IE782189L - 4-desacetoxy-4ó-hydroxyindole-dihydroindoles - Google Patents

4-desacetoxy-4ó-hydroxyindole-dihydroindoles

Info

Publication number
IE782189L
IE782189L IE782189A IE218978A IE782189L IE 782189 L IE782189 L IE 782189L IE 782189 A IE782189 A IE 782189A IE 218978 A IE218978 A IE 218978A IE 782189 L IE782189 L IE 782189L
Authority
IE
Ireland
Prior art keywords
taken together
nhnh2
dihydroindoles
desacetoxy
hydroxyindole
Prior art date
Application number
IE782189A
Other versions
IE47489B1 (en
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/848,837 external-priority patent/US4122082A/en
Priority claimed from US05/890,422 external-priority patent/US4195022A/en
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Priority to IE401/83A priority Critical patent/IE47490B1/en
Publication of IE782189L publication Critical patent/IE782189L/en
Publication of IE47489B1 publication Critical patent/IE47489B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Novel compounds of the formula <IMAGE> wherein R<2> is CH3 or CHO; when taken singly R<5> is H and one of R<3> and R<4> is OH or H and the other is C2H5, and when taken together R<4> and R<5> form an alpha - epoxide ring and R<3> is C2H5; when taken together R<6> is H and R<7> is OR' and when taken together R<6> and R<7> are oxo; R<1> is H or acetyl and R is OCH3 or NHNH2 with the proviso that if R is NHNH2, R' is H; and pharmaceutically acceptable acid addition salts thereof, which may be prepared by oxidation of the 4 beta - hydroxy compound optionally followed by modification of the oxo group formed, are useful as antimitotic agents. [GB2012260A]
IE2189/78A 1977-11-07 1978-11-06 4-desacetoxy-4a-hydroxyindole-dihydroindoles,pharmaceutical formulations containing them and their use as antimitotic agents IE47489B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IE401/83A IE47490B1 (en) 1977-11-07 1978-11-06 4-desacetoxy-oxo-indole-dihydroindole intermediates

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US05/848,837 US4122082A (en) 1977-11-07 1977-11-07 4-Desacetoxy-4-oxovinblastine
US05/890,422 US4195022A (en) 1978-03-27 1978-03-27 4-Desacetoxy-4α-hydroxyvinblastine and related compounds

Publications (2)

Publication Number Publication Date
IE782189L true IE782189L (en) 1979-05-07
IE47489B1 IE47489B1 (en) 1984-04-04

Family

ID=27126805

Family Applications (1)

Application Number Title Priority Date Filing Date
IE2189/78A IE47489B1 (en) 1977-11-07 1978-11-06 4-desacetoxy-4a-hydroxyindole-dihydroindoles,pharmaceutical formulations containing them and their use as antimitotic agents

Country Status (11)

Country Link
JP (1) JPS5473796A (en)
AR (1) AR227620A1 (en)
CH (1) CH638814A5 (en)
DK (1) DK147302C (en)
FR (1) FR2407935A1 (en)
GB (2) GB2089806B (en)
HU (1) HU184623B (en)
IE (1) IE47489B1 (en)
IL (1) IL55865A (en)
IT (1) IT1100920B (en)
LU (1) LU80474A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU185691B (en) * 1982-02-09 1985-03-28 Richter Gedeon Vegyeszet Process for preparing a new analgetic pharmaceutical composition
FR2894966B1 (en) * 2005-12-20 2008-03-14 Pierre Fabre Medicament Sa NEW CRYSTALLINE FORM OF VINFLUNINE
USD973040S1 (en) * 2020-11-06 2022-12-20 Lite-On Electronics (Guangzhou) Limited Antenna monitoring tool box

Also Published As

Publication number Publication date
IL55865A (en) 1982-11-30
GB2012260B (en) 1982-11-03
GB2089806B (en) 1982-11-24
DK494178A (en) 1979-05-08
GB2089806A (en) 1982-06-30
CH638814A5 (en) 1983-10-14
IL55865A0 (en) 1979-01-31
DK147302B (en) 1984-06-12
GB2012260A (en) 1979-07-25
FR2407935A1 (en) 1979-06-01
IE47489B1 (en) 1984-04-04
DK147302C (en) 1985-01-02
JPS5473796A (en) 1979-06-13
HU184623B (en) 1984-09-28
FR2407935B1 (en) 1981-06-26
AR227620A1 (en) 1982-11-30
IT1100920B (en) 1985-09-28
LU80474A1 (en) 1979-03-19
IT7829435A0 (en) 1978-11-03

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