IE913078A1 - Amino acid derivatives cyclized at the c-terminal - Google Patents

Amino acid derivatives cyclized at the c-terminal

Info

Publication number
IE913078A1
IE913078A1 IE307891A IE307891A IE913078A1 IE 913078 A1 IE913078 A1 IE 913078A1 IE 307891 A IE307891 A IE 307891A IE 307891 A IE307891 A IE 307891A IE 913078 A1 IE913078 A1 IE 913078A1
Authority
IE
Ireland
Prior art keywords
amino
compound according
indol
methyl
effective
Prior art date
Application number
IE307891A
Other languages
English (en)
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of IE913078A1 publication Critical patent/IE913078A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IE307891A 1990-08-31 1991-08-30 Amino acid derivatives cyclized at the c-terminal IE913078A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57629690A 1990-08-31 1990-08-31
US07/726,654 US5244915A (en) 1990-08-31 1991-07-12 Amico acid derivatives cyclized at the c-terminal

Publications (1)

Publication Number Publication Date
IE913078A1 true IE913078A1 (en) 1992-03-11

Family

ID=27076919

Family Applications (1)

Application Number Title Priority Date Filing Date
IE307891A IE913078A1 (en) 1990-08-31 1991-08-30 Amino acid derivatives cyclized at the c-terminal

Country Status (11)

Country Link
US (3) US5244915A (OSRAM)
EP (1) EP0546123A1 (OSRAM)
JP (1) JPH06502850A (OSRAM)
KR (1) KR930702296A (OSRAM)
AU (1) AU658377B2 (OSRAM)
CA (1) CA2088996A1 (OSRAM)
FI (1) FI930878A7 (OSRAM)
IE (1) IE913078A1 (OSRAM)
NZ (1) NZ239612A (OSRAM)
PT (1) PT98828A (OSRAM)
WO (1) WO1992004322A1 (OSRAM)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5631281A (en) * 1989-06-29 1997-05-20 Warner-Lambert Company N-substituted cycloalkyl and polycycloalkyl α-substituted Trp-Phe- and phenethylamine derivatives
US5593967A (en) * 1990-08-31 1997-01-14 Warner-Lambert Company Cholecystokinin antagonists, their preparation and therapeutic use
CA2088195A1 (en) * 1990-08-31 1992-03-01 David C. Horwell Cholecystokinin antagonists, their preparation and therapeutic use
JPH06509095A (ja) * 1991-07-12 1994-10-13 ワーナー−ランバート・コンパニー パニック発作の治療に有用なコレシストキニン拮抗薬
US5217957A (en) * 1991-08-20 1993-06-08 Warner-Lambert Company Cholecystokinin antagonists useful for treating depression
US5380872A (en) * 1992-07-14 1995-01-10 Glaxo Inc. Modulators of cholecystokinin
FR2700540B1 (fr) * 1993-01-15 1995-02-17 Irj alpha-méthyl-(R)-tryptophyl-arylcycloalkylalkylamides ligands aux récepteurs des gastrines, leur préparation et leur utilisation en thérapeutique.
US6129685A (en) * 1994-02-09 2000-10-10 The University Of Iowa Research Foundation Stereotactic hypothalamic obesity probe
US7077822B1 (en) 1994-02-09 2006-07-18 The University Of Iowa Research Foundation Stereotactic hypothalamic obesity probe
NZ266052A (en) * 1994-03-10 1999-07-29 Warner Lambert Co Tricyclodecyl ester of 1s-[2-[(2-hydroxycyclohexyl)amino]-1-(1h-indol-3-ylmethyl)-1- methyl-2-oxo ethyl]-carbamate
US5420353A (en) * 1994-03-11 1995-05-30 Merck & Co., Inc. Regiospecific process to make cis-1-amino-2-alkanol from epoxide
EP0885017A2 (en) * 1996-02-27 1998-12-23 Mallinckrodt Medical, Inc. Use of labelled cck-b receptor ligands for the detection and localization of malignant human tumours
AU2001268731A1 (en) * 2000-09-27 2002-04-08 Sarfaraz K. Niazi A combination of appetite controlling agents which create a synergy and produce a satiating result
US20060062864A1 (en) * 2000-12-28 2006-03-23 Mccleary Edward L Weight loss composition and method
CA2502209A1 (en) * 2002-10-15 2004-04-29 University Of Tennessee Research Foundation Methylene-bridged selective androgen receptor modulators and methods of use thereof
CN1897957A (zh) * 2003-11-25 2007-01-17 纽约大学西奈山医学院 尼曼－皮克病的基于陪伴分子的治疗
WO2005077915A1 (en) * 2004-02-10 2005-08-25 Janssen Pharmaceutica, N.V. Pyridazinones as antagonists of a4 integrins
US20050261302A1 (en) * 2004-04-29 2005-11-24 Hoff Ethan D Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme and their therapeutic application
US20100222316A1 (en) 2004-04-29 2010-09-02 Abbott Laboratories Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
US20050245534A1 (en) * 2004-04-29 2005-11-03 Link James T Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme
US8415354B2 (en) * 2004-04-29 2013-04-09 Abbott Laboratories Methods of use of inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
US7880001B2 (en) * 2004-04-29 2011-02-01 Abbott Laboratories Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme
US20090192198A1 (en) 2005-01-05 2009-07-30 Abbott Laboratories Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
KR101302627B1 (ko) 2005-01-05 2013-09-10 아비에 인코포레이티드 11-베타-하이드록시스테로이드 데하이드로게나제 타입 1 효소의 억제제
KR101496190B1 (ko) * 2005-01-05 2015-02-26 애브비 인코포레이티드 11-베타-하이드록시스테로이드 데하이드로게나제 타입 1 효소의 억제제로서의 아다만틸 유도체
US8198331B2 (en) * 2005-01-05 2012-06-12 Abbott Laboratories Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
JP5736098B2 (ja) 2007-08-21 2015-06-17 アッヴィ・インコーポレイテッド 中枢神経系障害を治療するための医薬組成物

