IE792070L - Cephalosporin derivatives. - Google Patents
Cephalosporin derivatives.Info
- Publication number
- IE792070L IE792070L IE792070A IE207079A IE792070L IE 792070 L IE792070 L IE 792070L IE 792070 A IE792070 A IE 792070A IE 207079 A IE207079 A IE 207079A IE 792070 L IE792070 L IE 792070L
- Authority
- IE
- Ireland
- Prior art keywords
- antibiotics
- alkyl group
- activity against
- high activity
- formula
- Prior art date
Links
- 229930186147 Cephalosporin Natural products 0.000 title abstract 2
- 229940124587 cephalosporin Drugs 0.000 title abstract 2
- 150000001780 cephalosporins Chemical class 0.000 title abstract 2
- 239000003242 anti bacterial agent Substances 0.000 abstract 3
- 229940088710 antibiotic agent Drugs 0.000 abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 231100000252 nontoxic Toxicity 0.000 abstract 2
- 230000003000 nontoxic effect Effects 0.000 abstract 2
- 241000588921 Enterobacteriaceae Species 0.000 abstract 1
- 241000589516 Pseudomonas Species 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/587—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with aliphatic hydrocarbon radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms, said aliphatic radicals being substituted in the alpha-position to the ring by a hetero atom, e.g. with m >= 0, Z being a singly or a doubly bound hetero atom
Abstract
Cephalosporin antibiotics of general formula <IMAGE> (wherein R<a> and R<b>, which may be the same or different, each represent a C1-4 alkyl group or R<a> and R<b> together with the carbon atom to which they are attached from a C3-7 cycloalkylidene group; and R<1> represents a C1-4 alkyl group) exhibit broad spectrum antibiotic activity with unusually high activity against strains of Pseudomonas organisms as well as high activity against various members of the Enterobacteriaceae. The invention also includes the non-toxic salts and non-toxic metabolically labile esters of compounds of formula (I). Also described are compositions containing the antibiotics of the invention and processes for the preparation of the antibiotics.
[GB2036724A]
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7842165 | 1978-10-27 | ||
| GB7842164 | 1978-10-27 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE792070L true IE792070L (en) | 1980-04-27 |
| IE49100B1 IE49100B1 (en) | 1985-07-24 |
Family
ID=26269350
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE2070/79A IE49100B1 (en) | 1978-10-27 | 1979-10-26 | Cephalosporin compounds |
Country Status (13)
| Country | Link |
|---|---|
| AT (1) | AT369009B (en) |
| CA (1) | CA1130280A (en) |
| CH (1) | CH644868A5 (en) |
| DE (1) | DE2943427A1 (en) |
| DK (1) | DK452679A (en) |
| ES (3) | ES485440A1 (en) |
| FR (1) | FR2439786A1 (en) |
| GB (1) | GB2036724B (en) |
| IE (1) | IE49100B1 (en) |
| IT (1) | IT1126819B (en) |
| NL (1) | NL7907882A (en) |
| NZ (1) | NZ191937A (en) |
| SE (1) | SE7908896L (en) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GR78245B (en) * | 1980-09-12 | 1984-09-26 | Ciba Geigy Ag | |
| KR860000487B1 (en) * | 1980-09-25 | 1986-04-30 | 도야마 가가꾸 고오교 가부시끼가이샤 | Process for preparing cephalosporins |
| NZ198350A (en) * | 1980-09-25 | 1985-02-28 | Toyama Chemical Co Ltd | Cephalosporins and intermediates;pharmaceutical compositions |
