IE781550L - Bis-(tetrahydroisoquinolinium) salt; neuromuscular blocking¹agent - Google Patents
Bis-(tetrahydroisoquinolinium) salt; neuromuscular blocking¹agentInfo
- Publication number
- IE781550L IE781550L IE781550A IE155078A IE781550L IE 781550 L IE781550 L IE 781550L IE 781550 A IE781550 A IE 781550A IE 155078 A IE155078 A IE 155078A IE 781550 L IE781550 L IE 781550L
- Authority
- IE
- Ireland
- Prior art keywords
- carbon atoms
- image
- pharmaceutically acceptable
- tetrahydroisoquinolinium
- neuromuscular
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/18—Aralkyl radicals
- C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Short acting reversible neuromuscular blocking agents of the formula: <IMAGE> where B and C are para or preferably meta, and each is <IMAGE> where m is 2, 3 or 4 and is preferably 2, R1, R2, R3, R4, R5, R6 and R7 are the same or different and are hydrogen or alkoxy of 1 to 4 carbon atoms, Y is alkyl of 1 to 4 carbon atoms, n is 2, 3 or 4, most preferably 3, provided that at least one of R1 to R4 and one of R5 to R7 is lower alkoxy, and X is a pharmaceutically acceptable anion are useful upon administration to a patient in providing muscular relaxation in the patient during surgery and are normally intravenously administered in a pharmaceutically acceptable carrier.
[GB2002758A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US82079477A | 1977-08-01 | 1977-08-01 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE781550L true IE781550L (en) | 1979-02-01 |
| IE47014B1 IE47014B1 (en) | 1983-11-30 |
Family
ID=25231743
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1550/78A IE47014B1 (en) | 1977-08-01 | 1978-07-31 | Neuromuscular blocking agents |
Country Status (21)
| Country | Link |
|---|---|
| JP (1) | JPS5455577A (en) |
| AT (1) | AT368496B (en) |
| AU (1) | AU523706B2 (en) |
| BE (1) | BE869415A (en) |
| CA (1) | CA1113096A (en) |
| DD (1) | DD143254A5 (en) |
| DE (1) | DE2833505A1 (en) |
| DK (1) | DK339078A (en) |
| ES (1) | ES472229A1 (en) |
| FI (1) | FI782363A (en) |
| FR (1) | FR2399429A1 (en) |
| GB (1) | GB2002758B (en) |
| IE (1) | IE47014B1 (en) |
| IL (1) | IL55254A (en) |
| LU (1) | LU80062A1 (en) |
| MC (1) | MC1197A1 (en) |
| NL (1) | NL7808067A (en) |
| PL (1) | PL121492B1 (en) |
| SE (1) | SE7808267L (en) |
| SU (1) | SU862820A3 (en) |
| ZA (1) | ZA784331B (en) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1125287A (en) * | 1978-07-21 | 1982-06-08 | John J. Savarese | Bis isoquinolinium compositions and methods of use |
| US4235906A (en) | 1978-07-21 | 1980-11-25 | Massachusetts General Hospital | Bis-isoquinolinium compounds, compositions and methods of use |
| JPS5645459A (en) * | 1979-09-20 | 1981-04-25 | Otsuka Pharmaceut Co Ltd | Cyclic amine |
| JPS5899465A (en) * | 1981-11-23 | 1983-06-13 | ザ・ウエルカム・フアウンデ−シヨン・リミテツド | Isoquinoline derivative |
| GB8418303D0 (en) * | 1984-07-18 | 1984-08-22 | Wellcome Found | Compounds |
| JPH0555438A (en) * | 1991-08-26 | 1993-03-05 | Rohm Co Ltd | Lead terminal structure of electronic component |
