IE76322B1 - Use of phenylethanolaminotetralines for preparing antidepressant and anti-stress medicines - Google Patents
Use of phenylethanolaminotetralines for preparing antidepressant and anti-stress medicinesInfo
- Publication number
- IE76322B1 IE76322B1 IE419591A IE419591A IE76322B1 IE 76322 B1 IE76322 B1 IE 76322B1 IE 419591 A IE419591 A IE 419591A IE 419591 A IE419591 A IE 419591A IE 76322 B1 IE76322 B1 IE 76322B1
- Authority
- IE
- Ireland
- Prior art keywords
- formula
- compound
- stress
- compounds
- group
- Prior art date
Links
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- 229940079593 drug Drugs 0.000 title abstract 2
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- 229960002510 mandelic acid Drugs 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 229940098779 methanesulfonic acid Drugs 0.000 description 1
- WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 description 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 description 1
- 239000010445 mica Substances 0.000 description 1
- 229910052618 mica group Inorganic materials 0.000 description 1
- 239000004530 micro-emulsion Substances 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 150000007530 organic bases Chemical class 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229940068917 polyethylene glycols Drugs 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 229960003415 propylparaben Drugs 0.000 description 1
- LVTJOONKWUXEFR-FZRMHRINSA-N protoneodioscin Natural products O(C[C@@H](CC[C@]1(O)[C@H](C)[C@@H]2[C@]3(C)[C@H]([C@H]4[C@@H]([C@]5(C)C(=CC4)C[C@@H](O[C@@H]4[C@H](O[C@H]6[C@@H](O)[C@@H](O)[C@@H](O)[C@H](C)O6)[C@@H](O)[C@H](O[C@H]6[C@@H](O)[C@@H](O)[C@@H](O)[C@H](C)O6)[C@H](CO)O4)CC5)CC3)C[C@@H]2O1)C)[C@H]1[C@H](O)[C@H](O)[C@H](O)[C@@H](CO)O1 LVTJOONKWUXEFR-FZRMHRINSA-N 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
- 230000036280 sedation Effects 0.000 description 1
- 230000001624 sedative effect Effects 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- -1 sodium or potassium Chemical class 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
- 239000008247 solid mixture Substances 0.000 description 1
- 230000002048 spasmolytic effect Effects 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 239000008174 sterile solution Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 230000006794 tachycardia Effects 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000003384 transverse colon Anatomy 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9015171A FR2669821A1 (fr) | 1990-12-04 | 1990-12-04 | Utilisation de phenylethanolaminotetralines pour la preparation de medicaments destines au traitement de la depression. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE914195A1 IE914195A1 (en) | 1992-06-17 |
| IE76322B1 true IE76322B1 (en) | 1997-10-22 |
Family
ID=9402882
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE419591A IE76322B1 (en) | 1990-12-04 | 1991-12-03 | Use of phenylethanolaminotetralines for preparing antidepressant and anti-stress medicines |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US5270341A (https=) |
| EP (1) | EP0489640B1 (https=) |
| JP (1) | JP2610735B2 (https=) |
| AT (1) | ATE143592T1 (https=) |
| AU (1) | AU653968B2 (https=) |
| CA (1) | CA2056906C (https=) |
| DE (1) | DE69122480T2 (https=) |
| DK (1) | DK0489640T3 (https=) |
| FR (1) | FR2669821A1 (https=) |
| HU (1) | HU207793B (https=) |
| IE (1) | IE76322B1 (https=) |
| MX (1) | MX9102365A (https=) |
