-05-08 NZ NZ242668A patent/NZ242668A/en unknown
- 1992-05-08 JP JP4115555A patent/JPH089634B2/ja not_active Expired - Fee Related
- 1992-05-08 CA CA002068263A patent/CA2068263A1/en not_active Abandoned
- 1992-05-08 RU SU925011567A patent/RU2088591C1/ru active
- 1992-05-08 NO NO92921835A patent/NO921835L/no not_active Application Discontinuation
- 1992-05-08 MX MX9202166A patent/MX9202166A/es not_active IP Right Cessation
- 1992-05-08 AU AU16086/92A patent/AU651196B2/en not_active Ceased
- 1992-05-09 CN CN92103438A patent/CN1039125C/zh not_active Expired - Fee Related
- 1992-05-10 IL IL101819A patent/IL101819A/xx not_active IP Right Cessation
- 1992-05-11 KR KR1019920008047A patent/KR920021503A/ko not_active Application Discontinuation
- 1992-07-01 IE IE921491A patent/IE68884B1/en not_active IP Right Cessation
-
1994
- 1994-01-25 US US08/190,682 patent/US5457114A/en not_active Expired - Fee Related
-
1995
- 1995-06-07 US US08/475,691 patent/US5627283A/en not_active Expired - Fee Related
- 1995-11-22 GR GR950403306T patent/GR3018182T3/el unknown
-
1998
- 1998-06-22 HK HK98105873A patent/HK1006717A1/xx not_active IP Right Cessation
- 1998-10-16 CY CY9800042A patent/CY2121B1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
JPH089634B2 (ja) | 1996-01-31 |
AU651196B2 (en) | 1994-07-14 |
DK0513543T3 (da) | 1996-02-26 |
US5627283A (en) | 1997-05-06 |
MX9202166A (es) | 1992-11-01 |
NZ242668A (en) | 1994-06-27 |
KR920021503A (ko) | 1992-12-18 |
AU1608692A (en) | 1992-11-12 |
NO921835D0 (no) | 1992-05-08 |
EP0513543A1 (de) | 1992-11-19 |
IE68884B1 (en) | 1996-07-24 |
IE921491A1 (en) | 1992-11-18 |
RU2088591C1 (ru) | 1997-08-27 |
HK1006717A1 (en) | 1999-03-12 |
EP0513543B1 (de) | 1995-10-25 |
JPH05155898A (ja) | 1993-06-22 |
CY2121B1 (en) | 2002-04-26 |
CN1039125C (zh) | 1998-07-15 |
DE59204094D1 (de) | 1995-11-30 |
US5457114A (en) | 1995-10-10 |
ATE129503T1 (de) | 1995-11-15 |
NO921835L (no) | 1992-11-12 |
IL101819A0 (en) | 1992-12-30 |
ES2079719T3 (es) | 1996-01-16 |
CA2068263A1 (en) | 1992-11-12 |
DE4115468A1 (de) | 1992-11-12 |
CN1067249A (zh) | 1992-12-23 |
GR3018182T3 (en) | 1996-02-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FF | Patent granted | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
MM9K | Patent not in force due to non-payment of renewal fees |