| AU745382B2 (en) * | 1997-03-25 | 2002-03-21 | Cornell Research Foundation Inc. | Substituted isoquinolines as ultra short acting neuromuscular blockers |
| ATE554769T1 (en) * | 2006-12-06 | 2012-05-15 | Cornell Res Foundation Inc | MEDIUM-DURING NEUROMUSCULAR BLOCKERS AND ANTAGONISTS ADVON |
| US8592451B2 (en) | 2009-03-17 | 2013-11-26 | Cornell University | Reversible nondepolarizing neuromuscular blockade agents and methods for their use |
| WO2011022491A1 (en) | 2009-08-19 | 2011-02-24 | Cornell University | Cysteine for physiological injection |
| CN114057642B (en) * | 2021-12-10 | 2023-03-28 | 广东嘉博制药有限公司 | Synthetic method of mickey ammonium chloride intermediate |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5156762U (en) * | 1974-10-28 | 1976-05-04 |
-
1978
- 1978-07-31 BE BE189624A patent/BE869415A/en not_active IP Right Cessation
- 1978-07-31 ES ES472229A patent/ES472229A1/en not_active Expired
- 1978-07-31 CA CA308,434A patent/CA1113096A/en not_active Expired
- 1978-07-31 AU AU38476/78A patent/AU523706B2/en not_active Expired
- 1978-07-31 NL NL787808067A patent/NL7808067A/en not_active Application Discontinuation
- 1978-07-31 SE SE7808267A patent/SE7808267L/en unknown
- 1978-07-31 LU LU80062A patent/LU80062A1/en unknown
- 1978-07-31 JP JP9353778A patent/JPS5455577A/en active Pending
- 1978-07-31 DD DD78207041A patent/DD143254A5/en unknown
- 1978-07-31 GB GB7831697A patent/GB2002758B/en not_active Expired
- 1978-07-31 IE IE1550/78A patent/IE47014B1/en unknown
- 1978-07-31 IL IL55254A patent/IL55254A/en unknown
- 1978-07-31 ZA ZA00784331A patent/ZA784331B/en unknown
- 1978-07-31 FI FI782363A patent/FI782363A/en not_active Application Discontinuation
- 1978-07-31 MC MC781316A patent/MC1197A1/en unknown
- 1978-07-31 SU SU782646252A patent/SU862820A3/en active
- 1978-07-31 DK DK339078A patent/DK339078A/en not_active Application Discontinuation
- 1978-07-31 AT AT0555478A patent/AT368496B/en not_active IP Right Cessation
- 1978-07-31 DE DE19782833505 patent/DE2833505A1/en not_active Withdrawn
- 1978-07-31 FR FR7822577A patent/FR2399429A1/en active Granted
- 1978-07-31 PL PL1978208757A patent/PL121492B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| LU80062A1 (en) | 1979-05-15 |
| FI782363A (en) | 1979-02-02 |
| DK339078A (en) | 1979-02-02 |
| BE869415A (en) | 1979-01-31 |
| PL208757A1 (en) | 1979-06-04 |
| PL121492B1 (en) | 1982-05-31 |
| ATA555478A (en) | 1982-02-15 |
| IE47014B1 (en) | 1983-11-30 |
| AU3847678A (en) | 1980-02-07 |
| JPS5455577A (en) | 1979-05-02 |
| AU523706B2 (en) | 1982-08-12 |
| DE2833505A1 (en) | 1979-04-05 |
| NL7808067A (en) | 1979-02-05 |
| ES472229A1 (en) | 1979-03-16 |
| CA1113096A (en) | 1981-11-24 |
| ZA784331B (en) | 1979-12-27 |
| MC1197A1 (en) | 1979-03-19 |
| SU862820A3 (en) | 1981-09-07 |
| IL55254A (en) | 1983-03-31 |
| SE7808267L (en) | 1979-02-02 |
| IL55254A0 (en) | 1978-09-29 |
| FR2399429B1 (en) | 1981-07-17 |
| GB2002758B (en) | 1982-02-03 |
| AT368496B (en) | 1982-10-11 |
| DD143254A5 (en) | 1980-08-13 |
| FR2399429A1 (en) | 1979-03-02 |
| GB2002758A (en) | 1979-02-28 |
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