| SG (1) | SG47450A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2826651B1 (fr) * | 2001-06-28 | 2005-09-02 | Sanofi Synthelabo | Forme cristalline d'une phenylethanolamine, sa preparation et compositions pharmaceutiques la contenant |
| EP1623705A1 (en) * | 2004-07-09 | 2006-02-08 | Sanofi-Aventis | Use of phenylethanolaminotetralines for preparing anxiolytic drugs |
| FR2890862B1 (fr) * | 2005-09-19 | 2008-01-25 | Sanofi Aventis Sa | Association d'agoniste aux recepteurs beta 3 et d'inhibiteur de la recapture de monoamnies, compostion pharmaceutique la contenant et son utilisation en therapeutique. |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH637363A5 (en) * | 1977-11-24 | 1983-07-29 | Sandoz Ag | Process for preparing novel 2-aminotetralins |
| FR2584712B1 (fr) * | 1985-07-10 | 1987-11-27 | Midy Spa | Phenylethanolamines a activite lipolytique, un procede pour leur preparation et compositions pharmaceutiques en contenant |
| IL79323A (en) * | 1985-07-10 | 1990-03-19 | Sanofi Sa | Phenylethanolaminotetralines,their preparation and pharmaceutical compositions containing them |
| US4927955A (en) * | 1987-08-12 | 1990-05-22 | Sanofi | Process for the O-alkylation of N-(hydroxy)aralkylphenylethanolamines |
| DE3872100T2 (de) * | 1987-08-12 | 1993-01-28 | Sanofi Elf | Verfahren zur herstellung von phenylaethanolaminotetralinen. |
| EP0452390B1 (en) * | 1989-01-09 | 1994-10-26 | The Upjohn Company | Halo substituted aminotetralins |
| FR2643076B1 (fr) * | 1989-02-14 | 1991-06-21 | Midy Spa | Carboxyalkyl-ethers de la 2-amino-7-hydroxytetraline |
| DE69028877T2 (de) * | 1989-06-13 | 1997-02-27 | Sanofi Sa | Verwendung von Phenylethanolaminen zur Herstellung von Medikamenten gegen Augenleiden |
-
1990
- 1990-12-04 FR FR9015171A patent/FR2669821A1/fr active Granted
-
1991
- 1991-12-03 SG SG1996001786A patent/SG47450A1/en unknown
- 1991-12-03 DK DK91403263.6T patent/DK0489640T3/da active
- 1991-12-03 AT AT91403263T patent/ATE143592T1/de not_active IP Right Cessation
- 1991-12-03 EP EP91403263A patent/EP0489640B1/fr not_active Expired - Lifetime
- 1991-12-03 IE IE419591A patent/IE76322B1/en not_active IP Right Cessation
- 1991-12-03 DE DE69122480T patent/DE69122480T2/de not_active Expired - Lifetime
- 1991-12-04 MX MX9102365A patent/MX9102365A/es unknown
- 1991-12-04 CA CA002056906A patent/CA2056906C/en not_active Expired - Lifetime
- 1991-12-04 HU HU913800A patent/HU207793B/hu not_active IP Right Cessation
- 1991-12-04 JP JP3320532A patent/JP2610735B2/ja not_active Expired - Lifetime
- 1991-12-04 US US07/804,580 patent/US5270341A/en not_active Expired - Lifetime
- 1991-12-04 AU AU88395/91A patent/AU653968B2/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| EP0489640B1 (fr) | 1996-10-02 |
| DE69122480T2 (de) | 1997-04-24 |
| JPH0525040A (ja) | 1993-02-02 |
| HUT59595A (en) | 1992-06-29 |
| JP2610735B2 (ja) | 1997-05-14 |
| SG47450A1 (en) | 1998-04-17 |
| US5270341A (en) | 1993-12-14 |
| CA2056906A1 (en) | 1992-06-05 |
| DK0489640T3 (da) | 1997-02-17 |
| FR2669821B1 (https=) | 1994-12-09 |
| IE914195A1 (en) | 1992-06-17 |
| AU653968B2 (en) | 1994-10-20 |
| HU207793B (en) | 1993-06-28 |
| DE69122480D1 (de) | 1996-11-07 |
| EP0489640A1 (fr) | 1992-06-10 |
| FR2669821A1 (fr) | 1992-06-05 |
| AU8839591A (en) | 1992-06-11 |
| CA2056906C (en) | 1998-04-28 |
| HU913800D0 (en) | 1992-02-28 |
| ATE143592T1 (de) | 1996-10-15 |
| MX9102365A (es) | 1992-09-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK9A | Patent expired |