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4757151A (en) * 1985-11-14 1988-07-12 Warner-Lambert Company 2-substituted-[2-substituted-amino]-N-arylalkyl-3-[indol-3-yl]
US4814463A (en) * 1985-12-31 1989-03-21 Biomeasure, Inc. CCK antagonists
JPH0761992B2 (ja) * 1987-02-06 1995-07-05 武田薬品工業株式会社 置換アミン誘導体
US4888427A (en) * 1987-04-07 1989-12-19 University Of Florida Amino acids containing dihydropyridine ring systems for site-specific delivery of peptides to the brain
US4877785A (en) * 1987-10-01 1989-10-31 G. D. Searle & Co. Non-peptidyl beta-succinamidoacyl aminodiols as anti-hypertensive agents
JPH03503650A (ja) * 1988-04-05 1991-08-15 アボツト・ラボラトリーズ Ｃｃｋアンタゴニストとしてのトリプトファン誘導体
NZ234264A (en) * 1989-06-29 1993-05-26 Warner Lambert Co N-substituted cycloalkyl and polycycloalkyl alpha-substituted trp-phe- and phenethylamine derivatives, and pharmaceutical compositions
FR2700540B1 (fr) * 1993-01-15 1995-02-17 Irj alpha-méthyl-(R)-tryptophyl-arylcycloalkylalkylamides ligands aux récepteurs des gastrines, leur préparation et leur utilisation en thérapeutique.

Also Published As

Publication number Publication date
EP0546123A1 (en) 1993-06-16
AU658377B2 (en) 1995-04-13
EP0546123A4 (OSRAM) 1994-04-27
FI930878A0 (fi) 1993-02-26
WO1992004322A1 (en) 1992-03-19
JPH06502850A (ja) 1994-03-31
FI930878L (fi) 1993-04-16
AU8866191A (en) 1992-03-30
US5244915A (en) 1993-09-14
US5397788A (en) 1995-03-14
CA2088996A1 (en) 1992-03-01
NZ239612A (en) 1994-02-25
PT98828A (pt) 1992-07-31
KR930702296A (ko) 1993-09-08
US5523306A (en) 1996-06-04
FI930878A7 (fi) 1993-04-16

Similar Documents

Publication Publication Date Title
AU658377B2 (en) Alpha-substituted tryptophane dipeptoid derivatives
AU644088B2 (en) N-substituted cycloalkyl and polycycloalkyl alpha-substituted Trp-Phe- and phenethylamine derivatives
US5622983A (en) N-substituted cycloalkyl and polycycloalkyl α-substituted Trp-Phe- and phenethylamine derivatives
EP0546108B1 (en) Pro-drugs for cck antagonists
US5574013A (en) N-substituted cycloalkyl and polycycloalkyl alpha-substituted Trp derivatives
IE67290B1 (en) Novel cholecystokinin antagonists their preparation and therapeutic use
US5278316A (en) N-substituted cycloalkyl and polycycloalkyl alpha-substituted Trp-Phe- and phenethylamine derivatives
US5244905A (en) N-substituted cycloalkyl and polycycloalkyl polyhydro-β-carboline-phenylalanine- and phenethylamine derivatives
US5340825A (en) Pro drugs for CCK antagonists
US5218123A (en) Didehydrotryptophan derivatives and pharmaceutical use thereof
AU651390C (en) Novel cholecystokinin antagonists, their preparation and therapeutic use
WO1995024389A1 (en) Indole derivatives as cck receptor antagonists