| DE3279470D1 (en) * | 1981-04-03 | 1989-04-06 | Fujisawa Pharmaceutical Co | New cephem compounds, processes for their preparation, pharmaceutical compositions containing them and their starting compounds |
| FR2533216A1 (en) * | 1982-09-22 | 1984-03-23 | Toyama Chemical Co Ltd | New cephalosporins and their salts. |
| DE3336757A1 (en) * | 1983-10-08 | 1985-04-25 | Hoechst Ag, 6230 Frankfurt | CEPHALOSPORINE DERIVATIVES AND METHOD FOR THEIR PRODUCTION |
| ATE82976T1 (en) * | 1985-09-03 | 1992-12-15 | Otsuka Kagaku Kk | CEPHALOSPORIN DERIVATIVES. |
| US4826834A (en) * | 1985-09-27 | 1989-05-02 | Takeda Chemical Industries, Ltd. | Cephem compounds |
| CN86107947A (en) * | 1985-11-22 | 1987-05-27 | 藤沢药品工业株式会社 | New cephem compounds and preparation method thereof |
| KR930009796B1 (en) * | 1991-05-25 | 1993-10-11 | 주식회사 대웅제약 | Cephalosporin derivatives |
| CN114105903B (en) * | 2021-12-16 | 2023-06-27 | 河北合佳医药科技集团股份有限公司 | Preparation method of high-purity desmethyl aminothiaoxime |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LU71550A1 (en) * | 1973-12-21 | 1976-04-13 | ||
| GB1496757A (en) * | 1973-12-21 | 1978-01-05 | Glaxo Lab Ltd | Cephalosporin derivatives |
| NO750810L (en) * | 1974-03-20 | 1975-09-23 | Hoeganaes Ab | |
| DK154939C (en) * | 1974-12-19 | 1989-06-12 | Takeda Chemical Industries Ltd | METHOD OF ANALOGUE FOR THE PREPARATION OF THIAZOLYLACETAMIDO-CEPHEM COMPOUNDS OR PHARMACEUTICAL ACCEPTABLE SALTS OR ESTERS THEREOF |
-
1979
- 1979-10-26 DK DK452679A patent/DK452679A/en not_active Application Discontinuation
- 1979-10-26 NL NL7907882A patent/NL7907882A/en not_active Application Discontinuation
- 1979-10-26 CH CH964579A patent/CH644868A5/en not_active IP Right Cessation
- 1979-10-26 IE IE2070/79A patent/IE49100B1/en unknown
- 1979-10-26 SE SE7908896A patent/SE7908896L/en not_active Application Discontinuation
- 1979-10-26 ES ES485440A patent/ES485440A1/en not_active Expired
- 1979-10-26 NZ NZ191937A patent/NZ191937A/en unknown
- 1979-10-26 IT IT50680/79A patent/IT1126819B/en active
- 1979-10-26 ES ES485439A patent/ES485439A1/en not_active Expired
- 1979-10-26 FR FR7926634A patent/FR2439786A1/en active Granted
- 1979-10-26 GB GB7937305A patent/GB2036724B/en not_active Expired
- 1979-10-26 CA CA338,576A patent/CA1130280A/en not_active Expired
- 1979-10-26 ES ES485441A patent/ES485441A1/en not_active Expired
- 1979-10-26 DE DE19792943427 patent/DE2943427A1/en not_active Withdrawn
- 1979-10-29 AT AT0698079A patent/AT369009B/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CH644868A5 (en) | 1984-08-31 |
| GB2036724A (en) | 1980-07-02 |
| CA1130280A (en) | 1982-08-24 |
| IT1126819B (en) | 1986-05-21 |
| SE7908896L (en) | 1980-04-28 |
| NZ191937A (en) | 1982-09-07 |
| DK452679A (en) | 1980-04-28 |
| NL7907882A (en) | 1980-04-29 |
| IT7950680A0 (en) | 1979-10-26 |
| ES485439A1 (en) | 1980-07-01 |
| AT369009B (en) | 1982-11-25 |
| FR2439786B1 (en) | 1983-05-20 |
| GB2036724B (en) | 1983-01-19 |
| FR2439786A1 (en) | 1980-05-23 |
| DE2943427A1 (en) | 1980-05-08 |
| IE49100B1 (en) | 1985-07-24 |
| ES485440A1 (en) | 1980-07-01 |
| ATA698079A (en) | 1982-04-15 |
| ES485441A1 (en) | 1980-07-01 |
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