IE791026L - Cephalosporin derivatives. - Google Patents

Cephalosporin derivatives.

Info

Publication number
IE791026L
IE791026L IE791026A IE102679A IE791026L IE 791026 L IE791026 L IE 791026L IE 791026 A IE791026 A IE 791026A IE 102679 A IE102679 A IE 102679A IE 791026 L IE791026 L IE 791026L
Authority
IE
Ireland
Prior art keywords
antibiotics
cephalosporin derivatives
formula
toxic
cephalosporin
Prior art date
Application number
IE791026A
Other versions
IE49174B1 (en
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of IE791026L publication Critical patent/IE791026L/en
Publication of IE49174B1 publication Critical patent/IE49174B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/587—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with aliphatic hydrocarbon radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms, said aliphatic radicals being substituted in the alpha-position to the ring by a hetero atom, e.g. with m >= 0, Z being a singly or a doubly bound hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Cephalosporin antibiotics of general formula (I) (wherein Ra and Rb, which may be the same or different, each represent a C1-4 alkyl group or Ra and Rb together with the carbon atom to which they are attached form a C3-7 cycloalkylidene group) exhibit broad spectrum antibiotic activity, particularly high activity against members of the Enterobacteriaceae, The invention also includes the non-toxic salts and non-toxic metabolically labile esters of compounds of formula (I), Also described are compositions containing the antibiotics of the invention and processes for the preparation of the antibiotics, [CA1130279A]
IE1026/79A 1978-05-26 1979-08-08 Cephalosporin antibiotics IE49174B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB2291478 1978-05-26
GB2291078 1978-05-26

Publications (2)

Publication Number Publication Date
IE791026L true IE791026L (en) 1979-11-26
IE49174B1 IE49174B1 (en) 1985-08-21

Family

ID=26256188

Family Applications (1)

Application Number Title Priority Date Filing Date
IE1026/79A IE49174B1 (en) 1978-05-26 1979-08-08 Cephalosporin antibiotics

Country Status (13)

Country Link
AT (1) AT365597B (en)
AU (1) AU524692B2 (en)
CA (1) CA1130279A (en)
CH (1) CH646705A5 (en)
DE (1) DE2921344A1 (en)
DK (1) DK217079A (en)
ES (1) ES480920A1 (en)
FR (1) FR2426692A1 (en)
IE (1) IE49174B1 (en)
IT (1) IT1116187B (en)
NL (1) NL7904126A (en)
NZ (1) NZ190556A (en)
SE (1) SE438508B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE878514A (en) * 1978-09-04 1980-02-29 Fujisawa Pharmaceutical Co PROCESS FOR THE PREPARATION OF 3-CEPHEM-4-CARBOXYLIC ACID COMPOUNDS WITH DISUBSTITUTION IN POSITIONS 3 AND 7, NOVEL PRODUCTS THUS OBTAINED AND THEIR USE FOR THEIR ANTIBACTERIAL ACTIVITY
US4237128A (en) * 1979-04-12 1980-12-02 E. R. Squibb & Sons, Inc. 7-[2-(2-Amino-4-thiazolyl)-2-[(1-carboxy-1,1-dialkyl)alkoxyimino]acetamido]cephem sulfoxides

Also Published As

Publication number Publication date
SE7904578L (en) 1979-11-27
ES480920A1 (en) 1980-02-01
AU4742179A (en) 1979-11-29
AU524692B2 (en) 1982-09-30
ATA383679A (en) 1981-06-15
DK217079A (en) 1979-11-27
AT365597B (en) 1982-01-25
CA1130279A (en) 1982-08-24
IE49174B1 (en) 1985-08-21
NL7904126A (en) 1979-11-28
SE438508B (en) 1985-04-22
IT7949180A0 (en) 1979-05-25
DE2921344A1 (en) 1979-12-06
CH646705A5 (en) 1984-12-14
FR2426692A1 (en) 1979-12-21
NZ190556A (en) 1982-05-25
FR2426692B1 (en) 1983-01-07
IT1116187B (en) 1986-02-10

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