FR2407935A1 - 4-DESACETOXY-4A-HYDROXYINDOLE-DIHYDROINDOLES DIMERES AND THEIR THERAPEUTIC USE - Google Patents

4-DESACETOXY-4A-HYDROXYINDOLE-DIHYDROINDOLES DIMERES AND THEIR THERAPEUTIC USE

Info

Publication number
FR2407935A1
FR2407935A1 FR7831134A FR7831134A FR2407935A1 FR 2407935 A1 FR2407935 A1 FR 2407935A1 FR 7831134 A FR7831134 A FR 7831134A FR 7831134 A FR7831134 A FR 7831134A FR 2407935 A1 FR2407935 A1 FR 2407935A1
Authority
FR
France
Prior art keywords
dimeres
dihydroindoles
desacetoxy
hydroxyindole
therapeutic use
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7831134A
Other languages
French (fr)
Other versions
FR2407935B1 (en
Inventor
Ian Glaisby Wright
Norbert Neuss
Gerald Lee Thompson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/848,837 external-priority patent/US4122082A/en
Priority claimed from US05/890,422 external-priority patent/US4195022A/en
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of FR2407935A1 publication Critical patent/FR2407935A1/en
Application granted granted Critical
Publication of FR2407935B1 publication Critical patent/FR2407935B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

INDOLE-DIHYDROINDOLE DE FORMULE: (CF DESSIN DANS BOPI) DANS LAQUELLE: R EST CH OU CHO; QUAND IL EST PRIS INDEPENDAMMENT, R EST H ET L'UN DE R ET R EST OH OU H ET L'AUTRE EST CH ET QUAND R ET R SONT PRIS ENSEMBLE, ILS FORMENT UN CYCLE A-EPOXYDE ET R EST UN GROUPEMENT CH; QUAND IL EST PRIS SEPAREMENT, R EST H, ET R EST OR ET QUAND R ET R SONT PRIS ENSEMBLE, ILS FORMENT UN SUBSTITUANT O; R EST H OU UN GROUPEMENT ACETYLE; ET R EST OCH OU NH-NH, POURVU QUE, QUAND R EST NH-NH, R SOIT H; ET SES SELS D'ADDITION D'ACIDE PHARMACEUTIQUEMENT ACCEPTABLES. LES COMPOSES DANS LESQUELS R EST UN GROUPEMENT OR ONT UNE ACTIVITE ANTI-TUMORALE.INDOLE-DIHYDROINDOLE OF FORMULA: (CF DRAWING IN BOPI) IN WHICH: R IS CH OR CHO; WHEN IT IS TAKEN INDEPENDENTLY, R IS H AND ONE OF R AND R IS OH OR H AND THE OTHER IS CH AND WHEN R AND R ARE TAKEN TOGETHER, THEY FORM AN A-EPOXIDE CYCLE AND R IS A CH GROUP; WHEN IT IS TAKEN SEPARATELY, R IS H, AND R IS OR AND WHEN R AND R ARE TAKEN TOGETHER, THEY FORM A SUBSTITUTE O; R IS H OR AN ACETYL GROUP; AND R IS OCH OR NH-NH, PROVIDED THAT WHEN R IS NH-NH, R IS H; AND ITS PHARMACEUTICALLY ACCEPTABLE ACID ADDITIONAL SALTS. THE COMPOUNDS IN WHICH R IS A GOLD GROUP HAVE ANTI-TUMOR ACTIVITY.

FR7831134A 1977-11-07 1978-11-03 4-DESACETOXY-4A-HYDROXYINDOLE-DIHYDROINDOLES DIMERES AND THEIR THERAPEUTIC USE Granted FR2407935A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US05/848,837 US4122082A (en) 1977-11-07 1977-11-07 4-Desacetoxy-4-oxovinblastine
US05/890,422 US4195022A (en) 1978-03-27 1978-03-27 4-Desacetoxy-4α-hydroxyvinblastine and related compounds

Publications (2)

Publication Number Publication Date
FR2407935A1 true FR2407935A1 (en) 1979-06-01
FR2407935B1 FR2407935B1 (en) 1981-06-26

Family

ID=27126805

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7831134A Granted FR2407935A1 (en) 1977-11-07 1978-11-03 4-DESACETOXY-4A-HYDROXYINDOLE-DIHYDROINDOLES DIMERES AND THEIR THERAPEUTIC USE

Country Status (11)

Country Link
JP (1) JPS5473796A (en)
AR (1) AR227620A1 (en)
CH (1) CH638814A5 (en)
DK (1) DK147302C (en)
FR (1) FR2407935A1 (en)
GB (2) GB2089806B (en)
HU (1) HU184623B (en)
IE (1) IE47489B1 (en)
IL (1) IL55865A (en)
IT (1) IT1100920B (en)
LU (1) LU80474A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU185691B (en) * 1982-02-09 1985-03-28 Richter Gedeon Vegyeszet Process for preparing a new analgetic pharmaceutical composition
FR2894966B1 (en) * 2005-12-20 2008-03-14 Pierre Fabre Medicament Sa NEW CRYSTALLINE FORM OF VINFLUNINE
USD973040S1 (en) * 2020-11-06 2022-12-20 Lite-On Electronics (Guangzhou) Limited Antenna monitoring tool box

Also Published As

Publication number Publication date
IL55865A0 (en) 1979-01-31
HU184623B (en) 1984-09-28
CH638814A5 (en) 1983-10-14
IE47489B1 (en) 1984-04-04
DK147302B (en) 1984-06-12
GB2012260B (en) 1982-11-03
AR227620A1 (en) 1982-11-30
GB2089806A (en) 1982-06-30
GB2089806B (en) 1982-11-24
JPS5473796A (en) 1979-06-13
DK494178A (en) 1979-05-08
DK147302C (en) 1985-01-02
IT7829435A0 (en) 1978-11-03
FR2407935B1 (en) 1981-06-26
GB2012260A (en) 1979-07-25
IL55865A (en) 1982-11-30
IE782189L (en) 1979-05-07
IT1100920B (en) 1985-09-28
LU80474A1 (en) 1979-03-19

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Date Code Title Description
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