IE56572B1 - Process for the manufacture of optically uniform 2-azetidinone derivatives - Google Patents

Process for the manufacture of optically uniform 2-azetidinone derivatives

Info

Publication number
IE56572B1
IE56572B1 IE114/84A IE11484A IE56572B1 IE 56572 B1 IE56572 B1 IE 56572B1 IE 114/84 A IE114/84 A IE 114/84A IE 11484 A IE11484 A IE 11484A IE 56572 B1 IE56572 B1 IE 56572B1
Authority
IE
Ireland
Prior art keywords
signifies
general formula
optically uniform
formula see
manufacture
Prior art date
Application number
IE114/84A
Other versions
IE840114L (en
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of IE840114L publication Critical patent/IE840114L/en
Publication of IE56572B1 publication Critical patent/IE56572B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

1. A process for the manufacture of optically uniform beta -lactams of the general formula see diagramm : EP0116854,P10,F1 wherein R**1 signifies lower alkanoyl, lower alkoxycarbonyl or benzoyl, R**2 signifies hydrogen, lower alkyl, lower alkanoyl, lower alkoxycarbonyl or cyano, R**3 signifies hydrogen or lower alkyl, B signifies lower alkylidene, lower cycloalkylidene or carbonyl and Z signifies lower 2-alkenyl or 2,4-di(lower alkoxy)benzyl, whereby the residues denoted as lower have a maximum of 7 carbon atoms, and their corresponding optical antipodes, characterized by reacting a salt of a carboxylic acid of the general formula see diagramm : EP0116854,P10,F2 wherein R**1, R**3 have the above significance, in the presence of a reactive derivative of an organic sulphonic acid and a base with an optically uniform compound of the general formula see diagramm : EP0116854,P11,F3 wherein B and Z have the above significance, or the optical antipode thereof.
IE114/84A 1983-01-20 1984-01-19 Process for the manufacture of optically uniform 2-azetidinone derivatives IE56572B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH32083 1983-01-20

Publications (2)

Publication Number Publication Date
IE840114L IE840114L (en) 1984-07-20
IE56572B1 true IE56572B1 (en) 1991-09-11

Family

ID=4184333

Family Applications (1)

Application Number Title Priority Date Filing Date
IE114/84A IE56572B1 (en) 1983-01-20 1984-01-19 Process for the manufacture of optically uniform 2-azetidinone derivatives

Country Status (13)

Country Link
EP (1) EP0116854B1 (en)
JP (1) JPS59137479A (en)
KR (1) KR840007230A (en)
AT (1) ATE37879T1 (en)
AU (1) AU566914B2 (en)
CA (1) CA1251454A (en)
DE (1) DE3474549D1 (en)
DK (1) DK24084A (en)
IE (1) IE56572B1 (en)
IL (1) IL70685A (en)
NZ (1) NZ206831A (en)
PH (1) PH19214A (en)
ZA (1) ZA84292B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK36784A (en) * 1983-02-25 1984-08-26 Hoffmann La Roche PROCEDURE FOR PREPARING CHIRAL ALDEHYDES
DK411384A (en) * 1983-10-03 1985-04-04 Hoffmann La Roche PROCEDURE FOR THE PREPARATION OF AZETIDINE UNDIVERIVES
US5138050A (en) * 1988-06-30 1992-08-11 Merck & Co., Inc. 6-amido-1-methyl carbapenems
US5395931A (en) * 1988-06-30 1995-03-07 Merck & Co., Inc. 6-amido-1-methyl-2-(substituted-thio)carbapenems

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1262128A (en) * 1981-08-27 1989-10-03 Christian N. Hubschwerlen .beta.-lactams
DE3372768D1 (en) * 1982-06-03 1987-09-03 Hoffmann La Roche 1-SULFO-2-OXOAZETIDINE DERIVATIVES
CA1204746A (en) * 1982-08-19 1986-05-20 Hoffmann-La Roche Limited .beta. LACTAMS
DK36784A (en) * 1983-02-25 1984-08-26 Hoffmann La Roche PROCEDURE FOR PREPARING CHIRAL ALDEHYDES

Also Published As

Publication number Publication date
CA1251454A (en) 1989-03-21
PH19214A (en) 1986-02-04
DK24084D0 (en) 1984-01-19
KR840007230A (en) 1984-12-06
EP0116854A3 (en) 1984-12-05
ATE37879T1 (en) 1988-10-15
IE840114L (en) 1984-07-20
EP0116854B1 (en) 1988-10-12
DE3474549D1 (en) 1988-11-17
ZA84292B (en) 1984-09-26
IL70685A0 (en) 1984-04-30
NZ206831A (en) 1987-04-30
AU566914B2 (en) 1987-11-05
DK24084A (en) 1984-07-21
EP0116854A2 (en) 1984-08-29
AU2328884A (en) 1984-07-26
IL70685A (en) 1988-09-30
JPS59137479A (en) 1984-08-07

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